J. Tesmer

发表

Snapshot of Activated G Proteins at the Membrane: The Gαq-GRK2-Gßγ Complex

T. Kozasa, V. Tesmer, Takeharu Kawano, 2005, Science.

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.

A. Mushegian, V. Gurevich, E. Gurevich, 2012, Pharmacology & therapeutics.

The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families

Janet L. Smith, V. Davisson, J. Tesmer, 1996, Nature Structural Biology.

Structure of RGS4 Bound to AlF4 −-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

S. Sprang, A. Gilman, J. Tesmer, 1997, Cell.

A GAIN in understanding autoproteolytic G protein‐coupled receptors and polycystic kidney disease proteins

J. Tesmer, 2012, The EMBO journal.

Expression, purification, and analysis of G-protein-coupled receptor kinases.

J. Tesmer, Kevin R. Michalski, R. Sterne‐Marr, 2013, Methods in enzymology.

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

D. Veprintsev, X. Deupí, G. Schertler, 2013, EMBO reports.

G Protein-Coupled Receptor Kinases

V. Gurevich, E. Gurevich, J. Tesmer, 2016, Methods in Pharmacology and Toxicology.

Unveiling the Membrane-Binding Properties of N-Terminal and C-Terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies

Zhan Chen, H. Mosberg, J. Tesmer, 2014, Langmuir : the ACS journal of surfaces and colloids.

A Global Map of G Protein Signaling Regulation by RGS Proteins

M. Babu, S. Chavali, S. Balaji, 2020, Cell.

Structural Insights into Phospholipase C-β Function

J. Tesmer, A. Lyon, 2013, Molecular Pharmacology.

Structural Insights into Phospholipase C-β Function

J. Tesmer, A. Lyon, 2013, Molecular Pharmacology.

An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gαq Activation

Shoaib Chowdhury, K. C. Suddala, J. Northup, 2011, Nature Structural &Molecular Biology.

Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.

R. Lefkowitz, D. Lodowski, W. D. Capel, 2003, Acta crystallographica. Section D, Biological crystallography.

Structure and function of regulator of G protein signaling homology domains.

J. Tesmer, 2009, Progress in molecular biology and translational science.

A Thermally Stable Form of Bacterial Cocaine Esterase: A Potential Therapeutic Agent for Treatment of Cocaine Abuse

R. Sunahara, C. Zhan, J. Woods, 2010, Molecular Pharmacology.

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

J. Gutkind, M. Zhalnina, L. Avramova, 2022, The Journal of biological chemistry.

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

J. Tesmer, A. Smrcka, J. Cash, 2020, Molecular Pharmacology.

Molecular Mechanisms of PLCβ3 Autoinhibition

J. Tesmer, A. Lyon, Jessica Begley, 2015 .

A New Approach to Producing Functional G α Subunits Yields the Activated and Deactivated Structures of G α 12/13 Proteins

Douglas M. Yau, Shihori Tanabe, T. Kozasa, 2009 .

Insulin inhibits protein phosphatase 2A to impair β-adrenergic receptor function

S. N. Naga Prasad, M. Mohan, A. Sahu, 2020 .

Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.

P. Kirchhoff, J. Tesmer, S. Larsen, 2018, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

J. Cheung, W. Koch, J. Tesmer, 2017, Journal of medicinal chemistry.

Paroxetine‐mediated GRK2 Inhibition Reverses Cardiac Dysfunction and Remodeling Post‐Myocardial Infarction

W. Koch, A. Feldman, E. Gao, 2015 .

A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor

Zara Y. Weinberg, M. Puthenveedu, J. Tesmer, 2020, Molecular Pharmacology.

Small-Molecule G Protein–Coupled Receptor Kinase Inhibitors Attenuate G Protein–Coupled Receptor Kinase 2–Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions

J. Tesmer, R. Challiss, S. Brennan, 2018, Molecular Pharmacology.

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

J. Cheung, W. Koch, L. Sklar, 2012, ACS chemical biology.

GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail.

Jamee Bresee, M. Carr, J. Tesmer, 2009, Biochemistry.

Regulation of G protein-coupled receptor kinases by phospholipids.

J. Tesmer, A. Glukhova, K. Homan, 2012, Current medicinal chemistry.

Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.

J. Tesmer, Qiuyan Chen, Prateek Sharma, 2019, Protein expression and purification.

G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.

J. Benovic, A. Pronin, P. Wedegaertner, 2003, The Journal of biological chemistry.

G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias

J. Tesmer, Qiuyan Chen, 2022, The Journal of biological chemistry.

Biochemical characterization of the interaction between KRAS and Argonaute 2

B. Ruotolo, Sunita Shankar, R. Siebenaler, 2019, Biochemistry and biophysics reports.

Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.

P. Karplus, A. Bretscher, R. Fehon, 2007, Journal of molecular biology.

A Receptor on Acid

J. Tesmer, Qiuyan Chen, 2017, Cell.

Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

Andrew D White, L. Avramova, J. Tesmer, 2021, Journal of medicinal chemistry.

Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gβ1γ2 Complex.

Pei Yang, J. Tesmer, Yaoxin Li, 2016, Biochemistry.

The Role of Gβγ and Domain Interfaces in the Activation of G Protein-Coupled Receptor Kinase 2†

R. Ghirlando, D. Lodowski, J. Tesmer, 2005 .

Structural Snapshots of a Dynamic Process in the Regulation of P-Rex, a Metastatic Factor

M. Cianfrocco, J. Tesmer, J. Cash, 2018, Microscopy and Microanalysis.

In Situ Investigation of Heterotrimeric G Protein βγ Subunit Binding and Orientation on Membrane Bilayers

Andrew P. Boughton, J. Tesmer, Xiaoyun Chen, 2007 .

Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1

Justin L. Black, T. Wieland, N. Ferreirós, 2020, Cells.

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias

T. Schall, A. Kossiakoff, T. Handel, 2022, Science advances.

Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha.

S. Sprang, R. Sunahara, A. Gilman, 2002, Methods in enzymology.

Membrane Orientation and Binding Determinants of G Protein-Coupled Receptor Kinase 5 as Assessed by Combined Vibrational Spectroscopic Studies

Pei Yang, J. Tesmer, A. Glukhova, 2013, PloS one.

Heterotrimeric G protein β1γ2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane

Andrew P. Boughton, Pei Yang, V. Tesmer, 2011, Proceedings of the National Academy of Sciences.

orientationuponcomplexformationwithGprotein- coupledreceptorkinase2(GRK2)onamodelmembrane

Andrew P. Boughton, V. Tesmer, J. Tesmer, 2011 .

Unique Hydrophobic Extension of the RGS2 Amphipathic Helix Domain Imparts Increased Plasma Membrane Binding and Function Relative to Other RGS R4/B Subfamily Members*

S. Heximer, R. Natesh, J. Hepler, 2007, Journal of Biological Chemistry.

Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes

J. Tesmer, 2016, Nature Reviews Molecular Cell Biology.

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding*

S. Sligar, T. H. Bayburt, V. Gurevich, 2010, The Journal of Biological Chemistry.

X-Ray Structure of a Calcium Activated TMEM16 Lipid Scramblase

Kristen I. Fread, G. Hummer, J. Hurley, 2015 .

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

J. Tesmer, H. Ali, Aetas Amponnawarat, 2022, Frontiers in Immunology.

Protein-ligand energetics assessed using deoxy and fluorodeoxy sugars in equilibrium binding and high resolution crystallographic studies.

F. Quiocho, J. Tesmer, P. Vermersch, 1992, Journal of molecular biology.

Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex

J. Tesmer, Veronica G. Taylor, P. Bommarito, 2016, The Journal of Biological Chemistry.

Preliminary x‐ray analysis of Escherichia coli GMP synthetase: Determination of anomalous scattering factors for a cysteinyl mercury derivative

Janet L. Smith, T. Stemmler, V. Davisson, 1994, Proteins.

Full-Length Gαq–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain

G. Skiniotis, J. Tesmer, S. Dutta, 2013, Nature Structural &Molecular Biology.

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

S R Sprang, S. Sprang, R. Sunahara, 1997 .

Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.

G. Mayer, V. Tesmer, J. Tesmer, 2012, Structure.

Using iterative fragment assembly and progressive sequence truncation to facilitate phasing and crystal structure determination of distantly related proteins.

Yan Wang, Zhidong Xue, Z. Xue, 2016, Acta crystallographica. Section D, Structural biology.

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

A. Chinnaiyan, Xuhong Cao, C. Kumar-Sinha, 2017, Nature Communications.

Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation*

K. Palczewski, Benlian Wang, P. Singh, 2008, Journal of Biological Chemistry.

The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs*

J. Benovic, D. Lodowski, V. Tesmer, 2006, Journal of Biological Chemistry.

Molecular mechanisms of phospholipase C β3 autoinhibition.

J. Tesmer, A. Lyon, Jessica Begley, 2014, Structure.

Crystal structure of the adenylyl cyclase activator Gsalpha.

S. Sprang, R. Sunahara, A. Gilman, 1997, Science.

Conserved Modular Domains Team up to Latch-open Active Protein Kinase Cα*

J. Tesmer, S. Sivaramakrishnan, M. Westfall, 2014, The Journal of Biological Chemistry.

Latch-open Active Protein Kinase C Conserved Modular Domains Team up to

J. Tesmer, M. Westfall, M. Ritt, 2014 .

Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central α-Helical Domain

P. Karplus, A. Bretscher, R. Fehon, 2007 .

Structural Determinants of RhoA Binding and Nucleotide Exchange in Leukemia-associated Rho Guanine-Nucleotide Exchange Factor*

J. Tesmer, G. Gao, John J. G. Tesmer, 2004, Journal of Biological Chemistry.

A Surface of the Kinase Domain Critical for the Allosteric Activation of G Protein-coupled Receptor Kinases*

J. Tesmer, Chih‐chin Huang, Kae Yoshino‐Koh, 2009, The Journal of Biological Chemistry.

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ

R. Lefkowitz, D. Lodowski, W. D. Capel, 2003, Science.

Navigating the conformational landscape of G protein–coupled receptor kinases during allosteric activation

Xin-Qiu Yao, B. Grant, J. Tesmer, 2017, The Journal of Biological Chemistry.

Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

J. Tesmer, K. Homan, 2014, ACS chemical biology.

Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

D. Lodowski, V. Tesmer, J. Tesmer, 2010, Journal of medicinal chemistry.

Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

M. Aittaleb, J. Tesmer, Cassandra A. Boguth, 2010, Molecular Pharmacology.

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

J. Cheung, W. Koch, P. Kirchhoff, 2016, Journal of medicinal chemistry.

Residue-wise local quality estimation for protein models from cryo-EM maps

Sai Raghavendra Maddhuri Venkata Subramaniya, D. Kihara, Genki Terashi, 2022, Nature Methods.

Structural and Functional Analysis of G Protein–Coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog

P. Singh, J. Tesmer, S. Larsen, 2014, Molecular Pharmacology.

Two-metal-Ion catalysis in adenylyl cyclase.

S R Sprang, S. Sprang, R. Sunahara, 1999, Science.

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2

M. Bouvier, J. Tesmer, Alexandre Beautrait, 2014, The Journal of Biological Chemistry.

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

Sheng Li, J. Gutkind, J. Tesmer, 2019, Science Signaling.

Subunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence Time

R. Sunahara, J. Woods, J. Tesmer, 2011, Molecular Pharmacology.

G Protein-coupled Receptor Kinase 2/Gαq/11Interaction: A NOVEL SURFACE ON A REGULATOR OF G PROTEIN SIGNALING HOMOLOGY DOMAIN FOR BINDING Gα SUBUNITS

J. Benovic, A. Pronin, P. Wedegaertner, 2003 .

Exchange of Substrate and Inhibitor Specificities between Adenylyl and Guanylyl Cyclases*

S. Sprang, R. Sunahara, A. Gilman, 1998, The Journal of Biological Chemistry.

Molecular basis for P-site inhibition of adenylyl cyclase.

S R Sprang, S. Sprang, R. Sunahara, 2000, Biochemistry.

The interactions of adenylate cyclases with P-site inhibitors.

S. Sprang, C. Dessauer, A. Gilman, 1999, Trends in pharmacological sciences.

Identification of a Giα Binding Site on Type V Adenylyl Cyclase*

S. Sprang, C. Dessauer, A. Gilman, 1998, The Journal of Biological Chemistry.

Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins.

S. Ferguson, J. Tesmer, R. Sterne‐Marr, 2004, Methods in enzymology.

The structure, catalytic mechanism and regulation of adenylyl cyclase.

S. Sprang, J. Tesmer, 1998, Current opinion in structural biology.

The Open Question of How GPCRs Interact with GPCR Kinases (GRKs)

J. Tesmer, R. Sterne‐Marr, M. C. Cato, 2021, Biomolecules.

Atypical Chemokine Receptor 3 ‘Senses’ CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

T. Handel, J. Tesmer, Qiuyan Chen, 2023, bioRxiv.

Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gβ1γ2

R. Lefkowitz, D. Lodowski, W. D. Capel, 2003 .

J. Tesmer, A. Smrcka, J. Cash, 2020, Molecular Pharmacology.

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

J. Tesmer, J. Cash, E. M. Davis, 2016, Structure.

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

L. Avramova, J. Tesmer, Qiuyan Chen, 2019, ACS medicinal chemistry letters.

Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Brain Synaptosomes.

H. Hamm, W. McDonald, J. Tesmer, 2017, Biochemistry.

Preliminary structure analysis of the DH/PH domains of leukemia-associated RhoGEF.

Lakshmi Krishnamoorthy, J. Tesmer, R. Kristelly, 2003, Acta crystallographica. Section D, Biological crystallography.

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Robert M. Williams, W. Koch, D. Sherman, 2019, Proceedings of the National Academy of Sciences.

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

P. Andrews, Xin-Qiu Yao, T. Klose, 2021, Nature.

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro

R. Ghirlando, V. Gurevich, J. Tesmer, 2015, Biochemistry.

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor*♦

J. Cheung, W. Koch, J. Tesmer, 2015, The Journal of Biological Chemistry.

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

J. Tesmer, D. Thal, R. Yeow, 2011, Molecular Pharmacology.

Molecular basis for activation of G protein‐coupled receptor kinases

P. Singh, J. Tesmer, Chih‐chin Huang, 2010, The EMBO journal.

Structural analysis of thermostabilizing mutations of cocaine esterase.

J. Macdonald, R. Sunahara, D. Gao, 2010, Protein engineering, design & selection : PEDS.

Strike a pose: Gαq complexes at the membrane.

J. Tesmer, Veronica G. Taylor, A. Lyon, 2014, Trends in pharmacological sciences.

Structural and functional analysis of the regulator of G protein signaling 2-gαq complex.

T. Kozasa, V. Tesmer, J. Tesmer, 2013, Structure.

Assembly of High Order Gαq-Effector Complexes with RGS Proteins*

R. Neubig, T. Kozasa, V. Tesmer, 2008, Journal of Biological Chemistry.

Characterization of the GRK2 Binding Site of Gαq*

J. Benovic, P. Wedegaertner, J. Tesmer, 2004, Journal of Biological Chemistry.

Recognition in the Face of Diversity: Interactions of Heterotrimeric G proteins and G Protein-coupled Receptor (GPCR) Kinases with Activated GPCRs*

J. Tesmer, Chih‐chin Huang, 2011, The Journal of Biological Chemistry.

Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.

A. Gilman, B. Posner, E. Ross, 1999, Biochemistry.

Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor

W. Koch, J. Tesmer, A. Cannavo, 2014, Molecules.

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

S. Knapp, J. Elkins, M. Szklarz, 2014, ACS chemical biology.

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

R. Neubig, M. Aittaleb, J. Tesmer, 2009, Cellular signalling.

A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.

Douglas M. Yau, Shihori Tanabe, T. Kozasa, 2006, Biochemistry.

A Ciliary SMOOTHENED-GRK2-PKA Signaling Pathway Initiates Hedgehog Signal Transduction

K. Kwan, Abhishek Poddar, J. Tesmer, 2023 .

Structure of the Regulator of G Protein Signaling 8 (RGS8)-G alpha q Complex: MOLECULAR BASIS FOR G alpha SELECTIVITY.

J. Tesmer, Veronica G. Taylor, P. Bommarito, 2016 .

Characterization of the GRK2 binding site of Galphaq.

J. Benovic, P. Wedegaertner, J. Tesmer, 2004, The Journal of biological chemistry.

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

C. Dessauer, T. Klose, V. Watts, 2023, bioRxiv.

High-throughput cryo-EM enabled by user-free preprocessing routines

Yilai Li, Jennifer N. Cash, John J. G. Tesmer, 2019, bioRxiv.

Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

Michael A. Cianfrocco, Sheng Li, Jennifer N. Cash, 2019, Science Advances.

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3

J. Tesmer, J. Cash, Prateek Sharma, 2018, Journal of structural biology: X.

The quest to understand heterotrimeric G protein signaling

J. Tesmer, 2010, Nature Structural &Molecular Biology.

Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases*

Julie A. Pitcher, Robert J. Lefkowitz, R. Lefkowitz, 1999, The Journal of Biological Chemistry.

Membrane orientation of Gα(i)β(1)γ(2) and Gβ(1)γ(2) determined via combined vibrational spectroscopic studies.

Andrew P. Boughton, Pei Yang, J. Tesmer, 2013, Journal of the American Chemical Society.

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

Anthony W. Azevedo, F. Rieke, T. Doan, 2015, eLife.

Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily

J. Tesmer, T. Beyett, S. Bandekar, 2016 .

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)*

A. Manglik, V. Gurevich, E. Gurevich, 2015, The Journal of Biological Chemistry.

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ

T. Klose, Ramizah Syahirah, J. Tesmer, 2023, bioRxiv.

A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.

F A Quiocho, F. Quiocho, D. Lemon, 1992, The Journal of biological chemistry.

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

R. Stahelin, J. Tesmer, Sandeep K. Ravala, 2020, The Journal of Biological Chemistry.

CHARACTERIZATION OF PHOSPHOLIPASE C-β 3 COMPLEXES BY X-RAY CRYSTALLOGRAPHY AND SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY

G. Skiniotis, J. Tesmer, S. Dutta, 2013 .

Gia1: Stabilization of the Transition State for GTP Hydrolysis

S. Sprang, A. Gilman, J. Tesmer, 1997 .

Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain.

K. Palczewski, B. Jastrzebska, T. Orban, 2011, Biochemistry.

Pharmacology. Hitting the hot spots of cell signaling cascades.

J. Tesmer, 2006, Science.

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

K. Kwan, Abhishek Poddar, J. Tesmer, 2023, bioRxiv.

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

S. Sprang, R. Sunahara, A. Gilman, 1997, Science.

Structural insights into G protein-coupled receptor kinase function.

J. Tesmer, K. Homan, 2014, Current opinion in cell biology.

Orientation of μ-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding

E. Nisenbaum, I. Lindberg, D. Tieleman, 2011, Molecular Pharmacology.

Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2.

J. Shayman, J. Tesmer, R. Bouley, 2019, Biochemistry.

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein–Coupled Receptor Kinase 2 Inhibitors

J. Cheung, Xin-Qiu Yao, W. Koch, 2017, Molecular Pharmacology.

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding.

S. Sligar, G. Schertler, V. Gurevich, 2013, Cellular signalling.

Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

D. Lodowski, V. Tesmer, J. Tesmer, 2010, Journal of medicinal chemistry.

ACKR3–arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

Xin-Qiu Yao, A. Kossiakoff, T. Handel, 2023, bioRxiv.

Assembly of High Order Gαq-Effector Complexes with RGS Proteins*

R. Neubig, T. Kozasa, V. Tesmer, 2008, Journal of Biological Chemistry.

Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).

K. Palczewski, B. Jastrzebska, T. Orban, 2012, Biochemistry.

Structural insights into G protein-coupled receptor kinase function.

J. Tesmer, K. Homan, 2014, Current opinion in cell biology.

Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.

F A Quiocho, F. Quiocho, D. Lemon, 1991, Biochemistry.

Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils

J. Tesmer, A. Smrcka, J. Cash, 2019 .

Biochemical characterization of the interaction between KRAS and Argonaute 2

B. Ruotolo, Sunita Shankar, J. Tesmer, 2021, Biochemistry and biophysics reports.

Conserved Modular Domains Team up to Latch-open Active Protein Kinase Cα*

J. Tesmer, S. Sivaramakrishnan, M. Westfall, 2014, The Journal of Biological Chemistry.

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade

K. Kwan, Abhishek Poddar, J. Tesmer, 2024, PLoS biology.

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

M. Cianfrocco, J. Tesmer, Sandeep K. Ravala, 2023, bioRxiv.

G Protein-Coupled Receptor Kinase 2 (GRK2)

R. Ghirlando, D. Lodowski, J. Tesmer, 2005 .

Atypical Chemokine Receptor 3 “Senses” CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

J. Tesmer, Christopher T. Schafer, Tracy M. Handel, 2023, Molecular Pharmacology.

Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution.

P. Singh, J. Tesmer, M. Nance, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)*

A. Manglik, V. Gurevich, E. Gurevich, 2015, The Journal of Biological Chemistry.

Atypical Chemokine Receptor 3 ‘Senses’ CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

T. Handel, J. Tesmer, Qiuyan Chen, 2023, bioRxiv.