J. Chambers

发表

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow‐Derived Mouse Mesenchymal Stem Cells via a p53‐Dependent Mechanism: Implications for Long‐Term Culture Expansion

P. Lograsso, L. Ortiz, Siddaraju Boregowda, 2012, Stem cells.

Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1).

P. Lograsso, J. Chambers, J. Laughlin, 2011, ACS chemical biology.

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation*

P. Lograsso, J. Chambers, 2011, The Journal of Biological Chemistry.

Residues in an ATP binding domain influence sugar binding in a trypanosome hexokinase.

Kerry S. Smith, J. Chambers, M. Morris, 2008, Biochemical and biophysical research communications.

Studies in the biochemistry and cell biology of Trypanosoma brucei hexokinases

J. Chambers, 2007 .

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

P. Lograsso, J. Habel, M. Cameron, 2010, Journal of medicinal chemistry.

Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo*

P. Lograsso, J. Chambers, S. Howard, 2012, The Journal of Biological Chemistry.

Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats*

P. Lograsso, J. Chambers, S. Iqbal, 2012, The Journal of Biological Chemistry.

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents

W. Reinhold, Y. Pommier, Y. Tse‐Dinh, 2019, bioRxiv.

Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity.

J. Chambers, Tara P Chambers, L. Santiesteban, 2017, Toxicology.

Radiolabeled Aminopyrazoles as Novel Isoform Selective Probes for pJNK3 Quantification.

J. Chambers, V. Cotero, D. E. Meyer, 2022, ACS medicinal chemistry letters.

Simultaneous Ca2+ Imaging and Optogenetic Stimulation of Cortical Astrocytes in Adult Murine Brain Slices

J. Lujan, Carolina Moncion, J. R. Diaz, 2020, Current protocols in neuroscience.

Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling.

J. Chambers, Gilda M. Portalatin, C. Robbins, 2015, Biochemical and biophysical research communications.

Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.

D. Wong, P. Ornstein, J. Deeter, 1989, Journal of medicinal chemistry.

Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays

A. Fusco, S. Vasile, F. Fernandez-Lima, 2020, Scientific Reports.

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

A. Fusco, S. Vasile, F. Fernandez-Lima, 2019, bioRxiv.

Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay.

S. Vasile, Daniele Boaretto, F. Leng, 2022, ACS pharmacology & translational science.

Activity of a Second Trypanosoma brucei Hexokinase Is Controlled by an 18-Amino-Acid C-Terminal Tail

Kerry S. Smith, J. Chambers, M. Morris, 2006, Eukaryotic Cell.

A rapid and sensitive high-throughput screening method to identify compounds targeting protein–nucleic acids interactions

F. Leng, J. Chambers, Nicole Alonso, 2015, Nucleic acids research.

Phosphoregulation on mitochondria: Integration of cell and organelle responses

J. Chambers, Maribel Lucero, Ana E Suarez, 2019, CNS neuroscience & therapeutics.

Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines.

J. Chambers, Gilda M. Portalatin, Tara P Chambers, 2018, The Biochemical journal.

Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection

J. Alwine, J. Chambers, T. Maguire, 2009, Journal of Virology.

The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1.

J. Chambers, M. Morris, James C. Morris, 2008, Molecular and biochemical parasitology.

A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

P. Lograsso, J. Chambers, Hajeung Park, 2013, ACS chemical biology.

Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Li Lin, P. Lograsso, M. Cameron, 2011, ACS chemical neuroscience.

Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS

F. Fernandez-Lima, J. Chambers, Monica Rodríguez-Silva, 2016, Journal of The American Society for Mass Spectrometry.

A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia

T. Guilarte, D. Azzam, J. Chambers, 2020, Molecular Neurobiology.

Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching

M. Muller, Z. Hua, F. Leng, 2019, ACS omega.

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases

W. Gonzalez, J. Miksovska, F. Leng, 2016, Scientific Reports.

Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1.

K. Christensen, J. Chambers, M. Morris, 2011, Experimental parasitology.

Assembly of Heterohexameric Trypanosome Hexokinases Reveals That Hexokinase 2 Is a Regulable Enzyme*

J. Chambers, M. Morris, James C. Morris, 2008, Journal of Biological Chemistry.

Sab is differentially expressed in the brain and affects neuronal activity

M. Sassoè-Pognetto, J. Chambers, C. Salio, 2017, Brain Research.

Assessment of Mitochondrial Stress in Neurons: Proximity Ligation Assays to Detect Recruitment of Stress-Responsive Proteins to Mitochondria

J. Chambers, Anthony D. Smith, Kristen Ashourian, 2019, Neuromethods.

6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.

P. Ornstein, D. Schoepp, D. Lodge, 1992, Journal of medicinal chemistry.

Biochemistry & Molecular Biology

J. Chambers, 2015 .

A trivalent approach for determining in vitro toxicology: Examination of oxime K027

J. Chambers, G. Petroianu, D. Lorke, 2015, Journal of applied toxicology : JAT.

Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection

J. Alwine, J. Chambers, T. Maguire, 2009, Journal of Virology.