S. Mittelstadt

发表

Potential functional and pathological side effects related to off-target pharmacological activity.

E. Blomme, J. J. Lynch, T. V. Van Vleet, 2017, Journal of pharmacological and toxicological methods.

Cardiac troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals.

P. O'Brien, S. Mittelstadt, G. Dameron, 1997, Laboratory animal science.

Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

E. Blomme, T. V. Van Vleet, S. Mittelstadt, 2019, Front. Genet..

Perceived exertion and blood lactate concentration during graded treadmill running

F. Dolgener, F. Kolkhorst, S. Mittelstadt, 2004, European Journal of Applied Physiology and Occupational Physiology.

Delta efficiency of uphill roller skiing with the double pole and diagonal stride techniques.

P. Clifford, M. Hoffman, P. Watts, 1995, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

Gary Gintant, Karluss Thomas, Alan S Bass, 2006, Journal of pharmacological and toxicological methods.

Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc.

R. Hamlin, B. Keene, S. Mittelstadt, 2004, Journal of pharmacological and toxicological methods.

The proconvulsant effects of leptin on glutamate receptor-mediated seizures in mice

V. Castagné, J. J. Lynch, S. Mittelstadt, 2010, Brain Research Bulletin.

Physiological effects of technique and rolling resistance in uphill roller skiing.

M. M. Roberts, P. Clifford, S. Gaskill, 1998, Medicine and science in sports and exercise.

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

O. Reizes, S. Mittelstadt, S. R. Klopfenstein, 2007, Bioorganic & medicinal chemistry letters.

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.

G. Gintant, Y. Koshman, S. Mittelstadt, 2020, Journal of pharmacological and toxicological methods.

The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency

S. Mittelstadt, B. J. Limberg, J. Rosenbaum, 2007, Peptides.

Age Dependent Effects on Cisapride Induced QTc Prolongation in the Isolated Guinea Pig Heart

S. Mittelstadt, R. Spruell, Nancy Adams, 2006, Journal of pharmacological and toxicological methods.

Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster

A. Souers, J. Segreti, A. King, 2009, Journal of Pharmacology and Experimental Therapeutics.

In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.

A. Souers, J. Segreti, A. King, 2010, European journal of pharmacology.

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Steven C. Cullen, P. Hajduk, A. Souers, 2012, Journal of medicinal chemistry.

Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.

D. B. Duignan, P. Honore, S. Mittelstadt, 2015, Journal of medicinal chemistry.

ffi cacy in a Rodent Model of Arthritis

D. B. Duignan, P. Honore, S. Mittelstadt, 2014 .

Effects of moxifloxacin on QT interval in conscious dogs.

S. Mittelstadt, S. Hart, 2005, Journal of veterinary pharmacology and therapeutics.

Effects of Azimilide and d,l-Sotalol on the Heart Rate and Blood Pressure Response to Isoproterenol in Anesthetized Rats

S. Mittelstadt, E. Lowe, Anne E. Maynard, 1997, Cardiovascular Drugs and Therapy.

Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

K. Marsh, J. J. Lynch, S. Mittelstadt, 2008, British journal of pharmacology.

Refinement of the rodent pentylenetetrazole proconvulsion assay, which is a good predictor of convulsions in repeat-dose toxicology studies.

J. J. Lynch, S. Mittelstadt, Laura Breidenbach, 2019, Journal of pharmacological and toxicological methods.

Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.

D. B. Duignan, P. Honore, S. Mittelstadt, 2015, Journal of medicinal chemistry.

Effects of fasting on evaluation of gastrointestinal transit with charcoal meal.

S. Mittelstadt, R. Spruell, C. Hemenway, 2005, Journal of pharmacological and toxicological methods.

Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats

D. B. Duignan, G. Gintant, J. Segreti, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.

G. Gintant, Y. Koshman, S. Mittelstadt, 2021, Journal of pharmacological and toxicological methods.

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.

G. Gintant, Y. Koshman, S. Mittelstadt, 2021, Journal of pharmacological and toxicological methods.

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model.

Y. Koshman, S. Mittelstadt, J. Polakowski, 2021, Comparative medicine.

Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Xin Huang, Mufeng Hu, E. Blomme, 2019, Front. Big Data.

Preclinical species gene expression database: Development and meta-analysis

Andy H. Vo, E. Blomme, T. V. Van Vleet, 2023, Frontiers in Genetics.

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics.

Liudmila Polonchuk, Jean-Pierre Valentin, Hugo M Vargas, 2008, Journal of pharmacological and toxicological methods.

Study Design and Statistics

S. Mittelstadt, 2013 .

Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies.

V. Castagné, J. J. Lynch, S. Mittelstadt, 2011, Journal of pharmacological and toxicological methods.

Cardiovascular Function in Nonclinical Drug Safety Assessment

S. Pettit, J. Koerner, R. Sarazan, 2011, International journal of toxicology.

Cardiac receptors modulate the renal sympathetic response to dynamic exercise in rabbits.

P. Clifford, S. Mittelstadt, L. Bell, 1994, Journal of applied physiology.

The effect of aging on adrenergic and nonadrenergic receptor expression and responsiveness in canine skeletal muscle.

P. Clifford, J. Tune, S. Mittelstadt, 2012, Journal of applied physiology.

Is tonic sympathetic vasoconstriction increased in the skeletal muscle vasculature of aged canines?

P. Clifford, S. Mittelstadt, D. Delorey, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Muscle chemoreflex causes renal vascular constriction.

P. Clifford, S. Mittelstadt, L. Bell, 1996, The American journal of physiology.

The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.

Eric I. Rossman, Jennifer L. Doyle, Jennifer B Pierson, 2015, Journal of pharmacological and toxicological methods.

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.

J. Segreti, K. Marsh, J. J. Lynch, 2019, Journal of pharmacological and toxicological methods.

Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1

A. King, P. Kym, M. Kort, 2012, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG.

S. Mittelstadt, J. Hove, M. Craig, 2008, Journal of pharmacological and toxicological methods.

The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs.

Y. Koshman, S. Mittelstadt, T. Seifert, 2018, Journal of pharmacological and toxicological methods.

Can locomotor screening be utilized as a first-tiered approach for pre-clinical CNS/neurobehavioral safety testing?

J. J. Lynch, S. Mittelstadt, 2009 .

Muscle chemoreflex alters vascular conductance in nonischemic exercising skeletal muscle.

P. Clifford, S. Mittelstadt, L. Bell, 1994, Journal of applied physiology.

Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

G. Gintant, A. King, K. Marsh, 2009, Journal of Cardiovascular Pharmacology.

Effect of dynamic exercise on renal sympathetic nerve activity in conscious rabbits.

P. Clifford, S. Mittelstadt, L. Bell, 1993, Journal of applied physiology.

An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.

Eric I. Rossman, Jennifer B Pierson, J. Koerner, 2017, Journal of pharmacological and toxicological methods.

RESPIRATORY ALTERATIONS WITH INTRAPERICARDIAL PROCAINE IN THE CONSCIOUS RABBIT

P. Clifford, S. Mittelstadt, L. Bell, 1993, Clinical and experimental pharmacology & physiology.

Lactate response to uphill roller skiing: diagonal stride versus double pole techniques.

P. Clifford, M. Hoffman, P. Watts, 1995, Medicine and science in sports and exercise.

Physiological comparison of uphill roller skiing: diagonal stride versus double pole.

P. Clifford, M. Hoffman, P. Watts, 1994, Medicine and science in sports and exercise.

Physiological responses to specific maximal exercise tests for cross-country skiing.

P. Clifford, M. Hoffman, P. Watts, 1993, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

Off-target pharmacological activity at various kinases: Potential functional and pathological side effects.

E. Blomme, T. V. Van Vleet, S. Mittelstadt, 2023, Journal of pharmacological and toxicological methods.

Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog.

Y. Koshman, S. Mittelstadt, C. M. Foley, 2024, Journal of pharmacological and toxicological methods.

The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists.

M. Dowty, O. Reizes, C. Obringer, 2007, Bioorganic & medicinal chemistry.

Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG.

M. Dowty, O. Reizes, C. Obringer, 2007, Bioorganic & medicinal chemistry letters.