S. Fynch

发表

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

T. Kay, G. Steinberg, Nirupa Sachithanandan, 2011, Diabetes.

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice

H. Thomas, T. Kay, K. Graham, 2021, Diabetologia.

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

H. Thomas, T. Kay, S. Litwak, 2020, Frontiers in Immunology.

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

G. Morahan, H. Thomas, T. Kay, 2012, Diabetes.

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

H. Thomas, T. Kay, A. Baxter, 2014, Diabetes.

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

S. Akira, A. Strasser, H. Thomas, 2014, Cell Death and Disease.

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes

A. Strasser, David C. S. Huang, H. Thomas, 2014, Diabetologia.

IL-21 regulates SOCS1 expression in autoreactive CD8+ T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

H. Thomas, T. Kay, K. Graham, 2019, Scientific Reports.

ABCA12 regulates insulin secretion from β‐cells

P. Das, H. Low, P. Meikle, 2020, EMBO reports.

Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes.

Z. Mollah, H. Thomas, T. Kay, 2011, The American journal of pathology.

Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

A. Strasser, C. Scott, T. Kay, 2009, Diabetes.

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse

A. Strasser, Z. Mollah, H. Thomas, 2011, Apoptosis.

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice

S. Robson, H. Thomas, J. Chia, 2013, Diabetes.

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice

S. Robson, H. Thomas, J. Chia, 2013, Diabetes.

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

H. Thomas, T. Kay, S. Litwak, 2020 .

Perforin facilitates beta cell killing and regulates autoreactive CD8+ T‐cell responses to antigen in mouse models of type 1 diabetes

H. Thomas, T. Kay, K. Graham, 2016, Immunology and cell biology.

Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor

L. Boon, H. Thomas, T. Kay, 2022, Clinical & translational immunology.

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

A. Strasser, L. O'Reilly, H. Thomas, 2019, Cell death discovery.

Intra‐islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression

H. Thomas, T. Kay, P. Santamaria, 2012, European journal of immunology.

IL-17F induces inflammation, dysfunction and cell death in mouse islets

H. Thomas, T. Kay, S. Fynch, 2020, Scientific Reports.

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

H. Thomas, T. Kay, A. Lew, 2017, Diabetes.

Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

S. Masters, H. Thomas, T. Kay, 2014, PloS one.

Liver‐specific suppressor of cytokine signaling‐3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity 1

Sofianos Andrikopoulos, A. Hevener, T. Kay, 2010, Hepatology.

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway

J. Trapani, P. Bird, Z. Mollah, 2017, Diabetes.

Isolation and Culture of the Islets of Langerhans from Mouse Pancreas

H. Thomas, T. Kay, K. Graham, 2016 .

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes

H. Thomas, H. Herzog, Yanchuan Shi, 2021, Molecular metabolism.

Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes

H. Thomas, H. Herzog, Yanchuan Shi, 2021, bioRxiv.

Liver‐specific suppressor of cytokine signaling‐3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity 1

A. Hevener, T. Kay, J. Proietto, 2010, Hepatology.

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

H. Thomas, T. Kay, A. Baxter, 2014, Diabetes.