K. Bottomly

发表

A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge.

A. Wisnewski, C. Herrick, Lan Xu, 2002, The Journal of allergy and clinical immunology.

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

A. Woods, J. West, K. Bottomly, 1987, Journal of immunology.

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells

A. Woodard, S. Constant, K. Bottomly, 1995, The Journal of experimental medicine.

Cytokines in T-cell development.

A. Hayday, S. Carding, K. Bottomly, 1991, Immunology today.

Combinatorial Effect of T-Cell Receptor Ligation and CD45 Isoform Expression on the Signaling Contribution of the Small GTPases Ras and Rap1

K. Bottomly, J. Czyzyk, D. Leitenberg, 2000, Molecular and Cellular Biology.

Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells.

M. Mooseker, K. Bottomly, J. Holt, 2007, Cell motility and the cytoskeleton.

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

S. Constant, K. Bottomly, X. Tao, 1997, Journal of immunology.

CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation

S. Nikiforow, G. Miller, K. Bottomly, 2001, Journal of Virology.

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

R. Flavell, S. Carding, K. Bottomly, 1993, Cell.

SubsetsSynapse in CD4 T Cell CTLA-4 Differentially Regulates the

F. Balamuth, K. Bottomly, Rachael P Jackman, 2013 .

CTLA-4 Differentially Regulates the Immunological Synapse in CD4 T Cell Subsets1

F. Balamuth, K. Bottomly, Rachael P Jackman, 2007, The Journal of Immunology.

Engineered Recombinant Peanut Protein and Heat-Killed Listeria monocytogenes Coadministration Protects Against Peanut-Induced Anaphylaxis in a Murine Model1

A. Burks, H. Sampson, Xiu-Min Li, 2003, The Journal of Immunology.

Innate immune control of pulmonary dendritic cell trafficking.

D. Cook, K. Bottomly, 2007, Proceedings of the American Thoracic Society.

Cytolytic CD4+-T-Cell Clones Reactive to EBNA1 Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation

S. Nikiforow, G. Miller, C. Münz, 2003, Journal of Virology.

Targeting Toll-like receptors on dendritic cells modifies the T(H)2 response to peanut allergens in vitro.

H. Sampson, B. Vickery, M. Caplan, 2010, The Journal of allergy and clinical immunology.

Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition.

P. Johnson, D. Farber, K. Bottomly, 1994, Immunity.

Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

R. Flavell, K. Bottomly, Tetsu Nakamura, 1997, Journal of immunology.

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

R. Flavell, E. Podack, K. Bottomly, 1997, Journal of immunology.

A polymerase chain reaction assay for the detection and quantitation of cytokine gene expression in small numbers of cells.

S. Carding, K. Bottomly, D. Lu, 1992, Journal of immunological methods.

CD4+ T Cells: Specificity and Function

C. Janeway, J. West, S. Carding, 1988, Immunological reviews.

Model Peanut-Induced Anaphylaxis in a Murine Coadministration Protects Against Listeria monocytogenes Heat-Killed Engineered Recombinant Peanut Protein and

A. Burks, H. Sampson, Xiu-Min Li, 2003 .

Regulated Recruitment of MHC Class II and Costimulatory Molecules to Lipid Rafts in Dendritic Cells1

I. Mellman, J. Unternaehrer, K. Bottomly, 2004, The Journal of Immunology.

Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.

A. Keegan, J. Elias, L. Cohn, 2009, Clinical immunology.

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo

A. Sette, S. Southwood, K. Bottomly, 1995, The Journal of experimental medicine.

Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV

K. Bottomly, C. Pfeiffer, J. Madri, 1991, Immunological reviews.

Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype

K. Bottomly, C. Pfeiffer, J. Madri, 1992, European journal of immunology.

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

A. Woods, K. Bottomly, T. Pasqualini, 1988, Journal of immunology.

Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.

R. Flavell, E. Podack, K. Bottomly, 1997, Journal of immunology.

p21 Ras/Impedes Mitogenic Signal Propagation Regulates Cytokine Production and Migration in CD4 T Cells*

R. Flavell, Hui-Chen Chen, K. Bottomly, 2008, Journal of Biological Chemistry.

Cell proliferation and cytokine production by CD4+ cells from old mice

B. Torbett, D. Noonan, K. Bottomly, 1991, Journal of cellular biochemistry.

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

B. Torbett, R. Hardy, K. Bottomly, 1990, Journal of immunology.

Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies

P. Johnson, I. Trowbridge, K. Bottomly, 1989, The Journal of experimental medicine.

Developmentally regulated fetal thymic and extrathymic T-cell receptor gene expression

S. Kyes, A. Hayday, E. Jenkinson, 2007 .

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

J. West, M. Luqman, S. Carding, 1989, European journal of immunology.

Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted

K. Bottomly, D. Mosier, 1981, The Journal of experimental medicine.

Quantitative variation in la antigen expression plays a central role in immune regulation.

C. Janeway, S. Conzen, J. Kaye, 1984, Immunology today.

Ly 9, an alloantigenic marker of lymphocyte differentiation.

B. Fowlkes, S. Sharrow, K. Bottomly, 1980, Journal of immunology.

Molecular associations on the T cell surface correlate with immunological memory

C. Janeway, U. Dianzani, A. Woods, 1990, European journal of immunology.

IL-13 Is Necessary, Not Simply Sufficient, for Epicutaneously Induced Th2 Responses to Soluble Protein Antigen1

A. McKenzie, C. Herrick, Lan Xu, 2003, The Journal of Immunology.

IL-4 (B cell stimulatory factor 1) exhibits thymocyte growth factor activity in the presence of IL-2.

S. Carding, K. Bottomly, 1988, Journal of immunology.

Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

R. Kingston, S. Kyes, A. Hayday, 1990, Genes & development.

Characterization of γ/δ T cell clones isolated from human fetal liverand thymus

S. Carding, K. Bottomly, J. Mcnamara, 1990 .

Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation.

C. Janeway, A. Golby, M. Bonneville, 1989, Journal of immunology.

EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation

C. Herrick, Lan Xu, K. Bottomly, 2011, Immunology.

Differential effect of interleukin 1 on naive and memory CD4+ T cells

M. Luqman, K. Bottomly, D. Lu, 1992, European journal of immunology.

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo.

J. West, S. Constant, K. Bottomly, 1995, Journal of immunology.

The Immunosuppressive Agent 15-Deoxyspergualin Functions by Inhibiting Cell Cycle Progression and Cytokine Production Following Naive T Cell Activation

C. Janeway, I. Mellman, K. Bottomly, 2002 .

ActivationProduction Following Naive T Cell Cell Cycle Progression and Cytokine 15-Deoxyspergualin Functions by Inhibiting The Immunosuppressive Agent Bottomly and

C. Janeway, I. Mellman, K. Bottomly, 2002 .

The selective ablation of interleukin 2-producing cells isolated from transgenic mice

R. Flavell, S. Carding, K. Bottomly, 1993, The Journal of experimental medicine.

Activation of CD4 T cells by Raf-independent effectors of Ras

R. Flavell, J. Brogdon, O. Henegariu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells.

M. Luqman, D. Farber, O. Acuto, 1995, Immunity.

Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny.

A. Hayday, S. Carding, K. Bottomly, 1991, The EMBO journal.

Characterization of gamma/delta T cell clones isolated from human fetal liver and thymus.

S. Carding, K. Bottomly, J. Mcnamara, 1990, European journal of immunology.

T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production

R. Homer, N. Niu, L. Cohn, 1999, The Journal of experimental medicine.

Transcription in Naive CD4+ T Cells Regulates NFATc/p Activity and Early IL-4 The Potency of TCR Signaling Differentially

J. Brogdon, K. Bottomly, D. Leitenberg, 2013 .

Transcription in Naive CD 4 Regulates NFATc / p Activity and Early IL-4 The Potency of TCR Signaling Differentially

J. Brogdon, K. Bottomly, D. Leitenberg, 2002 .

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.

L. Cohn, J. Tepper, K. Bottomly, 1998, Journal of immunology.

The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation

D. Farber, K. Bottomly, B. Smith, 1996, The Journal of experimental medicine.

Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.

R. Flavell, S. Constant, D. Levin, 1995, Journal of immunology.

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

R. Flavell, S. Constant, D. Levin, 1993, Journal of immunology.

Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu.

K. Bottomly, T. Boursalian, 1999, Journal of immunology.

IL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway Inflammation1

R. Homer, N. Niu, L. Cohn, 2001, The Journal of Immunology.

Soluble Protein Antigen Epicutaneously Induced Th2 Responses to IL-13 Is Necessary, Not Simply Sufficient, for

A. McKenzie, C. Herrick, Lan Xu, 2013 .

Regulation of naive T cell differentiation by varying the potency of TCR signal transduction.

K. Bottomly, D. Leitenberg, 1999, Seminars in immunology.

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.

L. Cohn, J. Tepper, K. Bottomly, 1998, Journal of immunology.

Airway Hyperresponsiveness by Th2, But Not Cutting Edge: IL-4-Independent Induction of

L. Cohn, J. Tepper, K. Bottomly, 1998 .

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.

S. Constant, K. Bottomly, C. Grant, 1997, Journal of immunology.

Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation.

A. Wisnewski, C. Herrick, Lan Xu, 2003, The Journal of allergy and clinical immunology.

Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo.

Lan Xu, A. Wisnewski, M. Karol, 2000, American journal of respiratory and critical care medicine.

Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2‐type differentiation

S. Constant, K. Bottomly, Karen S. Lee, 2000, European journal of immunology.

Session 10. Immune therapy and prevention: Is it just around the corner?

B. Lambrecht, A. Wardlaw, G. Marseglia, 2004 .

Absence of an antigen‐specific helper T cell required for the expression of the Tn 15 idiotype in mice treated with anti‐μ antibody

C. Janeway, D. Mosier, K. Bottomly, 1980, European journal of immunology.

Differentiat ion o f Naive CD 4 + T Cells

A. Woodard, S. Constant, K. Bottomly, 2003 .

CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR.

S. Constant, K. Bottomly, D. Leitenberg, 1998, Journal of immunology.

MHC control of CD4+ T cell subset activation

S. Carding, K. Bottomly, J. Tite, 1989, The Journal of experimental medicine.

Distinct functional phenotypes of cloned Ia-restricted helper T cells

A. Woods, K. Bottomly, J. Kim, 1985, The Journal of experimental medicine.

Differential activation of cytokine genes in normal CD4‐bearing T cells is stimulus dependent

A. Woods, J. West, S. Carding, 1989, European journal of immunology.

An important regulatory role for CD4+CD8αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease

A. Ray, P. Ray, M. Augustine, 2003, Proceedings of the National Academy of Sciences of the United States of America.

T Helper 1 Cells and Interferon (cid:103) Regulate Allergic Airway Inﬂammation and Mucus Production

R. Homer, N. Niu, L. Cohn, 1999 .

SubsetsImmunological Synapse in CD4 T Cell CTLA-4 Differentially Regulates the

F. Balamuth, K. Bottomly, Rachael P Jackman, 2007 .

IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation.

R. Homer, N. Niu, L. Cohn, 2001, Journal of immunology.

In vivo administration of interleukin 1 elicits increased Ia antigen expression on B cells through the induction of interleukin 4

S. Carding, G. Winterrowd, K. Bottomly, 1989, European journal of immunology.

CD4 1 T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation

S. Nikiforow, G. Miller, K. Bottomly, 2001 .

Are primed CD4+ T lymphocytes different from unprimed cells?

J. West, S. Constant, K. Bottomly, 1994, European journal of immunology.

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.

S. Constant, K. Bottomly, 1997, Annual review of immunology.

CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells

B. Smith, S. Constant, K. Bottomly, 1995, European journal of immunology.

Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes.

A. Vignery, K. Bottomly, F. Wang, 1992, The Journal of biological chemistry.

Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes.

M. Diamond, A. Walsh, S. Carding, 1989, The Journal of clinical endocrinology and metabolism.

25 – Antigen-Presenting Cell Lysis: Role in Immune Responses and Effect on Quantitative Analyses of Antigen Presentation to T Cells

C. Janeway, J. Kaye, K. Bottomly, 1988 .

Control of B Cell Activation by Helper T Cells

C. Janeway, A. Kupfer, J. Kaye, 1986 .

Quantitative Variation in Ia and Non-Ia B-Cell Surface Molecules Regulates T-Cell : B-Cell Interactions

C. Janeway, J. Kaye, K. Bottomly, 1985 .

The Role of B‐Cell I Region Encoded Antigens in T‐Cell Dependent B‐Cell Activation: I Region Encoded Antigen Density Correlates With Idiotype Expression

K. Bottomly, E. Dunn, KIM BOTTOMLY, 1983, Annals of the New York Academy of Sciences.

Helper T cells specific for protein antigens: role of self major histocompatibility complex and immunoglobulin gene products.

C. Janeway, L. Matis, R. Schwartz, 1982, Advances in experimental medicine and biology.

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

C. Janeway, U. Dianzani, A. Pileri, 1992, European journal of immunology.

Differential expression of the alternatively spliced exons of murine CD45 in Th1 and Th2 cell clones

M. Luqman, I. Trowbridge, K. Bottomly, 1991, European journal of immunology.

Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation.

D. Farber, D. Metz, K. Bottomly, 1998, Journal of immunology.

Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate

A. Wisnewski, C. Herrick, C. Redlich, 2003 .

Thymic and extrathymic development of human gamma/delta T cells.

A. Hayday, S. Carding, K. Bottomly, 1991, Current topics in microbiology and immunology.

Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation.

K. Bottomly, D. Leitenberg, Y. Boutin, 1999, Immunity.

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

R. Homer, L. Cohn, J. Rankin, 1997, The Journal of experimental medicine.

Helper T-Lymphocyte Influences on Idiotype-Bearing B Cells

K. Bottomly, E. Dunn, 1984 .

Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate.

A. Woods, J. West, K. Bottomly, 1987, Journal of immunology.

A cloned, antigen-specific, Ia-restricted Lyt-1+,2- T cell with suppressive activity.

C. Janeway, K. Bottomly, B. Jones, 1983, The Journal of molecular and cellular immunology : JMCI.

Infection of BALB/cByJ mice with the JHM strain of mouse hepatitis virus alters in vitro splenic T cell proliferation and cytokine production.

M. de Souza, A. Smith, K. Bottomly, 1991, Laboratory animal science.

Mice whose B cells cannot produce the T15 idiotype also lack an antigen- specific helper T cell required for T15 expression

K. Bottomly, D. Mosier, 1979, The Journal of experimental medicine.

Functional CD4 T cell subset interplay in an intact immune system.

K. Bottomly, T. Pasqualini, J. Madri, 1993, Journal of immunology.

An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease.

A. Ray, P. Ray, M. Augustine, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Clonal Expansion and Differentiation to Effector Function in Normal CD4 T Cell Subpopulations

A. Woods, J. West, M. Luqman, 1989 .

Understanding asthma pathogenesis: linking innate and adaptive immunity

S. Cassel, S. Eisenbarth, K. Bottomly, 2004, Current opinion in pediatrics.

The master regulators of allergic inflammation: dendritic cells in Th2 sensitization.

Kim Bottomly, S. Eisenbarth, K. Bottomly, 2003, Current opinion in immunology.

T Cells and Dendritic Cells Get Intimate

K. Bottomly, 1999, Science.

A functional dichotomy in CD4+ T lymphocytes.

K. Bottomly, 1988, Immunology today.

The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells1

Kim Bottomly, David Leitenberg, J. Brogdon, 2002, The Journal of Immunology.

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*

A. Ray, P. Ray, L. Cohn, 1997, The Journal of Biological Chemistry.

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

Kim Bottomly, Stephanie C. Eisenbarth, S. Eisenbarth, 2002, The Journal of experimental medicine.

The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM

M. de Souza, S. Barthold, Abigail L. Smith, 2005, Archives of Virology.

Hepatoma and hepatitis B virus.

K. Bottomly, C. McCarthy, M. Little, 1977, Irish medical journal.

Signals and signs for lymphocyte responses

C. Janeway, K. Bottomly, 1994, Cell.

Cultured human luteal peripheral monocytes secrete increased levels of interleukin-1.

M. Polan, K. Bottomly, A. Kuo, 1990, The Journal of clinical endocrinology and metabolism.

Regulation of Early IL-4 Expression in Naive Signal-Regulated Kinase Activation in the Role of TCR-Induced Extracellular

J. Brogdon, K. Bottomly, P. Jorritsma, 2013 .

Role of TCR-Induced Extracellular Signal-Regulated Kinase Activation in the Regulation of Early IL-4 Expression in Naive CD4+ T Cells1

J. Brogdon, K. Bottomly, P. Jorritsma, 2003, The Journal of Immunology.

Alteration at a Single Amino Acid Residue in the T Cell Receptor α Chain Complementarity Determining Region 2 Changes the Differentiation of Naive Cd4 T Cells in Response to Antigen from T Helper Cell Type 1 (Th1) to Th2

C. Janeway, J. Blander, K. Bottomly, 2000, The Journal of experimental medicine.

IL-4-Dependent Th2 Collateral Priming to Inhaled Antigens Independent of Toll-Like Receptor 4 and Myeloid Differentiation Factor 881

S. Eisenbarth, C. Herrick, K. Bottomly, 2004, The Journal of Immunology.

Factor 88 Receptor 4 and Myeloid Differentiation Inhaled Antigens Independent of Toll-Like IL-4-Dependent Th2 Collateral Priming to

S. Eisenbarth, C. Herrick, K. Bottomly, 2004 .

Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells.

I. Mellman, J. Unternaehrer, F. Balamuth, 2001, Immunity.

Dual receptor T cells extend the immune repertoire for foreign antigens

C. Janeway, C. Viret, Xin He, 2002, Nature Immunology.

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

R. Kingston, A. Hayday, E. Jenkinson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

P27kip1 regulates the cell cycle arrest and survival of activated T lymphocytes in response to interleukin‐2 withdrawal

K. Bottomly, I. N. Crispe, J. Huleatt, 2003, Immunology.

Measurement of Human and Murine Interleukin 2 and Interleukin 4

L. Davis, P. Lipsky, K. Bottomly, 2000, Current protocols in immunology.

Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice

D. Mosier, K. Bottomly, B. Mathieson, 1978, The Journal of experimental medicine.

Contains Effector Memory Precursors A Pool of Central Memory-Like CD4 T Cells

Charles A. Janeway, Sangwon V. Kim, Richard A. Flavell, 2013 .

A Pool of Central Memory-Like CD4 T Cells Contains Effector Memory Precursors

C. Janeway, R. Flavell, D. Metz, 2003, The Journal of Immunology.

Effector Memory Precursors A Pool of Central Memory-Like CD 4 T Cells

C. Janeway, R. Flavell, D. Metz, 2003 .

1984: All Idiotypes are Equal, But Some are More Equal Than Others

K. Bottomly, 1984, Immunological reviews.

Antigen-specific helper T cells required for dominant production of an idiotype (THId) are not under immune response (Ir) gene control

K. Bottomly, P. Maurer, 1980, The Journal of experimental medicine.

A cloned T cell line that selectively augments antibody responses of phosphorylcholine-specific B cells bearing the T15 idiotype.

K. Bottomly, J. Kim, E. Dunn, 1986, The Journal of molecular and cellular immunology : JMCI.

ANALOGOUS DUAL SPECIFICITY OF HELPER T CELLS COOPERATING IN THE GENERATION OF CLONALLY RESTRICTED ANTIBODY RESPONSES

K. Bottomly, D. Mosier, 1980 .

Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate.

A. Wisnewski, C. Herrick, C. Redlich, 2003, The Journal of allergy and clinical immunology.

The PTK-STAT signaling pathway has essential roles in T-cell activation in response to antigen stimulation.

C. Janeway, A. Bothwell, K. Bottomly, 1999, Cold Spring Harbor symposia on quantitative biology.

Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells

S. Kyes, A. Hayday, W. Allan, 1990, The Journal of experimental medicine.

STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation.

C. Janeway, Xin-Yuan Fu, A. Bothwell, 1999, Science.

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ.

J. Brogdon, S. Constant, I. Visintin, 2002, The Journal of clinical investigation.

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity.

C. Janeway, U. Dianzani, K. Bottomly, 1994, Immunity.

CD4 Raft Association and Signaling Regulate Molecular Clustering at the Immunological Synapse Site1

J. Brogdon, F. Balamuth, K. Bottomly, 2004, Journal of Immunology.

Subsets of CD4 T cells and B cell activation.

K. Bottomly, 1989, Seminars in immunology.

Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages.

R. Stout, K. Bottomly, Robert D. Stout, 1989, Journal of immunology.

Activation requirements for CD4+ T cells differing in CD45R expression.

M. Luqman, K. Bottomly, 1992, Journal of immunology.

Function and regulation of memory CD4 T cells

Kim Bottomly, D. Metz, K. Bottomly, 1999, Immunologic research.

ActivationResting Memory Versus Naive CD4 T Cell Differential Role of CTLA-4 in Regulation of

D. Farber, D. Metz, K. Bottomly, 1998 .

Differential T cell receptor‐mediated signaling in naive and memory CD4 T cells

Kim Bottomly, Oreste Acuto, D. Farber, 1997, European journal of immunology.

Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4.

C. Herrick, K. Bottomly, R. Tigelaar, 2000, The Journal of clinical investigation.

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

R. Homer, F. Brombacher, L. Cohn, 1999, Journal of immunology.

Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells

J. Kaye, K. Bottomly, B. Jones, 1983, The Journal of experimental medicine.

To respond or not to respond: T cells in allergic asthma

C. Herrick, K. Bottomly, 2003, Nature Reviews Immunology.

Immune recognition and effector function in subsets of CD4 T cells.

C. Janeway, M. Luqman, S. Carding, 1988, Princess Takamatsu symposia.

MyD88-dependent induction of allergic Th2 responses to intranasal antigen.

S. Eisenbarth, S. Constant, C. Herrick, 2005, The Journal of clinical investigation.

Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction.

D. Farber, D. Metz, K. Bottomly, 1997, Journal of immunology.

Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 Diabetes

E. Esplugues, R. Flavell, K. Herold, 2012, The Journal of Immunology.

1 Inhibits Autoimmune Inflammation in Type Enhanced Anti-Serpin Antibody Activity

E. Esplugues, K. Herold, P. Preston-Hurlburt, 2012 .

Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen‐specific helper T cell required for dominant production of the T15 idiotype

K. Bottomly, C. Janeway Jr., 1981, European journal of immunology.

T15‐specific helper T cells: analysis of idiotype specificity by competitive inhibition analysis

K. Bottomly, E. Dunn, 1985, European Journal of Immunology.

Cells. Factor 1(bsf-1) Fail to Help Antigen-specific B Produce Interleukin 4(il 4)/b Cell Stimulatory Cloned, Ia-restricted T Cells That Do Not

A. Woods, K. Bottomly, 2022 .

Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes.

S. Carding, W. Born, K. Bottomly, 1996, Journal of immunology.

Reprints Available Directly from the Publisher Photocopying Permitted by License Only Expansion of Cd4/t Cells with A-naive Phenotype in the Periphery

K. Bottomly, J. Rozing, L. Nagelkerken, 2022 .

Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation.

F. Balamuth, K. Bottomly, D. Leitenberg, 2001, Seminars in immunology.

Stability of naive and memory phenotypes on resting CD4 T cells in vivo.

K. Bottomly, T. Boursalian, 1999, Journal of immunology.

Modes of cell:cell communication in the immune system.

C. Janeway, K. Bottomly, J. Tite, 1985, Journal of immunology.

Activation status of the CD4-8- gamma delta-T cells recovered from mice with influenza pneumonia.

M. Eichelberger, W. Allan, P. Doherty, 1991, Journal of immunology.

Responses of T cells to ligands for the T-cell receptor.

C. Janeway, K. Bottomly, 1996, Seminars in immunology.

Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets.

K. Bottomly, D. Leitenberg, Y. Boutin, 1997, Journal of immunology.

This information is current as Resting CD 4 T Cells In Vivo Stability of Naive and Memory Phenotypes on

K. Bottomly, T. Boursalian, 1998 .

Altered splenic T cell function of BALB/cByJ mice infected with mouse hepatitis virus or Sendai virus.

K. Bottomly, D. F. Winograd, A. Smith, 1987, Journal of immunology.

T-cell development, survival, and signalling: A new concept of the role of self-peptide: Self-MHC complexes

C. Janeway, J. Goverman, A. Kupfer, 1998 .

Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes.

A. Vignery, K. Bottomly, F. Wang, 1992, The Journal of biological chemistry.

Involvement of γδ T Cells in Respiratory Virus Infections

M. Eichelberger, W. Allan, P. Doherty, 1991 .

Involvement of gamma delta T cells in respiratory virus infections.

M. Eichelberger, W. Allan, P. Doherty, 1991, Current topics in microbiology and immunology.

Quantitative variation in la antigen expression plays a central role in immune regulation.

C. Janeway, S. Conzen, J. Kaye, 1984, Immunology today (Amsterdam. Regular ed.).

Mice whose B cells cannot produce the T15 idiotype also lack an antigen- specific helper T cell required for T15 expression

K. Bottomly, D. Mosier, 1979, The Journal of experimental medicine.

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo

S. Southwood, K. Bottomly, Christiane Pfeiffer, 1995, The Journal of experimental medicine.

EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation

C. Herrick, Lan Xu, K. Bottomly, 2011, Immunology.

The Involvement of the Intestinal Microflora in the Expansion of CD4+ T Cells with a-Naive Phenotype in the Periphery

K. Bottomly, J. Rozing, L. Nagelkerken, 1992, Developmental immunology.

Synergizing Helper T Cell Sets and the Regulation of Antibody Quality

C. Janeway, D. Mosier, E. Dzierzak, 1980 .