Mitsuhiro Watanabe

发表

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

J. Auwerx, T. Kodama, J. Harney, 2006, Nature.

Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice

J. Auwerx, L. Fajas, Mitsuhiro Watanabe, 2004 .

Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.

J. Auwerx, L. Fajas, Mitsuhiro Watanabe, 2004, The Journal of clinical investigation.

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Johan Auwerx, Stefano Fumagalli, Mitsuhiro Watanabe, 2004, Nature.

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice

J. Auwerx, M. Champy, A. Dierich, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.

J. Auwerx, T. Kodama, Haruhisa Iguchi, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.

T. Noda, S. Tsukita, M. Wada, 2011, Gastroenterology.

Bile acid binding resin improves hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver.

Kohkichi Morimoto, H. Itoh, Arata Itoh, 2015, Diabetes research and clinical practice.

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure*

J. Auwerx, Kohkichi Morimoto, H. Itoh, 2011, The Journal of Biological Chemistry.

Effects of vegetarian diets on blood pressure

Mitsuhiro Watanabe, Y. Yokoyama, Kazuo Tsubota, 2016 .

Aerobic exercise increases tear secretion in type 2 diabetic mice.

K. Tsubota, Kohkichi Morimoto, M. Kawashima, 2014, Investigative ophthalmology & visual science.

Cornea Aerobic Exercise Increases Tear Secretion in Type 2 Diabetic Mice

K. Tsubota, Kohkichi Morimoto, M. Kawashima, 2014 .

Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis.

J. Auwerx, T. Hibi, Y. Kanai, 2013, Gastroenterology.

Impaired pancreatic growth, β cell mass, and β cell function in E2F1-7-/- mice

J. Auwerx, L. Fajas, Mitsuhiro Watanabe, 2004 .

Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery.

H. Itoh, H. Hirose, Mitsuhiro Watanabe, 2009, Metabolism: clinical and experimental.

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

J. Auwerx, Kohkichi Morimoto, H. Itoh, 2012, PloS one.

The Effect of Colestimide on Visceral Fat Mass and Cytokine Levels in Patients with Metabolic Syndrome

H. Nakano, J. Auwerx, Kentaro Watanabe, 2013 .

Neuroprotective role of retinal SIRT3 against acute photo-stress

K. Tsubota, Y. Ozawa, K. Yuki, 2017, npj Aging and Mechanisms of Disease.

Peroxisome Proliferator-activated Receptor (PPAR)-2 Controls Adipocyte Differentiation and Adipose Tissue Function through the Regulation of the Activity of the Retinoid X Receptor/PPARγ Heterodimer*

J. Auwerx, V. Schreiber, G. de Murcia, 2007, Journal of Biological Chemistry.

Ligand‐dependent contribution of RXRβ to cholesterol homeostasis in Sertoli cells

J. Auwerx, P. Chambon, M. Mark, 2004, EMBO reports.

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver

Mitsuhiro Watanabe, Y. Yokoyama, Kazuo Tsubota, 2019, Foods.

Participation of the arachidonic acid cascade pathway in macrophage binding/uptake of oxidized low density lipoprotein.

Mitsuhiro Watanabe, K. Kikugawa, M. Beppu, 2002, Biological & pharmaceutical bulletin.

Inhibition of the Activity of Mouse Macrophage Scavenger Receptors by Antioxidants

Mitsuhiro Watanabe, K. Kikugawa, M. Beppu, 2001 .

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

Stacy A. Johnson, D. Moore, Mitsuhiro Watanabe, 2008, Hepatology.

Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function

Mitsuhiro Watanabe, Y. Yokoyama, Kazuo Tsubota, 2019, Nutrients.

Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism

D. Moore, S. Kennedy, N. Davidson, 2014, Hepatology research : the official journal of the Japan Society of Hepatology.

Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in Male Mice.

Kohkichi Morimoto, H. Itoh, J. Irie, 2016, Endocrinology.

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

J. Auwerx, K. Schoonjans, Mitsuhiro Watanabe, 2012, Scientific Reports.

Dietary Cholesterol Reduces Plasma Triacylglycerol in Apolipoprotein E-Null Mice: Suppression of Lipin-1 and -2 in the Glycerol-3-Phosphate Pathway

S. Arata, H. Itabe, R. Kato, 2011, PloS one.

Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice.

H. Eguchi, H. Nagano, H. Hikita, 2014, Gastroenterology.

Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice.

M. Zerial, S. Tsukita, Kirstin Meyer, 2018, Journal of hepatology.

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

H. Saito, Mitsuhiro Watanabe, Yoshimasa Saito, 2018, Oncotarget.

The Niemann-Pick C1 like 1 (NPC1L1) inhibitor ezetimibe improves metabolic disease via decreased liver X receptor (LXR) activity in liver of obese male mice.

Kohkichi Morimoto, H. Itoh, T. Miyazaki, 2014, Endocrinology.

Dietary Lactoferrin Alleviates Age-Related Lacrimal Gland Dysfunction in Mice

K. Tsubota, T. Kawakita, M. Kawashima, 2012, PloS one.

Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

K. Tsubota, T. Kawakita, M. Kawashima, 2013, Experimental Gerontology.

Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness.

J. Goedert, I. Gombos, J. Szabó, 2018, Biochimica et biophysica acta. Bioenergetics.

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Johan Auwerx, Masashi Yanagisawa, Mitsuhiro Watanabe, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Role of bile acids in the regulation of the metabolic pathways.

Kohkichi Morimoto, Mitsuhiro Watanabe, Y. Yokoyama, 2016, World journal of diabetes.

Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

J. Auwerx, S. Fumagalli, S. Kozma, 2004, Nature.

Tysnd1 Deficiency in Mice Interferes with the Peroxisomal Localization of PTS2 Enzymes, Causing Lipid Metabolic Abnormalities and Male Infertility

S. Wakana, Y. Okazaki, T. Noda, 2013, PLoS genetics.

The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT–liver communication

S. Kajimura, Mark P. Jedrychowski, D. Nomura, 2020, EMBO reports.

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.

Sander M Houten, Johan Auwerx, David D Moore, 2004, The Journal of clinical investigation.

Vitamin D and energy homeostasis—of mice and men

J. Auwerx, R. Bouillon, G. Carmeliet, 2014, Nature Reviews Endocrinology.

Endocrine functions of bile acids

J. Auwerx, S. Houten, Mitsuhiro Watanabe, 2006, The EMBO journal.

Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway

T. Hibi, T. Kanai, H. Itoh, 2012, Immunology.

PARP-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the RXR/PPARγ heterodimer

J. Auwerx, V. Schreiber, S. Houten, 2007 .

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter (*)

J Auwerx, B Staels, A. Mahfoudi, 1995, The Journal of Biological Chemistry.

Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis.

N. Barnard, S. Levin, Mitsuhiro Watanabe, 2014, Cardiovascular diagnosis and therapy.

Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.

N. McKenna, D. Moore, S. Ochsner, 2011, The Journal of clinical investigation.

A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice

Mitsuhiro Watanabe, Y. Yokoyama, Takahiro J. Nakamura, 2020, PloS one.

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen

K. Tsubota, M. Kawashima, S. Inoue, 2021, Scientific Reports.

Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways

Mitsuhiro Watanabe, Y. Ogawa, Y. Yokoyama, 2021, Scientific Reports.

Bile Acids and Metabolic Syndrome

Mitsuhiro Watanabe, Hiroki Taoka, 2017 .

Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice.

Kohkichi Morimoto, H. Itoh, Y. Oike, 2017, Metabolism: clinical and experimental.

Developments in understanding bile acid metabolism

Kohkichi Morimoto, H. Itoh, Mitsuhiro Watanabe, 2013, Expert review of endocrinology & metabolism.

Tysnd 1 Deficiency in Mice Interferes with the Peroxisomal Localization of PTS 2 Enzymes , Causing Lipid Metabolic Abnormalities and Male Infertility

S. Wakana, Y. Okazaki, T. Noda, 2018 .

Metabolic Effects of Bee Larva-Derived Protein in Mice: Assessment of an Alternative Protein Source

A. Hirayama, S. Fukuda, Mitsuhiro Watanabe, 2021, Foods.

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

J. Auwerx, K. Tsubota, G. Benegiamo, 2020, iScience.

Sodium ferrous citrate and 5‐aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

J. Auwerx, G. Benegiamo, Mitsuhiro Watanabe, 2023, Obesity.

The Antiaging Approach for the Treatment of Dry Eye

K. Tsubota, T. Kawakita, M. Doğru, 2012, Cornea.

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer.

J. Auwerx, V. Schreiber, J. Ménissier-de murcia, 2007, The Journal of biological chemistry.

Bioenergetic changes in breast cancer cells by lithocholic acid

J. Goedert, I. Gombos, J. Szabó, 2018, Biochimica et Biophysica Acta.

Glutathione production by glutathione‐degrading enzymes displayed on proteoliposomes reconstituted from bovine kidney brush border membranes

K. Kikuchi, Mitsuhiro Watanabe, T. Gotoh, 2004 .