P. Gaussem

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Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.

A. Bura, J. Hulot, C. Goyenvalle, 2006, Blood.

Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells

I. Bièche, M. Aiach, P. Gaussem, 2008, Journal of cellular and molecular medicine.

DNA‐bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

F. Meziani, J. Helms, E. Angles-cano, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Wnt Antagonist Dickkopf-1 Increases Endothelial Progenitor Cell Angiogenic Potential

F. Lallemand, S. Germain, L. weiswald, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvilli.

F. Soncin, P. Gaussem, D. Evain-Brion, 1998, Placenta.

Impact of Aspirin and Clopidogrel Interruption on Platelet Function in Patients Undergoing Major Vascular Surgery

M. Loriot, P. Coriat, Y. Le Manach, 2014, PloS one.

Effect of clopidogrel on circulating biomarkers of angiogenesis and endothelial activation.

A. Bura, A. Blanchard, M. Azizi, 2012, Journal of cardiology.

Role of the P2Y12 gene polymorphism in platelet responsiveness to clopidogrel in healthy subjects

A. Bura, M. Aiach, P. Gaussem, 2006, Journal of thrombosis and haemostasis : JTH.

PAR-1 genotype influences platelet aggregation and procoagulant responses in patients with coronary artery disease prior to and during clopidogrel therapy

R. Storey, P. Gaussem, G. Peters, 2005, Platelets.

No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19

G. Kroemer, E. Solary, E. Vacchelli, 2020, Oncoimmunology.

Endothelial Colony-Forming Cells Do Not Participate to Fibrogenesis in a Bleomycin-Induced Pulmonary Fibrosis Model in Nude Mice

I. Bièche, T. Gille, P. Dorfmüller, 2018, Stem Cell Reviews and Reports.

Amino acids 225–235 of the protein C serine‐protease domain are important for the interaction with the thrombin‐thrombomodulin complex

M. Aiach, P. Gaussem, S. Debost, 1995, FEBS letters.

Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential

X. Loyer, J. Vilar, J. Silvestre, 2015, Thrombosis and Haemostasis.

Induced forms of α2-macroglobulin neutralize heparin and direct oral anticoagulant effects.

C. Samama, S. Pasquali, I. Gouin-Thibault, 2021, International journal of biological macromolecules.

Rivaroxaban pharmacodynamics in healthy volunteers evaluated with thrombin generation and the active protein C system: Modeling and assessing interindividual variability

M. Loriot, C. Funck-Brentano, J. Salem, 2019, Journal of thrombosis and haemostasis : JTH.

Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats.

P. Gaussem, V. Siguret, B. L. Le Bonniec, 2018, Pesticide biochemistry and physiology.

Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.

C. Samama, Anne-Céline Martin, C. Marchand-Leroux, 2013, International journal of cardiology.

A New Assay Based on Thrombin Generation Inhibition to Detect Both Protein C and Protein S Deficiencies in Plasma

S. Béguin, M. Alhenc-Gelas, M. Aiach, 1994, Thrombosis and Haemostasis.

Comparison of Endothelial Biomarkers According to Reversibility of Pulmonary Hypertension Secondary to Congenital Heart Disease

D. Bonnet, V. Remones, P. Gaussem, 2010, Pediatric Cardiology.

Circulating Endothelial Cells: A New Candidate Biomarker of Irreversible Pulmonary Hypertension Secondary to Congenital Heart Disease

D. Bonnet, P. Vouhé, F. Dignat-George, 2009, Circulation.

Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic Properties

I. Bièche, I. Laurendeau, P. Bruneval, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood: A diagnostic test study

C. Samama, J. Golmard, I. Gouin-Thibault, 2019, European journal of anaesthesiology.

Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin

M. Loriot, P. Beaune, C. Funck-Brentano, 2017, Journal of thrombosis and haemostasis : JTH.

Current and Novel Antiplatelet Therapies for the Treatment of Cardiovascular Diseases

M. Lordkipanidzé, P. Gaussem, A. Philippe, 2021, International journal of molecular sciences.

Antiplatelet Therapy in Atherothrombotic Diseases: Similarities and Differences Across Guidelines

M. Lordkipanidzé, Anne-Céline Martin, A. Godier, 2022, Frontiers in Pharmacology.

Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel

C. Samama, J. Emmerich, A. Godier, 2010, Thrombosis and Haemostasis.

FXa-α2-Macroglobulin Complex Neutralizes Direct Oral Anticoagulants Targeting FXa In Vitro and In Vivo

I. Gouin-Thibault, P. Gaussem, V. Siguret, 2018, Thrombosis and Haemostasis.

Multimodal assessment of non‐specific hemostatic agents for apixaban reversal

C. Samama, I. Gouin-Thibault, A. Godier, 2015, Journal of thrombosis and haemostasis : JTH.

Interleukin-8 release by endothelial colony-forming cells isolated from idiopathic pulmonary fibrosis patients might contribute to their pathogenicity

I. Bièche, S. Chevret, B. Crestani, 2019, Angiogenesis.

Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway

M. Humbert, E. Boscolo, I. Bièche, 2014, Thrombosis and Haemostasis.

Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis.

D. Valeyre, P. Gaussem, D. Smadja, 2014, Pathologie-biologie.

The profibrotic cytokine transforming growth factor‐β1 increases endothelial progenitor cell angiogenic properties

I. Bièche, J. Kovacic, P. Gaussem, 2012, Journal of thrombosis and haemostasis : JTH.

Venous Thrombosis in Older People: Prevalence of the Factor V Gene Mutation Q506

M. Alhenc-Gelas, P. Gaussem, V. Siguret, 1998, Journal of the American Geriatrics Society.

Arterial and venous thrombosis is associated with different angiogenic cytokine patterns in patients with antiphospholipid syndrome

J. Emmerich, P. Gaussem, D. Smadja, 2010, Lupus.

Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension

A. Harroche, P. Gaussem, D. Smadja, 2018, Pediatric pulmonology.

Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population‐based study (the Three‐City cohort study)

O. Rouaud, J. Ryan, P. Gaussem, 2012, Clinical endocrinology.

Inefficacy of platelet transfusion to reverse ticagrelor.

A. Godier, P. Gaussem, G. Taylor, 2015, The New England journal of medicine.

The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study

C. Samama, Anne-Céline Martin, I. Gouin-Thibault, 2016, European journal of anaesthesiology.

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

J. Michel, J. Egido, J. Emmerich, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Clinical and Population Studies Peripheral Artery Disease Is Associated With a High CD 163 / TWEAK Plasma Ratio

J. Michel, J. Egido, J. Emmerich, 2010 .

Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia

M. Cavazzana‐Calvo, P. Bruneval, J. Emmerich, 2008, Modern Pathology.

Impaired platelet activation and cAMP homeostasis in MRP 4-deficient mice Short title : MRP 4 controls platelet cAMP homeostasis

C. Denis, J. Hulot, A. Lompré, 2015 .

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.

C. Denis, J. Hulot, A. Lompré, 2015, Blood.

Evolution of platelet functions in cirrhotic patients undergoing liver transplantation: A prospective exploration over a month

L. Puybasset, J. Vaillant, D. Eyraud, 2018, PloS one.

Cerebral haemorrhagic risk in children with sickle‐cell disease

O. Naggara, F. Brunelle, T. Blauwblomme, 2015, Developmental medicine and child neurology.

Anticoagulation Before Hospitalization Is a Potential Protective Factor for COVID‐19: Insight From a French Multicenter Cohort Study

J. Alsac, E. Messas, A. Cohen, 2021, Journal of the American Heart Association.

D-dimers at hospital admission for COVID-19 are associated with in hospital mortality independently of venous thromboembolism: Insight from a French multicenter cohort study

J. Alsac, E. Messas, G. Bonnet, 2020 .

The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies

B. Jude, J. Reny, C. Thalamas, 2005, Journal of thrombosis and haemostasis : JTH.

Antiplatelet therapy in (cardio)vascular disease

J. Rogers, F. Dudbridge, A. Coffey, 2012 .

Effect of an increased clopidogrel maintenance dose or lansoprazole co‐administration on the antiplatelet response to clopidogrel in CYP2C19‐genotyped healthy subjects

J. Hulot, C. Funck-Brentano, G. Wuerzner, 2010, Journal of thrombosis and haemostasis : JTH.

2 C 19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

A. Bura, J. Hulot, C. Goyenvalle, 2006 .

Angiogenic potential of BM MSCs derived from patients with critical leg ischemia

J. Emmerich, J. Silvestre, P. Gaussem, 2012, Bone Marrow Transplantation.

Endothelial progenitor cells: Characterization, in vitro expansion, and prospects for autologous cell therapy

J. Emmerich, M. Aiach, P. Gaussem, 2007, Cell Biology and Toxicology.

Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers.

C. Funck-Brentano, O. Steichen, M. Azizi, 2013, Archives of cardiovascular diseases.

Haemorrhagic Complications of Vitamin K Antagonists in the Elderly

I. Gouin-Thibault, P. Gaussem, É. Pautas, 2006, Drugs & aging.

Potential usefulness Utility of activated charcoal ( DOAC remove ® ) for dRVVT testing in patients receiving Direct Oral AntiCoagulants

P. Gaussem, V. Siguret, L. Darnige, 2019 .

Potential usefulness of activated charcoal (DOAC remove®) for dRVVT testing in patients receiving Direct Oral AntiCoagulants.

I. Gouin-Thibault, P. Gaussem, V. Siguret, 2019, Thrombosis research.

A monoclonal antibody recognizing the activation domain of protein C in its calcium‐free conformation

M. Aiach, P. Gaussem, A. Vincenot, 1998, FEBS letters.

Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells

S. Susen, F. Soncin, V. Mattot, 2018, Stem Cell Reviews and Reports.

Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity.

M. Aiach, P. Gaussem, S. Gandrille, 1993, Blood.

No influence of the VAMP8 rs1010 single nucleotide polymorphism on platelet functions in vitro

C. Pullinger, P. Fontana, M. Aiach, 2009, Journal of cellular and molecular medicine.

Distinct patterns of circulating endothelial cells in pulmonary hypertension

J. Silvestre, A. Godier, P. Gaussem, 2010, European Respiratory Journal.

Correction: Circulating Endothelial Cells in Refractory Pulmonary Hypertension in Children: Markers of Treatment Efficacy and Clinical Worsening

D. Celermajer, D. Bonnet, P. Gaussem, 2014, PLoS ONE.

Circulating Endothelial Cells in Refractory Pulmonary Hypertension in Children: Markers of Treatment Efficacy and Clinical Worsening

D. Celermajer, D. Bonnet, P. Gaussem, 2013, PloS one.

Autoregulation of Pulsatile Bioprosthetic Total Artificial Heart is Involved in Endothelial Homeostasis Preservation

A. Carpentier, P. Gaussem, D. Smadja, 2020, Thrombosis and Haemostasis.

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

P. Gaussem, D. Smadja, J. Bischoff, 2015, Thrombosis and Haemostasis.

Human Endothelial Colony Forming Cells Express Intracellular CD133 that Modulates their Vasculogenic Properties

I. Bièche, A. Schnitzler, P. Gaussem, 2019, Stem Cell Reviews and Reports.

LETTER TO THE EDITOR: P2Y1 gene polymorphism and ADP‐induced platelet response

P. Fontana, J. Reny, V. Remones, 2005, Journal of thrombosis and haemostasis : JTH.

Treprostinil increases the number and angiogenic potential of endothelial progenitor cells in children with pulmonary hypertension

D. Celermajer, D. Bonnet, P. Gaussem, 2010, Angiogenesis.

Forearm ischemia decreases endothelial colony-forming cell angiogenic potential.

P. Boutouyrie, E. Bozec, M. Azizi, 2014, Cytotherapy.

Recent Advances in Anticoagulant Treatment of Immune Thrombosis: A Focus on Direct Oral Anticoagulants in Heparin-Induced Thrombocytopenia and Anti-Phospholipid Syndrome

P. Gaussem, L. Darnige, N. Gendron, 2021, International journal of molecular sciences.

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis

E. Angles-cano, P. Gaussem, D. Smadja, 2018, Stem Cell Reviews and Reports.

Elderly Patients Treated with Tinzaparin (Innohep®) Administered once Daily (175 Anti-Xa IU/kg): Anti-Xa and Anti-IIa Activities over 10 Days

P. Gaussem, É. Pautas, V. Siguret, 2000, Thrombosis and Haemostasis.

Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant

S. Mundell, A. Mumford, P. Gaussem, 2013, Journal of thrombosis and haemostasis : JTH.

Protein C and protein S deficiencies.

J. Emmerich, M. Aiach, P. Gaussem, 1997, Seminars in hematology.

Usefulness of initial plasma dabigatran concentration to predict rebound after reversal

P. Gaussem, D. Smadja, N. Gendron, 2018, Haematologica.

Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers

P. Fontana, J. Reny, V. Remones, 2006, Thrombosis and Haemostasis.

Acute anemia after dental extraction: A case report

P. Gaussem, A. Alantar, S. Aïche, 2014 .

P2Y 12 H2 Haplotype Is Associated With Peripheral Arterial Disease A Case-Control Study

P. Fontana, J. Reny, J. Emmerich, 2003 .

Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status.

J. Emmerich, M. Aiach, P. Gaussem, 2007, Clinical chemistry.

Physiological plasma Gas6 levels do not influence platelet aggregation.

P. Fontana, V. Remones, M. Aiach, 2005, Arteriosclerosis, thrombosis, and vascular biology.

CD34+ Hematopoietic Stem Cell Count Is Predictive of Vascular Event Occurrence in Children with Sickle Cell Disease

I. Desguerre, D. Bonnet, P. Gaussem, 2018, Stem Cell Reviews and Reports.

[Thrombopathy induced by selective serotonin reuptake inhibitors: a case report].

L. Amar, P. Gaussem, D. Smadja, 2014, Annales de biologie clinique.

Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease

A. Carpentier, I. Bièche, S. Susen, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Interleukin 8 is differently expressed and modulated by PAR‐1 activation in early and late endothelial progenitor cells

I. Bièche, S. Susen, I. Laurendeau, 2009, Journal of cellular and molecular medicine.

Bone Morphogenetic Proteins 2 and 4 Are Selectively Expressed by Late Outgrowth Endothelial Progenitor Cells and Promote Neoangiogenesis

S. Germain, I. Bièche, M. Vidaud, 2008, Arteriosclerosis, thrombosis, and vascular biology.

PAR-1 Activation on Human Late Endothelial Progenitor Cells Enhances Angiogenesis In Vitro With Upregulation of the SDF-1/CXCR4 System

L. Muller, I. Bièche, M. Vidaud, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Placental growth factor level in plasma predicts COVID‐19 severity and in‐hospital mortality

C. Samama, B. Rance, F. Pène, 2021, Journal of Thrombosis and Haemostasis.

Successful Use of Recombinant Activated Factor VII to Reverse Ticagrelor-Induced Bleeding Risk: A Case Report

J. Desilles, Anne-Céline Martin, A. Godier, 2018, TH open : companion journal to thrombosis and haemostasis.

Beta-1,4-galactosyltransferase 2 c.909C>T gene variant is predictive of on-clopidogrel platelet reactivity.

M. Loriot, N. Pallet, P. Gaussem, 2018, Pharmacogenomics.

Platelet Functions During Extracorporeal Membrane Oxygenation. Platelet–Leukocyte Aggregates Analyzed by Flow Cytometry as a Promising Tool to Monitor Platelet Activation

I. Gouin-Thibault, P. Gaussem, E. Flécher, 2020, Journal of clinical medicine.

MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease.

J. Hulot, P. Gaussem, C. Bachelot-Loza, 2016, Pharmacological research.

Antiplatelet and antithrombotic effect of F 16618, a new thrombin proteinase‐activated receptor‐1 (PAR1) antagonist

T. Mirault, P. Gaussem, F. Grelac, 2012, British journal of pharmacology.

[Monitoring of tinzaparin in a ten day treatment dose in elderly patients].

P. Gaussem, É. Pautas, V. Siguret, 2001, La Revue de medecine interne.

Functional identification of t-PA in crude and purified systems.

E. Angles-cano, P. Gaussem, B. L. Le Bonniec, 1988, Thrombosis research. Supplement.

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit.

C. Samama, J. Emmerich, A. Godier, 2012, British journal of anaesthesia.

Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia.

P. Bruneval, J. Emmerich, A. Blanchard, 2012, Cytotherapy.

The determination of functional plasminogen activator inhibitors (PAI) based on the inhibition of urokinase: PAI normal range and circadian variations in healthy donors; Comparison with other methods

M. Alessi, M. Aiach, P. Gaussem, 1990 .

Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells

S. Vacher, I. Bièche, P. Gaussem, 2020, Stem Cell Reviews and Reports.

[Characterization of endothelial progenitor cells and putative strategies to improve their expansion].

P. Gaussem, D. Smadja, 2009, Journal de la Societe de biologie.

Caractrisation des progniteurs endothliaux et stratgies d'expansion in vitro

P. Gaussem, D. Smadja, 2009 .

PAR‐1 activation has different effects on the angiogenic activity of endothelial progenitor cells derived from human adult and cord blood

I. Bièche, J. Emmerich, M. Aiach, 2006, Journal of thrombosis and haemostasis : JTH.

The angiopoietin pathway is modulated by PAR‐1 activation on human endothelial progenitor cells

M. Vidaud, I. Laurendeau, M. Aiach, 2006, Journal of thrombosis and haemostasis : JTH.

Pulsed cavitational therapy using high-frequency ultrasound for the treatment of deep vein thrombosis in an in vitro model of human blood clot

M. Tanter, M. Pernot, E. Messas, 2017, Physics in Medicine and Biology.

Comparative In Vitro Study of Various α2-Adrenoreceptor Agonist Drugs for Ticagrelor Reversal

Anne-Céline Martin, A. Godier, P. Gaussem, 2020, Journal of clinical medicine.

Epinephrine restores platelet functions inhibited by ticagrelor: A mechanistic approach.

M. Alessi, Anne-Céline Martin, A. Godier, 2019, European journal of pharmacology.

Ticagrelor reversal: in vitro assessment of four haemostatic agents

Anne-Céline Martin, I. Gouin-Thibault, A. Godier, 2017, Journal of Clinical Pathology.

Place de l’épuration extracorporelle de CO2 (ECCO2R) dans la prise en charge des pathologies respiratoires

P. Gaussem, D. Smadja, J. Diehl, 2017 .

[The role of extracorporeal removal of CO2 (ECCO2R) in the management of respiratory diseases].

P. Gaussem, D. Smadja, N. Aissaoui, 2017, Revue des maladies respiratoires.

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

P. Gaussem, D. Smadja, J. Bischoff, 2015, Thrombosis and Haemostasis.

Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.

J. Chun, S. Coughlin, T. Hla, 2016, Circulation research.

Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets

P. Gaussem, Sonia Poirault-Chassac, B. Dizier, 2021, Thrombosis and Haemostasis.

P2RY1 and P2RY12 polymorphisms and on‐aspirin platelet reactivity in patients with coronary artery disease

Deepak L. Bhatt, J. Barnard, R. Silverstein, 2012, International journal of laboratory hematology.

Neutralization of plasminogen activator inhibitor-1 (PAI-1) by activated protein C is species-dependent

E. Angles-cano, P. Gaussem, A. Bezeaud, 1993 .

Ruling Out Acute Deep Vein Thrombosis by ELISA Plasma D-Dimer Assay Versus Ultrasound in Inpatients More Than 70 Years Old

C. Settegrana, P. Gaussem, V. Siguret, 1999, Angiology.

Dose-effect relationship for several coagulation markers during administration of the direct thrombin inhibitor S 18326 in healthy subjects.

I. Richard-Lordereau, M. Aiach, P. Gaussem, 2002, British journal of clinical pharmacology.

Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism

I. Bièche, J. Silvestre, C. Cochain, 2015, Angiogenesis.

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis‐related characteristics in vitro: a rebuttal

I. Bièche, S. Susen, P. Gaussem, 2009, Journal of thrombosis and haemostasis : JTH.

Biphasic myosin II light chain activation during clot retraction

A. Kauskot, P. Gaussem, C. Bachelot-Loza, 2013, Thrombosis and Haemostasis.

Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis.

P. Gaussem, B. Dizier, C. Bachelot-Loza, 2019, Prostaglandins, leukotrienes, and essential fatty acids.

Human Endothelial Colony Forming Cells Express Intracellular CD133 that Modulates their Vasculogenic Properties

I. Bièche, A. Schnitzler, P. Gaussem, 2019, Stem Cell Reviews and Reports.

The Carmat Bioprosthetic Total Artificial Heart Is Associated With Early Hemostatic Recovery and no Acquired von Willebrand Syndrome in Calves.

Antoine Capel, Alain Carpentier, Piet Jansen, 2017, Journal of cardiothoracic and vascular anesthesia.

Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.

M. Aiach, P. Gaussem, C. Garbay, 2001, The Biochemical journal.

Lupus Anticoagulant Single Positivity During the Acute Phase of COVID‐19 Is Not Associated With Venous Thromboembolism or In‐Hospital Mortality

C. Samama, C. Goulvestre, F. Pène, 2021, Arthritis & rheumatology.

Antiplatelet Therapy for Atherothrombotic Disease in 2022—From Population to Patient-Centered Approaches

M. Lordkipanidzé, A. Godier, P. Gaussem, 2022, Frontiers in Cardiovascular Medicine.

Adenosine Diphosphate–Induced Platelet Aggregation Is Associated With P2Y12 Gene Sequence Variations in Healthy Subjects

P. Fontana, J. Reny, M. Aiach, 2003, Circulation.

Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)

A. Munnich, C. Picard, B. Isidor, 2008, Nature Genetics.

Delivery management in a woman with thrombocytopenia of the May-Hegglin anomaly type.

P. Gaussem, G. Tchernia, Y. Gallais, 2001, European journal of obstetrics, gynecology, and reproductive biology.

Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells

S. Vacher, I. Bièche, P. Gaussem, 2020, Stem Cell Reviews and Reports.

Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

M. Aiach, P. Gaussem, D. Borgel, 2000, Thrombosis research.

Thrombopénie ferriprive : un diagnostic différentiel rare du purpura thrombopénique auto-immun

J. Pouchot, P. Gaussem, J. Arlet, 2010 .

Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells

J. Vincent, D. De Backer, O. Pradier, 2015, Intensive Care Medicine.

Interleukin-8 release by endothelial colony-forming cells isolated from idiopathic pulmonary fibrosis patients might contribute to their pathogenicity

I. Bièche, S. Chevret, B. Crestani, 2019, Angiogenesis.

Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism

I. Bièche, J. Silvestre, C. Cochain, 2015, Angiogenesis.

The formation of complexes between human plasminogen activator inhibitor-1 (PAI-1) and sodium dodecyl sulfate: possible implication in the functional properties of PAI-1.

P. Gaussem, E. Anglés-Cano, 1991, Biochimica et biophysica acta.

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device

N. Nesseler, I. Gouin-Thibault, P. Gaussem, 2021, Anesthesiology.

Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.

R. Proia, N. Debili, J. Chun, 2019, Blood advances.

An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation.

M. Aiach, P. Gaussem, V. Picard, 1994, Blood.

An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation

M. Aiach, P. Gaussem, V. Picard, 1994 .

Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol

V. Remones, M. Aiach, P. Gaussem, 2011, Thrombosis and Haemostasis.

Pain assessment and factors influencing pain during bone marrow aspiration: A prospective study

P. Gaussem, V. Siguret, L. Darnige, 2019, PloS one.

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

E. Messas, D. Duffy, J. Hadjadj, 2020, Angiogenesis.

Assessment of DOAC in GEriatrics ( Adage Study): Rivaroxaban/Apixaban Concentrations and Thrombin Generation Profiles in NVAF Very Elderly Patients

E. Puymirat, I. Gouin-Thibault, P. Gaussem, 2022, Thrombosis and Haemostasis.

Thrombosis and Haemostasis Assessment of DOAC in GEriatrics (ADAGE study): rivaroxaban/apixaban concentrations and thrombin generation profiles in NVAF very elderly patients academic prospective exploratory multicenter study

E. Puymirat, I. Gouin-Thibault, P. Gaussem, 2022 .

No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease

M. Loriot, L. Hindorff, J. Emmerich, 2008, Thrombosis and Haemostasis.

Effect of rivaroxaban and dabigatran on platelet functions: in vitro study.

M. Fontenay, P. Gaussem, Sonia Poirault-Chassac, 2019, Thrombosis research.

A HAPLOTYPE OF THE EPCR GENE IS ASSOCIATED WITH INCREASED PLASMA LEVELS OF sEPCR AND IS A CANDIDATE RISK FACTOR FOR THROMBOSIS Short title : EPCR gene , sEPCR level and thrombotic

J. Reny, J. Emmerich, M. Aiach, 2003 .

D-dimer at hospital admission for COVID-19 are associated with in-hospital mortality, independent of venous thromboembolism: Insights from a French multicenter cohort study

J. Alsac, E. Messas, A. Cohen, 2021, Archives of Cardiovascular Diseases.

Predictive Factor for COVID-19 Worsening: Insights for High-Sensitivity Troponin and D-Dimer and Correlation With Right Ventricular Afterload

E. Messas, B. Vedie, H. Péré, 2020, Frontiers in Medicine.

Curative anticoagulation prevents endothelial lesion in COVID‐19 patients

D. Lebeaux, E. Messas, B. Rance, 2020, Journal of Thrombosis and Haemostasis.

The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE–Platelets project

F. Rosendaal, D. Herrington, H. Vos, 2010, Journal of thrombosis and haemostasis : JTH.

In Vitro Plasma-Induced Endothelial Oxidative Stress and Circulating Markers of Endothelial Dysfunction in Preeclampsia: An Observational Study

J. Pottecher, V. Tsatsaris, O. Huet, 2009, Hypertension in pregnancy.

Serum antibodies to distinct epitopes of the tissue‐type plasminogen activator (t‐PA) in patients with systemic lupus erythematosus

D. Alarcón-Segovia, A. Ruiz-Arguelles, P. Gaussem, 1995, American journal of hematology.

Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin α6

L. Muller, I. Bièche, I. Laurendeau, 2007, Journal of cellular and molecular medicine.

The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers

I. Bièche, M. Vidaud, I. Laurendeau, 2004, Thrombosis and Haemostasis.

Human endoglin as a potential new partner involved in platelet–endothelium interactions

F. Blanco, P. Gaussem, D. Smadja, 2017, Cellular and Molecular Life Sciences.

Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene.

B. Jude, J. Abgrall, P. Gaussem, 1995, Blood.

Platelet receptor gain-of-function single nucleotide polymorphisms in carotid and vertebral stenosis patients

M. Brown, P. Gaussem, M. Forestier, 2011, Journal of Thrombosis and Thrombolysis.

P2Y12 H2 Haplotype Is Associated With Peripheral Arterial Disease: A Case-Control Study

P. Fontana, J. Reny, J. Emmerich, 2003, Circulation.

P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation

N. Nesseler, I. Gouin-Thibault, P. Gaussem, 2020, International journal of molecular sciences.

Platelet activation and coronavirus disease 2019 mortality: Insights from coagulopathy, antiplatelet therapy and inflammation

C. Samama, G. Bonnet, J. Hadjadj, 2023, Archives of Cardiovascular Diseases.

Reduced endothelial thioredoxin‐interacting protein protects arteries from damage induced by metabolic stress in vivo

P. Bigey, J. Paul, V. Escriou, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of oculocerebrorenal syndrome of Lowe (OCRL) protein in megakaryocyte maturation, platelet production and functions: a study in patients with Lowe syndrome

C. Elie, R. Salomon, D. Baruch, 2021, British journal of haematology.

Evidence that MRP4 is Only Partly Involved in S1P Secretion during Platelet Activation

P. Gaussem, P. Thérond, C. Bachelot-Loza, 2018, Thrombosis and Haemostasis.

Development of an Internal Standard for Plasminogen Activator Inhibitor-1 PAI-1 and its Use in a Simplified Assay for Measuring PAI-1 Activity in Human Plasma

P. Gaussem, E. Anglés-Cano, C. Masson-Lunven, 1990 .

Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects

J. Hulot, P. Fontana, P. Moerloose, 2007, Journal of thrombosis and haemostasis : JTH.

A Plasma Clot Lysis Assay Based on the Release of Fibrin Degradation Products: Application to the Diagnosis of Hypofibrinolytic States

J. Fiessinger, M. Aiach, P. Gaussem, 1990, Thrombosis and Haemostasis.

Sodium dodecyl sulfate-induced dissociation of complexes between human tissue plasminogen activator and its specific inhibitor.

P. Gaussem, P. Grailhe, E. Anglés-Cano, 1993, The Journal of biological chemistry.

Response to DDAVP stimulation in thirteen patients with Buerger's disease.

J. Fiessinger, M. Aiach, P. Gaussem, 1997, Thrombosis research.

Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

F. Pène, M. Fontenay, T. Mirault, 2021, Angiogenesis.

Endoglin Is an Endothelial Housekeeper against Inflammation: Insight in ECFC-Related Permeability through LIMK/Cofilin Pathway

S. Pasquali, A. Kauskot, P. Gaussem, 2021, International journal of molecular sciences.

Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy

R. Storey, P. Fontana, P. Gaussem, 2006, Platelets.

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism.

P. Ridker, D. Chasman, R. Zee, 2008, Atherosclerosis.

An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.

I. Bièche, P. Fontana, J. Reny, 2003, Blood.

Plasma Levels of Single-Chain Urokinase in the Elderly

G. Dooijewaard, P. Gaussem, O. Saint‐Jean, 1992 .

Elevated plasma fibrin D‐dimer as a risk factor for vascular dementia: the Three‐City cohort study

M. Giroud, P. Scarabin, P. Ducimetiere, 2009, Journal of thrombosis and haemostasis : JTH.

Vascular endothelial growth factor, as compared with placental growth factor, is increased in severe sepsis but not in organ failure

P. Gaussem, D. Borgel, J. Diehl, 2012, Journal of thrombosis and haemostasis : JTH.

Endoglin regulates mural cell adhesion in the circulatory system

E. Boscolo, A. Kauskot, M. Arévalo, 2015, Cellular and Molecular Life Sciences.

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Andrew J. Oler, Eglantine Ferrand Devouge, P. Gregersen, 2023, Genome Medicine.

Characterization of Cleaved Plasma Protein S with a Monoclonal Antibody-based Assay

M. Aiach, P. Gaussem, D. Borgel, 2000, Thrombosis and Haemostasis.

Human thrombin variable region 1, including E39, is involved in interactions with α1‐antitrypsin M358R and protein C

M. Aiach, P. Gaussem, V. Picard, 1995, FEBS letters.

Impact of age on in vitro metabolism of clopidogrel: a potential explanation for high on-treatment platelet reactivity in the elderly?

I. Gouin-Thibault, P. Gaussem, C. Bachelot-Loza, 2022, Research and practice in thrombosis and haemostasis.

Imbalance of circulating endothelial cells and progenitors in idiopathic pulmonary fibrosis

R. Borie, B. Crestani, D. Valeyre, 2012, Angiogenesis.

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Andrew J. Oler, Eglantine Ferrand Devouge, P. Gregersen, 2023, Genome Medicine.

Prospective observational study of the effect of dual antiplatelet therapy with tranexamic acid treatment on platelet function and bleeding after cardiac surgery.

J. Amour, Y. Le Manach, B. Riou, 2016, British journal of anaesthesia.

Pain Assessment Using Virtual Reality Facemask During Bone Marrow Aspiration: Prospective Study Including Propensity-Matched Analysis

B. Cholley, P. Gaussem, D. Smadja, 2022, JMIR serious games.

Optimizing the Use of Anticoagulants (Heparins and Oral Anticoagulants) in the Elderly

I. Gouin-Thibault, P. Gaussem, É. Pautas, 2013, Drugs & Aging.

Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells

D. Revets, T. Mirault, P. Gaussem, 2020, Stem Cell Reviews and Reports.

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

E. Messas, D. Duffy, J. Hadjadj, 2020, Angiogenesis.

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

C. Samama, J. Golmard, Anne-Céline Martin, 2015, Thrombosis and Haemostasis.

Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo

S. Mundell, Mario Mauri, M. Parenti, 2017, Biochemical pharmacology.

scanning method for the analysis of the protein S active gene three polymorphisms in 19 patients with protein S deficiency using a Identification of 15 different candidate causal point mutations and

B. Jude, P. Gaussem, D. Borgel, 2011 .

Endothelial Cell Markers (vWF, t-PA and PAI-1) in the Elderly

M. Verny, P. Gaussem, E. Anglés-Cano, 1994, Thrombosis and Haemostasis.

High on-clopidogrel platelet reactivity: genotyping can help to optimize antiplatelet treatment.

M. Loriot, M. Desnos, C. Moreau, 2011, Thrombosis research.

Factor VII Qualitative Deficiency and Pregnancy

P. Gaussem, V. Siguret, J. Andreux, 1998, Thrombosis and Haemostasis.

Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery

S. Susen, J. Fabiani, A. Godier, 2009, Thrombosis and Haemostasis.

Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential

P. Carmeliet, I. Bièche, M. Vidal, 2014, Angiogenesis.

[Myelodysplastic syndromes].

M. Andreux, P. Gaussem, É. Pautas, 2000, Annales de biologie clinique.

Platelet activation with the Aeson Bioprosthetic Total Artificial Heart: insight from aspirin treatment and outcomes

A. Vincentelli, P. Gaussem, F. Gustafsson, 2023, medRxiv.

Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study

G. Siest, S. Visvikis-Siest, J. Hulot, 2013, International journal of molecular sciences.

Nestin is a New Partner in Endothelial Colony Forming Cell Angiogenic Potential

J. Larghero, P. Gaussem, D. Smadja, 2023, Stem Cell Reviews and Reports.

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Mark S. Anderson, P. Gregersen, R. Nussbaum, 2021, Science Immunology.

Hemostasis, Thrombosis, and Vascular Biology

F. Rosendaal, J. Reny, J. Emmerich, 2007 .

Hemostasis, Thrombosis, and Vascular Biology

J. Reny, J. Emmerich, M. Aiach, 2022 .

VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients.

É. Mousseaux, P. Gaussem, D. Smadja, 2023, Angiogenesis.

Influence of Six Mutations of the Protein C Gene on the Gla Domain Conformation and Calcium Affinity

J. Emmerich, M. Aiach, P. Gaussem, 1994, Thrombosis and Haemostasis.

The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers

I. Bièche, M. Vidaud, I. Laurendeau, 2004, Thrombosis and Haemostasis.

The thrombomodulin-1208/-1209delTT gene promoter polymorphism does not affect basal or LPSdependent monocyte TM mRNA transcription in healthy volunteers

I. Bièche, P. Fontana, J. Reny, 2005, Thrombosis and Haemostasis.

Tissue factor expression and P2Y12 gene polymorphism

P. Fontana, J. Reny, J. Emmerich, 2004, Journal of thrombosis and haemostasis : JTH.

Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells

A. Carpentier, M. Ollert, T. Mirault, 2020, Stem cell reviews and reports.

levels of sEPCR and is a candidate risk factor for thrombosis A haplotype of the EPCR gene is associated with increased plasma

J. Reny, J. Emmerich, M. Aiach, 2013 .

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

J. Reny, J. Emmerich, M. Aiach, 2004 .

Hemostasis, Thrombosis, and Vascular Biology

D. Staunton, R. Alon, J. Reny, 2003 .

Dabigatran Level Before Reversal Can Predict Hemostatic Effectiveness of Idarucizumab in a Real-World Setting

P. Morange, L. Bertoletti, E. de Raucourt, 2020, Frontiers in Medicine.

Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells

S. Susen, F. Soncin, V. Mattot, 2017, Stem Cell Reviews and Reports.

Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic Properties

I. Bièche, I. Laurendeau, P. Bruneval, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis

P. Gaussem, D. Smadja, C. Boulanger, 2017, Stem Cell Reviews and Reports.

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

J. Michel, J. Egido, J. Emmerich, 2010, Arteriosclerosis, thrombosis, and vascular biology.

CD34+ Hematopoietic Stem Cell Count Is Predictive of Vascular Event Occurrence in Children with Sickle Cell Disease

I. Desguerre, D. Bonnet, P. Gaussem, 2018, Stem Cell Reviews and Reports.

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis.

J. Reny, J. Emmerich, M. Aiach, 2004, Blood.

[Assessment of platelet function in man].

P. Gaussem, 2006, Therapie.

[Characterization of endothelial progenitor cells and putative strategies to improve their expansion].

P. Gaussem, D. Smadja, 2009, Journal de la Societe de biologie.

Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant

S. Mundell, A. Mumford, P. Gaussem, 2013, Journal of Thrombosis and Haemostasis.

Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population‐based study (the Three‐City cohort study)

O. Rouaud, J. Ryan, P. Gaussem, 2012, Clinical endocrinology.

Biphasic myosin II light chain activation during clot retraction

A. Kauskot, P. Gaussem, C. Bachelot-Loza, 2013, Thrombosis and Haemostasis.

[Evaluation of hemostasis in venous thromboembolism pathology].

M. Aiach, P. Gaussem, V. Siguret, 1998, Annales de biologie clinique.

Imbalanced coagulation profile as a biomarker of migraine in children with sickle cell: Is this a link with cerebral ischemia?

I. Desguerre, P. Gaussem, M. de Montalembert, 2014, The Journal of pediatrics.

Combined Platelet and Red Blood Cell Recovery during On-pump Cardiac Surgery Using same™ by i-SEP Autotransfusion Device: A First-in-human Noncomparative Study (i-TRANSEP Study)

B. Rozec, N. Nesseler, A. Godier, 2023, Anesthesiology.