P. Krastel

发表

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

John A. Tallarico, Jeffrey A. Porter, Mathias Frederiksen, 2014, Microbiological research.

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.

Nathan T. Ross, Trixie Wagner, Francesca Perruccio, 2015, Angewandte Chemie.

Dark chemical matter as a promising starting point for drug lead discovery.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2015, Nature chemical biology.

Recent developments in antibacterial drug discovery: microbe-derived natural products – from collection to the clinic

Philipp Krastel, J. Leeds, E. Schmitt, 2006, Expert opinion on investigational drugs.

Recent trends and observations in the design of high-quality screening collections.

Florian Nigsch, Edgar Jacoby, Ansgar Schuffenhauer, 2011, Future medicinal chemistry.

Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

H. Naegeli, C. Parker, R. Morris, 2009, Journal of the American Chemical Society.

Antibacterial and Solubility Optimization of Thiomuracin A.

F. Lombardo, Jian Ding, J. Leeds, 2016, Journal of medicinal chemistry.

Antibiotic optimization and chemical structure stabilization of thiomuracin A.

J. Leeds, M. LaMarche, J. Dzink-Fox, 2012, Journal of medicinal chemistry.

4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.

J. Leeds, E. Schmitt, M. LaMarche, 2011, Journal of medicinal chemistry.

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Eric A. Franzosa, Daniel J. O'Connell, C. Huttenhower, 2017, Cell host & microbe.

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Alex M. Ascensión, M. Araúzo-Bravo, M. Gorospe, 2020, The Journal of clinical investigation.

The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.

P. Niyomrattanakit, D. Jeffery, M. Riwanto, 2011, Angewandte Chemie.

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus

M. Zimmerman, T. Dick, V. Dartois, 2021, Antimicrobial agents and chemotherapy.

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.

J. Bastien, Christoph Potting, D. Hoepfner, 2017, Nature chemical biology.

Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus

K. Dettner, A. Zeeck, H. Fiedler, 2002 .

Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells.

Anthony E. Boitano, P. Schultz, M. Cooke, 2013, ACS chemical biology.

Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.

Anthony E. Boitano, P. Schultz, A. Newton, 2012, Chemistry & biology.

Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.

Stephen M. Canham, John A. Tallarico, J. Tallarico, 2021, Cell chemical biology.

Biosynthesis of the Antibiotic Echinosporin by a Novel Branch of the Shikimate Pathway

A. Zeeck, P. Krastel, H. Floss, 2002 .

Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy.

E. Mandelkow, C. Griesinger, S. Jeganathan, 2010, Angewandte Chemie.

Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods.

D. Schmid, K. Dettner, A. Zeeck, 2002, FEMS microbiology letters.

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

Trixie Wagner, Philipp Krastel, Frank Petersen, 2010, Journal of medicinal chemistry.

Antibacterial Investigation using Spectrophotometric Assay of the Polar Leaf Extracts of Ficus capensis (Moraceae)

Achimugu Dickson Musa, P. Krastel, Muhammad Shuaib, 2020 .

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.

T. Dick, N. Ma, T. Keller, 2008, Journal of Antimicrobial Chemotherapy.

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

R. Bruccoleri, T. Rapoport, S. Schuierer, 2015, Journal of Cell Science.

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.

Nathan T. Ross, Stephen M. Canham, John A. Tallarico, 2021, Cell chemical biology.

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

Mathias Frederiksen, S. Reinker, S. Schuierer, 2015, Nature Communications.

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

Nathan T. Ross, P. Raman, Jian Ding, 2015, PloS one.

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

Christopher J. Wilson, J. Tallarico, R. Riedl, 2012, PloS one.

Natural products as probes in pharmaceutical research

D. Hoepfner, E. Schmitt, P. Krastel, 2016, Journal of Industrial Microbiology & Biotechnology.

Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin

P. Mrak, P. Krastel, J. Tao, 2018, The Journal of Biological Chemistry.

Natural products as catalysts for innovation: a pharmaceutical industry perspective.

E. Schmitt, P. Krastel, F. Petersen, 2011, Current opinion in chemical biology.

Structure and biosynthesis of cetoniacytone A, a cytotoxic aminocarba sugar produced by an endosymbiontic Actinomyces.

K. Dettner, I. Usón, A. Zeeck, 2002, The Journal of antibiotics.

Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities.

K. Dettner, A. Zeeck, H. Fiedler, 2003, The Journal of antibiotics.

Endophenazines A-D, new phenazine antibiotics from the athropod associated endosymbiont Streptomyces anulatus II. Structure elucidation.

A. Zeeck, H. Fiedler, K. Gebhardt, 2002, The Journal of antibiotics.

Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic Fungus Aspergillus niveus LU 9575. II. Structure elucidation.

G. Jung, D. Schmid, G. Nicholson, 2004, The Journal of antibiotics.

Aspochalamins A—D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus niveus LU 9575. Part 2. Structure Elucidation.

D. Schmid, G. Nicholson, A. Zeeck, 2005 .

Enterobactin: the characteristic catecholate siderophore of Enterobacteriaceae is produced by Streptomyces species.(1).

A. Zeeck, H. Fiedler, K. Gebhardt, 2001, FEMS microbiology letters.

Streptazones A, B(1), B(2), C, and D: new piperidine alkaloids from streptomycetes.

A. Zeeck, C. Puder, P. Krastel, 2000, Journal of natural products.

Evolution of Novartis' Small Molecule Screening Deck Design.

A. Schuffenhauer, Eugen Lounkine, N. Stiefl, 2020, Journal of medicinal chemistry.

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis growth and metastasis

Daniela Gerovska, A. Carracedo, E. Serra, 2022 .

Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

H. Naegeli, C. Parker, R. Morris, 2009, Journal of the American Chemical Society.

Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells.

Anthony E. Boitano, M. Cooke, Ying Wang, 2013, ACS Chemical Biology.