Chuanzheng Zhou

发表

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

J. Kjems, Eugenio Fava, M. Zerial, 2009, Nucleic acids research.

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Z. Xi, Chuanzheng Zhou, Qiang-Zhe Zhang, 2020, Scientific Reports.

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome

N. Huang, N. Zheng, Hong Lin, 2020, Proceedings of the National Academy of Sciences.

A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates

Juanjuan Du, Z. Xi, Chuanzheng Zhou, 2019, Chemical science.

SYNTHESIS AND STRUCTURE OF NEW METHYLENE-BRIDGED HEXOPYRANOSYL NUCLEOSIDE (BHNA)

N. Badgujar, Chuanzheng Zhou, J. Chattopadhyaya, 2009 .

The synthesis of therapeutic locked nucleos(t)ides.

Chuanzheng Zhou, J. Chattopadhyaya, 2009, Current opinion in drug discovery & development.

The cationization mechanism study of novel oligo (p-phenyleneethynylene)s

H. Chen, Zhi-Kuan Chen, Chuanzheng Zhou, 2005, Journal of the American Society for Mass Spectrometry.

Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Gong Chen, Z. Xi, Chuanzheng Zhou, 2020, Nature Communications.

UV Photooxidation of a Homologous Series of n-Alkanethiolate Monolayers on GaAs(001): A Static SIMS Investigation

A. Walker, Chuanzheng Zhou, 2008 .

Poly(naphthylenethiophene)s and poly(naphthylenevinylenephenylenevinylene)s: effect of naphthalene positional isomers on the light emitting properties of their polymers

Zhi-Kuan Chen, Chuanzheng Zhou, K. K. Lin, 2004 .

Determination of chemical composition in multilayer polymer film using ToF-SIMS

Chuanzheng Zhou, R. Garcia, F. Stevie, 2018 .

Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.

Chuanzheng Zhou, J. Chattopadhyaya, 2012, Chemical reviews.

4'-Fluorinated RNA: Synthesis, Structure, and Applications as a Sensitive 19F NMR Probe of RNA Structure and Function.

J. Plavec, Z. Xi, Chuanzheng Zhou, 2020, Journal of the American Chemical Society.

Synthesis of 2',4'-propylene-bridged (carba-ENA) thymidine and its analogues: the engineering of electrostatic and steric effects at the bottom of the minor groove for nuclease and thermodynamic stabilities and elicitation of RNase H.

Chuanzheng Zhou, J. Chattopadhyaya, Yi Liu, 2010, The Journal of organic chemistry.

5-Formylcytosine Yields DNA-Protein Cross-Links in Nucleosome Core Particles.

Z. Xi, Chuanzheng Zhou, M. Greenberg, 2017, Journal of the American Chemical Society.

High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions

S. Chatterjee, W. Pathmasiri, J. Barman, 2007 .

2-(4-Tolylsulfonyl)ethoxymethyl (TEM)-a new 2'-OH protecting group for solid-supported RNA synthesis.

Chuanzheng Zhou, D. Honcharenko, J. Chattopadhyaya, 2007, Organic & biomolecular chemistry.

Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.

Chuanzheng Zhou, J. Chattopadhyaya, A. Földesi, 2011, The Journal of organic chemistry.

Unusual radical 6-endo cyclization to carbocyclic-ENA and elucidation of its solution conformation by 600 MHz NMR and ab initio calculations.

Chuanzheng Zhou, J. Chattopadhyaya, O. Plashkevych, 2008, Organic & biomolecular chemistry.

Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.

S. Acharya, S. Chatterjee, A. Engström, 2006, Organic & biomolecular chemistry.

4'-C-Trifluoromethyl modified oligodeoxynucleotides: synthesis, biochemical studies, and cellular uptake properties.

Z. Xi, Chuanzheng Zhou, Xin Wen, 2019, Organic & biomolecular chemistry.

Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

Chuanzheng Zhou, M. Greenberg, Liwei Weng, 2014, ACS chemical biology.

Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones.

Yonghui Xie, Marc M Greenberg, Z. Xi, 2017, Journal of the American Chemical Society.

A thermostable azo-linker for reversible photoregulation of DNA replication

Z. Xi, Chuanzheng Zhou, Long Yi, 2008 .

Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification.

J. Plavec, Q. Peng, Z. Xi, 2018, Journal of the American Chemical Society.

Synthesis and biological applications of fluoro-modified nucleic acids.

Chuanzheng Zhou, Qiang Li, Fengmin Guo, 2017, Organic & biomolecular chemistry.

Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Gong Chen, Z. Xi, Chuanzheng Zhou, 2020, Nature Communications.

DNA damage in nucleosomes

Z. Xi, Chuanzheng Zhou, Mengtian Ren, 2019, Science China Chemistry.

Histone modification via rapid cleavage of C4'-oxidized abasic sites in nucleosome core particles.

Chuanzheng Zhou, M. Greenberg, Jonathan T. Sczepanski, 2013, Journal of the American Chemical Society.

Nucleosome core particle-catalyzed strand scission at abasic sites.

Chuanzheng Zhou, M. Greenberg, Jonathan T. Sczepanski, 2013, Biochemistry.

Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles.

Chuanzheng Zhou, M. Greenberg, Jonathan T. Sczepanski, 2012, Journal of the American Chemical Society.

Transesterification Reaction and the Repair of Embedded Ribonucleotides in DNA Are Suppressed upon the Assembly of DNA into Nucleosome Core Particles †.

Chuanzheng Zhou, Mengtian Ren, Yiran Cheng, 2019, Chemical research in toxicology.

Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.

N. Badgujar, Chuanzheng Zhou, J. Chattopadhyaya, 2009, The Journal of organic chemistry.

In vivo efficacy and off-target effects of Locked Nucleic Acid (LNA) and Unlocked Nucleic Acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

F. Baas, J. Wengel, K. Fluiter, 2010, Artificial DNA, PNA & XNA.

Challenges in the Chemistry of Small Interfering RNA as Potential Therapeutics to Inhibit Cellular mRNA Expression

Chuanzheng Zhou, J. Chattopadhyaya, 2013 .

Participation of Histones in DNA Damage and Repair within Nucleosome Core Particles: Mechanism and Applications.

Chuanzheng Zhou, M. Greenberg, Mengtian Ren, 2022, Accounts of chemical research.

Formation and biological consequences of 5-Formylcytosine in genomic DNA.

Chuanzheng Zhou, Yingqian Zhang, 2019, DNA repair.

Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles

Z. Xi, Chuanzheng Zhou, Huawei Wang, 2020, Nucleic acids research.

Oxidation of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Leads to Substantial DNA-Histone Cross-Links within Nucleosome Core Particles.

Z. Xi, Chuanzheng Zhou, M. Greenberg, 2018, Chemical research in toxicology.

A Nitrogen Mustard Induces Formation of DNA-Histone Cross-Links in Nucleosome Core Particles.

Chuanzheng Zhou, Mengtian Ren, Mengdi Shang, 2019, Chemical research in toxicology.

ToF-SIMS quantification of bromine based insecticide in mosquito netting

Stephen C. Smith, Chuanzheng Zhou, F. Stevie, 2017 .

Method for quantification of insecticide in mosquito netting using ion implantation and ToF-SIMS analysis

Stephen C. Smith, Chuanzheng Zhou, F. Stevie, 2016 .

Morphology and photophysical properties of phenyleneethynylene oligomer

Tianxi Liu, Zhi-Kuan Chen, Chuanzheng Zhou, 2005 .

Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.

Chuanzheng Zhou, J. Chattopadhyaya, O. Plashkevych, 2009, The Journal of organic chemistry.

Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide.

Chuanzheng Zhou, D. Honcharenko, J. Chattopadhyaya, 2008, The Journal of organic chemistry.

Electron-Beam-Induced Damage of Alkanethiolate Self-Assembled Monolayers (SAMs): Dependence on Monolayer Structure and Substrate Conductivity

J. Hsu, A. Walker, Chuanzheng Zhou, 2010 .

Time-of-flight secondary ion mass spectrometry, fluorescence microscopy and scanning electron microscopy: combined tools for monitoring the process of patterning and layer-by-layer assembly of synthetic and biological materials.

A. Walker, K. Wooley, K. Qi, 2008, Colloids and surfaces. B, Biointerfaces.

Bioconjugation via Hetero-Selective Clamping of Two Different Amines with ortho-Phthalaldehyde.

Hao-Yang Liu, G. He, Gong Chen, 2022, Angewandte Chemie.

TOF SIMS analyses of stray Ga during FIB milling

B. Gorman, L. Giannuzzi, C. Santeufemio, 2013 .

Toward molecular electronic circuitry: selective deposition of metals on patterned self-assembled monolayer surfaces.

G. Nagy, A. Walker, Chuanzheng Zhou, 2005, Journal of the American Chemical Society.

C4' -Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies.

Chuanzheng Zhou, Chaochao Fan, Qiang Li, 2021, Chemistry.

Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.

Chuanzheng Zhou, J. Chattopadhyaya, O. Plashkevych, 2010, The Journal of organic chemistry.

Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone.

Chuanzheng Zhou, M. Greenberg, 2012, Journal of the American Chemical Society.

AFM characterization of nanoscale ribbons grown from a series of oligo(p-phenyleneethynylene) derivatives.

Jingmei Xu, Zhi-Kuan Chen, Chuanzheng Zhou, 2004, Langmuir : the ACS journal of surfaces and colloids.

Electron Beam-Induced Damage of Alkanethiolate Self-Assembled Monolayers Adsorbed on GaAs (001): A Static SIMS Investigation†

J. Hsu, A. Walker, Chuanzheng Zhou, 2010 .

DNA Damage by Histone Radicals in Nucleosome Core Particles

Chuanzheng Zhou, M. Greenberg, 2014, Journal of the American Chemical Society.

New methylene-bridged hexopyranosyl nucleoside modified oligonucleotides (BHNA): synthesis and biochemical studies

Chuanzheng Zhou, J. Chattopadhyaya, 2008 .

Designing in vivo active DNAzymes

Chuanzheng Zhou, Yifei Zhou, 2021, Nature Chemistry.