J. Engels

发表

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

J. Kjems, Eugenio Fava, M. Zerial, 2009, Nucleic acids research.

Efficient Solid Phase Synthesis of Cleavable Oligodeoxynucleotides Based on a Novel Strategy for the Synthesis of 5′‐S‐(4,4′‐Dimethoxytrityl)‐2′‐deoxy‐5′‐thionucleoside Phosphoramidites

Joachim W. Engels, Kerstin Jahn-Hofmann, K. Jahn-Hofmann, 2004 .

Inhibition of hepatitis C virus RNA translation by antisense bile acid conjugated phosphorothioate modified oligodeoxynucleotides (ODN).

R. Bartenschlager, T. Sauerbruch, W. Caselmann, 2013, Antiviral research.

The ribosome assembly factor Nep1 responsible for Bowen–Conradi syndrome is a pseudouridine-N1-specific methyltransferase

K. Entian, P. Kötter, J. Wöhnert, 2010, Nucleic acids research.

Photo-physical properties of 2-(1-ethynylpyrene)-adenosine: influence of hydrogen bonding on excited state properties.

C. Slavov, J. Wachtveitl, M. Braun, 2014, Physical chemistry chemical physics : PCCP.

Synthesis of deoxynucleoside methylphosphonates via a phosphonamidite approach

J. Engels, A. Jäger, 1984 .

Fluoride-Cleavable, Fluorescently Labelled Reversible Terminators: Synthesis and Use in Primer Extension

M. Remm, A. Kurg, S. Serva, 2011, Chemistry.

Chemical 5′-phosphorylation of oligonucleotidesvaluable in automated DNA synthesis

J. Engels, E. Uhlmann, 1986 .

A sequencing method for RNA oligonucleotides based on mass spectrometry.

J. Engels, K. Faulstich, K. Wörner, 1997, Analytical chemistry.

RECENT DEVELOPMENTS IN MASS SPECTROMETRY : RNA SEQUENCING

J. Engels, K. Faulstich, K. Wörner, 1997 .

Overexpression, Purification, and Use of a Soluble Human Interleukin-4 Receptor α-chain/Igγ1 Fusion Protein for Ligand Binding Studies☆☆☆

J. Engels, Jürgen M. Schmidt, S. Hoffmann, 1997 .

Synthesis and Application of 3′-Amino-Dye-Terminators For Dna Sequencing

J. Engels, K. Faulstich, C. Wojczewski, 1997 .

High yield fermentation and purification of Tendamistat disulphide analogues secreted by Streptomyces lividans

M. Neeb, J. Engels, Sigrid Haas-Lauterbach, 1993, Applied Microbiology and Biotechnology.

Selective uncaging of DNA through reaction rate selectivity.

A. Heckel, J. Engels, A. Rodrigues-Correia, 2014, Organic letters.

Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells.

H. Ragg, J. Engels, J. Glauder, 1990, Biochemical and biophysical research communications.

Peptide Nucleic Acids(PNAs)—Unusual Properties of Nonionic Oligonucleotide Analogues

J. Engels, C. Meier, 1992 .

Synthesis of 2'-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus.

A. Ely, P. Arbuthnot, J. Engels, 2012, Bioorganic & medicinal chemistry.

Chemical synthesis of 2'-O-alkylated siRNAs.

Romualdas Smicius, D. Odadzic, Jens Haas, 2010, Methods in molecular biology.

Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference.

J. Kjems, J. B. Bramsen, Romualdas Smicius, 2008, Bioorganic & medicinal chemistry.

Different Strategies for the Synthesis of 2′- O -Aminoethyl Adenosine Building Blocks

D. Odadzic, J. Engels, 2007, Nucleosides, nucleotides & nucleic acids.

PELDOR spectroscopy reveals preorganization of the neomycin-responsive riboswitch tertiary structure.

B. Suess, Deniz Sezer, J. E. Weigand, 2010, Journal of the American Chemical Society.

Synthesis of 2′‐Aminoalkyl‐Substituted Fluorinated Nucleobases and Their Influence on the Kinetic Properties of Hammerhead Ribozymes

J. Engels, A. E. Klöpffer, 2004, Chembiochem : a European journal of chemical biology.

Enzymatic amidation of recombinant (Leu27) growth hormone releasing hormone-Gly45.

J. Engels, D. Tripier, E. Uhlmann, 1987, Protein engineering.

Inhibition of replication of hepatitis B virus in transgenic mice following administration of hepatotropic lipoplexes containing guanidinopropyl-modified siRNAs.

D. Scherman, V. Escriou, A. Ely, 2015, Journal of Controlled Release.

Antisense oligonucleotides as potential drugs

F. Eckstein, J. Engels, 2006 .

Selective Recognition of Triplex and Duplex Melting in Triple-Helical Nucleic Acids by Circular Dichroism Spectroscopy

J. Engels, K. Wörner, U. Parsch, 1999 .

Microwave-assisted Ribosylation of modified heterocyclic bases by Vorbrüggen method

J. Engels, Jelena Božilović, Nadja V. Nikolaus, 2007, Nucleosides, nucleotides & nucleic acids.

C-F...H-C hydrogen bonds in ribonucleic acids.

J. Engels, Jörg Parsch, 2002, Journal of the American Chemical Society.

The Synthesis Of Epr Differentiable Spinlabels And Their Coupling To Uridine

J. Engels, B. Bode, O. Frolow, 2007, Nucleosides, nucleotides & nucleic acids.

Building Blocks for Polyamide Nucleic Acids: Facile Synthesis Using Potassium Fluoride Doped Natural Phosphate as Basic Catalyst

S. Sebti, J. Engels, M. Taourirte, 2003, Nucleosides, nucleotides & nucleic acids.

Primary structures of new ‘iso‐hirudins’

J. Engels, D. Tripier, M. Scharf, 1989, FEBS letters.

Postsynthetic on column RNA labeling via Stille coupling.

J. Engels, Lena Wicke, 2012, Bioconjugate chemistry.

Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate-benzyltriesters

E. Schlaeger, J. Engels, 1977 .

Analysis of a soluble mutant des-methionine interleukin-2 receptor alpha chain (Tac protein) produced by transfected mammalian cells.

H. Hauser, J. Engels, D. Hüsken, 1990, European journal of biochemistry.

The Three Possible 2-(Pyrenylethynyl) Adenosines: Rotameric Energy Barriers Govern the Photodynamics of These Structural Isomers.

J. Wachtveitl, M. Braun, J. Engels, 2016, Chemphyschem : a European journal of chemical physics and physical chemistry.

A New Concept for DNA-Arrays

K. Jahn-Hofmann, T. Ellinger, J. Engels, 2003, Nucleosides, nucleotides & nucleic acids.

Thermodynamic studies on hairpin forming antisense-oligodeoxynucleotides directed against hepatitis C virus RNA.

J. Engels, T. Lehmann, S. Eisenhardt, 1999, Nucleosides & nucleotides.

Synthesis and structure assignments of amide protected nucleosides and their use as phosphoramidites in deoxyoligonucleotide synthesis.

J. Engels, M. Mag, 1988, Nucleic acids research.

Thermal unfolding of tendamistat probed by Fourier-transform infrared spectroscopy

W. Mäntele, J. Engels, C. Zscherp, 1999 .

A novel entry to 2′-O-aminopropyl modified nucleosides amenable for further modifications

Jens Haas, J. Engels, 2007 .

Analysis of double-stranded oligonucleotides by laser-induced liquid beam mass spectrometry

W. Kleinekofort, J. Engels, B. Brutschy, 1997 .

Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

S. Benjelloun, J. Engels, M. Taourirte, 2014, Molecules.

Diastereomeric dinucleoside-methylphosphonates: determination of configuration with the 2-D NMR ROESY technique.

J. Engels, T. Löschner, 1990, Nucleic acids research.

Gene-targeted inhibition of transactivation of human immunodeficiency virus type-1 (HIV-1)-LTR by antisense oligonucleotides

V. Vlassov, P. Chandra, F. Svinarchuk, 2005, Virus Genes.

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

D. Schols, G. Andrei, R. Snoeck, 2015, Archiv der Pharmazie.

Identification and characterization of a highly efficient anti-HIV pol hammerhead ribozyme.

J. Engels, G. Capalbo, S. Klein, 2009, Oligonucleotides.

Gene Synthesis [New Synthetic Methods (77)]

J. Engels, E. Uhlmann, 1989 .

2‐(1‐Ethynylpyrene)‐Adenosine as a Folding Probe for RNA—Pyrene in or out

J. Wachtveitl, D. Sauter, U. Förster, 2010, Chembiochem : a European journal of chemical biology.

RNA as scaffold for pyrene excited complexes.

J. Wachtveitl, U. Förster, J. Engels, 2008, Bioorganic & medicinal chemistry.

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase α

R. Halcomb, R. Kuchta, J. Engels, 2005, Nucleic acids research.

STACKING AND STABILITY OF RNA DUPLEXES CONTAINING FLUOROBENZENE AND FLUOROBENZIMIDAZOLE NUCLEOSIDES

J. Engels, Jörg Parsch, 2001, Nucleosides, nucleotides & nucleic acids.

Three-State Fluorescence of a 2-Functionalized Pyrene-Based RNA Label.

J. Wachtveitl, J. Engels, C. Grünewald, 2017, The journal of physical chemistry. B.

Synthesis of Fluorobenzene and Benzimidazole Nucleic-Acid Analogues and Their Influence on Stability of RNA Duplexes

J. Engels, Jörg Parsch, 2000 .

Influence of the matrix on the analysis of small oligoribonucleotides by fast atom bombardment mass spectrometry

L. Montanarella, S. Facchetti, J. Engels, 1995 .

J. Bats, J. Engels, M. Taourirte, 2013, Acta crystallographica. Section C, Crystal structure communications.

Synthesis of Pyrene Labeled Rna for Fluorescence Measurements

J. Engels, C. Grünewald, Taewoo Kwon, 2007, Nucleosides, nucleotides & nucleic acids.

Benzimidazole-1,2,3-triazole Hybrid Molecules: Synthesis and Evaluation for Antibacterial/Antifungal Activity

J. Engels, M. Taourirte, H. Lazrek, 2014, Archiv der Pharmazie.

Crystal structure of 2-benzamido-N-(2,2-diethoxyethyl)benzamide

J. Engels, M. Bolte, M. Taourirte, 2015, Acta crystallographica. Section E, Crystallographic communications.

Nucleic Acid Drugs

J. Engels, Jörg Parsch, 2005 .

Doped Natural Phosphate: A New and Environmentally Friendly Catalyst in Nucleoside Synthesis

S. Sebti, J. Engels, M. Taourirte, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis and Antiproliferative Activity of Quinolone Nucleosides Against the Human Myelogenous Leukemia K‐562 Cell Line

R. Gambari, J. Engels, Antoine M. Saab, 2013, Archiv der Pharmazie.

Microwave-assisted click chemistry: synthesis of mono and bis-1,2,3-triazole acyclonucleoside analogues of ACV via copper(I)-catalyzed cycloaddition

J. Engels, M. Taourirte, E. Rakib, 2009 .

Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase

J. Bats, Z. Debyser, M. Witvrouw, 2006 .

SYNTHESIS OF 3′-THIOAMIDO-MODIFIED 3′-DEOXYTHYMIDINE-5′-TRIPHOSPHATES AND THEIR USE AS CHAIN TERMINATORS IN SANGER-DNA SEQUENCING

J. Engels, C. Wojczewski, K. Schwarzer, 2001, Nucleosides, nucleotides & nucleic acids.

Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.

Michal Hocek, R. Kuchta, J. Engels, 2006, Biochemistry.

Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines.

J. Engels, M. Taourirte, C. Grünewald, 2012, Bioorganic & medicinal chemistry.

Fluorescent labeling of (oligo)nucleotides by a new fluoride cleavable linker capable of versatile attachment modes.

J. Engels, J. D’Onofrio, D. Knapp, 2010, Bioconjugate chemistry.

Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition

J. Engels, M. Taourirte, Jamal Krim, 2011, Molecules.

Phosphoramidate Analogs of Dinucleotides: Synthesis and 1H Assignment by Two Dimensional NMR Spectroscopy (1H,1H-COSY)

J. Engels, M. Mag, 1988 .

Chemical synthesis of 13C-labelled monomers for the solid-phase and template controlled enzymatic synthesis of DNA and RNA oligomers

H. Schwalbe, C. Griesinger, R. Wechselberger, 1994 .

One pot RP-diastereoselective synthesis of dinucleoside methylphosphonates using methyldichlorophosphine

J. Engels, T. Löschner, 1989 .

Three different fluoro- or chloro-substituted 1'-deoxy-1'-phenyl-β-D-ribofuranoses.

J. Bats, J. Engels, A. Zivkovic, 2014, Acta crystallographica. Section C, Structural chemistry.

1-Deoxy-1-(4-fluorophenyl)-β-d-ribofuranose, its hemihydrate, and 1-deoxy-1-(2,4-difluorophenyl)-β-d-ribofuranose: structural evidence for intermolecular C—H⋯F—C interactions

J. Bats, J. Engels, Jörg Parsch, 2000 .

Selective Electrochemical Removal of Protecting Groups in Nucleotide Synthesis

J. Engels, 1979 .

Site-Directed Spin Labeling of RNA for Distance Measurements by EPR

J. Engels, Lena Wicke, C. Grünewald, 2014 .

Fluorescent Oligonucleotides - Versatile Tools as Probes and Primers for DNA and RNA Analysis

J. Engels, C. Wojczewski, K. Stolze, 1999 .

Triarylmethyl Substituted 4,5-Dicyanoimidazoles as Activators for Rp-Diastereoselective Synthesis of TpN Dinucleoside Methylphosphonates

J. Engels, P. Schell, W. Laux, 1999 .

Synthesis and properties of bile acid phosphoramidites 5'-tethered to antisense oligodeoxynucleotides against HCV.

J. Engels, T. Lehmann, 2001, Bioorganic & medicinal chemistry.

Long-range distance measurements on nucleic acids in cells by pulsed EPR spectroscopy.

Volker Dötsch, Ivan Krstić, V. Dötsch, 2011, Angewandte Chemie.

Base-specific spin-labeling of RNA for structure determination

G. Stock, Y. Mu, J. Engels, 2007, Nucleic acids research.

The High Resolution NMR Structure of Parvulustat (Z‐2685) from Streptomyces parvulus FH‐1641: Comparison with Tendamistat from Streptomyces tendae 4158

H. Schwalbe, H. R. Jonker, J. Engels, 2009, Chembiochem : a European journal of chemical biology.

Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins.

A. Henschen, H. Niemann, M. Hudel, 1986, The EMBO journal.

Native-like β-structure in a Trifluoroethanol-induced Partially Folded State of the All-β-sheet Protein Tendamistat

Joachim Engels, J. Wey, T. Kiefhaber, 1996 .

Native-like beta-structure in a trifluoroethanol-induced partially folded state of the all-beta-sheet protein tendamistat.

J. Wey, T. Kiefhaber, J. Engels, 1996, Journal of molecular biology.

Synthesis and Structure of Fluoroindole Nucleosides.

J. Bats, J. Engels, Jelena Božilović, 2007 .

8‐Chinolinsulfonsäure‐(3‐nitro‐1,2,4‐triazolid), ein neues, effektives Kondensationsmittel für die Oligonucleotid‐Synthese

L. Zsolnai, G. Huttner, J. Engels, 1982 .

Sequence specific hybridization properties of methylphosphonate oligodeoxynucleotides.

J. Engels, M. Schweitzer, 1999, Journal of biomolecular structure & dynamics.

5-[2-(2-Methoxy)bornyl]tetrazole as Catalyst for Diastereoselective Synthesis of 2′-Deoxy Dinucleoside (3′, 5′)-Methylphosphonates

J. Engels, P. Schell, 1997 .

Synthesis and binding properties of oligodeoxynucleotides containing phenylphosphon(othio)ate linkages.

J. Engels, J. Muth, G. Kretzschmar, 1997, Bioorganic & medicinal chemistry.

Attachment of Nitroxide Spin Labels to Nucleic Acids for EPR

Xavier Elduque, J. Engels, Olga Romainczyk, 2012, Current protocols in nucleic acid chemistry.

Spin labeling of oligonucleotides with the nitroxide TPA and use of PELDOR, a pulse EPR method, to measure intramolecular distances

J. Engels, T. Prisner, B. Bode, 2007, Nature Protocols.

The RNA-DNA hybrid structure determined by EPR, CD and RNase H1.

J. Engels, T. Prisner, B. Endeward, 2011, Molecular bioSystems.

Influence of Specific Signal Peptide Mutations on the Expression and Secretion of the α-Amylase Inhibitor Tendamistat in Streptomyces lividans*

J. Engels, Silke H. Faß, 1996, The Journal of Biological Chemistry.

Secretory synthesis of human interleukin-2 by Streptomyces lividans.

J. Engels, K. Koller, E. Bender, 1990, Gene.

2-C-methyluridine modified hammerhead ribozyme against the estrogen receptor.

J. Montserrat, J. Engels, A. Iribarren, 2010, Bioorganic & medicinal chemistry letters.

Chemical 5′-Phosphorylation of Oligonucleotides Valuable in Automated DNA Synthesis.

J. Engels, E. Uhlmann, 1986 .

An unexpected methyl group migration during on-column Stille derivatization of RNA

J. Engels, Lena Wicke, 2014 .

Synthesis of deoxynucleoside methylphosphonates via a phosphonamidite approach

J. Engels, A. Jäger, 1984 .

Synthesis and properties of hammerhead ribozymes stabilized against nucleases by different 2′-modifications: methoxyethoxy-, fluoro- and amino groups

A. Ganser, R. Häner, J. Engels, 1997 .

Synthesis of 2′-end modified 2′-5′-adenylate trimers

J. Engels, 1980 .

Synthesis and selective cleavage of an oligodeoxynucleotide containing a bridged non-chiral internucleotide 3′-phosphoramidate linkage

J. Engels, M. Mag, R. Schmidt, 1992 .

Solid-state transformation of 4,2′-anhydro-5-(β-d-arabinofuranosyl)uracil dihydrate to 4,2′-anhydro-5-(β-d-arabinofuranosyl)uracil monohydrate

J. Bats, J. Engels, U. Parsch, 2000 .

Synthesis and selective cleavage of oligodeoxyribonucleotides containing non-chiral internucleotide phosphoramidate linkages.

J. Engels, M. Mag, 1989, Nucleic acids research.

Synthesis of dinucleotides containing a bridged non-chiral internucleotide 5′- or 3′-phosphoramidate linkage

J. Engels, M. Mag, 1994 .

Synthesis and Selective Cleavage of an Oligodeoxynucleotide Containing a Bridged Non‐Chiral Internucleotide 3′‐Phosphoramidate Linkage.

J. Engels, M. Mag, R. Schmidt, 1993 .

Ultrafast dynamics of 1-ethynylpyrene-modified RNA: a photophysical probe of intercalation.

J. Wachtveitl, U. Förster, J. Engels, 2010, The journal of physical chemistry. B.

A NEW FACILE METHOD FOR SPIN-LABELING OF OLIGONUCLEOTIDES

J. Engels, T. Prisner, O. Schiemann, 2001, Nucleosides, nucleotides & nucleic acids.

Direct mass spectrometric sequencing of low-picomole amounts of oligodeoxynucleotides with up to 21 bases by matrix-assisted laser desorption/ionization mass spectrometry

E. Nordhoff, M. Karas, F. Kirpekar, 1995 .

pH-independent triple-helix formation with 6-oxocytidine as cytidine analogue.

J. Engels, U. Parsch, 2000, Chemistry.

6-Oxocytidine a novel protonated C-base analogue for stable triple helix formation.

J. Engels, R. Berressem, 1995, Nucleic Acids Research.

Rp-Diastereoselective synthesis of dinucleoside methylphosphonates by the phosphoramidite approach

J. Engels, P. Schell, 1998 .

New proline derived chiral building blocks for nucleoside methylphosphonate synthesis

J. Bats, J. Engels, S. Eisenhardt, 1994 .

Determination and prediction of the absolute configuration of dinucleoside alkylphosphonates using conformational analysis and multivariate statistics

A. Lebedev, J. Engels, A. Frauendorf, 1993 .

Synthesis of specific diastereomers of a DNA methylphosphonate heptamer, d(CpCpApApApCpA), and stability of base pairing with the normal DNA octamer d(TPGPTPTPTPGPGPC).

E. Wickstrom, A. Lebedev, E. Savchenko, 1994, Nucleic Acids Research.

3′-Amino-Modified Nucleotides Useful as Potent Chain Terminators for current DNA sequencing methods

R. Konrad, J. Engels, D. Cech, 1994 .

SYNTHESIS AND PURIFICATION OF FLUORINATED BENZIMIDAZOLE AND BENZENE NUCLEOSIDE-5′-TRIPHOSPHATES

J. Engels, A. E. Klöpffer, 2005, Nucleosides, nucleotides & nucleic acids.

A PELDOR-based nanometer distance ruler for oligonucleotides.

G. Stock, Y. Mu, J. Engels, 2004, Journal of the American Chemical Society.

Synthesis of Dinucleotides Containing a Bridged Non-Chiral Internucleotide 5′- or 3′-Phosphoramidate Linkage.

J. Engels, M. Mag, 1995 .

Determination of RNA Tertiary Structure by Electron Paramagnetic Resonance Spectroscopy (EPR)

J. Engels, Nelly Piton, 2003, Nucleosides, nucleotides & nucleic acids.

Aromatic N versus aromatic F: bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs

H. Gohlke, J. Engels, Jelena Božilović, 2010, Nucleic acids research.

RNA RECOGNITION BY FLUOR-AROMATIC SUBSTITUTED

J. Engels, A. Zivkovic, A. Živković, 2005, Nucleosides, nucleotides & nucleic acids.

Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides.

M. Buckle, J. Mouscadet, M. Pinskaya, 2002, Biochemistry.

6-OXOCYTIDINE CONTAINING OLIGONUCLEOTIDES INHIBIT THE HIV-1 INTEGRASE IN VITRO

J. Mouscadet, M. Pinskaya, E. Romanova, 2001, Nucleosides, nucleotides & nucleic acids.

Synthesis of 5′-Ethynyl-2′-deoxynucleoside Analogues as Building Block for Antisense Oligonucleotide

J. Engels, H. Lazrek, A. Rochdi, 1999 .

Synthesis and Properties of Fluorinated Nucleobases in DNA and RNA

H. Gohlke, J. Engels, Jelena Božilović, 2013 .

Synthesis of Modified RNA-Oligonucleotides for Structural Investigations

J. Engels, A. [Zbreve]ivković, 2003, Nucleosides, nucleotides & nucleic acids.

Use of guanidinopropyl-modified siRNAs to silence gene expression.

A. Ely, P. Arbuthnot, J. Engels, 2015, Methods in molecular biology.

Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy

H. Schwalbe, B. Reif, C. Griesinger, 1997 .

Preparation of zwitterionic ribonucleoside phosphoramidites for solid-phase siRNA synthesis.

Romualdas Smicius, J. Engels, 2008, The Journal of organic chemistry.

A Novel Synthesis of Nucleoside Methylphosphonates

J. Engels, A. Jäger, 1982 .

New Proline‐Derived Chiral Building Blocks for Nucleoside Methylphosphonate Synthesis.

J. Bats, J. Engels, S. Eisenhardt, 1994 .

Stereoselective synthesis of phosphate-modified building blocks of DNA

J. Engels, W. Samstag, 1992 .

5-[(1R,2R,4R)-2-Methoxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-1H-tetrazole

Jan W. Bats, Joachim W. Engels, Peter Schell, 2013, Acta crystallographica. Section E, Structure reports online.

Biphenyl- and phenylnaphthalenyl-substituted 1H-imidazole-4,5-dicarbonitrile catalysts for the coupling reaction of nucleoside methyl phosphonamidites.

J. Bats, J. Engels, P. Schell, 2013, Acta crystallographica. Section C, Crystal structure communications.

Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates.

R. Kuchta, J. Engels, A. Zivkovic, 2004, Biochemistry.

Conformational states of 2'-C-methylpyrimidine nucleosides in single and double nucleic acid stranded structures.

D. Estrin, J. Montserrat, J. Engels, 2013, The journal of physical chemistry. B.

Directed Synthesis of the Trimeric Isoadenylate A2′p5′A2′p5′A

J. Engels, U. Krahmer, 1979 .

SYNTHESIS AND CHARACTERIZATION OF PHOSPHATE-MODIFIED DNA-DIMERS WITH FLUORINE AS AN UNCHARGED LIGAND

J. Engels, T. Lehmann, S. Eisenhardt, 1997 .

Amide Protection in Oligodeoxynucleotide Synthesis

J. Engels, M. Mag, 1987 .

Inhibition of hepatitis B virus replication in cultured cells and in vivo using 2'-O-guanidinopropyl modified siRNAs.

A. Ely, P. Arbuthnot, J. Engels, 2013, Bioorganic & medicinal chemistry.

Synthesis and reactivity of guanosine 3′,5′-phosphoric acid alkyl esters☆

J. Engels, 1979 .

Methylphosphonamidites: Preparation and Application in Oligodeoxynucleoside Methyl-Phosphonate Synthesis

J. Engels, T. Löschner, 1988 .

Microwave-Assisted Click Chemistry for Nucleoside Functionalization: Useful Derivatives for Analytical and Biological Applications

J. Engels, I. Krstić, M. Taourirte, 2013 .

Synthesis of Fluorinated Indoles as RNA Analogues

J. Engels, Jelena Božilović, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis and structure of fluoroindole nucleosides

J. Bats, J. Engels, Jelena Božilović, 2007 .

Meeting Review: ESF Workshop on ‘Impact of Nucleic Acid Chemistry on Gene Function Analysis: Antisense, Aptamers, Ribozymes and RNAi’

H. Prydz, J. Engels, K. Heermeier, 2002, Comparative and functional genomics.

Promoter constructions for efficient secretion expression in Streptomyces lividans

J. Engels, T. Schmitt-John, T. Schmitt‐John, 2004, Applied Microbiology and Biotechnology.

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

J. Kjems, P. Herdewijn, J. Wengel, 2010, Nucleic acids research.

Gene silencing by chemically modified siRNAs.

J. Engels, 2013, New biotechnology.

Specific Hammerhead Ribozyme-mediated Cleavage of Mutant N-ras mRNA in Vitro and ex Vivo

A. Ganser, M. Grez, J. Engels, 1997, The Journal of Biological Chemistry.

Cell type‐specific tyrosine phosphorylation of IL‐2 receptor β chain in response to IL‐2

H. Asao, K. Sugamura, J. Engels, 1992, FEBS letters.

Expression and characterization of a des-methionine mutant interleukin-2 receptor (Tac protein) with interleukin-2 binding affinity.

H. Hauser, J. Engels, D. Hüsken, 1988, The Journal of biological chemistry.

Isolation and refolding of a mutant methionine-free interleukin-2-receptor alpha chain synthesized as a fusion protein in Escherichia coli.

J. Engels, I. Seipelt, 1994, European journal of biochemistry.

Overexpression in Escherichia coli of a methionine-free designed interleukin-2 receptor (Tac protein) based on a chemically cleavable fusion protein.

J. Engels, D. Hüsken, T. Beckers, 1990, European journal of biochemistry.

Thermodynamics of unfolding of the alpha-amylase inhibitor tendamistat. Correlations between accessible surface area and heat capacity.

H. Hinz, J. Engels, M. Scharf, 1992, Journal of molecular biology.

A new class of 3′-modified nucleotides as chain-terminators for DNA-sequencing

C. Griesinger, R. Konrad, J. Engels, 1994 .

The nuclear-magnetic-resonance solution structure of the mutant alpha-amylase inhibitor [R19L] Tendamistat and comparison with wild-type Tendamistat.

K. Wüthrich, J. Engels, K. Koller, 1994, European journal of biochemistry.

Gene synthesis on microchips.

J. Engels, 2005, Angewandte Chemie.

Effect of proline to alanine mutation on the thermal stability of the all-beta-sheet protein tendamistat.

Werner Mäntele, Hüseyin Aygün, W. Mäntele, 2003, Biochimica et biophysica acta.

Synthesis and secretion of hirudin by Streptomyces lividans

J. Engels, K. Koller, E. Bender, 1990, Applied Microbiology and Biotechnology.

Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate benzyl triesters.

E. Schlaeger, J. Engels, 1977, Journal of medicinal chemistry.

Determinants of the Unexpected Stability of RNA Fluorobenzene Self Pairs

H. Gohlke, J. Engels, Hannes Kopitz, 2008, Chembiochem : a European journal of chemical biology.

4-Ethynyl-2,2,6,6-tetramethyl-1,2,5,6-tetrahydropyridine N-oxide

Jan W. Bats, Joachim W. Engels, Olga Frolow, 2009, Acta crystallographica. Section E, Structure reports online.

CYCLOPHOSPHATES. VIII: SYNTHESIS AND PROPERTIES OF 8-SUBSTITUTED BENZYL ADENOSINE-3′,5′-PHOSPHATES

J. Engels, A. Jaeger, 1982 .

Synthesis and application of the photolabile guanosine 3′,5′-phosphoric-o-nitrobenzylester

J. Engels, R. Reidys, 2005, Experientia.

Nitroxide spin labeled RNA for long range distance measurements by EPR-PELDOR.

J. Engels, O Schiemann, T. Prisner, 2008, Nucleic acids symposium series.

A Glutaric Acid Ester as Carrier System for Sustained Delivery of Lamuvidine (3TC) Dimers

J. Vasseur, J. Engels, J. Secrist, 2007, Nucleosides, Nucleotides & Nucleic Acids.

HOMO AND HETERODIMERS OF DDI, D4T AND AZT: INFLUENCE OF (5′-5′) THIOLCABONATE-CARBAMATE LINKAGE ON ANTI-HIV ACTIVITY

J. Vasseur, J. Engels, M. Taourirte, 2005, Nucleosides, nucleotides & nucleic acids.

Structure and dynamic properties of the single disulfide‐deficient α‐amylase inhibitor [C45A/C73A]tendamistat: An NMR study

H. Kessler, J. Balbach, J. Engels, 1998, Proteins.

Influence of a fluorobenzene nucleobase analogue on the conformational flexibility of RNA studied by molecular dynamics simulations.

M. Zacharias, J. Engels, 2004, Nucleic acids research.

Measurement of 2J(H,C)- and 3J(H,C)-coupling constants by α/β selective HC(C)H-TOCSY

H. Schwalbe, B. Reif, S. Glaser, 2001, Journal of biomolecular NMR.

A New Experiment for the Measurement of nJ(C,P) Coupling Constants Including 3J(C4′i,Pi) and 3J(C4′i,Pi+1) in Oligonucleotides

H. Schwalbe, B. Reif, C. Richter, 1998, Journal of biomolecular NMR.

Rnai Activity of Sirnas Modified with 2′-Aminoalkyl-Substituted Fluorinated Nucleobases

Jens Haas, J. Engels, Thea Mueller-Kuller, 2007, Nucleosides, Nucleotides & Nucleic Acids.

Biophysical characterization of α-amylase inhibitor Parvulustat (Z-2685) and comparison with Tendamistat (HOE-467).

J. Engels, Sigeng Han, Alma Sokočević, 2011, Biochimica et biophysica acta.

Nonprolyl cis peptide bonds in unfolded proteins cause complex folding kinetics

Ulf Reimer, Joachim W. Engels, Hüseyin Aygün, 2001, Nature Structural Biology.

Synthesis and antibacterial activity of unsaturated pyrimidine carboacyclonucleoside analogues

J. Engels, S. Eddarir, M. Taourirte, 2011 .

Effect of preformed correct tertiary interactions on rapid two-state tendamistat folding: evidence for hairpins as initiation sites for beta-sheet formation.

T. Kiefhaber, J. Engels, N. Schönbrunner, 1997, Biochemistry.

Modified Hammerhead Ribozymes as Potential Therapeutics

A. Ganser, M. Grez, J. Engels, 1998 .

Determinants of the Unexpected Stability of RNA Fluorobenzene Self Pairs

H. Gohlke, J. Engels, Hannes Kopitz, 2008, ChemBioChem.

2‐(1‐Ethynylpyrene)‐Adenosine as a Folding Probe for RNA—Pyrene in or out

J. Wachtveitl, D. Sauter, U. Förster, 2010, Chembiochem : a European journal of chemical biology.

The crystal and molecular structure of 2'-acetyluridine-3',5'-cyclophosphate benzyl triester, a pyrimidine nucleotide with syn conformation

J. Engels, W. Depmeier, K. Klaska, 1977 .

Kinetic mechanism and catalysis of a native-state prolyl isomerization reaction.

T. Kiefhaber, A. Bachmann, J. Engels, 2003, Journal of molecular biology.

Synthesis of 2'-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus.

A. Ely, P. Arbuthnot, J. Engels, 2012, Bioorganic & medicinal chemistry.

Design, delivery and efficacy testing of therapeutic nucleic acidsused to inhibit hepatitis C virus gene expression in vitro and in vivo.

B. Sproat, W. Caselmann, J. Engels, 2000, World journal of gastroenterology.

Overexpression, purification, and use of a soluble human interleukin-4 receptor alpha-chain/Ig gamma 1 fusion protein for ligand binding studies. Characterization of ligand binding to soluble IL-4 receptor alpha-chain by surface plasmon resonance measurements and by microtiter-plate-based ELISA with

J. Engels, J. Schmidt, S. Hoffmann, 1997, Biochemical and biophysical research communications.

Photophysics of 1-ethynylpyrene-modified RNA base adenine

J. Wachtveitl, U. Förster, J. Engels, 2009 .

Synthesis and Stability of GNRA-Loop Analogs

J. Engels, K. Wörner, T. Strube, 1999 .

SYNTHESIS OF SPIN-LABELED RNAS FOR LONG RANGE DISTANCE MEASUREMENTS BY PELDOR

G. Stock, Y. Mu, J. Engels, 2005, Nucleosides, nucleotides & nucleic acids.

Mechanism of protein stabilization by disulfide bridges: calorimetric unfolding studies on disulfide-deficient mutants of the alpha-amylase inhibitor tendamistat.

T. Vogl, H. Hinz, J. Engels, 1995, Journal of molecular biology.

Nanoelectrospray Mass Spectrometry/Mass Spectrometry for the Analysis of Modified Oligoribonucleotides

J. Engels, M. A. Wolter, 1995 .