K. Brookes

发表

Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

J. Hardy, K. Morgan, C. Holmes, 2019, Translational Psychiatry.

Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways

Alan J. Thomas, J. Attems, N. Cairns, 2020, Brain communications.

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Nick C Fox, Cory C. Funk, D. G. Clark, 2017, Nature Genetics.

Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease

D. Hernandez, A. Singleton, J. Hardy, 2018, Neurobiology of Aging.

DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: No evidence for association

P. Sham, I. Craig, J. Mill, 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

D. G. Clark, M. Fornage, A. Hofman, 2018, Alzheimer's & dementia.

Genetic variability in response to Aβ deposition influences Alzheimer’s risk

F. Edwards, J. Hardy, Sevinc Bayram, 2018 .

Title : Polygenic risk score in post-mortem diagnosed sporadic early onset Alzheimer ’ s disease

D. Hernandez, A. Singleton, J. Hardy, 2018 .

Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathways

J. Attems, N. Cairns, R. Sims, 2020 .

OP-BRAI200337 3763..3775

Alan J. Thomas, J. Mill, K. Morgan, 2021 .

Screening Exon 16 and 17 of the Amyloid Precursor Protein Gene in Sporadic Early-Onset Alzheimer’s Disease (sEOAD)

A. Singleton, K. Morgan, D. Mann, 2016 .

Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples

P. Asherson, Xiaohui Xu, Yu-Yu Wu, 2007, BMC psychiatry.

Investigating Splicing Variants Uncovered by Next-Generation Sequencing the Alzheimer’s Disease Candidate Genes, CLU, PICALM, CR1, ABCA7, BIN1, the MS4A Locus, CD2AP, EPHA1 and CD33

K. Morgan, P. Passmore, D. Mann, 2016 .

Candidate gene studies of attention deficit hyperactivity disorder (ADHD).

K. Brookes, 2006 .

Full Ectopic Hedgehog signalling causes cleft palate and defective osteogenesis.

M. Dixon, K. Brookes, N. Hammond, 2019 .

Running Title: Whole-exome sequencing of the BDR cohort: Evidence to support the role of the PILRA gene in Alzheimer’s disease

D. Hernandez, A. Singleton, J. Hardy, 2017 .

Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk

J. Hardy, Sevinc Bayram, K. Morgan, 2019, Brain communications.

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Nick C Fox, Catherine A. Macleod, W. M. van der Flier, 2022, Nature Genetics.

Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes

J. Hardy, Sevinc Bayram, K. Morgan, 2021, bioRxiv.

The VNTR in complex disorders: the forgotten polymorphisms? A functional way forward?

K. Brookes, K J Brookes, Keeley J. Brookes, 2013, Genomics.

Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease

K. Morgan, E. Hollox, K. Brookes, 2018, bioRxiv.

Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings

B. Franke, M. Gill, R. Anney, 2008, Biological Psychiatry.

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

Sevinc Bayram, K. Morgan, M. Shoai, 2021, Brain : a journal of neurology.

Partial replication of a DRD 4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test 2007

B. Franke, M. Gill, R. Ebstein, 2011 .

Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder

Michael Gill, M. Gill, D. Coghill, 2009, Neuroscience Letters.

Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples

N. Ilott, P. Asherson, Xiaohui Xu, 2009, BMC Research Notes.

Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program

B. Franke, M. Gill, R. Anney, 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD

B. Franke, M. Gill, B. Neale, 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene-environment interaction.

B. Franke, M. Gill, R. Anney, 2008, Journal of child psychology and psychiatry, and allied disciplines.

Intelligence in DSM‐IV combined type attention‐deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention‐deficit/hyperactivity disorder

B. Franke, M. Gill, R. Anney, 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Partial Replication of a DRD4 Association in ADHD Individuals Using a Statistically Derived Quantitative Trait for ADHD in a Family-Based Association Test

B. Franke, M. Gill, J. Buitelaar, 2007, Biological Psychiatry.

Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD.

B. Franke, M. Gill, R. Ebstein, 2007, The American journal of psychiatry.

Association of Fatty Acid Desaturase Genes with Attention-Deficit/Hyperactivity Disorder

E. Taylor, P. Asherson, Xiaohui Xu, 2006, Biological Psychiatry.

A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.

Gerome Breen, Jo Knight, Philip Asherson, 2006, Archives of general psychiatry.

Family‐based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: No evidence for association in UK and Taiwanese samples

J. Mill, E. Taylor, P. Asherson, 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study

P. Asherson, Xiaohui Xu, Yu-Yu Wu, 2005, BMC Medical Genetics.

New insights on the genetic etiology of Alzheimer’s and related dementia

Nick C Fox, Catherine A. Macleod, W. M. van der Flier, 2020 .

A common haplotype of the dopamine transporter gene is associated with attention deficit hyperactivity disorder and interacts with prenatal exposure to alcohol

G. Breen, J. Mill, E. Taylor, 2005 .

Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array

D. Hernandez, A. Singleton, J. Hardy, 2017, Neurobiology of Aging.

Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset

D. Hernandez, A. Singleton, D. Neary, 2015 .

Methylation Profiling RIN3 and MEF2C Identifies Epigenetic Marks Associated with Sporadic Early Onset Alzheimer’s Disease

K. Morgan, J. Craigon, G. Seymour, 2017, Journal of Alzheimer's disease reports.

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex

Alan J. Thomas, J. Mill, K. Morgan, 2020, bioRxiv.

Genome-wide association findings from the brains for dementia research cohort

Alan J. Thomas, K. Morgan, K. Brookes, 2021, Neurobiology of Aging.

Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment

K. Morgan, C. Holmes, W. Schlotz, 2020, Scientific Reports.

DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

J. Mill, K. Morgan, S. Love, 2022, bioRxiv.

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

Michelle K. Lupton, D. Hernandez, A. Singleton, 2018, Molecular Psychiatry.

The DRD4 receptor Exon 3 VNTR and 5′ SNP variants and mRNA expression in human post‐mortem brain tissue

L. Kent, K. Brookes, J. Simpson, 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways

J. Attems, N. Cairns, J. Mill, 2020, medRxiv.

Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post‐mortem midbrain tissue

Philip Asherson, Benjamin M Neale, Karen Sugden, 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genetic variants in glutamate-, Aβ−, and tau-related pathways determine polygenic risk for Alzheimer's disease

Alan J. Thomas, J. Hardy, K. Morgan, 2020, Neurobiology of Aging.

Endpoint PCR Detection of Sars-CoV-2 RNA

Q. Hanley, K. Brookes, C. Warren, 2020, medRxiv.

Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: Genetic and molecular studies

D. Skuse, M. Gill, L. Gallagher, 2010, Neuroscience Letters.

5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study.

M. Rutter, E. Sonuga-Barke, W. Schlotz, 2010, Journal of child psychology and psychiatry, and allied disciplines.

The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.

K. Morgan, A. Smith, P. Kehoe, 2019, Journal of Alzheimer's disease : JAD.

Family‐based association study between brain‐derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

J. Mill, P. Asherson, Xiaohui Xu, 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Increased cerebral perfusion in adult attention deficit hyperactivity disorder is normalised by stimulant treatment: A non-invasive MRI pilot study

David C. Alsop, Ruth L. O'Gorman Tuura, Mitul A. Mehta, 2008, NeuroImage.

DNA pooling identifies association of the noradrenergic transporter gene (NET1) with attention deficit hyperactivity disorder (ADHD).

P. Sham, J. Mill, P. Asherson, 2003 .

Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer’s disease

K. Morgan, P. Francis, K. Brookes, 2018, BMC Research Notes.

Whole‐exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease

D. Hernandez, A. Singleton, J. Hardy, 2018, Neuropathology and applied neurobiology.

Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene–environment interplay

M. Rutter, E. Sonuga-Barke, R. Kumsta, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

No association between two polymorphisms of the serotonin transporter gene and combined type attention deficit hyperactivity disorder

B. Franke, R. Anney, J. Sergeant, 2009 .

Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder

M. Gill, L. Kent, Z. Hawi, 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

Henrik, B. Franke, M. Gill, 2008, Molecular Psychiatry.

Evaluating the Classification Accuracy of Expression Quantitative Trait Loci Calculated Polygenic Risk Scores in Alzheimer's Disease.

K. Brookes, 2023, International journal of molecular sciences.

An alternative method of SNP inclusion to develop a generalized polygenic risk score analysis across Alzheimer's disease cohorts

K. Morgan, K. Brookes, Alan Thomas, 2023, Frontiers in Dementia.

Brief Research Communication No Association Between Two Polymorphisms of the Serotonin Transporter Gene and Combined Type Attention Deficit Hyperactivity Disorder

B. Franke, M. Gill, R. Anney, 2008 .

Association of ADHD with genetic variants in the 5′‐region of the dopamine transporter gene: Evidence for allelic heterogeneity

B. Franke, M. Gill, R. Anney, 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Utilising Polygenic Risk Score Analysis for AD to Determine the “Sphere of Influence” of the APOE Isoform SNPs

K. Brookes, Connor Farrell, 2022, Journal of Neurology & Neuromedicine.

Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment

K. Morgan, C. Holmes, W. Schlotz, 2020, Scientific Reports.

DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters

P. Asherson, J. Knight, X. Xu, 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples

N. Ilott, P. Asherson, Xiaohui Xu, 2009, BMC Research Notes.

Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD

L. Kent, Z. Hawi, K. Brookes, 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

J Sergeant, R Plomin, A Rothenberger, 2006, Molecular Psychiatry.

No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study

P. Asherson, Xiaohui Xu, Yu-Yu Wu, 2005, BMC Medical Genetics.

Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array

D. Warden, C. Medway, H. Kölsch, 2017, Neurobiology of Aging.

No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study

P. Asherson, Xiaohui Xu, Yu-Yu Wu, 2005, BMC Medical Genetics.