K. Wimalasena

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Detailed Characterization of p-Toluenesulfonic Acid Monohydrate as a Convenient, Recoverable, Safe, and Selective Catalyst for Alkylation of the Aromatic Nucleus

Mathew P. D. Mahindaratne and, K. Wimalasena, 1998 .

Vesicular monoamine transporters: Structure‐function, pharmacology, and medicinal chemistry

K. Wimalasena, 2011, Medicinal research reviews.

Continuous spectrophotometric assay for ascorbate oxidase based on a novel chromophoric substrate, 2-aminoascorbic acid.

K. Wimalasena, S. Dharmasena, 1993, Analytical biochemistry.

Characteristics of the mitochondrial and cellular uptake of MPP+, as probed by the fluorescent mimic, 4′I-MPP+

K. Wimalasena, Viet Q Le, M. S. Mapa, 2018, bioRxiv.

Characteristics of the mitochondrial and cellular uptake of MPP+, as probed by the fluorescent mimic, 4'I-MPP+

K. Wimalasena, Viet Q Le, M. S. Mapa, 2018, bioRxiv.

Perturbation of Dopamine Metabolism by 3-Amino-2-(4′-halophenyl)propenes Leads to Increased Oxidative Stress and Apoptotic SH-SY5Y Cell Death

K. Wimalasena, Warren C. Samms, R. P. Perera, 2007, Molecular Pharmacology.

Copper ions disrupt dopamine metabolism via inhibition of V‐H+‐ATPase: a possible contributing factor to neurotoxicity

K. Wimalasena, T. J. Wiese, D. S. Wimalasena, 2007, Journal of neurochemistry.

2, 2′‐ and 4, 4′‐Cyanines are transporter‐independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP+

K. Wimalasena, Chamila C. Kadigamuwa, Viet Q Le, 2015, Journal of neurochemistry.

Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study.

K. Wimalasena, R. P. Perera, D. S. Wimalasena, 2008, Journal of medicinal chemistry.

action illuminated through optical monitoring of synaptic vesicles in Drosophila brain.

R. Freyberg, J. Flores, D. Sulzer, 2016 .

Mechanistic studies on non-heme iron monooxygenase catalysis: epoxidation, aldehyde formation and demethylation by the .omega.-hydroxylation system of Pseudomonas oleovorans

K. Wimalasena, A. Katopodis, S. W. May, 1984 .

P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct.

Mehul N Bhakta, K. Wimalasena, P. Hollenberg, 2005, Journal of the American Chemical Society.

Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid.

Mehul N Bhakta, A. Wilks, K. Wimalasena, 2008, Journal of inorganic biochemistry.

MPP + Scaffold Containing Lipophilic Compounds are Potent Complex I Inhibitors and Selective Dopaminergic Toxins

K. Wimalasena, Virangika K. Wimalasena, Bryan Lickteig, 2020 .

The inherent high vulnerability of dopaminergic neurons toward mitochondrial toxins may contribute to the etiology of Parkinson's disease

K. Wimalasena, 2016, Neural regeneration research.

Rubredoxin from Pseudomonas oleovorans: effects of selective chemical modification and metal substitution

K. Wimalasena, A. Katopodis, S. W. May, 1984 .

Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors.

K. Wimalasena, R. P. Perera, D. S. Wimalasena, 2003, Journal of medicinal chemistry.

The reduction of membrane-bound dopamine beta-monooxygenase in resealed chromaffin granule ghosts. Is intragranular ascorbic acid a mediator for extragranular reducing equivalents?

K. Wimalasena, D. S. Wimalasena, 1995, The Journal of biological chemistry.

Are SH‐SY5Y and MN9D cell lines truly dopaminergic?

K. Wimalasena, Inoka S. Balasooriya, 2007 .

N,N,N′,N′-Tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine β-monooxygenase

K. Wimalasena, D. S. Wimalasena, 1991 .

Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction.

K. Wimalasena, D. Haines, D. S. Wimalasena, 2002, The Biochemical journal.

A Mechanistic Comparison between Cytochrome P450‐ and Chloroperoxidase‐Catalyzed N‐Dealkylation of N,N‐Dialkyl Anilines

Mehul N Bhakta, K. Wimalasena, 2005 .

Autocatalytic Radical Ring Opening of N‐Cyclopropyl‐N‐phenylamines Under Aerobic Conditions − Exclusive Formation of the Unknown Oxygen Adducts, N‐(1,2‐Dioxolan‐3‐yl)‐N‐phenylamines

H. Wickman, K. Wimalasena, M. Mahindaratne, 2001 .

A convenient entry to C2- and C3-substituted gulono-γ-lactone derivatives from L-ascorbic acid

K. Wimalasena, Ayodele O. Olabisi, M. Mahindaratne, 2005 .

Reduction of dopamine beta-monooxygenase. A unified model for apparent negative cooperativity and fumarate activation.

K. Wimalasena, D. Hughbanks-Wheaton, S. Dharmasena, 1996, The Journal of biological chemistry.

Continuous spectrophotometric assays for dopamine beta-monooxygenase based on two novel electron donors: N,N-dimethyl-1,4-phenylenediamine and 2-aminoascorbic acid.

K. Wimalasena, D. S. Wimalasena, 1991, Analytical biochemistry.

Mechanistic studies on dopamine .beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. Evidence for a single-electron-transfer mechanism

K. Wimalasena, S. W. May, 1987 .

Kinetic Evidence for Channeling of Dopamine between Monoamine Transporter and Membranous Dopamine-β-monooxygenase in Chromaffin Granule Ghosts*

K. Wimalasena, D. S. Wimalasena, 2004, Journal of Biological Chemistry.

Olefin oxygenation and N-dealkylation by dopamine beta-monooxygenase: catalysis and mechanism-based inhibition.

S. Padgette, K. Wimalasena, S. Sirimanne, 1985, Biochemistry.

A general progress curve method for the kinetic analysis of suicide enzyme inhibitors.

K. Wimalasena, D. Haines, 1996, Analytical biochemistry.

Demonstration of the ascorbate dependence of membrane-bound dopamine beta-monooxygenase in adrenal chromaffin granule ghosts.

K. Wimalasena, S. W. May, L. Fowler, 1988, The Journal of biological chemistry.

Substrate specificity of ascorbate oxidase: unexpected similarity to the reduction site of dopamine beta-monooxygenase.

K. Wimalasena, S. Dharmasena, 1994, Biochemical and biophysical research communications.

Nucleophilic Substitution Reactions of Phenacyl Bromide Oxime: Effect of the Solvent and the Basicity of the Nucleophile

K. Wimalasena, D. Haines, 1994 .

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

R. Freyberg, J. Flores, D. Sulzer, 2016, Nature Communications.

Single enantiomer drugs: should they be developed?

S. Preskorn, Ahsan Y. Khan, K. Wimalasena, 2006, Essential psychopharmacology.

Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+

K. Wimalasena, 2017 .

pH-induced alteration and oxidative destruction of heme in purified chromaffin granule cytochrome b(561): implications for the oxidative stress in catecholaminergic neurons.

P. Kahol, K. Wimalasena, D. Haines, 2003, Biochemistry.

Caenorhabditis elegans Model Studies Show MPP+ Is a Simple Member of a Large Group of Related Potent Dopaminergic Toxins.

H. Patel, K. Wimalasena, David Murphy, 2021, Chemical research in toxicology.

Rapid kinetics of insertion and accessibility of spin-labeled phospholipid analogs in lipid membranes: a stopped-flow electron paramagnetic resonance approach.

A. Herrmann, P. Müller, K. Wimalasena, 1997, Biophysical journal.

Lipophilic Cationic Cyanines Are Potent Complex I Inhibitors and Specific in Vitro Dopaminergic Toxins with Mechanistic Similarities to Both Rotenone and MPP(.).

K. Wimalasena, Chamila C. Kadigamuwa, Mapa S. T. Mapa, 2016, Chemical research in toxicology.

Extracellular H+ Ions are a Novel Signal for Tyrosine Hydroxylase Activation in Catecholaminergic Cells.

K. Wimalasena, Viet Q Le, Maya Eldani, 2023, ACS chemical neuroscience.

A slow-tight binding inhibitor of dopamine beta-monooxygenase: a transition state analogue for the product release step.

K. Wimalasena, S. Dharmasena, D. S. Wimalasena, 2002, Biochemistry.

N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase.

K. Wimalasena, D. S. Wimalasena, 1991, Biochemical and Biophysical Research Communications - BBRC.

Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations.

Mehul N Bhakta, K. Wimalasena, P. Hollenberg, 2005, Chemical communications.

N-Methyl-4-phenylpyridinium Scaffold-Containing Lipophilic Compounds Are Potent Complex I Inhibitors and Selective Dopaminergic Toxins.

K. Wimalasena, Virangika K. Wimalasena, Bryan Lickteig, 2019, ACS chemical neuroscience.

Reduction of Dopamine β-Monooxygenase

K. Wimalasena, D. Hughbanks-Wheaton, S. Dharmasena, 1996, The Journal of Biological Chemistry.

Chemistry of L-ascorbic acid : regioselective and stereocontrolled 2-C- and 3-C-allylation via thermal claisen rearrangement

K. Wimalasena, M. Mahindaratne, 1994 .

Chemistry of L‐Ascorbic Acid: Regioselective and Stereocontrolled 2‐C‐ and 3‐C‐Allylation via Thermal Claisen Rearrangement.

K. Wimalasena, M. Mahindaratne, 2010 .

Colicin E 1 opens its hinge to plug

D. Case, J. Biteen, J. Kaelber, 2022 .

Vesicular monoamine transporters: Structure‐function, pharmacology, and medicinal chemistry

K. Wimalasena, 2011, Medicinal research reviews.

Metabolic energy decline coupled dysregulation of catecholamine metabolism in physiologically highly active neurons: implications for selective neuronal death in Parkinson’s disease

K. Wimalasena, Maya Eldani, Oluwatosin Adetuyi, 2024, Frontiers in Aging Neuroscience.

Novel antihypertensives targeted at dopamine beta-monooxygenase: turnover-dependent cofactor depletion by phenyl aminoethyl selenide.

S W May, K. Wimalasena, S. W. May, 1988, Journal of medicinal chemistry.