R. Wynn

发表

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

Zhaoping Li, D. Chuang, A. Lusis, 2019, Diabetes.

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

D. Chuang, O. Ilkayeva, C. Newgard, 2018, Cell metabolism.

GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules

R. Wynn, Z. Zhang, Jen-Hsuan Wei, 2015, Cell.

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket*

D. Chuang, P. Scherer, N. Williams, 2013, The Journal of Biological Chemistry.

Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity*

Jun Li, D. Chuang, Masato Kato, 2008, Journal of Biological Chemistry.

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

D. Chuang, Mingliang Lou, Cheng-Yang Wu, 2018, Molecular metabolism.

Real-time hyperpolarized 13C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers

D. Chuang, A. Sherry, C. Malloy, 2019, Scientific Reports.

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

D. Chuang, B. Tu, Philippe M. Campeau, 2013, Proceedings of the National Academy of Sciences.

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase*

D. Chuang, S. Strom, K. Dorko, 2014, The Journal of Biological Chemistry.

Structural and Biochemical Characterization of Human Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Phosphatase*

Jun Li, D. Chuang, C. Brautigam, 2012, The Journal of Biological Chemistry.

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Christoph D. Rau, Svati H Shah, X. Xiao, 2016, Circulation.

Expression and assembly of a functional E1 component (α2β2) of mammalian branched-chain α-ketoacid dehydrogenase complex in Escherichia coli

D. Chuang, J. Davie, R. Wynn, 1992 .

Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.

K. Uyeda, R. Wynn, Qingyu Ge, 2010, Biochemical and biophysical research communications.

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

D. Chuang, S. Burgess, A. Sherry, 2018, The Journal of Biological Chemistry.

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

D. Chuang, C. Brautigam, M. Rosen, 2010, Analytical biochemistry.

Metabolite Regulation of Nucleo-cytosolic Trafficking of Carbohydrate Response Element-binding Protein (ChREBP)

T. Nakagawa, K. Uyeda, R. Veech, 2013, The Journal of Biological Chemistry.

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP)

B. Tu, Sunil Laxman, T. Nakagawa, 2016, The Journal of Biological Chemistry.

Importin-α Protein Binding to a Nuclear Localization Signal of Carbohydrate Response Element-Binding Protein (ChREBP)*

Y. Chook, T. Nakagawa, K. Uyeda, 2011, The Journal of Biological Chemistry.

Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP)

K. Gardner, J. Repa, H. Mizuguchi, 2008, Journal of Biological Chemistry.

The membrane-bound electron-transfer components of aerobically grown Chromatium vinosum

R. Wynn, D. Knaff, R. Shaw, 1985 .

Phenylbutyrate therapy for maple syrup urine disease.

N. Brunetti‐Pierri, Jun Li, M. Hegde, 2011, Human molecular genetics.

Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation.

Jun Li, D. Chuang, M. Machius, 2004, Structure.

Structural and functional properties of the cyanobacterial photosystem I complex.

R. Wynn, R. Malkin, J. Omaha, 1989, Biochemistry.

Maple syrup urine disease in Cypriot families: identification of three novel mutations and biochemical characterization of the p.Thr211Met mutation in the E1alpha subunit.

D. Chuang, A. Drousiotou, R. Wynn, 2009, Genetic testing and molecular biomarkers.

Maple syrup urine disease: biochemical, clinical and therapeutic considerations

D. Chuang, R. Wynn, R. Cox, 2020 .

Maple Syrup Urine Disease: Clinical and Therapeutic Considerations

D. Chuang, R. Wynn, J. Chuang, 2014 .

Lessons from genetic disorders of branched-chain amino acid metabolism.

D. Chuang, R. Wynn, J. Chuang, 2006, The Journal of nutrition.

Expression and Characterization of Branched-chain α-Ketoacid Dehydrogenase Kinase from the Rat

D. Chuang, J. Davie, R. Wynn, 1995, The Journal of Biological Chemistry.

Molecular and biochemical basis of intermediate maple syrup urine disease. Occurrence of homozygous G245R and F364C mutations at the E1 alpha locus of Hispanic-Mexican patients.

D. Chuang, J. Davie, R. Wynn, 1995, The Journal of clinical investigation.

Branched-Chain Amino Acids : Metabolism , Physiological Function , and Application Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism

D. Chuang, R. Wynn, J. Chuang, 2005 .

Branched-Chain Amino Acids : Metabolism , Physiological Function , and Application Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism 1 – 3

D. Chuang, R. Wynn, J. Chuang, 2005 .

Structural and Biochemical Basis for Novel Mutations in Homozygous Israeli Maple Syrup Urine Disease Patients

Jun Li, H. Mandel, D. Chuang, 2004, Journal of Biological Chemistry.

Three-Dimensional Structures for Components and Domain of the Mammalian Branched-Chain a-Ketoacid Dehydrogenase Complex

D. Chuang, R. Wynn, J. Chuang, 2003 .

Branched‐Chain α‐Keto Acid Dehydrogenase Complex, Human

D. Chuang, R. Wynn, J. Chuang, 2002 .

Carbohydrates | Carbohydrate-Responsive Element Binding Protein (ChREBP)

H. Yamashita, K. Uyeda, R. Wynn, 2020 .

Structure, function and assembly of mammalian branched-chain α-ketoacid dehydrogenase complex

D. Chuang, J. Davie, R. Wynn, 1996 .

The electron transfer chain of aerobically grown Rhodopseudomonas viridis

R. Wynn, D. Knaff, R. Shaw, 1987 .

Maize Photosystem I : Identification of the Subunit which Binds Plastocyanin.

C. Luong, R. Wynn, R. Malkin, 1989, Plant physiology.

Interaction of plastocyanin with photosystem I: a chemical cross-linking study of the polypeptide that binds plastocyanin.

R. Wynn, R. Malkin, R. M. Wynn, 1988, Biochemistry.

Reactivity, electrochemical, and spectroscopic studies of type 2 copper-depleted Rhus vernicifera laccase

R. Wynn, D. Knaff, R. Holwerda, 1984 .

Branched-chain Amino Acid Metabolon

M. M. Islam, D. Chuang, S. Hutson, 2009, The Journal of Biological Chemistry.

Green algal cytochrome b6-f complexes: isolation and characterization from Dunaliella saline, Chlamydomonas reinhardtii and Scenedesmus obliquus.

B. Bruce, R. Wynn, R. Malkin, 1988, Biochimica et biophysica acta.

Reactivity comparison of iron(II) reductant with type 1 copper(II) in native and type 2 copper-depleted Rhus vernicifera laccase

R. Wynn, D. Knaff, H. K. Baek, 1984 .

Isolation of cytochrome bc1 complexes from the photosynthetic bacteria Rhodopseudomonas viridis and Rhodospirillum rubrum

R. Wynn, D. Knaff, R. Shaw, 2004, Photosynthesis Research.

Identification of the components of a putative cytochrome bc1 complex in Rhodopseudomonas viridis.

R. Wynn, D. Knaff, R. Shaw, 1985, Archives of biochemistry and biophysics.

Binding site on Rhodospirillum rubrum cytochrome c2 for the Rhodospirillum rubrum cytochrome bc1 complex

H. Bosshard, R. Wynn, D. Knaff, 1987 .

Subunit and Catalytic Component Stoichiometries of an in Vitro Reconstituted Human Pyruvate Dehydrogenase Complex*

D. Chuang, C. Brautigam, R. Wynn, 2009, Journal of Biological Chemistry.

A Novel Branched-chain Amino Acid Metabolon

Mohammad Mainul Islam, M. M. Islam, D. Chuang, 2007, Journal of Biological Chemistry.

A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase.

Jun Li, Chad A Brautigam, Jun Li, 2006, Structure.

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.

Chad A Brautigam, D. Chuang, M. Machius, 2006, Structure.

Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex*

D. Chuang, C. Brautigam, Tai-Huang Huang, 2011, The Journal of Biological Chemistry.

Chaperonins GroEL and GroES promote assembly of heterotetramers (α2β2) of mammalian mitochondrial branched-chain α-keto acid decarboxylase in Escherichia coli

Rody P. Cox, D. Chuang, J. Davie, 1992 .

Identification of the ferredoxin interaction sites on ferredoxin-dependent glutamate synthase from Synechocystis sp. PCC 6803

R B Sutton, R. Wynn, M. Hirasawa, 2017, Photosynthesis Research.

Therapeutic Effect of Targeting Branched‐Chain Amino Acid Catabolic Flux in Pressure‐Overload Induced Heart Failure

D. Chuang, Yibin Wang, Haipeng Sun, 2019, Journal of the American Heart Association.

Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase ( E 3 ) and E 3 Binding Protein of Human Pyruvate Dehydrogenase Complex

D. Chuang, M. Machius, D. Tomchick, 2022 .

The structure of spinach Photosystem I studied by electron microscopy

E. Boekema, R. Wynn, R. Malkin, 1990 .

Organization of PSI Subunits in Thylakoid Membranes

A. Webber, R. Wynn, R. Malkin, 1990 .

Crystal structure of human branched-chain α-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease

W. Hol, D. Chuang, S. Turley, 2000 .

Structural Characterization of a Unique Interface between Carbohydrate Response Element-binding Protein (ChREBP) and 14-3-3β Protein*

K. Uyeda, Hong Zhang, R. Wynn, 2012, The Journal of Biological Chemistry.

Roles of His291-α and His146-β′ in the Reductive Acylation Reaction Catalyzed by Human Branched-chain α-Ketoacid Dehydrogenase

Jun Li, Jun Li, D. Chuang, 2003, Journal of Biological Chemistry.

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site.

Jun Li, Jun Li, D. Chuang, 2003, The Journal of biological chemistry.

Structural and Biochemical Characterization of Human Mitochondrial Branched-chain -Ketoacid Dehydrogenase

Jun Li, D. Chuang, C. Brautigam, 2012 .

The Rhodospirillum rubrum cytochrome bc1 complex: peptide composition, prosthetic group content and quinone binding.

A. Kriauciunas, R. Wynn, D. Knaff, 1989, Biochimica et biophysica acta.

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

D. Chuang, Mingliang Lou, N. Williams, 2017, Journal of medicinal chemistry.

Electron Transport Chains of Phototrophically and Chemotrophically Grown Chloroflexus Aurantiacus

Robert Eugene Blankenship, R. Wynn, R. Fuller, 1987 .

Photosynthetic and respiratory electron transport chains in purple and green phototrophic bacteria

R. Wynn, R. M. Wynn, 1986 .

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

D. Chuang, A. Sherry, W. Luo, 2019, Scientific Reports.

Green algal cyt~hrome bd complexes: isolation and chara.oterization from Duttaliella saline, Chlamyd Jmonas rem~rdsii and Scenedesmus obliquus

B. Bruce, R. Wynn, R. Malkin, 1988 .

Differential processing of human and rat E1 α precursors of the branched-chain α-keto acid dehydrogenase complex caused by an N-terminal proline in the rat sequence

D. Chuang, R. Wynn, R. Cox, 1994 .

Structural Organization and Function of Polypeptide Subunits in Photosystem I

B. Bruce, R. Wynn, R. Malkin, 1989 .

Cross-talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-chain α-Keto Acid Decarboxylase/Dehydrogenase*

Jun Li, D. Chuang, M. Machius, 2004, Journal of Biological Chemistry.

The C-terminal Hinge Region of Lipoic Acid-bearing Domain of E2b Is Essential for Domain Interaction with Branched-chain α-Keto Acid Dehydrogenase Kinase*

D. Chuang, R. Wynn, J. Chuang, 2002, The Journal of Biological Chemistry.