G. Zhanel

发表

Trends in antibiotic resistance over time among pathogens from Canadian hospitals: results of the CANWARD study 2007-11.

M. Mulvey, J. Blondeau, D. Low, 2013, The Journal of antimicrobial chemotherapy.

Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents.

G. Zhanel, Ronald Domalaon, F. Schweizer, 2016, Current topics in medicinal chemistry.

In vitro interactions of anidulafungin with azole antifungals, amphotericin B and 5-fluorocytosine against Candida species.

J. Karlowsky, D. Hoban, B. Goldstein, 2006, International journal of antimicrobial agents.

Fluoroquinolone-Resistant Urinary Isolates of Escherichia coli from Outpatients Are Frequently Multidrug Resistant: Results from the North American Urinary Tract Infection Collaborative Alliance-Quinolone Resistance Study

J. Karlowsky, D. Hoban, G. Zhanel, 2006, Antimicrobial Agents and Chemotherapy.

Activity of NXL104 in Combination with β-Lactams against Genetically Characterized Escherichia coli and Klebsiella pneumoniae Isolates Producing Class A Extended-Spectrum β-Lactamases and Class C β-Lactamases

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2011, Antimicrobial Agents and Chemotherapy.

Streptococcus pneumoniae: Does Antimicrobial Resistance Matter?

J. Lynch, G. Zhanel, George Zhanel2, 2009, Seminars in respiratory and critical care medicine.

Changes in fluoroquinolone resistance over 5 years (CANWARD 2007-11) in bacterial pathogens isolated in Canadian hospitals.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, The Journal of antimicrobial chemotherapy.

Antimicrobial Resistance in Urinary Tract Pathogens in Canada from 2007 to 2009: CANWARD Surveillance Study

Patricia J. Simner, J. Karlowsky, D. Hoban, 2011, Antimicrobial Agents and Chemotherapy.

Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA).

D. Low, J. Karlowsky, D. Hoban, 2006, International journal of antimicrobial agents.

Antibiotic resistance in outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA).

L. Nicolle, G. Harding, D. Hoban, 2005, International journal of antimicrobial agents.

Predictors of receipt of a fluoroquinolone versus trimethoprim‐sulfamethoxazole for treatment of acute pyelonephritis in women in Manitoba, Canada

C. Metge, G. Harding, G. Zhanel, 2004, Pharmacoepidemiology and drug safety.

Use of administrative healthcare claims to examine the effectiveness of trimethoprim-sulfamethoxazole versus fluoroquinolones in the treatment of community-acquired acute pyelonephritis in women.

C. Metge, G. Harding, G. Zhanel, 2004, The Journal of antimicrobial chemotherapy.

A Canadian National Surveillance Study of Urinary Tract Isolates from Outpatients: Comparison of the Activities of Trimethoprim-Sulfamethoxazole, Ampicillin, Mecillinam, Nitrofurantoin, and Ciprofloxacin

T. Mazzulli, D. Low, G. Harding, 2000, Antimicrobial Agents and Chemotherapy.

Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis

J. Karlowsky, A. Walkty, G. Zhanel, 2016, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

The ketolides: a critical review.

S. Douthwaite, D. Hoban, A. Noreddin, 2002, Drugs.

The glycylcyclines: a comparative review with the tetracyclines.

J. Karlowsky, D. Hoban, A. Noreddin, 2004, Drugs.

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2016, Drugs.

Comparative pharmacodynamics of garenoxacin, gemifloxacin, and moxifloxacin in community-acquired pneumonia caused by Streptococcus pneumoniae: a Monte Carlo simulation analysis.

D. Hoban, A. Noreddin, G. Zhanel, 2007, Clinical therapeutics.

Comparison of gatifloxacin and levofloxacin administered at various dosing regimens to hospitalised patients with community-acquired pneumonia: pharmacodynamic target attainment study using North American surveillance data for Streptococcus pneumoniae.

D. Hoban, A. Noreddin, G. Zhanel, 2005, International journal of antimicrobial agents.

Pharmacodynamic target attainment analysis against Streptococcus pneumoniae using levofloxacin 500 mg, 750 mg and 1000 mg once daily in plasma (P) and epithelial lining fluid (ELF) of hospitalized patients with community acquired pneumonia (CAP).

D. Hoban, A. Noreddin, G. Zhanel, 2004, International journal of antimicrobial agents.

Dual activity of fluoroquinolones against Streptococcus pneumoniae: the facts behind the claims.

D. Hoban, K. Nichol, G. Zhanel, 2002, The Journal of antimicrobial chemotherapy.

Streptococcus pneumoniae: Epidemiology, Risk Factors, and Strategies for Prevention

J. Lynch, G. Zhanel, George Zhanel2, 2009, Seminars in respiratory and critical care medicine.

Antibacterial Activity of Ultrashort Cationic Lipo-β-Peptides

G. Zhanel, F. Schweizer, G. N. Serrano, 2009, Antimicrobial Agents and Chemotherapy.

AFN-1252, a FabI Inhibitor, Demonstrates a Staphylococcus-Specific Spectrum of Activity

N. Kaplan, J. Karlowsky, D. Hoban, 2009, Antimicrobial Agents and Chemotherapy.

In Vitro Activity of API-1252, a Novel FabI Inhibitor, against Clinical Isolates of Staphylococcus aureus and Staphylococcus epidermidis

N. Kaplan, J. Karlowsky, D. Hoban, 2007, Antimicrobial Agents and Chemotherapy.

Asymptomatic bacteriuria. Which patients should be treated?

D. Guay, G. Harding, G. Zhanel, 1990, Archives of internal medicine.

Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.

Xuan Yang, Y. Lyu, A. Shan, 2017, Journal of medicinal chemistry.

Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin

J. Karlowsky, D. Hoban, H. Adam, 2012, Expert review of anti-infective therapy.

Review of Macrolides and Ketolides

J. Karlowsky, D. Hoban, G. Zhanel, 2012, Drugs.

Clinical implications of macrolide resistance in community-acquired respiratory tract infections

D. Hoban, G. Zhanel, 2006, Expert review of anti-infective therapy.

Expression of the mef(E) Gene Encoding the Macrolide Efflux Pump Protein Increases in Streptococcus pneumoniae with Increasing Resistance to Macrolides

M. Mulvey, D. Boyd, D. Hoban, 2005, Antimicrobial Agents and Chemotherapy.

Macrolide-Resistant Streptococcus pneumoniae in Canada during 1998–1999: Prevalence ofmef(A) and erm(B) and Susceptibilities to Ketolides

D. Hoban, K. Nichol, G. Zhanel, 2001, Antimicrobial Agents and Chemotherapy.

Antimicrobial Resistance : Endgame for Antibiotics ?

G. Zhanel, A. Gin, 2002 .

Risk versus Benefit of Using Hydroxychloroquine to Treat Patients with COVID-19

J. Karlowsky, G. Zhanel, Kevin F. Boreskie, 2021, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Aminoglycoside Adaptive Resistance

J. Karlowsky, G. Zhanel, S. Zelenitsky, 1997, Pharmacotherapy.

Overview of Seizure-Inducing Potential of Doripenem

N. Ketter, G. Zhanel, R. Redman, 2009, Drug safety.

Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects.

L. Mandell, G. Zhanel, A. Simor, 1998, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

A review of clinical failures associated with macrolide-resistant Streptococcus pneumoniae.

W. Bishai, J. Conly, D. Hoban, 2004, International journal of antimicrobial agents.

Epidemic Clonal Groups of Escherichia coli as a Cause of Antimicrobial-Resistant Urinary Tract Infections in Canada, 2002 to 2004

M. Kuskowski, James R. Johnson, K. Nichol, 2009, Antimicrobial Agents and Chemotherapy.

Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results from CANWARD 2007.

M. Mulvey, J. Karlowsky, D. Hoban, 2009 .

ESBL genotypes in fluoroquinolone-resistant and fluoroquinolone-susceptible ESBL-producing Escherichia coli urinary isolates in Manitoba.

M. Mulvey, L. Nicolle, M. Alfa, 2007, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

J. Karlowsky, D. Hoban, K. Nichol, 2007, Diagnostic microbiology and infectious disease.

In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone, against 2,440 Clinical Isolates

D. Hoban, H. Adam, G. Zhanel, 2009, Antimicrobial Agents and Chemotherapy.

Stability of Fluoroquinolone Resistance in Streptococcus pneumoniae Clinical Isolates and Laboratory-Derived Mutants

D. Hoban, K. Nichol, G. Zhanel, 2005, Antimicrobial Agents and Chemotherapy.

Designing Fluoroquinolone Breakpoints for Streptococcus pneumoniae by Using Genetics instead of Pharmacokinetics-Pharmacodynamics

H. J. Smith, C. Hoban, D. Hoban, 2004, Antimicrobial Agents and Chemotherapy.

Presence of the narrow-spectrum OXA-1 β-lactamase enzyme is associated with elevated piperacillin/tazobactam MIC values among ESBL-producing Escherichia coli clinical isolates (CANWARD, 2007–18)

M. Mulvey, J. Karlowsky, P. Lagacé-Wiens, 2022, JAC-antimicrobial resistance.

Activity of cefepime/taniborbactam and comparators against whole genome sequenced ertapenem-non-susceptible Enterobacterales clinical isolates: CANWARD 2007–19

M. Mulvey, Denice C. Bay, J. Karlowsky, 2022, JAC-antimicrobial resistance.

Use of Fosfomycin Etest To Determine In Vitro Susceptibility of Clinical Isolates of Enterobacterales Other than Escherichia coli, Nonfermenting Gram-Negative Bacilli, and Gram-Positive Cocci

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2021, Journal of clinical microbiology.

A Dimer, but Not Monomer, of Tobramycin Potentiates Ceftolozane against Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa and Delays Resistance Development

G. Zhanel, F. Schweizer, T. Idowu, 2020, Antimicrobial Agents and Chemotherapy.

Susceptibility of Clinical Isolates of Escherichia coli to Fosfomycin as Measured by Four In Vitro Testing Methods

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2020, Journal of Clinical Microbiology.

Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria

G. Zhanel, Ronald Domalaon, F. Schweizer, 2019, Front. Microbiol..

Heterodimeric Rifampicin-Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model.

G. Zhanel, F. Schweizer, G. Arthur, 2019, European journal of medicinal chemistry.

The Anthelmintic Drug Niclosamide Synergizes with Colistin and Reverses Colistin Resistance in Gram-Negative Bacilli

G. Zhanel, Ronald Domalaon, F. Schweizer, 2019, Antimicrobial Agents and Chemotherapy.

Tobramycin-Linked Efflux Pump Inhibitor Conjugates Synergize Fluoroquinolones, Rifampicin and Fosfomycin against Multidrug-Resistant Pseudomonas aeruginosa

Xuan Yang, Y. Lyu, G. Zhanel, 2018, Journal of clinical medicine.

In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study

J. Karlowsky, H. Adam, M. Baxter, 2018, Antimicrobial Agents and Chemotherapy.

Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa

Y. Lyu, Yaroslav Sanchak, G. Zhanel, 2018, Antimicrobial Agents and Chemotherapy.

Review of macrolides and ketolides: focus on respiratory tract infections.

J. Karlowsky, D. Hoban, G. Zhanel, 2001, Drugs.

In Vitro Antimicrobial Susceptibilities of Streptococcus pneumoniae Clinical Isolates Obtained in Canada in 2002

O. Vanderkooi, D. Church, T. Mazzulli, 2004, Antimicrobial Agents and Chemotherapy.

Ribosomal resistance: Emerging problems and potential solutions

J. Karlowsky, G. Zhanel, 1999, Current infectious disease reports.

Activity of Dapsone versus Community and Hospital Pathogens from the CANWARD Study.

G. Zhanel, J. D. Del Rosso, 2016, ˜The œJournal of clinical and aesthetic dermatology.

Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery.

R. Ariano, G. Zhanel, J. Lipman, 2016, The Journal of antimicrobial chemotherapy.

Mature Pseudomonas aeruginosa Biofilms Prevail Compared to Young Biofilms in the Presence of Ceftazidime

T. Ball, G. Zhanel, Laura L. Bowler, 2012, Antimicrobial Agents and Chemotherapy.

A Critical Review of the Fluoroquinolones

D. Hoban, A. Walkty, G. Zhanel, 2002, Drugs.

Modulation of the Local Neutrophil Response by a Novel Hyaluronic Acid-Binding Peptide Reduces Bacterial Burden during Staphylococcal Wound Infection

G. Zhanel, Jerry C. Lee, R. McLoughlin, 2010, Infection and Immunity.

Molecular Epidemiology of Penicillin-Resistant and Ciprofloxacin-Resistant Streptococcus pneumoniae in Canada

D. Hoban, K. Nichol, G. Zhanel, 2003, Antimicrobial Agents and Chemotherapy.

Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity.

G. Zhanel, F. Schweizer, Smritilekha Bera, 2010, Journal of medicinal chemistry.

Community Acquired Pneumonia (CAP): An Update

Z. Memish, G. Zhanel, A. Shibl, 2001, Journal of chemotherapy.

Amphiphilic tobramycins with immunomodulatory properties.

Xuan Yang, N. Mookherjee, G. Zhanel, 2015, Angewandte Chemie.

Structure–activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity

Xuan Yang, N. Mookherjee, G. Zhanel, 2014, Amino Acids.

Microbiology and Preclinical Review of Omadacycline

J. Karlowsky, G. Zhanel, J. Steenbergen, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Tigecycline: a novel glycylcycline antibiotic

J. Karlowsky, D. Hoban, G. Zhanel, 2006, Expert review of anti-infective therapy.

Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against MDR and XDR Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates.

G. Zhanel, F. Schweizer, G. Arthur, 2019, The Journal of antimicrobial chemotherapy.

A critical review of the fluoroquinolones: focus on respiratory infections.

D. Hoban, A. Walkty, G. Zhanel, 2002, Drugs.

Characterization of the inoculum effect with Haemophilus influenzae and beta-lactams.

J. Karlowsky, D. Hoban, G. Zhanel, 1999, Diagnostic microbiology and infectious disease.

Pharmacodynamic activity of telithromycin against macrolide-susceptible and macrolide-resistant Streptococcus pneumoniae simulating clinically achievable free serum and epithelial lining fluid concentrations.

D. Hoban, A. Noreddin, G. Zhanel, 2004, The Journal of antimicrobial chemotherapy.

Antimicrobial Resistance in Respiratory Tract Streptococcus pneumoniae Isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002

D. Low, D. Hoban, K. Nichol, 2003, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations.

D. Hoban, A. Noreddin, K. Nichol, 2003, The Journal of antimicrobial chemotherapy.

Pharmacodynamic Modeling of Clarithromycin against Macrolide-Resistant [PCR-Positive mef(A) or erm(B)] Streptococcus pneumoniae Simulating Clinically Achievable Serum and Epithelial Lining Fluid Free-Drug Concentrations

D. Hoban, A. Noreddin, K. Nichol, 2002, Antimicrobial Agents and Chemotherapy.

The new fluoroquinolones: A critical review.

J. Karlowsky, D. Hoban, A. Walkty, 1999, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Association between fluoroquinolone usage and a dramatic rise in ciprofloxacin-resistant Streptococcus pneumoniae in Canada, 1997-2006.

D. Hoban, H. Adam, G. Zhanel, 2009, International journal of antimicrobial agents.

Scissors: A Potential Source of Nosocomial Infection

D. Hoban, G. Zhanel, J. Embil, 2002, Infection Control & Hospital Epidemiology.

Comparative Analysis of Outer Membrane Vesicle Isolation Methods With an Escherichia coli tolA Mutant Reveals a Hypervesiculating Phenotype With Outer-Inner Membrane Vesicle Content

Patrick M. Chong, D. Beniac, T. Booth, 2021, Frontiers in Microbiology.

Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, The Journal of antimicrobial chemotherapy.

In Vitro Activity of Ceftaroline against Gram-Positive and Gram-Negative Pathogens Isolated from Patients in Canadian Hospitals in 2009

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2011, Antimicrobial Agents and Chemotherapy.

Fluoroquinolone-associated tendinopathy: a critical review of the literature.

G. Zhanel, Y. Khaliq, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparison of antimicrobial resistance patterns in Streptococcus pneumoniae from respiratory and blood cultures in Canadian hospitals from 2007-16.

W. Demczuk, I. Martin, M. Mulvey, 2019, The Journal of antimicrobial chemotherapy.

Serotype distribution of invasive Streptococcus pneumoniae in adults 65 years of age and over after the introduction of childhood 13-valent pneumococcal conjugate vaccination programs in Canada, 2010-2016.

P. V. Van Caeseele, W. Demczuk, I. Martin, 2018, Vaccine.

Phylogenetic analysis of emergent Streptococcus pneumoniae serotype 22F causing invasive pneumococcal disease using whole genome sequencing

G. Horsman, P. V. Van Caeseele, W. Demczuk, 2017, PloS one.

Invasive Streptococcus pneumoniae in Canada, 2011-2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F.

H. Adam, G. Zhanel, A. Golden, 2016, Vaccine.

Cephalosporin-Induced Nephrotoxicity: Does it Exist?

G. Zhanel, 1990, DICP : the annals of pharmacotherapy.

Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity.

G. Zhanel, F. Schweizer, Smritilekha Bera, 2008, Journal of medicinal chemistry.

Synthesis of glucose-templated lysine analogs and incorporation into the antimicrobial dipeptide sequence kW-OBn.

G. Zhanel, F. Schweizer, D. Mondal, 2008, Carbohydrate research.

Mecillinam Activity Compared to Ampicillin, Trimethoprim/Sulfamethoxazole, Ciprofloxacin and Nitrofurantoin against Urinary Tract Isolates of Gram-Negative Bacilli

J. Karlowsky, D. Hoban, G. Zhanel, 1998, Chemotherapy.

Low prevalence of gastrointestinal colonization with antimicrobial-resistant bacteria in high risk units in a Canadian tertiary care centre.

L. Nicolle, A. Kabani, G. Zhanel, 1996, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria

G. Zhanel, Ronald Domalaon, F. Schweizer, 2018, Amino Acids.

Vaccine strategies for prevention of community-acquired pneumonia in Canada: Who would benefit most from pneumococcal immunization?

M. Loeb, C. Mody, P. Arsenault, 2019, Canadian family physician Medecin de famille canadien.

Penicillin-Binding Protein 1A, 2B, and 2X Alterations in Canadian Isolates of Penicillin-Resistant Streptococcus pneumoniae

D. Hoban, K. Nichol, G. Zhanel, 2002, Antimicrobial Agents and Chemotherapy.

Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients: the SAVE study, 2011-15.

M. Gilmour, W. Demczuk, I. Martin, 2018, The Journal of antimicrobial chemotherapy.

Increasing Genetic Relatedness of Ciprofloxacin-Resistant Streptococcus pneumoniae Isolated in Canada from 1997 to 2005

J. Karlowsky, D. Hoban, H. Adam, 2008, Antimicrobial Agents and Chemotherapy.

Subinhibitory antimicrobial concentrations: A review of in vitro and in vivo data.

G. Harding, D. Hoban, G. Zhanel, 1992, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Drug, Healthcare and Patient Safety Dovepress Cumulative Clinical Experience from over a Decade of Use of Levofloxacin in Community-acquired Pneumonia: Critical Appraisal and Role in Therapy

W. Elkhatib, A. Noreddin, G. Zhanel, 2022 .

Analysis of multidrug resistance in the predominant Streptococcus pneumoniae serotypes in Canada: the SAVE study, 2011-15.

M. Gilmour, W. Demczuk, I. Martin, 2018, The Journal of antimicrobial chemotherapy.

Levofloxacin for the treatment of community-acquired pneumonia

G. Zhanel, Thomas M. File Jr., J. P. Lynch Iii, 2006, Expert review of anti-infective therapy.

Characterization of Acinetobacter baumannii and meropenem-resistant Pseudomonas aeruginosa in Canada: results of the CANWARD 2007-2009 study.

M. Mulvey, D. Hoban, V. Loo, 2011, Diagnostic microbiology and infectious disease.

In Vitro Activity of Colistin (Polymyxin E) against 3,480 Isolates of Gram-Negative Bacilli Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007-2008

J. Karlowsky, D. Hoban, K. Nichol, 2009, Antimicrobial Agents and Chemotherapy.

Antibiotic Use in a Canadian Province, 1995–1998

C. Metge, G. Zhanel, A. Carrie, 2000, The Annals of pharmacotherapy.

Selection of a gyrA Mutation and Treatment Failure with Gatifloxacin in a Patient with Streptococcus pneumoniae with a Preexisting parC Mutation

J. Jacobi, G. Zhanel, M. Kays, 2007, Pharmacotherapy.

Antimicrobial Resistance in Respiratory Tract Streptococcus pneumoniae Isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002

D. Low, D. Hoban, K. Nichol, 2003, Antimicrobial Agents and Chemotherapy.

Bioequivalence and interchangeability of narrow therapeutic range drugs. Canadian Society for Pharmaceutical Sciences discussion.

R. Tsuyuki, G. Zhanel, S. Alessi-Severini, 1998, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

In vitro pharmacodynamic modelling simulating free serum concentrations of fluoroquinolones against multidrug-resistant Streptococcus pneumoniae.

D. Hoban, G. Zhanel, N. Laing, 2001, The Journal of antimicrobial chemotherapy.

Activity of the ketolide antibacterial telithromycin against typical community-acquired respiratory pathogens.

D. Hoban, G. Zhanel, D. Felmingham, 2001, The Journal of antimicrobial chemotherapy.

Pharmacodynamic activity of ertapenem versus penicillin-susceptible and penicillin-non-susceptible Streptococcus pneumoniae using an in vitro model.

D. Hoban, A. Noreddin, G. Zhanel, 2006, The Journal of antimicrobial chemotherapy.

Ertapenem: review of a new carbapenem

D. Hoban, A. Noreddin, G. Zhanel, 2005, Expert review of anti-infective therapy.

Antimicrobial treatment in diabetic women with asymptomatic bacteriuria.

M. Cheang, L. Nicolle, G. Harding, 2002, The New England journal of medicine.

Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data.

D. Low, J. Karlowsky, G. Zhanel, 2014, The Journal of antimicrobial chemotherapy.

Prevalence of Antimicrobial Resistance in Respiratory Tract Isolates of Streptococcus pneumoniae: Results of a Canadian National Surveillance Study

D. Low, J. Karlowsky, D. Hoban, 1999, Antimicrobial Agents and Chemotherapy.

A Review of New Fluoroquinolones

D. Hoban, A. Noreddin, H. Adam, 2006, Treatments in respiratory medicine.

Comparison of PCV-10 and PCV-13 vaccine coverage for invasive pneumococcal isolates obtained across Canadian geographic regions, SAVE 2011 to 2017.

W. Demczuk, I. Martin, M. Mulvey, 2020, Diagnostic microbiology and infectious disease.

J. Karlowsky, G. Zhanel, Kevin D Wolter, 2015, The Journal of antimicrobial chemotherapy.

Pharmacodynamic Activity of Telithromycin at Simulated Clinically Achievable Free-Drug Concentrations in Serum and Epithelial Lining Fluid against Efflux (mefE)-Producing Macrolide- Resistant Streptococcus pneumoniae for Which Telithromycin MICs Vary

D. Hoban, G. Zhanel, N. Laing, 2005, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and pharmacodynamics of the new fluoroquinolones: focus on respiratory infections.

A. Noreddin, G. Zhanel, 2001, Current opinion in pharmacology.

Ceftazidime-Avibactam: a Novel Cephalosporin/β-lactamase Inhibitor Combination

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, Drugs.

Asymptomatic bacteriuria in patients with diabetes mellitus.

L. Nicolle, G. Harding, G. Harding, 1991, Reviews of infectious diseases.

Candidemia in a Canadian tertiary care hospital from 1976 to 1996.

J. Karlowsky, D. Hoban, A. Kabani, 1997, Diagnostic microbiology and infectious disease.

A short communication article: A Clostridioides difficile surveillance study of Canadian retail meat samples from 2016-2018.

M. Mulvey, Denice C. Bay, G. Zhanel, 2022, Anaerobe.

Antimicrobial susceptibility of Clostridioides difficile isolated from diarrhoeal stool specimens of Canadian patients: summary of results from the Canadian Clostridioides difficile (CAN-DIFF) surveillance study from 2013 to 2017.

J. Karlowsky, H. Adam, M. Baxter, 2020, The Journal of antimicrobial chemotherapy.

PCR ribotyping and antimicrobial susceptibility testing of isolates of Clostridium difficile cultured from toxin-positive diarrheal stools of patients receiving medical care in Canadian hospitals: the Canadian Clostridium difficile Surveillance Study (CAN-DIFF) 2013-2015.

J. Karlowsky, H. Adam, M. Baxter, 2018, Diagnostic microbiology and infectious disease.

Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11.

M. Mulvey, J. Pitout, J. Karlowsky, 2013, The Journal of antimicrobial chemotherapy.

Comparative Review of the Carbapenems

J. Karlowsky, D. Hoban, A. Noreddin, 2012, Drugs.

In Vitro Activity of Ceftazidime Combined with NXL104 versus Pseudomonas aeruginosa Isolates Obtained from Patients in Canadian Hospitals (CANWARD 2009 Study)

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2011, Antimicrobial Agents and Chemotherapy.

Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13.

M. Gilmour, J. Karlowsky, D. Hoban, 2015, The Journal of antimicrobial chemotherapy.

Assessment of multidrug resistance, clonality and virulence in non-PCV-13 Streptococcus pneumoniae serotypes in Canada, 2011-13.

M. Gilmour, W. Demczuk, I. Martin, 2015, The Journal of antimicrobial chemotherapy.

Amphiphilic nebramine-based hybrids Rescue legacy antibiotics from intrinsic resistance in multidrug-resistant Gram-negative bacilli.

Xuan Yang, G. Zhanel, Ronald Domalaon, 2019, European journal of medicinal chemistry.

Horizontal transfer of antibiotic resistance from Enterococcus faecium of fermented meat origin to clinical isolates of E. faecium and Enterococcus faecalis.

R. Holley, R. Sparling, G. Zhanel, 2015, International journal of food microbiology.

Antibacterial Use in Community Practice

G. Zhanel, A. Carrie, 1999, Drugs.

A One Health Genomic Investigation of Gentamicin Resistance in Escherichia coli from Human and Chicken Sources in Canada, 2014 to 2017

E. J. Parmley, A. Bharat, M. Mulvey, 2022, Antimicrobial agents and chemotherapy.

Emergence of antimicrobial resistance among Acinetobacter species: a global threat

J. Lynch, G. Zhanel, N. Clark, 2016, Current opinion in critical care.

In Vitro Susceptibilities of Candida andCryptococcus neoformans Isolates from Blood Cultures of Neutropenic Patients

J. Karlowsky, D. Hoban, G. Zhanel, 1999, Antimicrobial Agents and Chemotherapy.

Piperacillin–tazobactam: a β-lactam/β-lactamase inhibitor combination

J. Karlowsky, A. Walkty, G. Zhanel, 2007 .

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy.

S. McKenna, Soumya Deo, G. Zhanel, 2016, Angewandte Chemie.

Antibiotic activity against urinary tract infection (UTI) isolates of vancomycin-resistant enterococci (VRE): results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS).

D. Hoban, A. Noreddin, K. Nichol, 2003, The Journal of antimicrobial chemotherapy.

Pharmacokinetics and Pharmacodynamics of the New Quinolones

A. Noreddin, G. Zhanel, V. Haynes, 2005 .

Pharmacokinetics and pharmacodynamics (PK/PD) of fluoroquinolones: tools for combating bacteria and preventing resistance

A. Noreddin, G. Zhanel, 2003 .

Homodimeric Tobramycin Adjuvant Repurposes Novobiocin as an Effective Antibacterial Agent against Gram-negative Bacteria.

G. Zhanel, F. Schweizer, Heather Rossong, 2019, Journal of medicinal chemistry.

A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria.

Xuan Yang, Y. Lyu, G. Zhanel, 2017, Journal of medicinal chemistry.

Ceftolozane/Tazobactam: A Novel Cephalosporin/b-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli George G. ZhanelPhillip ChungHeather AdamSheryl ZelenitskyAndrew Denisuik • Frank SchweizerPhilippe R. S. Lagace ´-WiensEthan RubinsteinAlfred S. GinAndrew

D. Hoban, H. Adam, A. Walkty, 2014 .

Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, Drugs.

Clinical significance of bioequivalence and interchangeability of narrow therapeutic range drugs: focus on warfarins.

G. Zhanel, L. Vercaigne, 1998, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Synthesis and Antibacterial Activities of Amphiphilic Neomycin B-based Bilipid Conjugates and Fluorinated Neomycin B-based Lipids

G. Zhanel, F. Schweizer, Smritilekha Bera, 2012, Molecules.

Guanidylation and Tail Effects in Cationic Antimicrobial Lipopeptoids

G. Zhanel, F. Schweizer, B. Findlay, 2012, PloS one.

Investigating the antimicrobial peptide 'window of activity' using cationic lipopeptides with hydrocarbon and fluorinated tails.

G. Zhanel, F. Schweizer, B. Findlay, 2012, International journal of antimicrobial agents.

Mechanisms of resistance to telithromycin in Streptococcus pneumoniae.

D. Hoban, G. Zhanel, T. Hisanaga, 2005, The Journal of antimicrobial chemotherapy.

Erratum to New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin

G. Zhanel, F. Schweizer, D. Calic, 2012, Drugs.

Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.

Maliha Aziz, Glen Hansen, Sujay Chattopadhyay, 2013, The Journal of infectious diseases.

In vitro kill curves of a new semisynthetic echinocandin, LY-303366, against fluconazole-sensitive and -resistant Candida species

J. Karlowsky, D. Hoban, A. Kabani, 1997, Antimicrobial agents and chemotherapy.

Influence of pharmacokinetic and pharmacodynamic principles on antibiotic selection

G. Zhanel, 2001, Current infectious disease reports.

Intravenous Fosfomycin: An Assessment of Its Potential for Use in the Treatment of Systemic Infections in Canada

J. Karlowsky, G. Zhanel, Michael A. Zhanel, 2018, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Characterization of carbapenem-resistant and XDR Pseudomonas aeruginosa in Canada: results of the CANWARD 2007-16 study.

M. Mulvey, J. Blondeau, J. Karlowsky, 2019, The Journal of antimicrobial chemotherapy.

Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps

D. Beniac, T. Booth, Denice C. Bay, 2022, Scientific Reports.

Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines

J. Lynch, G. Zhanel, 2010, Current opinion in pulmonary medicine.

In vitro characterization of aminoglycoside adaptive resistance in Pseudomonas aeruginosa

J. Karlowsky, D. Hoban, G. Zhanel, 1996, Antimicrobial agents and chemotherapy.

Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones

R. Hancock, L. Nicolle, R. Hancock, 1995, Antimicrobial agents and chemotherapy.

Molecular characterization of fluoroquinolone resistant Streptococcus pneumoniae clinical isolates obtained from across Canada.

D. Hoban, A. Noreddin, K. Nichol, 2003, Diagnostic microbiology and infectious disease.

Pharmacodynamic activity of fluoroquinolones against ciprofloxacin-resistant Streptococcus pneumoniae.

D. Hoban, A. Noreddin, K. Nichol, 2002, The Journal of antimicrobial chemotherapy.

Polybasic peptide-levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria.

G. Zhanel, Ronald Domalaon, F. Schweizer, 2019, MedChemComm.

Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates.

G. Zhanel, F. Schweizer, Smritilekha Bera, 2011, Carbohydrate research.

Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2016, Drugs.

Which Patients Should Be Treated

D. Guay, G. Harding, G. Zhanel, 2016 .

Asymptomatic bacteriuria. Which patients should be treated?

D. Guay, G. Harding, G. Harding, 1990, Archives of internal medicine.

Molecular characterisation of Canadian paediatric multidrug-resistant Streptococcus pneumoniae from 1998-2004.

M. Mulvey, D. Hoban, K. Nichol, 2006, International journal of antimicrobial agents.

Molecular Epidemiology and Prevalence of Macrolide Efflux Genes mef(A) and mef(E) in Streptococcus pneumoniae Obtained in Canada from 1997 to 2002

M. Mulvey, D. Boyd, D. Hoban, 2005, Antimicrobial Agents and Chemotherapy.

Limitations of ceftriaxone compared with cefazolin against MSSA: an integrated pharmacodynamic analysis

R. Ariano, G. Zhanel, Nathan P. Beahm, 2018, The Journal of antimicrobial chemotherapy.

Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria

G. Zhanel, F. Schweizer, G. Arthur, 2022, Antibiotics.

In Vitro Activity of Cefiderocol against Extensively Drug-Resistant Pseudomonas aeruginosa: CANWARD, 2007 to 2019

M. Mulvey, Denice C. Bay, J. Karlowsky, 2022, Microbiology spectrum.

In vitro activity of ceftolozane/tazobactam versus antimicrobial non-susceptible Pseudomonas aeruginosa clinical isolates including MDR and XDR isolates obtained from across Canada as part of the CANWARD study, 2008–16

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2018, The Journal of antimicrobial chemotherapy.

In vitro activity of Oritavancin against gram-positive pathogens isolated in Canadian hospital laboratories from 2011 to 2015.

J. Karlowsky, H. Adam, M. Baxter, 2017, Diagnostic microbiology and infectious disease.

Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents.

G. Zhanel, F. Schweizer, Smritilekha Bera, 2010, Bioorganic & medicinal chemistry letters.

Pharmacokinetic Contributions to Postantibiotic Effects

W. Craig, G. Zhanel, 1994, Clinical pharmacokinetics.

Antibiotic–Heparin Lock: In Vitro Confirmation of Antibacterial Activity

G. Zhanel, L. Vercaigne, 2000 .

Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals.

Amanpreet Singh, J. Karlowsky, D. Hoban, 2012, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Dalbavancin and telavancin: novel lipoglycopeptides for the treatment of Gram-positive infections

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2008, Expert review of anti-infective therapy.

Ceftobiprole: a review of a broad-spectrum and anti-MRSA cephalosporin.

J. Karlowsky, D. Hoban, A. Noreddin, 2008, American journal of clinical dermatology.

Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli

G. Zhanel, Ronald Domalaon, F. Schweizer, 2019, The Journal of Antibiotics.

Real-life experience with ceftobiprole in Canada; results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry.

Y. Keynan, M. Bergevin, C. Tascini, 2021, Journal of global antimicrobial resistance.

Tedizolid: A Novel Oxazolidinone with Potent Activity Against Multidrug-Resistant Gram-Positive Pathogens

M. Gilmour, J. Karlowsky, D. Hoban, 2015, Drugs.

Clinical Pharmacokinetics of Vancomycin

G. Matzke, D. Guay, G. Zhanel, 1986, Clinical pharmacokinetics.

Once-daily aminoglycoside dosing assessed by MIC reversion time with Pseudomonas aeruginosa

J. Karlowsky, D. Hoban, G. Zhanel, 1994, Antimicrobial Agents and Chemotherapy.

Single-Dose versus Traditional Therapy for Uncomplicated Urinary Tract Infections

G. Zhanel, A. Ronald, 1988, Drug intelligence & clinical pharmacy.

Antibiofilm activity of sodium bicarbonate, sodium metaperiodate and SDS combination against dental unit waterline‐associated bacteria and yeast

N. Yakandawala, D. Cvitkovitch, T. Romeo, 2008, Journal of applied microbiology.

Piperacillin-tazobactam: a beta-lactam/beta-lactamase inhibitor combination.

J. Karlowsky, A. Walkty, G. Zhanel, 2007, Expert review of anti-infective therapy.

Mechanisms of resistance and mobility among multidrug-resistant CTX-M-producing Escherichia coli from Canadian intensive care units: the 1st report of QepA in North America.

M. Mulvey, D. Boyd, D. Hoban, 2009, Diagnostic microbiology and infectious disease.

Cost-Effectiveness Analysis of Fosfomycin for Treatment of Uncomplicated Urinary Tract Infections in Ontario

J. LeLorier, G. Zhanel, A. Iliza, 2017, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

The Ketolides

S. Douthwaite, D. Hoban, A. Noreddin, 2012, Drugs.

Ketolides in the treatment of respiratory infections

D. Hoban, G. Zhanel, 2002, Expert opinion on pharmacotherapy.

New Lipoglycopeptides

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2010, Drugs.

Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria

Denice C. Bay, J. Karlowsky, K. Naber, 2022, Drugs.

In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2018, Antimicrobial Agents and Chemotherapy.

Faropenem: review of a new oral penem

J. Karlowsky, D. Hoban, G. Zhanel, 2007, Expert review of anti-infective therapy.

The Glycylcyclines

J. Karlowsky, D. Hoban, A. Noreddin, 2004, Drugs.

Telithromycin in the treatment of acute bacterial sinusitis, acute exacerbations of chronic bronchitis, and community-acquired pneumonia

D. Hoban, G. Zhanel, T. Hisanaga, 2006, Therapeutics and clinical risk management.

Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae

D. Hoban, K. Nichol, G. Zhanel, 2003, Expert opinion on emerging drugs.

In vitro activity of the novel ketolide HMR 3647 and comparative oral antibiotics against Canadian respiratory tract isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

J. Karlowsky, D. Hoban, G. Zhanel, 1999, Diagnostic microbiology and infectious disease.

Escalation of antimicrobial resistance among MRSA part 1: focus on global spread

G. Zhanel, J. P. Lynch, J. Lynch, 2022, Expert review of anti-infective therapy.

Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.

G. Zhanel, F. Schweizer, B. Gorityala, 2016, Journal of Medicinal Chemistry.

Kisameet Clay Isolated from the Central Coast of British Columbia, Canada, Demonstrates Broad-Spectrum Antimicrobial Activity

J. Karlowsky, G. Zhanel, 2016, mBio.

Oritavancin: mechanism of action.

J. Karlowsky, G. Zhanel, F. Schweizer, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007-2009 study.

J. Blondeau, D. Low, J. Karlowsky, 2011, Diagnostic microbiology and infectious disease.

In vitro activity of dalbavancin and telavancin against staphylococci and streptococci isolated from patients in Canadian hospitals: results of the CANWARD 2007-2009 study.

S. Poutanen, J. Karlowsky, D. Hoban, 2011, Diagnostic microbiology and infectious disease.

Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada: Canadian National Intensive Care Unit Study, 2005/2006.

M. Mulvey, J. Karlowsky, D. Hoban, 2008, Diagnostic microbiology and infectious disease.

In vitro activity of oritavancin against Gram-positive pathogens isolated in Canadian hospital laboratories from 2011 to 2013.

J. Karlowsky, H. Adam, M. Baxter, 2014, Diagnostic microbiology and infectious disease.

Time-kill curves for a semisynthetic glycopeptide, LY333328, against vancomycin-susceptible and vancomycin-resistant Enterococcus faecium strains

J. Karlowsky, D. Hoban, G. Zhanel, 1997, Antimicrobial agents and chemotherapy.

Synergy of an Investigational Glycopeptide, LY333328, with Once-Daily Gentamicin against Vancomycin-ResistantEnterococcus faecium in a Multiple-Dose, In Vitro Pharmacodynamic Model

J. Karlowsky, D. Hoban, G. Zhanel, 1999, Antimicrobial Agents and Chemotherapy.

Role of efflux mechanisms on fluoroquinolone resistance in Streptococcus pneumoniae and Pseudomonas aeruginosa.

J. Karlowsky, D. Hoban, G. Zhanel, 2004, International journal of antimicrobial agents.

Antibiofilm Activity of GlmU Enzyme Inhibitors against Catheter-Associated Uropathogens

N. Yakandawala, A. Friesen, T. Romeo, 2006, Antimicrobial Agents and Chemotherapy.

Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold

G. Zhanel, F. Schweizer, B. Findlay, 2010, Antimicrobial Agents and Chemotherapy.

Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates.

G. Zhanel, F. Schweizer, Smritilekha Bera, 2010, The Journal of antimicrobial chemotherapy.

Anti-infective research and development--problems, challenges, and solutions.

J. Bartlett, J. Powers, D. Pompliano, 2007, The Lancet. Infectious diseases.

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

G. Zhanel, Ronald Domalaon, F. Schweizer, 2018, Clinical Microbiology Reviews.

The Value of Single-Dose Therapy as a Therapeutic Maneuver to Localize Urinary Infection

G. Zhanel, A. Ronald, 1988 .

In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species

J. Karlowsky, D. Hoban, A. Kabani, 1997, Antimicrobial agents and chemotherapy.

Susceptibilities of Candida Species Isolated from the Lower Gastrointestinal Tracts of High-Risk Patients to the New Semisynthetic Echinocandin LY303366 and Other Antifungal Agents

J. Karlowsky, D. Hoban, G. Zhanel, 1998, Antimicrobial Agents and Chemotherapy.

The accumulation of fluoroquinolones in Staphylococcus aureus during the postantibiotic effect.

J. Karlowsky, D. Hoban, G. Zhanel, 1994, The Journal of antimicrobial chemotherapy.

In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth

J. Karlowsky, D. Hoban, G. Zhanel, 1993, Antimicrobial Agents and Chemotherapy.

Effect of pooled human cerebrospinal fluid on the postantibiotic effects of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli

J. Karlowsky, D. Hoban, G. Zhanel, 1992, Antimicrobial Agents and Chemotherapy.

Antimicrobial activity of subinhibitory concentrations of ciprofloxacin against Pseudomonas aeruginosa as determined by the killing curve method and the postantibiotic effect.

L. Nicolle, D. Hoban, G. Zhanel, 1992, Chemotherapy.

Human serum enhances the postantibiotic effect of fluoroquinolones against Staphylococcus aureus

D. Hoban, G. Zhanel, R. Davidson, 1991, Antimicrobial Agents and Chemotherapy.

The Postantibiotic Effect: A Review of in Vitro and in Vivo Data

G. Harding, D. Hoban, G. Zhanel, 1991, DICP : the annals of pharmacotherapy.

Influence of human urine on the in vitro activity and postantibiotic effect of ciprofloxacin against Escherichia coli.

J. Karlowsky, D. Hoban, G. Zhanel, 1991, Chemotherapy.

Antimicrobial activity of subinhibitory concentrations of aminoglycosides against Pseudomonas aeruginosa as determined by the killing-curve method and the postantibiotic effect.

J. Karlowsky, D. Hoban, G. Zhanel, 1991, Chemotherapy.

Reproducibility of the in-vitro postantibiotic effect of fluoroquinolones against Staphylococcus aureus.

D. Hoban, G. Zhanel, R. Davidson, 1990, The Journal of antimicrobial chemotherapy.

Once versus Thrice Daily Tobramycin Alone and in Combination with Ceftazidime, Ciprofloxacin and Imipenem in an in vitro Pharmacodynamic Model

J. Karlowsky, D. Hoban, A. Kabani, 1997, Chemotherapy.

Once daily aminoglycoside dosing: maintained efficacy with reduced nephrotoxicity?

R. Ariano, G. Zhanel, 1992, Renal failure.

Screening of Stool Samples for Identification of Vancomycin-Resistant Enterococcus Isolates Should Include the Methyl-α-dGlucopyranoside Test To Differentiate Nonmotile Enterococcus gallinarum from E. faecium

J. Karlowsky, D. Hoban, A. Kabani, 1998, Journal of Clinical Microbiology.

Phenotypic and multi-omics characterization of Escherichia coli K-12 adapted to quaternary ammonium compounds identifies lipid A and cell envelope alterations regulated by mar-sox-rob and stress inducible pathways

Patrick M. Chong, D. Beniac, T. Booth, 2020, bioRxiv.

Preferential Emergence of Reduced Vancomycin Susceptibility in Health Care-Associated Methicillin-Resistant Staphylococcus aureus Isolates during Continuous-Infusion Vancomycin Therapy in an In Vitro Dynamic Model

R. Ariano, G. Zhanel, S. Zelenitsky, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of empirical antibiotic monotherapies for an intensive care unit (ICU) population based on Canadian surveillance data.

R. Ariano, G. Zhanel, S. Zelenitsky, 2011, The Journal of antimicrobial chemotherapy.

Influence of Human Serum on Pharmacodynamic Properties of an Investigational Glycopeptide, LY333328, and Comparator Agents against Staphylococcus aureus

J. Karlowsky, D. Hoban, A. Kabani, 1998, Antimicrobial Agents and Chemotherapy.

Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris

G. Zhanel, I. Critchley, Lynn-Yao Lin, 2018, Antimicrobial Agents and Chemotherapy.

Multi-center evaluation of antifungal time-kill methods

M. Klepser, M. Pfaller, D. Nicolau, 2001 .

Influence of Human Serum on Antifungal Pharmacodynamics with Candida albicans

J. Karlowsky, D. Hoban, G. Zhanel, 2001, Antimicrobial Agents and Chemotherapy.

Characterization of Cefoxitin-Resistant Escherichia coli Isolates from Recreational Beaches and Private Drinking Water in Canada between 2004 and 2006

N. Neumann, M. Mulvey, G. Zhanel, 2009, Antimicrobial Agents and Chemotherapy.

Evidence that a novel quaternary compound and its organic N-chloramine derivative do not select for resistant mutants of Pseudomonas aeruginosa.

S. Logsetty, G. Zhanel, C. Ning, 2015, Journal of Hospital Infection.

Biocide Selective TolC-Independent Efflux Pumps in Enterobacteriaceae

Denice C. Bay, G. Zhanel, Carmine J. Slipski, 2017, The Journal of Membrane Biology.

Imipenem–Relebactam and Meropenem–Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2017, Drugs.

Comparison of Antimicrobial Resistance Profiles among Extended-Spectrum-β-Lactamase-Producing and Acquired AmpC β-Lactamase-Producing Escherichia coli Isolates from Canadian Intensive Care Units

M. Mulvey, D. Hoban, K. Nichol, 2008, Antimicrobial Agents and Chemotherapy.

Prevalence and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli: results of the CANWARD 2007-2009 study.

M. Mulvey, J. Pitout, D. Hoban, 2011, Diagnostic microbiology and infectious disease.

Dramatic rise in the proportion of ESBL-producing Escherichia coli and Klebsiella pneumoniae among clinical isolates identified in Canadian hospital laboratories from 2007 to 2016.

M. Mulvey, J. Karlowsky, D. Hoban, 2019, The Journal of antimicrobial chemotherapy.

Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results of the CANWARD 2007-2009 study.

M. Mulvey, D. Hoban, P. Lagacé-Wiens, 2011, Diagnostic microbiology and infectious disease.

Stretching the mutant prevention concentration (MPC) beyond its limits.

D. Hoban, K. Nichol, G. Zhanel, 2003, The Journal of antimicrobial chemotherapy.

In vitro potency and combination testing of antimicrobial agents against Neisseria gonorrhoeae.

I. Martin, A. Bharat, M. Mulvey, 2016, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Emergence of Antimicrobial Resistance among Pseudomonas aeruginosa: Implications for Therapy

J. Lynch, G. Zhanel, N. Clark, 2017, Seminars in Respiratory and Critical Care Medicine.

Antimicrobial resistance in hospital-acquired gram-negative bacterial infections.

J. Lynch, B. Mehrad, G. Zhanel, 2015, Chest.

Pharmacodynamic activity of ceftobiprole compared with vancomycin versus methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate Staphylococcus aureus (VISA) and vancomycin-resistant Staphylococcus aureus (VRSA) using an in vitro model.

J. Karlowsky, D. Hoban, A. Noreddin, 2009, The Journal of antimicrobial chemotherapy.

In Vitro Activity of Ceftaroline-Avibactam against Gram-Negative and Gram-Positive Pathogens Isolated from Patients in Canadian Hospitals from 2010 to 2012: Results from the CANWARD Surveillance Study

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, Antimicrobial Agents and Chemotherapy.

Mutant Prevention Concentrations for Single-Step Fluoroquinolone-Resistant Mutants of Wild-Type, Efflux-Positive, or ParC or GyrA Mutation-Containing Streptococcus pneumoniae Isolates

D. Hoban, G. Zhanel, T. Hisanaga, 2004, Antimicrobial Agents and Chemotherapy.

Comparative In Vitro Potency of Gemifloxacin and Fluoroquinolones Against Recent European Clinical Isolates from a Global Surveillance Study

D. Hoban, G. Zhanel, L. Miller, 2001, European Journal of Clinical Microbiology & Infectious Diseases.

Pseudomonas aeruginosa Pneumonia: Evolution of Antimicrobial Resistance and Implications for Therapy.

G. Zhanel, J. P. Lynch, J. Lynch, 2022, Seminars in respiratory and critical care medicine.

Triclosan Can Select for an AdeIJK-Overexpressing Mutant of Acinetobacter baumannii ATCC 17978 That Displays Reduced Susceptibility to Multiple Antibiotics

P. Loewen, G. Zhanel, Ayush Kumar, 2014, Antimicrobial Agents and Chemotherapy.

Prevalence of antimicrobial resistant pathogens from blood cultures from Canadian hospitals: results of the CANWARD 2007-2009 study.

R. Rennie, J. Karlowsky, D. Hoban, 2011, Diagnostic microbiology and infectious disease.

Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2008)

Michael R. Mulvey, M. Mulvey, J. Karlowsky, 2010, Antimicrobial Agents and Chemotherapy.

Molecular epidemiology of urinary tract isolates of vancomycin-resistant Enterococcus faecium from North America.

D. Hoban, K. Nichol, G. Zhanel, 2006, International journal of antimicrobial agents.

Treatment of lower urinary tract infection caused by multidrug-resistant extended-spectrum-beta-lactamase-producing Escherichia coli with amoxicillin/clavulanate: case report and characterization of the isolate.

M. Mulvey, L. Nicolle, P. Lagacé-Wiens, 2006, The Journal of antimicrobial chemotherapy.

Antibiotic activity in microbiological media versus that in human urine: comparison of ampicillin, ciprofloxacin, and trimethoprim-sulfamethoxazole

J. Karlowsky, D. Hoban, G. Zhanel, 1996, Antimicrobial agents and chemotherapy.

Chicken as Reservoir for Extraintestinal Pathogenic Escherichia coli in Humans, Canada

A. Manges, L. Dutil, G. Zhanel, 2012, Emerging infectious diseases.

Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases)

J. Lynch, G. Zhanel, N. Clark, 2013, Expert opinion on pharmacotherapy.

Susceptibility of community Gram-negative urinary tract isolates to mecillinam and other oral agents.

T. Mazzulli, D. Low, D. Hoban, 2001, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 1: Antibiotic Prescribing Patterns, Sources of Antibiotic Exposure, Antibiotic Consumption and Emergence of Antibiotic Resistance, Impact of Alterations in Antibiotic Prescribing,

J. Leyden, D. Thiboutot, R. Gallo, 2016, The Journal of clinical and aesthetic dermatology.

New Biocide with Both N‐Chloramine and Quaternary Ammonium Moieties Exerts Enhanced Bactericidal Activity

W. Ens, Song Liu, N. Zhao, 2012, Advanced healthcare materials.

Mutant Prevention Concentrations of Levofloxacin Alone and in Combination with Azithromycin, Ceftazidime, Colistin (Polymyxin E), Meropenem, Piperacillin-Tazobactam, and Tobramycin against Pseudomonas aeruginosa

H. Adam, G. Zhanel, N. Laing, 2006, Antimicrobial Agents and Chemotherapy.

Changing epidemiology of methicillin-resistant Staphylococcus aureus in Canada.

D. Hoban, P. Lagacé-Wiens, H. Adam, 2013, The Journal of antimicrobial chemotherapy.

Frequency of 16S ribosomal RNA methyltransferase detection among Escherichia coli and Klebsiella pneumoniae clinical isolates obtained from patients in Canadian hospitals (CANWARD, 2013-2017).

A. Bharat, M. Mulvey, M. Bergevin, 2019, Diagnostic microbiology and infectious disease.

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria

G. Zhanel, Ronald Domalaon, F. Schweizer, 2018, Amino Acids.

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli

J. Karlowsky, A. Noreddin, P. Lagacé-Wiens, 2019, Drugs.

In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

J. Karlowsky, H. Adam, M. Baxter, 2017, Diagnostic microbiology and infectious disease.

Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component.

G. Zhanel, Ronald Domalaon, F. Schweizer, 2018, Bioorganic chemistry.

ATCC17978 that displays reduced susceptibility to multiple antibiotics 2

P. Loewen, G. Zhanel, Ayush Kumar, 2014 .

Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia

L. Mandell, Denice C. Bay, J. Karlowsky, 2020, Drugs.

Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent

Denice C. Bay, J. Karlowsky, P. Lagacé-Wiens, 2020, Drugs.

Role of glycoside hydrolase genes in sinigrin degradation by E. coli O157:H7.

R. Holley, R. Sparling, G. Zhanel, 2015, International journal of food microbiology.

Comparative in vitro activity of gemifloxacin, ciprofloxacin, levofloxacin and ofloxacin in a North American surveillance study.

D. Hoban, G. Zhanel, L. Miller, 2001, Diagnostic microbiology and infectious disease.

Antibacterial activity of amphiphilic tobramycin

G. Zhanel, F. Schweizer, Smritilekha Bera, 2012, The Journal of Antibiotics.

Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants.

G. Zhanel, F. Schweizer, D. Mondal, 2011, Carbohydrate research.

Neomycin-phenolic conjugates: polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding.

G. Zhanel, F. Schweizer, B. Findlay, 2012, Bioorganic & medicinal chemistry letters.

Linear Regression Equations To Predict β-Lactam, Macrolide, Lincosamide, and Fluoroquinolone MICs from Molecular Antimicrobial Resistance Determinants in Streptococcus pneumoniae

P. V. Van Caeseele, W. Demczuk, I. Martin, 2021, Antimicrobial agents and chemotherapy.

Characterization of Proteobacterial Plasmid Integron-Encoded qac Efflux Pump Sequence Diversity and Quaternary Ammonium Compound Antiseptic Selection in Escherichia coli Grown Planktonically and as Biofilms

Denice C. Bay, G. Zhanel, Carmine J. Slipski, 2021, Antimicrobial agents and chemotherapy.

Launching of the CAN-R Web site -The official Web site of the Canadian Antimicrobial Resistance Alliance.

D. Low, G. Zhanel, 2007, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit‐isolated methicillin‐resistant Staphylococcus aureus

S. Ibrahim, A. Salem, A. Noreddin, 2014, Clinical and experimental pharmacology & physiology.

Emergence of fluoroquinolone resistance in Neisseria gonorrhoeae isolates from four clinics in three regions of Kenya.

J. Kimani, P. Lagacé-Wiens, G. Zhanel, 2012, Sexually transmitted diseases.

Concepts on the use of liposomal antimicrobial agents: applications for aminoglycosides.

J. Karlowsky, G. Zhanel, 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Prevalence of asymptomatic bacteriuria and associated host factors in women with diabetes mellitus. The Manitoba Diabetic Urinary Infection Study Group.

L. Nicolle, G. Harding, G. Zhanel, 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Postantibiotic effect in Pseudomonas aeruginosa following single and multiple aminoglycoside exposures in vitro.

J. Karlowsky, D. Hoban, G. Zhanel, 1994, The Journal of antimicrobial chemotherapy.

Fosfomycin resistance mediated by fos genes remains rare among extended-spectrum beta-lactamase-producing Escherichia coli clinical isolates recovered from the urine of patients evaluated at Canadian hospitals (CANWARD, 2007-2017).

M. Mulvey, Denice C. Bay, J. Karlowsky, 2019, Diagnostic microbiology and infectious disease.

Escalation of antimicrobial resistance among MRSA part 2: focus on infections and treatment

G. Zhanel, J. P. Lynch, 2022, Expert review of anti-infective therapy.

Musculoskeletal injury associated with fluoroquinolone antibiotics.

G. Zhanel, Y. Khaliq, 2005, Clinics in plastic surgery.

Telavancin: mechanisms of action, in vitro activity, and mechanisms of resistance.

J. Karlowsky, K. Nichol, G. Zhanel, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacodynamic activity of ertapenem versus multidrug-resistant genotypically characterized extended-spectrum beta-lactamase-producing Escherichia coli using an in vitro model.

D. Hoban, A. Noreddin, G. Zhanel, 2008, The Journal of antimicrobial chemotherapy.

Vancomycin-Resistant Enterococci

G. Zhanel, A. Gin, 1996, The Annals of pharmacotherapy.

Antiseptic quaternary ammonium compound tolerance by gram-negative bacteria can be rapidly detected using an impermeant fluorescent dye-based assay

M. Mulvey, Mazdak Khajehpour, D. Beniac, 2020, Scientific Reports.

Pharmacodynamic activity of ertapenem versus genotypically characterized extended-spectrum β-lactamase (ESBL)-, KPC- or NDM-producing Escherichia coli with reduced susceptibility or resistance to ertapenem using an in vitro model.

D. Hoban, H. Adam, A. Denisuik, 2014, The Journal of antimicrobial chemotherapy.

Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010-2012.

M. Gilmour, W. Demczuk, I. Martin, 2012, Canadian journal of microbiology.

Baseline epidemiology of Streptococcus pneumoniae serotypes in Canada prior to the introduction of the 13-valent pneumococcal vaccine.

M. Gilmour, J. Karlowsky, D. Hoban, 2012, Microbial drug resistance.

Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: CANWARD 2008-2011.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2012, Diagnostic microbiology and infectious disease.

Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian intensive care units as part of the Canadian National Intensive Care Unit study.

M. Mulvey, D. Hoban, K. Nichol, 2008, Diagnostic microbiology and infectious disease.

Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America

M. Mulvey, R. Bonnet, A. Mather, 2022, Nature communications.

Oral Fosfomycin for the Treatment of Acute and Chronic Bacterial Prostatitis Caused by Multidrug-Resistant Escherichia coli

J. Karlowsky, G. Zhanel, Michael A. Zhanel, 2018, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Antimicrobial Prophylaxis in Coronary Bypass Surgery: A Critical Appraisal

M. Raebel, R. Ariano, G. Zhanel, 1991, DICP : the annals of pharmacotherapy.

Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults.

R. Grossman, G. Evans, G. Zhanel, 2008, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Canadian practice guidelines for surgical intra-abdominal infections.

A. Nathens, A. Kirkpatrick, C. Ball, 2010, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Community-Acquired Pneumonia in Canada During Coronavirus Disease 2019

L. Mandell, M. Loeb, J. Muscedere, 2022, Open forum infectious diseases.

Antimicrobial Resistance in Haemophilus influenzae and Moraxella catarrhalis Respiratory Tract Isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002

D. Low, D. Hoban, K. Nichol, 2003, Antimicrobial Agents and Chemotherapy.

Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in Canada during 2000

D. Church, T. Mazzulli, D. Low, 2002, Antimicrobial Agents and Chemotherapy.

Prevalence of Antimicrobial Resistance in Respiratory Tract Isolates of Streptococcus pneumoniae: Results of a Canadian National Surveillance Study

D. Low, J. Karlowsky, D. Hoban, 1999, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic target attainment potential of azithromycin, clarithromycin, and telithromycin in serum and epithelial lining fluid of community-acquired pneumonia patients with penicillin-susceptible, intermediate, and resistant Streptococcus pneumoniae.

A. Salem, A. Noreddin, G. Zhanel, 2009, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps

D. Beniac, T. Booth, Denice C. Bay, 2022, Scientific Reports.

In Vitro Activity of OPT-80 Tested against Clinical Isolates of Toxin-Producing Clostridium difficile

J. Karlowsky, G. Zhanel, N. Laing, 2008, Antimicrobial Agents and Chemotherapy.

Antimicrobial-Resistant Pathogens in Intensive Care Units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005-2006

Michael R. Mulvey, M. Mulvey, J. Karlowsky, 2008, Antimicrobial Agents and Chemotherapy.

Virulence of Escherichia coli Clinical Isolates in a Murine Sepsis Model in Relation to Sequence Type ST131 Status, Fluoroquinolone Resistance, and Virulence Genotype

E. Denamur, M. Kuskowski, James R. Johnson, 2012, Infection and Immunity.

La fidaxomicine : un nouvel agent pour traiter l ’ infection à Clostridium difficile

J. Karlowsky, A. Walkty, G. Zhanel, 2015 .

Fidaxomicin: A novel agent for the treatment of Clostridium difficile infection

J. Karlowsky, A. Walkty, G. Zhanel, 2015, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Infections Due to Acinetobacter baumannii-calcoaceticus Complex: Escalation of Antimicrobial Resistance and Evolving Treatment Options.

G. Zhanel, N. Clark, J. P. Lynch, 2022, Seminars in respiratory and critical care medicine.

Infections Due to Acinetobacter baumannii in the ICU: Treatment Options

J. Lynch, G. Zhanel, N. Clark, 2017, Seminars in Respiratory and Critical Care Medicine.

Characterization of plasmids encoding CMY-2 AmpC beta-lactamases from Escherichia coli in Canadian intensive care units.

M. Mulvey, D. Hoban, G. Zhanel, 2009, Diagnostic microbiology and infectious disease.

Cadaverine Suppresses Persistence to Carboxypenicillins in Pseudomonas aeruginosa PAO1

T. D. de Kievit, G. Zhanel, Jerrylynn Manuel, 2010, Antimicrobial Agents and Chemotherapy.

Riboswitch-Associated Guanidinium-Selective Efflux Pumps Frequently Transmitted on Proteobacterial Plasmids Increase Escherichia coli Biofilm Tolerance to Disinfectants

Denice C. Bay, G. Zhanel, T. Jamieson, 2020, Journal of Bacteriology.

42936 pathogens from Canadian hospitals: 10 years of results (2007-16) from the CANWARD surveillance study.

M. Mulvey, Denice C. Bay, J. Karlowsky, 2019, The Journal of antimicrobial chemotherapy.

Presence of ROB-1 beta-lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae.

J. Karlowsky, D. Hoban, G. Zhanel, 2000, The Journal of antimicrobial chemotherapy.

Brief reports Presence of ROB-1 -lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae

J. Karlowsky, D. Hoban, G. Zhanel, 2000 .

Altered denA and anr gene expression in aminoglycoside adaptive resistance in Pseudomonas aeruginosa.

J. Karlowsky, D. Hoban, G. Zhanel, 1997, The Journal of antimicrobial chemotherapy.

Antibacterial use in community practice: assessing quantity, indications and appropriateness, and relationship to the development of antibacterial resistance.

G. Zhanel, A. Carrie, 1999, Drugs.

positive clinical isolates obtained from patients in Canadian hospitals as

D. Hoban, P. Lagacé-Wiens, H. Adam, 2014 .

Comparison of Escherichia coli ST131 Pulsotypes, by Epidemiologic Traits, 1967–2009

A. Robicsek, M. Kuskowski, M. Castanheira, 2012, Emerging infectious diseases.

Key research issues in Clostridium difficile.

G. Zhanel, G. Hammond, 2005, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2007)

Michael R. Mulvey, M. Mulvey, J. Karlowsky, 2009 .

The role of anion-exchange resins in the treatment of antibiotic-associated pseudomembranous colitis.

R. Ariano, G. Harding, G. Zhanel, 1990, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Microbiological outcomes in women with diabetes and untreated asymptomatic bacteriuria

L. Nicolle, G. Harding, G. Zhanel, 2006, World Journal of Urology.

In Vitro Activity of Ceftolozane-Tazobactam against Pseudomonas aeruginosa Isolates Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007 to 2012

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, Antimicrobial Agents and Chemotherapy.

Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2009, Drugs.

Regenerability of antibacterial activity of interpenetrating polymeric N‐halamine and poly(ethylene terephthalate)

Song Liu, N. Zhao, G. Zhanel, 2011 .

Invasive pneumococcal disease caused by serotypes 22F and 33F in Canada: the SAVE study 2011-2018.

W. Demczuk, I. Martin, J. Karlowsky, 2021, Diagnostic microbiology and infectious disease.

G. Zhanel, L. Vercaigne, 1994, The Annals of pharmacotherapy.

Pharmacokinetics/pharmacodynamics of levofloxacin 750 mg once daily in young women with acute uncomplicated pyelonephritis.

L. Nicolle, D. Sitar, G. Zhanel, 2008, International journal of antimicrobial agents.

Uncomplicated urinary tract infection in women. Current practice and the effect of antibiotic resistance on empiric treatment.

Peter A M Anderson, J Curtis Nickel, L. Nicolle, 2006, Canadian family physician Medecin de famille canadien.

Comparative In Vitro Surveillance of Amoxicillin-Clavulanic Acid and Four Oral Comparators Against 21,232 Clinical Isolates from Europe

D. Hoban, G. Zhanel, L. Miller, 2003, European Journal of Clinical Microbiology and Infectious Diseases.

Antimicrobial susceptibility of clinical isolates of Neisseria gonorrhoeae to alternative antimicrobials with therapeutic potential

I. Martin, M. Mulvey, J. Karlowsky, 2017, The Journal of antimicrobial chemotherapy.

Multilocus sequence typing and virulence gene profiles associated with Escherichia coli from human and animal sources.

T. Edens, A. Manges, J. Harel, 2015, Foodborne pathogens and disease.

Species distribution and antifungal susceptibility of invasive Candida isolates from Canadian hospitals: results of the CANWARD 2011-16 study.

T. Dingle, J. Karlowsky, H. Adam, 2019, The Journal of antimicrobial chemotherapy.

Molecular characterization of predominant Streptococcus pneumoniae serotypes causing invasive infections in Canada: the SAVE study, 2011-15.

M. Gilmour, P. V. Van Caeseele, W. Demczuk, 2018, The Journal of antimicrobial chemotherapy.

Evolution and molecular characterization of macrolide-resistant Streptococcus pneumoniae in Canada between 1998 and 2008.

J. Karlowsky, D. Hoban, H. Adam, 2014, The Journal of antimicrobial chemotherapy.

Annual macrolide prescription rates and the emergence of macrolide resistance among Streptococcus pneumoniae in Canada from 1995 to 2005.

D. Low, J. Karlowsky, P. Lagacé-Wiens, 2009, International journal of antimicrobial agents.

Antibiotic resistance in respiratory tract isolates of Haemophilus influenzae and Moraxella catarrhalis collected from across Canada in 1997-1998.

D. Low, J. Karlowsky, D. Hoban, 2000, The Journal of antimicrobial chemotherapy.

Genomic Characterization of Ciprofloxacin Resistance in a Laboratory-Derived Mutant and a Clinical Isolate of Streptococcus pneumoniae

P. Leprohon, M. Ouellette, G. Zhanel, 2013, Antimicrobial Agents and Chemotherapy.

pneumoniae and a Clinical Isolate of Streptococcus Resistance in a Laboratory-Derived Mutant Genomic Characterization of Ciprofloxacin

P. Leprohon, G. Zhanel, Andréanne Lupien, 2013 .

Comparison of pathogens and their antimicrobial resistance patterns in paediatric, adult and elderly patients in Canadian hospitals.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, The Journal of antimicrobial chemotherapy.

In vitro activity of ceftobiprole against frequently encountered aerobic and facultative Gram-positive and Gram-negative bacterial pathogens: results of the CANWARD 2007-2009 study.

J. Karlowsky, D. Hoban, H. Adam, 2011, Diagnostic microbiology and infectious disease.

Introduction to the CANWARD Study (2007-2009).

D. Hoban, G. Zhanel, 2011, Diagnostic microbiology and infectious disease.

Characterization of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Escherichia coli in intensive care units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) study (2005-2006).

M. Mulvey, J. Karlowsky, D. Hoban, 2008, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Antimicrobial-resistant pathogens in Canadian ICUs: results of the CANWARD 2007 to 2016 study

M. Mulvey, J. Karlowsky, D. Hoban, 2018, The Journal of antimicrobial chemotherapy.

Ten years of the CANWARD Study (2007-16).

H. Adam, G. Zhanel, 2019, The Journal of antimicrobial chemotherapy.

Introduction to the CANWARD study (2007–11).

D. Hoban, G. Zhanel, 2013, The Journal of antimicrobial chemotherapy.

Analysis of 3789 in- and outpatient Escherichia coli isolates from across Canada--results of the CANWARD 2007-2009 study.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2011, Diagnostic microbiology and infectious disease.

In Vitro Activity of Plazomicin against 5,015 Gram-Negative and Gram-Positive Clinical Isolates Obtained from Patients in Canadian Hospitals as Part of the CANWARD Study, 2011-2012

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2014, Antimicrobial Agents and Chemotherapy.

In Vitro Activity of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacilli Isolated from Patients in Canadian Intensive Care Units.

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2020, Diagnostic microbiology and infectious disease.

Real-life experience with ceftolozane/tazobactam in Canada; results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry.

M. Bassetti, R. Ariano, J. Karlowsky, 2021, Journal of global antimicrobial resistance.

Escalating antimicrobial resistance among Enterobacteriaceae: focus on carbapenemases

J. Lynch, G. Zhanel, N. Clark, 2021, Expert opinion on pharmacotherapy.

Integrating pharmacokinetics, pharmacodynamics and MIC distributions to assess changing antimicrobial activity against clinical isolates of Pseudomonas aeruginosa causing infections in Canadian hospitals (CANWARD).

R. Ariano, G. Zhanel, E. Rubinstein, 2013, The Journal of antimicrobial chemotherapy.

Determination of the pharmacodynamic activity of clinically achievable tigecycline serum concentrations against clinical isolates of Escherichia coli with extended-spectrum beta-lactamases, AmpC beta-lactamases and reduced susceptibility to carbapenems using an in vitro model.

J. Karlowsky, D. Hoban, G. Zhanel, 2009, The Journal of antimicrobial chemotherapy.

An Assessment of Vancomycin Use in 2 Tertiary Care Hospitals

R. Ariano, M. Makowsky, G. Zhanel, 2004 .

In Vitro Activity of Iclaprim against Respiratory and Bacteremic Isolates of Streptococcus pneumoniae

J. Karlowsky, G. Zhanel, 2009, Antimicrobial Agents and Chemotherapy.

Analysis of 1560 inpatient and outpatient Escherichia coli isolates from across Canada - Results from the CANWARD 2007 study

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2009 .

Differences in antimicrobial susceptibility in Escherichia coli from Canadian intensive care units based on regional and demographic variables.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2008, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Antibacterial Drivers of Resistance

G. Zhanel, 2005, Treatments in respiratory medicine.

Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa

J. Karlowsky, D. Hoban, G. Zhanel, 2009 .

Whole genome characterization of Streptococcus pneumoniae from respiratory and blood cultures collected from Canadian hospitals before and after PCV-13 implementation in Canada: Focus on serotypes 22F and 33F from CANWARD 2007-2018.

W. Demczuk, I. Martin, M. Mulvey, 2021, Vaccine.

Escalation of Antimicrobial Resistance among Streptococcus pneumoniae: Implications for Therapy

J. Lynch, G. Zhanel, George Zhanel2, 2005, Seminars in respiratory and critical care medicine.

Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli

G. Zhanel, Ronald Domalaon, F. Schweizer, 2019, The Journal of Antibiotics.

In vitro activity and resistance rates of topical antimicrobials fusidic acid, mupirocin and ozenoxacin against skin and soft tissue infection pathogens obtained across Canada (CANWARD 2007-18).

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2021, The Journal of antimicrobial chemotherapy.

Phenotypic and Multi-Omics Characterization of Escherichia coli K-12 Adapted to Chlorhexidine Identifies the Role of MlaA and Other Cell Envelope Alterations Regulated by Stress Inducible Pathways in CHX Resistance

Patrick M. Chong, D. Beniac, T. Booth, 2021, Frontiers in Molecular Biosciences.

Genomic Analyses of DNA Transformation and Penicillin Resistance in Streptococcus pneumoniae Clinical Isolates

P. Leprohon, M. Ouellette, M. Bergeron, 2013, Antimicrobial Agents and Chemotherapy.

In vitro activity of ceftobiprole against clinical isolates of Pseudomonas aeruginosa obtained from Canadian intensive care unit (ICU) patients as part of the CAN-ICU Study.

J. Karlowsky, D. Hoban, K. Nichol, 2008, The Journal of antimicrobial chemotherapy.

Ceftaroline pharmacodynamic activity versus community-associated and healthcare-associated methicillin-resistant Staphylococcus aureus, heteroresistant vancomycin-intermediate S. aureus, vancomycin-intermediate S. aureus and vancomycin-resistant S. aureus using an in vitro model.

J. Karlowsky, D. Hoban, A. Noreddin, 2011, The Journal of antimicrobial chemotherapy.

Identification of a novel metallo-β-lactamase, CAM-1, in clinical Pseudomonas aeruginosa isolates from Canada.

T. Dingle, M. Mulvey, R. Rennie, 2019, The Journal of antimicrobial chemotherapy.

Antimicrobial susceptibility of 2906 Pseudomonasaeruginosa clinical isolates obtained from patients in Canadian hospitals over a period of 8 years: Results of the Canadian Ward surveillance study (CANWARD), 2008-2015.

M. Mulvey, J. Karlowsky, P. Lagacé-Wiens, 2017, Diagnostic microbiology and infectious disease.

Streptococcus pneumoniae serotyping and antimicrobial susceptibility: assessment for vaccine efficacy in Canada after the introduction of PCV13.

H. Adam, G. Zhanel, J. P. Lynch, 2023, The Journal of antimicrobial chemotherapy.

Converting patients from intravenous lidocaine to oral tocainide treatment.

G. Zhanel, B. Bleske, 1986, JAMA.

Phenazopyridine in Urinary Tract Infections

G. Zhanel, Sheryl A Zelenitsky, 1996, The Annals of pharmacotherapy.

In Vitro Activity of Fosfomycin against Escherichia coli Isolated from Patients with Urinary Tract Infections in Canada as Part of the CANWARD Surveillance Study

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic activity of fosfomycin simulating urinary concentrations achieved after a single 3-g oral dose versus Escherichia coli using an in vitro model.

J. Pitout, J. Karlowsky, A. Noreddin, 2017, Diagnostic microbiology and infectious disease.

Oral and Intravenous Fosfomycin for the Treatment of Complicated Urinary Tract Infections

J. Karlowsky, G. Zhanel, Michael A. Zhanel, 2020, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

In vitro susceptibility of urinary Escherichia coli isolates to first- and second-line empirically prescribed oral antimicrobials: CANWARD surveillance study results for Canadian outpatients, 2007-2016.

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2019, International Journal of Antimicrobial Agents.

The use of macrolides in treatment of upper respiratory tract infections

D. Hoban, G. Zhanel, M. Decorby, 2006 .

The use of macrolides in treatment of upper respiratory tract infections

D. Hoban, G. Zhanel, M. Decorby, 2005, Current allergy and asthma reports.

Identification and Characterization of a Novel FosA7 Member from Fosfomycin-Resistant Escherichia coli Clinical Isolates from Canadian Hospitals

M. Mulvey, Denice C. Bay, J. Karlowsky, 2020, Antimicrobial Agents and Chemotherapy.

Nitrofurantoin Is Active against Vancomycin-Resistant Enterococci

J. Karlowsky, D. Hoban, G. Zhanel, 2001, Antimicrobial Agents and Chemotherapy.

Epidemiology of Vancomycin-Resistant Enterococci in Canadian Hospitals (CANWARD Study, 2007 to 2013)

M. Gilmour, J. Karlowsky, D. Hoban, 2015, Antimicrobial Agents and Chemotherapy.

Antibiotic and oral contraceptive drug interactions: Is there a need for concern?

L. Mandell, G. Zhanel, K. Slayter, 1999, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

In vitro activity of sulopenem against 1880 bacterial pathogens isolated from Canadian patients with urinary tract infections (CANWARD, 2014-21).

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2022, Journal of Antimicrobial Chemotherapy.

Trends in antimicrobial resistance over 10 years among key bacterial pathogens from Canadian hospitals: results of the CANWARD study 2007-16.

M. Mulvey, S. Poutanen, J. Karlowsky, 2019, The Journal of antimicrobial chemotherapy.

Frequency of MCR-1-mediated colistin resistance among Escherichia coli clinical isolates obtained from patients in Canadian hospitals (CANWARD 2008-2015).

M. Mulvey, S. Poutanen, J. Karlowsky, 2016, CMAJ open.

A critical review of oxazolidinones: an alternative or replacement for glycopeptides and streptogramins?

D. Hoban, G. Zhanel, A. Gin, 2001, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

Prevalence of Antimicrobial Resistance among Clinical Isolates of Bacteroides fragilis Group in Canada in 2010-2011: CANWARD Surveillance Study

J. Karlowsky, D. Hoban, H. Adam, 2011, Antimicrobial Agents and Chemotherapy.

In vitro susceptibility of common bacterial pathogens causing respiratory tract infections in Canada to lefamulin, a new pleuromutilin.

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2021, Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada.

Molecular Characterization of Increasing Fluoroquinolone Resistance in Streptococcus pneumoniae Isolates in Canada, 1997 to 2005

C. Hoban, D. Hoban, H. Adam, 2006, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic activity of garenoxacin against ciprofloxacin-resistant Streptococcus pneumoniae.

D. Hoban, A. Noreddin, G. Zhanel, 2006, The Journal of antimicrobial chemotherapy.

Fluoroquinolone AUIC Break Points and the Link to Bacterial Killing Rates: In Vitro Models

A. Noreddin, G. Zhanel, 2003, The Annals of pharmacotherapy.

Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004).

J. Karlowsky, D. Hoban, K. Nichol, 2007, The Journal of antimicrobial chemotherapy.

Antimicrobial resistance patterns of bacterial pathogens recovered from the urine of patients at Canadian hospitals from 2009 to 2020

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2022, JAC-antimicrobial resistance.

Effect of subinhibitory concentrations of Ciprofloxacin and gentamicin on the adherence of Pseudomonas aeruginosa to Vero cells and voided uroepithelial cells.

L. Nicolle, D. Hoban, G. Zhanel, 1993, Chemotherapy.

Comparison of In Vivo and In Vitro Pharmacodynamics of a Humanized Regimen of 600 Milligrams of Ceftaroline Fosamil Every 12 Hours against Staphylococcus aureus at Initial Inocula of 106 and 108 CFU per Milliliter

D. Nicolau, G. Zhanel, J. Crandon, 2014, Antimicrobial Agents and Chemotherapy.

The use of ketolides in treatment of upper respiratory tract infections

D. Hoban, G. Zhanel, T. Hisanaga, 2004, Current infectious disease reports.

Genomic investigation of the most common Streptococcus pneumoniae serotypes causing invasive infections in Canada: the SAVE study, 2011-2020.

P. V. Van Caeseele, W. Demczuk, I. Martin, 2023, The Journal of antimicrobial chemotherapy.

In Vitro Activity of Garenoxacin, a Novel Des-F(6)-Fluoroquinolone

G. Zhanel, 2003 .

Analysis of MDR in the predominant Streptococcus pneumoniae serotypes in Canada: the SAVE study, 2011-2020.

W. Demczuk, I. Martin, M. Mulvey, 2023, The Journal of antimicrobial chemotherapy.

Comparison of PCV10, PCV13, PCV15, PCV20 and PPSV23 vaccine coverage of invasive Streptococcus pneumoniae isolate serotypes in Canada: the SAVE study, 2011-20.

W. Demczuk, I. Martin, M. Mulvey, 2023, The Journal of antimicrobial chemotherapy.

Characterization of MRSA in Canada from 2007 to 2016.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2019, The Journal of antimicrobial chemotherapy.

Part 1: Mucormycosis: prevalence, risk factors, clinical features, and diagnosis

F. Abtin, M. Fishbein, G. Zhanel, 2023, Expert review of anti-infective therapy.

Assessment of the activity of ceftaroline against clinical isolates of penicillin-intermediate and penicillin-resistant Streptococcus pneumoniae with elevated MICs of ceftaroline using an in vitro pharmacodynamic model.

J. Karlowsky, D. Hoban, A. Noreddin, 2012, The Journal of antimicrobial chemotherapy.

Pharmacodynamic profiling of antimicrobials against Gram-negative respiratory isolates from Canadian hospitals.

D. Nicolau, G. Zhanel, S. Zelenitsky, 2011, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

In vitro activity of the investigational ketolide cethromycin against macrolide- and penicillin-resistant Streptococcus pneumoniae: review of the 1998 to 2006 Canadian Respiratory Organism Susceptibility Study (CROSS).

J. Karlowsky, D. Hoban, G. Zhanel, 2009, The Journal of antimicrobial chemotherapy.

Emergence of ADC-5 Cephalosporinase in environmental Acinetobacter baumannii from a German tank milk with a novel Sequence Type

J. Dettman, G. Zhanel, S. Castillo-Ramírez, 2023, Access Microbiology.

Effect of interventions on prescribing of antimicrobials for prophylaxis in obstetric and gynecologic surgery.

T. Louie, G. Zhanel, A. Gin, 1989, American journal of hospital pharmacy.

Part 2: mucormycosis: focus on therapy

G. Zhanel, J. P. Lynch, J. Lynch, 2023, Expert review of anti-infective therapy.

In vitro activities of ceftobiprole and doripenem tested against frequently encountered aerobic and facultative Gram-positive and Gram-negative bacterial pathogens isolated from patients in Canadian hospitals in 2007.

J. Karlowsky, D. Hoban, G. Zhanel, 2009 .

Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients: the SAVE study, 2011-2020.

W. Demczuk, I. Martin, M. Mulvey, 2023, Journal of Antimicrobial Chemotherapy.

Grepafloxacin Activity Against 3000 Canadian Respiratory Tract Pathogens

J. Karlowsky, D. Hoban, G. Zhanel, 1999, Drugs.

Multidrug-resistant North American pulsotype 2 Clostridium difficile was the predominant toxigenic hospital-acquired strain in the province of Manitoba, Canada, in 2006-2007.

J. Wylie, M. Mulvey, J. Karlowsky, 2012, Journal of medical microbiology.

Authors' Reply

G. Zhanel, A. Gin, 1996 .

Are fluoroquinolone-susceptible isolates of Streptococcus pneumoniae really susceptible? A comparison of resistance mechanisms in Canadian isolates from 1997 and 2003.

C. Hoban, D. Hoban, H. Adam, 2005, Journal of Antimicrobial Chemotherapy.

Molecular Epidemiology and Prevalence of Macrolide Efflux Genes mef(A) and mef(E) in Streptococcus pneumoniae Obtained in Canada from 1997 to 2002

M. Mulvey, D. Boyd, D. Hoban, 2005, Antimicrobial Agents and Chemotherapy.

Ceftaroline

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2012, Drugs.

Call for the international adoption of microbiological breakpoints for fluoroquinolones and Streptococcus pneumoniae.

D. Hoban, H. Adam, G. Zhanel, 2006, International journal of antimicrobial agents.

Short communication Call for the international adoption of microbiological breakpoints for fluoroquinolones and Streptococcus pneumoniae

D. Hoban, H. Adam, G. Zhanel, 2006 .

Comparative in vitro potency of amoxycillin-clavulanic acid and four oral agents against recent North American clinical isolates from a global surveillance study.

D. Hoban, G. Zhanel, L. Miller, 2003, International journal of antimicrobial agents.

Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa.

G. Zhanel, F. Schweizer, G. Arthur, 2023, ACS infectious diseases.

In vitro activity of imipenem-relebactam against various resistance phenotypes/genotypes of Enterobacterales and Pseudomonas aeruginosa isolated from patients across Canada as part of the CANWARD study, 2016-2019.

J. Karlowsky, P. Lagacé-Wiens, H. Adam, 2021, Diagnostic microbiology and infectious disease.

Ceftobiprole

J. Karlowsky, D. Hoban, A. Noreddin, 2008, American journal of clinical dermatology.

Drug, Healthcare and Patient Safety Dovepress Cumulative Clinical Experience from over a Decade of Use of Levofloxacin in Community-acquired Pneumonia: Critical Appraisal and Role in Therapy

A. Noreddin, G. Zhanel, K. Cunnion, 2022 .

Antimicrobial-Resistant Streptococcus pneumoniae in Canadian Hospitals: Results from the 2007 CANWARD Study

J. Karlowsky, D. Hoban, K. Nichol, 2009 .

Introduction to CANWARD 2007

D. Hoban, G. Zhanel, 2009 .

Antimicrobial susceptibility of 6685 organisms isolated from Canadian hospitals: CANWARD 2007.

M. Mulvey, J. Karlowsky, D. Hoban, 2009 .

Characterization of Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: Results of the CANWARD 2007 study

M. Mulvey, J. Karlowsky, D. Hoban, 2009 .

Prevalence and characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated in Canadian hospitals: Results from CANWARD 2007

M. Mulvey, D. Hoban, P. Lagacé-Wiens, 2009 .

Plasmid transmitted small multidrug resistant (SMR) efflux pumps differ in gene regulation and enhance tolerance to quaternary ammonium compounds (QAC) when grown as biofilms

Denice C. Bay, G. Zhanel, T. Jamieson, 2019, bioRxiv.

Antibiotic resistance and expression of resistance-nodulation-division pump- and outer membrane porin-encoding genes in Acinetobacter species isolated from Canadian hospitals.

G. Zhanel, Ayush Kumar, Dinesh M. Fernando, 2013, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Development of a nebramine-cyclam conjugate as an antibacterial adjuvant to potentiate β-lactam antibiotics against multidrug-resistant P. aeruginosa

G. Zhanel, F. Schweizer, T. Idowu, 2019, The Journal of Antibiotics.

Infections Due to Acinetobacter baumannii in the ICU: Treatment Options

J. Lynch, G. Zhanel, N. Clark, 2017, Seminars in Respiratory and Critical Care Medicine.

Polybasic peptide-levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria.

G. Zhanel, Ronald Domalaon, F. Schweizer, 2019, MedChemComm.

Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy

A. Noreddin, G. Zhanel, K. Cunnion, 2011 .

Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy

A. Noreddin, G. Zhanel, K. Cunnion, 2011 .

In vitro activity of ceftobiprole against clinical isolates of Pseudomonas aeruginosa obtained from Canadian intensive care unit (ICU) patients as part of the CAN-ICU Study.

J. Karlowsky, D. Hoban, K. Nichol, 2008, The Journal of antimicrobial chemotherapy.

Antimicrobial resistance in hospital-acquired gram-negative bacterial infections.

J. Lynch, B. Mehrad, G. Zhanel, 2015, Chest.

Fluoroquinolone resistance in Escherichia coli isolated from patients attending Canadian hospitals is associated with the ST131 clone.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2011, Diagnostic microbiology and infectious disease.

Epidemic Clonal Groups of Escherichia coli as a Cause of Antimicrobial-Resistant Urinary Tract Infections in Canada, 2002 to 2004

M. Kuskowski, James R. Johnson, K. Nichol, 2009, Antimicrobial Agents and Chemotherapy.

Multidrug-resistant North American pulsotype 2 Clostridium difficile was the predominant toxigenic hospital-acquired strain in the province of Manitoba, Canada, in 2006-2007.

J. Wylie, M. Mulvey, J. Karlowsky, 2012, Journal of medical microbiology.

Overview of Seizure-Inducing Potential of Doripenem

N. Ketter, G. Zhanel, R. Redman, 2009, Drug safety.

Assessment of multidrug resistance, clonality and virulence in non-PCV-13 Streptococcus pneumoniae serotypes in Canada, 2011-13.

M. Gilmour, W. Demczuk, I. Martin, 2015, The Journal of antimicrobial chemotherapy.

Evidence that a novel quaternary compound and its organic N-chloramine derivative do not select for resistant mutants of Pseudomonas aeruginosa.

G. Zhanel, Sadegh Ghanbar, M. D. Silva, 2015, The Journal of hospital infection.

In vitro pharmacodynamic modelling simulating free serum concentrations of fluoroquinolones against multidrug-resistant Streptococcus pneumoniae.

D. Hoban, G. Zhanel, Michael Walters, 2001, Journal of Antimicrobial Chemotherapy.

Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases)

J. Lynch, G. Zhanel, N. Clark, 2013, Expert opinion on pharmacotherapy.

Uncomplicated urinary tract infection in women. Current practice and the effect of antibiotic resistance on empiric treatment.

L. Nicolle, J. Conly, V. Senikas, 2006, Canadian family physician Medecin de famille canadien.

Asymptomatic bacteriuria. Which patients should be treated?

D. Guay, G. Harding, G. Zhanel, 1990, Archives of internal medicine.

Vancomycin-resistant enterococci (VRE) colonization of high-risk patients in tertiary care Canadian hospitals

J. Karlowsky, D. Hoban, G. Zhanel, 1999 .

Comparison of pathogens and their antimicrobial resistance patterns in paediatric, adult and elderly patients in Canadian hospitals.

J. Karlowsky, D. Hoban, P. Lagacé-Wiens, 2013, The Journal of antimicrobial chemotherapy.