I. Tavares

发表

Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

Sara M. Santos, M. Castanho, E. Bardaji, 2016, Front. Aging Neurosci..

Correlation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: Involvement of spino-medullary and intra-medullary connections

D. Lima, I. Tavares, M. Pinto, 2006, Neuroscience Letters.

Imbalance between the expression of NK1 and GABAB receptors in nociceptive spinal neurons during secondary hyperalgesia: A c-fos study in the monoarthritic rat

D. Lima, I. Tavares, M. Pinto, 2005, Neuroscience.

Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: The preventive action of IGF1

I. Tavares, C. Morgado, Liliana Silva, 2011, Neurobiology of Disease.

Descending control of nociception: Specificity, recruitment and plasticity

M. Heinricher, B. Lumb, I. Tavares, 2009, Brain Research Reviews.

Pain Modulation from the Locus Coeruleus in a Model of Hydrocephalus: Searching for Oxidative Stress-Induced Noradrenergic Neuroprotection

I. Tavares, R. Vaz, Marta Louçano, 2022, International journal of molecular sciences.

Pain modulation from the brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla

D. Martins, I. Tavares, Marta Silva, 2016, Neurobiology of Disease.

Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems? Pain modulation in the hypertensive-monoarthritic rat.

D. Pinho, M. Morato, J. Marques-Lopes, 2011, The journal of pain : official journal of the American Pain Society.

Lesions of the caudal ventrolateral medulla block the hypertension‐induced inhibition of noxious‐evoked c‐fos expression in the rat spinal cord

D. Lima, A. Albino-Teixeira, I. Tavares, 1997, European journal of pain.

GABA decreases in the spinal cord dorsal horn after peripheral neurectomy

I. Tavares, A. Coimbra, J. Castro-Lopes, 1993, Brain Research.

Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

M. Castanho, E. Bardaji, M. Heras, 2011, British journal of pharmacology.

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation.

M. Castanho, E. Bardaji, M. Lopes-Ferreira, 2016, ACS chemical neuroscience.

Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer’s Disease Patients: Potential Diagnostic and Pharmacological Implications

J. Cocho, Sara M. Santos, M. Castanho, 2013, Front. Aging Neurosci..

Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: The role of spinal 5‐HT3 receptors

I. Tavares, P. Serrão, J. T. Costa-Pereira, 2020, The European journal of neuroscience.

Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia‐induced changes in the expression of the potassium chloride co‐transporter 2 (KCC2) at the spinal cord

I. Tavares, C. Morgado, P. Pereira-Terra, 2011, Diabetes, obesity & metabolism.

Effects of prolonged ingestion of epigallocatechin gallate on diabetes type 1-induced vascular modifications in the erectile tissue of rats

I. Tavares, C. Morgado, C. Lombo, 2016, International Journal of Impotence Research.

Nociceptive spinal cord neurons of laminae I–III exhibit oxidative stress damage during diabetic neuropathy which is prevented by early antioxidant treatment with epigallocatechin-gallate (EGCG)

I. Tavares, C. Morgado, P. Pereira-Terra, 2015, Brain Research Bulletin.

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Samira G. Ferreira, A. Köfalvi, R. Cunha, 2020, Brain Research Bulletin.

Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine

P. Goadsby, P. Holland, I. Tavares, 2022, Cephalalgia : an international journal of headache.

Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia.

Marco M. Domingues, M. Castanho, E. Bardaji, 2011, Molecular pharmaceutics.

Neuroimaging uncovers neuronal and metabolic changes in pain modulatory brain areas in a rat model of chemotherapy-induced neuropathy – MEMRI and ex vivo spectroscopy studies

P. López-Larrubia, I. Tavares, M. Guillén, 2022, Brain Research Bulletin.

RETRACTED: Inhibition of spinal 5-HT3R reverted diabetes-induced mechanical hypersensitivity in a GABAAR-mediated neurotransmission-dependent manner

D. Martins, I. Tavares, C. Morgado, 2015, Neuroscience.

Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs

Sara M. Santos, M. Castanho, E. Bardaji, 2013, Amino Acids.

C‐fos expression at the spinal dorsal horn of streptozotocin‐induced diabetic rats

I. Tavares, C. Morgado, 2007, Diabetes/metabolism research and reviews.

Neuroimaging uncovers neuronal and metabolic changes in pain modulatory brain areas in a rat model of chemotherapy-induced neuropathy – MEMRI and ex vivo spectroscopy studies

P. López-Larrubia, I. Tavares, M. Guillén, 2022, Brain Research Bulletin.

Neuroendocrine signaling modulates specific neural networks relevant to migraine

P. Goadsby, P. Holland, I. Tavares, 2017, Neurobiology of Disease.

Increase in GABAergic Cells and GABA Levels in the Spinal Cord in Unilateral Inflammation of the Hindlimb in the Rat

T. Tölle, A. Coito, I. Tavares, 1992, The European journal of neuroscience.

Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats

T. Sousa, D. Pinho, M. Morato, 2006, Brain Research.

Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: Effects of gabapentin

I. Tavares, C. Morgado, Patrícia Daniela Pereira Terra, 2010, European journal of pain.

Diabetes affects the expression of GABA and potassium chloride cotransporter in the spinal cord: A study in streptozotocin diabetic rats

I. Tavares, F. Pinto-Ribeiro, C. Morgado, 2008, Neuroscience Letters.

Dynamic of migration of HSV‐1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene

D. Lima, I. Tavares, M. Pinto, 2008, The European journal of neuroscience.

Brain afferents to the medullary dorsal reticular nucleus: a retrograde and anterograde tracing study in the rat

D. Lima, I. Tavares, Á. Cobos, 2002, The European journal of neuroscience.

Brain afferents to the lateral caudal ventrolateral medulla: a retrograde and anterograde tracing study in the rat

D. Lima, I. Tavares, A. Almeida, 2003, Neuroscience.

The Caudal Medullary Ventrolateral Reticular Formation in Nociceptive‐Cardiovascular Integration. An Experimental Study in the Rat

D. Lima, A. Albino-Teixeira, I. Tavares, 2002, Experimental physiology.

The ventrolateral medulla of the rat is connected with the spinal cord dorsal horn by an indirect descending pathway relayed in the A5 noradrenergic cell group

D. Lima, I. Tavares, A. Coimbra, 1996, The Journal of comparative neurology.

Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain

J. Fadel, D. Lima, I. Tavares, 2010, PAIN.

Neuropathic Pain Induced Alterations in the Opioidergic Modulation of a Descending Pain Facilitatory Area of the Brain

I. Tavares, G. Flik, I. Martins, 2019, Front. Cell. Neurosci..

Inhibition of nociceptive responses of spinal cord neurones during hypertension involves the spinal GABAergic system and a pain modulatory center located at the caudal ventrolateral medulla

T. Sousa, D. Pinho, M. Morato, 2006, Journal of neuroscience research.

Was it something I ate? Understanding the bidirectional interaction of migraine and appetite neural circuits

P. Goadsby, I. Tavares, M. Martins-Oliveira, 2021, Brain Research.

Monoaminergic and Opioidergic Modulation of Brainstem Circuits: New Insights Into the Clinical Challenges of Pain Treatment?

I. Tavares, I. Martins, J. T. Costa-Pereira, 2021, Frontiers in Pain Research.

Shift of µ-opioid Receptor Signaling in the Dorsal Reticular Nucleus Is Implicated in Morphine-induced Hyperalgesia in Male Rats

A. Teixeira-Pinto, I. Tavares, I. Martins, 2020, Anesthesiology.

Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy

V. Marzo, D. Martins, I. Tavares, 2016, Neuropharmacology.

The caudal ventrolateral medulla as an important inhibitory modulator of pain transmission in the spinal cord.

D. Lima, I. Tavares, 2002, The journal of pain : official journal of the American Pain Society.

Projection sites of superficial and deep spinal dorsal horn cells in the nucleus tractus solitarii of the rat

T. Batten, D. Lima, I. Tavares, 2001, Brain Research.

Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia

D. Pinho, M. Morato, J. Marques-Lopes, 2009, Neuroscience.

Is the Pathway Connecting the Caudal Ventrolateral Medulla with the Dorsal Horn of the Spinal Cord of the Rat Noradrenergic?

I. Tavares, A. Coimbra, D. Lima, 1993, Regional Anesthesia & Pain Medicine.

α‐Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats

I. Tavares, C. Morgado, P. Pereira-Terra, 2011, Diabetes, obesity & metabolism.

Decrease in the expression of N‐methyl‐D‐aspartate receptors in the nucleus tractus solitarii induces antinociception and increases blood pressure

D. Pinho, M. Morato, J. Marques-Lopes, 2012, Journal of neuroscience research.

Increased Noradrenergic Neurotransmission to a Pain Facilitatory Area of the Brain Is Implicated in Facilitation of Chronic Pain

B. Westerink, A. Teixeira-Pinto, I. Tavares, 2015, Anesthesiology.

Noradrenaline increases pain facilitation from the brain during inflammatory pain

A. Teixeira-Pinto, J. Fadel, I. Tavares, 2013, Neuropharmacology.

Tract Tracing Methods at the Ultrastructural Level

D. Lima, I. Tavares, Deolinda Lima, 2002 .

“Hotheaded”: The role OF TRPV1 in brain functions

D. Martins, I. Tavares, C. Morgado, 2014, Neuropharmacology.

Opioids modulate pain facilitation from the dorsal reticular nucleus

D. Lima, I. Tavares, M. Pinto, 2008, Molecular and Cellular Neuroscience.

Reciprocal connections between the medullary dorsal reticular nucleus and the spinal dorsal horn in the rat

D. Lima, I. Tavares, A. Almeida, 2000, European journal of pain.

Descending projections from the medullary dorsal reticular nucleus make synaptic contacts with spinal cord lamina I cells projecting to that nucleus: An electron microscopic tracer study in the rat

D. Lima, I. Tavares, A. Coimbra, 1993, Neuroscience.

Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y1 receptor: implications for migraine

P. Goadsby, I. Tavares, S. Akerman, 2016, Pain.

Role of Spinal Cord α2-Adrenoreceptors in Noradrenergic Inhibition of Nociceptive Transmission During Chemotherapy-Induced Peripheral Neuropathy

I. Tavares, I. Martins, J. T. Costa-Pereira, 2020, Frontiers in Neuroscience.

Pronociceptive changes in the activity of rostroventromedial medulla (RVM) pain modulatory cells in the streptozotocin-diabetic rat

A. Almeida, I. Tavares, D. Amorim, 2013, Brain Research Bulletin.

Reticular Formation and Pain: The Past and the Future

Isabel Martins, I. Tavares, Isaura Tavares, 2017, Front. Neuroanat..

TRPV1 in pain control from the brain

D. Martins, I. Tavares, Marta Silva, 2016, Oncotarget.

From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system

D. Lima, I. Tavares, 2007, Journal of anatomy.

The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A5 noradrenergic cell group

D. Pinho, J. Marques-Lopes, A. Albino-Teixeira, 2010, Brain Research.

Noxious‐evoked c‐fos expression in brainstem neurons immunoreactive for GABAB, µ‐opioid and NK‐1 receptors

D. Lima, I. Tavares, M. Pinto, 2003, The European journal of neuroscience.

Can the dopaminergic‐related effects of general anesthetics be linked to mechanisms involved in drug abuse and addiction?

J. Pêgo, I. Tavares, N. Sousa, 2015, Acta anaesthesiologica Scandinavica.

Gene Therapy for Chronic Pain Management

I. Tavares, I. Martins, 2013 .

Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment

T. Tölle, I. Tavares, A. Coimbra, 1994, Pain.

Medullary control of nociceptive transmission: Reciprocal dual communication with the spinal cord

H. Leite-Almeida, A. Almeida, I. Tavares, 2006 .

Chronic Pain After Spinal Cord Injury: Is There a Role for Neuron-Immune Dysregulation?

I. Tavares, C. Cruz, S. Chambel, 2020, Frontiers in Physiology.

Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives

M. Castanho, Antónia R. T. Pinto, V. Ramu, 2015, Biopolymers.

Neurons in the superficial dorsal horn of the rat spinal cord projecting to the medullary ventrolateral reticular formation express c-fos after noxious stimulation of the skin

D. Lima, I. Tavares, A. Coimbra, 1993, Brain Research.

Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: A behavior and c-fos study

D. Lima, I. Tavares, M. Pinto, 2006, Neuroscience.

Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: A c-fos study in acute and chronic articular inflammation

D. Lima, I. Tavares, M. Pinto, 2007, Neuroscience.

Descending projections from the caudal medulla oblongata to the superficial or deep dorsal horn of the rat spinal cord

D. Lima, I. Tavares, 2004, Experimental Brain Research.

Participation of μ‐opioid, GABAB, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission

D. Lima, I. Tavares, M. Pinto, 2008, The Journal of comparative neurology.

Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?

I. Tavares, I. Martins, 2015 .

How do opioids control pain circuits in the brainstem during opioid-induced disorders and in chronic pain? Implications for the treatment of chronic pain.

I. Tavares, I. Martins, A. Costa, 2023, Pain.

Mu-opioid receptor signalling switch to excitatory following chronic morphine persists upon treatment cessation

I. Tavares, I. Martins, A. Costa, 2019, Frontiers in Cellular Neuroscience.

Nociceptive spinal neurons expressing NK1 and GABAB receptors are located in lamina I

D. Lima, I. Tavares, M. Pinto, 2004, Brain Research.

GABA acting on GABAB receptors located in a medullary pain facilitatory area enhances nociceptive behaviors evoked by intraplantar formalin injection

B. Westerink, A. Teixeira-Pinto, I. Tavares, 2015, Pain.

Reversal of inflammatory pain by HSV‐1‐mediated overexpression of enkephalin in the caudal ventrolateral medulla

D. Lima, I. Tavares, I. Martins, 2011, European journal of pain.

Increased Noradrenergic Neurotransmission to a Pain Facilitatory Area of the Brain Is Implicated in Facilitation of Chronic Pain

B. Westerink, A. Teixeira-Pinto, I. Tavares, 2015, Anesthesiology.

Differential expression of NK1 and GABAB receptors in spinal neurones projecting to antinociceptive or pronociceptive medullary centres

D. Lima, I. Tavares, A. R. Castro, 2006, Brain Research Bulletin.

Projection sites of superficial or deep dorsal horn in the dorsal reticular nucleus.

D. Lima, I. Tavares, A Almeida, 1995, Neuroreport.

Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives

M. Castanho, E. Bardaji, Antónia R. T. Pinto, 2015, Biopolymers.

Improvement of the pharmacological properties of amidated kyotorphin by means of iodination

J. Correia, M. Castanho, E. Bardaji, 2016 .

Human neural stem cell transplantation in spinal cord injury models: how far from clinical application?

I. Tavares, 2013, Stem Cell Research & Therapy.