D. Hughes

发表

Mechanisms and consequences of bacterial resistance to antimicrobial peptides.

D. Andersson, D. Hughes, J. Kubicek-Sutherland, 2016, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Virulence of antibiotic-resistant Salmonella typhimurium.

D. Andersson, D. Hughes, J. Björkman, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Evolution of antibiotic resistance at non-lethal drug concentrations.

D. Andersson, D. Hughes, 2012, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

Linus Sandegren, Diarmaid Hughes, Erik Gullberg, 2011, PLoS pathogens.

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance.

O. Berg, D. Andersson, D. Hughes, 2000, Science.

Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus

J. Gustafson, D. Hughes, Sha Cao, 2011, PloS one.

Antibiotic resistance and its cost: is it possible to reverse resistance?

Diarmaid Hughes, D. Andersson, D. Hughes, 2010, Nature Reviews Microbiology.

Biological Cost of Single and Multiple Norfloxacin Resistance Mutations in Escherichia coli Implicated in Urinary Tract Infections

D. Sandvang, D. Hughes, N. Frimodt-Møller, 2005, Antimicrobial Agents and Chemotherapy.

Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity.

D. Hughes, Mirjana Macvanin, 2010, Methods in molecular biology.

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.

O. Cars, E. Nielsen, D. Andersson, 2017, International journal of antimicrobial agents.

The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

D. Hughes, G. Brandis, 2020, PLoS genetics.

Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

D. Hughes, Sha Cao, G. Brandis, 2019, Molecular biology and evolution.

Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

D. Hughes, Sha Cao, D. Huseby, 2022, Molecular biology and evolution.

Biological roles of translesion synthesis DNA polymerases in eubacteria

D. Andersson, S. Koskiniemi, D. Hughes, 2010, Molecular microbiology.

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).

A. Karlén, S. Mowbray, M. D. De Rosa, 2017, Bioorganic & medicinal chemistry.

Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

O. Ercan, S. Hobbie, E. Liepinsh, 2020, Clinical pharmacology and therapeutics.

Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli.

O. Cars, D. Hughes, Linda L. Marcusson, 2005, The Journal of antimicrobial chemotherapy.

Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics.

D. Hughes, Mirjana Macvanin, 2005, FEMS microbiology letters.

Error‐prone EF‐Tu reduces in vivo enzyme activity and cellular growth rate

D. Hughes, 1991, Molecular microbiology.

Mutant ribosomes can generate dominant kirromycin resistance

R. Buckingham, I. Tubulekas, D. Hughes, 1991, Journal of bacteriology.

Both genes for EF-Tu in Salmonella typhimurium are individually dispensable for growth.

D. Hughes, 1990, Journal of molecular biology.

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

D. Andersson, D. Hughes, J. Björkman, 1999, Molecular microbiology.

Mutants of elongation factor Tu promote ribosomal frameshifting and nonsense readthrough.

J. F. Atkins, D. Hughes, S. Thompson, 1987, The EMBO journal.

Selection of resistance at lethal and non-lethal antibiotic concentrations.

D. Andersson, D. Hughes, 2012, Current opinion in microbiology.

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

D. Hughes, G. Brandis, 2013, Antibiotics.

Antibiotic development and resistance.

D. Andersson, D. Hughes, 2001 .

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

I. Bekeredjian-Ding, B. Kerscher, D. Hughes, 2022, Frontiers in Microbiology.

Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

B. Levin, D. Hughes, D. Huseby, 2021, Proceedings of the National Academy of Sciences.

Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating Staphylococcus aureus infections

B. Levin, D. Hughes, D. Huseby, 2020 .

Adventures with Mutation and Selection in Beehive and Cow Country

D. Andersson, D. Hughes, 2011 .

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

O. Cars, D. Hughes, Linda L. Marcusson, 2006, The Journal of antimicrobial chemotherapy.

Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues.

V. Ryabova, K. Yadav, D. Hughes, 2020, Bioorganic & medicinal chemistry.

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.

C. Charrier, M. Craighead, D. Hughes, 2016, Bioorganic & medicinal chemistry letters.

Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

D. Hughes, G. Brandis, E. Garmendia, 2018, mBio.

Homologous recombination between the tuf genes of Salmonella typhimurium.

D. Hughes, F. Abdulkarim, 1996, Journal of molecular biology.

Discovery and preclinical development of new antibiotics

A. Karlén, D. Hughes, 2014, Upsala journal of medical sciences.

Genetic and Phenotypic Identiﬁcation of Fusidic Acid-Resistant Mutants with the Small-Colony-Variant Phenotype in Staphylococcus aureus (cid:1)

D. Hughes, J. Lannergård, T. Norström, 2007 .

MutantRibosomes CanGenerate DominantKirromycin Resistance

D. Hughes, 1991 .

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates.

D. Hughes, G. Brandis, 2013, The Journal of antimicrobial chemotherapy.

Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness

D. Hughes, N. Frimodt-Møller, Linda L. Marcusson, 2009, PLoS pathogens.

Diarmaid Hughes, O. Cars, D. Hughes, 2007, The Journal of antimicrobial chemotherapy.

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase.

A. Karlén, S. Mowbray, D. Hughes, 2018, European journal of medicinal chemistry.

Expression of the qepA1 gene is induced under antibiotic exposure

L. Guy, D. Hughes, G. Brandis, 2021, The Journal of antimicrobial chemotherapy.

Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

K. Yadav, D. Hughes, Linnéa Garoff, 2017, The Journal of antimicrobial chemotherapy.

Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain.

A. Namouchi, D. Hughes, H. Mardassi, 2016, The Journal of antimicrobial chemotherapy.

Fitness‐compensatory mutations in rifampicin‐resistant RNA polymerase

L. Liljas, D. Hughes, G. Brandis, 2012, Molecular microbiology.

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

D. Hughes, D. Huseby, G. Brandis, 2020, Proceedings of the National Academy of Sciences.

Environmental and genetic modulation of the phenotypic expression of antibiotic resistance

D. Andersson, D. Hughes, 2017, FEMS microbiology reviews.

Persistence of antibiotic resistance in bacterial populations.

D. Andersson, D. Hughes, 2011, FEMS microbiology reviews.

Microbiological effects of sublethal levels of antibiotics

Diarmaid Hughes, D. Andersson, D. Hughes, 2014, Nature Reviews Microbiology.

Editorial: Bacterial pathogens, antibiotics and antibiotic resistance.

O. Kuipers, E. Banin, D. Hughes, 2017, FEMS microbiology reviews.

Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance

D. Hughes, 2003, Nature Reviews Genetics.

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

O. Ercan, S. Hobbie, J. Teo, 2019, The Journal of antimicrobial chemotherapy.

Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes

D. Andersson, D. Hughes, T. K. Petersen, 2005, Antimicrobial Agents and Chemotherapy.

Isopedopeptins A–H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

B. Guss, A. Strömstedt, B. Öberg, 2020, ACS chemical biology.

Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic.

L. Hansen, A. Petersen, K. Udekwu, 2012, The Journal of antimicrobial chemotherapy.

Effects of Antibiotic Resistance on Bacterial Fitness, Virulence, and Transmission

D. Andersson, D. Hughes, 2008 .

Biological cost and compensatory evolution in fusidic acid‐resistant Staphylococcus aureus

D. Andersson, D. Hughes, J. Björkman, 2001, Molecular microbiology.

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

Diarmaid Hughes, D. Andersson, D. Hughes, 2015, Nature Reviews Genetics.

tRNA-ribosome interactions.

M. Ehrenberg, D. Hughes, N. Bilgin, 1995, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The processive kinetics of gene conversion in bacteria

Johan Paulsson, Meriem El Karoui, Diarmaid Hughes, 2017, Molecular microbiology.

Gene amplification and adaptive evolution in bacteria.

Diarmaid Hughes, D. Andersson, D. Hughes, 2009, Annual review of genetics.

Growth and translation elongation rate are sensitive to the concentration of EF‐Tu

I. Tubulekas, D. Hughes, 1993, Molecular microbiology.

Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

Nurcan Tuncbag, D. Andersson, B. Kacar, 2016, mBio.

Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

S. Nordlander, K. Udekwu, J. Hennemann, 2017, Front. Immunol..

The role of EF-Tu and other translation components in determining translocation step size.

J. F. Atkins, R. Gesteland, T. Tuohy, 1990, Biochimica et biophysica acta.

Suppression of a -1 frameshift mutation by a recessive tRNA suppressor which causes doublet decoding

J. F. Atkins, D. Hughes, D. O'mahony, 1989, Journal of bacteriology.

Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu

D. Hughes, M. Aulin, Monica Rydén Aulin, 1990, Journal of bacteriology.

Genetic characterization of frameshift suppressors with new decoding properties

J. F. Atkins, T. Tuohy, B. Nichols, 1989, Journal of bacteriology.

Missense substitutions lethal to essential functions of EF-Tu.

R. Buckingham, T. Tuohy, D. Hughes, 1991, Biochimie.

Novel Mutants of EF-Tu

C. Kurland, D. Hughes, 1989 .

Mutant forms of tufA and tufB independently suppress nonsense mutations.

D. Hughes, 1987, Journal of molecular biology.

Limitations of translational accuracy

Måns Ehrenberg, Diarmaid Hughes, M. Ehrenberg, 1996 .

Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

D. Hughes, Sha Cao, D. Huseby, 2020, The Journal of antimicrobial chemotherapy.

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

D. Hughes, D. Huseby, Linnéa Garoff, 2018, The Journal of antimicrobial chemotherapy.

Acetate Availability and Utilization Supports the Growth of Mutant Sub-Populations on Aging Bacterial Colonies

D. Hughes, Marie Wrande, Jessica M. Bergman, 2014, PloS one.

Mutants of the RNA‐processing enzyme RNase E reverse the extreme slow‐growth phenotype caused by a mutant translation factor EF‐Tu

Disa L. Hammarlöf, D. Hughes, 2008, Molecular microbiology.

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.

A. Mankin, J. Bolla, C. Cotteaux-Lautard, 2018, Molecular cell.

Co‐evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

D. Hughes, Sha Cao, G. Brandis, 2018, Molecular microbiology.

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data

E. Nielsen, D. Andersson, D. Hughes, 2017, The Journal of antimicrobial chemotherapy.

Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

Georg Peters, Diarmaid Hughes, R. Proctor, 2008, Antimicrobial Agents and Chemotherapy.

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome

I. Tubulekas, D. Hughes, 1993, Journal of bacteriology.

Antibacter ial Agents that Cause Miscoding by Binding at a New Ribosomal Site Graphical Abstract Highlights

A. Mankin, J. Bolla, C. Cotteaux-Lautard, 2022 .

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

D. Hughes, G. Brandis, 2016, PLoS genetics.

Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions.

D. Hughes, 2000, Journal of molecular biology.

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants.

O. Cars, E. Nielsen, D. Andersson, 2015, The Journal of antimicrobial chemotherapy.

Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes

Diarmaid Hughes, D. Hughes, 2000, Genome Biology.

The Dynamic Bacterial Genome: Biological consequences for bacteria of homologous recombination

D. Hughes, T. Norström, 2005 .

Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria

D. Andersson, M. Nilsson, Song Sun, 2012, PloS one.

Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site.

A. Liljas, K. Martemyanov, A. Gudkov, 2000, Journal of molecular biology.

Evolutionary Trajectories to Antibiotic Resistance.

D. Andersson, D. Hughes, 2017, Annual review of microbiology.

Selection and evolution of resistance to antimicrobial drugs

D. Hughes, 2014, IUBMB life.

Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus

D. Hughes, J. Lannergård, T. Norström, 2009, Antimicrobial Agents and Chemotherapy.

Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium with Low Fitness In Vivo Are Defective in RpoS Induction

S. Eriksson, D. Andersson, D. Hughes, 2003, Antimicrobial Agents and Chemotherapy.

The States, Conformational Dynamics, and Fusidic Acid-Resistant Mutants of Elongation Factor G

A. Liljas, S. Al-Karadaghi, K. Martemyanov, 2000 .

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

S. Cole, A. Karlén, S. Mowbray, 2022, ACS infectious diseases.

The Origin of Mutants under Selection: Interactions of Mutation, Growth, and Selection.

J. Roth, D. Andersson, D. Hughes, 2011, EcoSal Plus.

Selection and Transmission of Antibiotic-Resistant Bacteria

Diarmaid Hughes, D. Andersson, D. Hughes, 2017, Microbiology spectrum.

Impact of Homologous Recombination on Genome Organization and Stability

D. Hughes, 1999 .

Genetic and Phenotypic Identification of Fusidic Acid-Resistant Mutants with the Small-Colony-Variant Phenotype in Staphylococcus aureus

D. Hughes, J. Lannergård, T. Norström, 2007, Antimicrobial Agents and Chemotherapy.

Effect of Translesion DNA Polymerases, Endonucleases and RpoS on Mutation Rates in Salmonella typhimurium

D. Andersson, S. Koskiniemi, D. Hughes, 2010, Genetics.

Accumulation of mutants in “aging” bacterial colonies is due to growth under selection, not stress-induced mutagenesis

J. Roth, D. Hughes, Marie Wrande, 2008, Proceedings of the National Academy of Sciences.

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

D. Hughes, A. Zorzet, Linda L. Marcusson, 2017, The Journal of antimicrobial chemotherapy.

Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates

D. Andersson, D. Hughes, 1997, Journal of bacteriology.

Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

L. Guy, D. Hughes, Sha Cao, 2021, mBio.

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB

D. Hughes, G. Brandis, 2018, Scientific Reports.

Turnover of mRNAs is one of the essential functions of RNase E

Disa L. Hammarlöf, D. Hughes, E. Garmendia, 2015, Molecular microbiology.

Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

D. Hughes, D. Huseby, G. Brandis, 2020, Molecular biology and evolution.

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Tua Lilja, D. Hughes, D. Huseby, 2020, Molecular biology and evolution.

Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.

O. Cars, T. Cars, D. Hughes, 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary Tract Infections

D. Hughes, P. Komp Lindgren, A. Karlsson, 2003, Antimicrobial Agents and Chemotherapy.

Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

D. Hughes, D. Huseby, G. Brandis, 2022, Genome biology and evolution.

Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

K. Yadav, D. Hughes, D. Huseby, 2021, The Journal of antimicrobial chemotherapy.

Mutations to kirromycin resistance occur in the interface of domains I and III of EF‐Tu·GTP

D. Hughes, F. Abdulkarim, Farhad Abdulkarim, 1994, FEBS letters.

Autoregulation of the tufB operon in Salmonella

D. Hughes, G. Brandis, Jessica M. Bergman, 2016, Molecular microbiology.

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

K. Becker, S. Hobbie, E. Böttger, 2021, EBioMedicine.

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli

D. Hughes, D. Huseby, G. Brandis, 2017, The Journal of antimicrobial chemotherapy.

Åsa Karlsson and Diarmaid Tract Infections Isolates from Patients with Urinary coli Escherichia Fluoroquinolone Resistance in Mutation Rate and Evolution of

D. Hughes, P. Komp Lindgren, A. Karlsson, 2003 .

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.

K. Becker, S. Hobbie, E. Böttger, 2020, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.

J. Lindberg, S. Hobbie, D. Hughes, 2022, Clinical Microbiology and Infection.

ENABLE: an engine for European antibacterial drug discovery and development

A. Karlén, D. Hughes, Marie Olliver, 2021, Nature Reviews Drug Discovery.

Can phylogenetic type predict resistance development?

F. Hasan, D. Hughes, Sha Cao, 2011, The Journal of antimicrobial chemotherapy.

Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

D. Hughes, D. Huseby, G. Brandis, 2020, The Journal of antimicrobial chemotherapy.

Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli

D. Hughes, D. Huseby, G. Brandis, 2017, Molecular biology and evolution.

Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli

D. Hughes, H. Örlén, 2006, Antimicrobial Agents and Chemotherapy.

Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu

Disa L. Hammarlöf, D. Hughes, Jessica M. Bergman, 2014, PloS one.

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

D. Hughes, Sha Cao, D. Huseby, 2017, mBio.

Using the power of genetic suppressors to probe the essential functions of RNase E

D. Hughes, 2016, Current Genetics.

The isolation and mapping of EF-Tu mutations in Salmonella typhimurium

D. Hughes, 2004, Molecular and General Genetics MGG.

Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium.

D. Hughes, Ola Arwidsson, 2004, Journal of molecular biology.

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Guido V. Janssen, C. Pál, L. Pardo, 2023, Journal of medicinal chemistry.

Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

I. Bekeredjian-Ding, B. Kerscher, D. Hughes, 2022, Frontiers in Microbiology.

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Guido V. Janssen, B. Birnir, C. Stevenson, 2023, Journal of medicinal chemistry.

Muller's ratchet decreases fitness of a DNA-based microbe.

D. Andersson, D. Hughes, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Elongation Factors: Translation

D. Hughes, 2013 .

Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Kim Vestö, D. Hughes, M. Rhen, 2018, bioRxiv.

Temperature-Sensitive Mutants of RNase E in Salmonella enterica

L. Liljas, Disa L. Hammarlöf, D. Hughes, 2011, Journal of bacteriology.

[Antibiotic resistance here to stay? Compensatory mutations restore virulence of resistant bacteria].

D. Andersson, D. Hughes, J. Björkman, 1998, Lakartidningen.

Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility.

O. Cars, D. Hughes, Linda L. Marcusson, 2014, International Journal of Antimicrobial Agents.

Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model

P. Tulkens, F. Van Bambeke, D. Hughes, 2011, Antimicrobial Agents and Chemotherapy.

Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate

I. Tubulekas, D. Hughes, 1993, Molecular microbiology.

Mutants of EF‐Tu defective in binding aminoacyl‐tRNA

M. Ehrenberg, D. Hughes, F. Abdulkarim, 1996, FEBS letters.

Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance

D. Hughes, 2003, Nature Reviews Genetics.

Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium Have Low Levels of Heme and a Reduced Rate of Respiration and Are Sensitive to Oxidative Stress

D. Hughes, Mirjana Macvanin, A. Ballagi, 2004, Antimicrobial Agents and Chemotherapy.

The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants.

A. Liljas, D. Hughes, U. Johanson, 1996, Journal of molecular biology.

Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium.

D. Hughes, U. Johanson, D. Hughes, 1994, Gene.

Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli.

D. Hughes, U. Johanson, D. Hughes, 1992, Gene.

Selection of resistance at lethal and non-lethal antibiotic concentrations.

D. Andersson, D. Hughes, 2012, Current opinion in microbiology.

Evolution of antibiotic resistance at non-lethal drug concentrations.

D. Andersson, D. Hughes, 2012, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis.

D. Hughes, G. Brandis, Franziska Pietsch, 2015, The Journal of antimicrobial chemotherapy.