S. Agrawal

发表

Utilizing Low-Volume Aqueous Acoustic Transfer with the Echo 525 to Enable Miniaturization of qRT-PCR Assay

David S. Pechter, M. Wildey, S. Agrawal, 2016, Journal of laboratory automation.

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.

V. Pazienza, K. Abid, F. Negro, 2006, The Journal of antimicrobial chemotherapy.

In vitro antiviral activity of SCH 446211 ( SCH 6 ) , a novel inhibitor of the hepatitis C virus NS 3 serine protease

V. Pazienza, K. Abid, F. Negro, 2006 .

Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.

M. Rudd, P. Coleman, J. Vacca, 2014, ACS medicinal chemistry letters.

I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.

B. Feld, R. Palermo, J. Duca, 2011, Bioorganic & medicinal chemistry letters.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Rebecca T. Ruck, Yongxin Han, J. Howe, 2016, ACS medicinal chemistry letters.

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.

Rebecca T. Ruck, E. Asante-Appiah, Kung-I Feng, 2017, Journal of medicinal chemistry.

Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.

E. Asante-Appiah, M. Dwyer, A. Nomeir, 2018, Bioorganic & medicinal chemistry letters.

Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.

F. G. Njoroge, K. Cheng, S. Agrawal, 2014, ACS medicinal chemistry letters.

Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.

J. Duca, F. G. Njoroge, S. Agrawal, 2014, Bioorganic & medicinal chemistry.

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

N. Butkiewicz, F. Gheyas, X. Tong, 2006, Antimicrobial Agents and Chemotherapy.

Discovery of potent macrocyclic HCV NS5A inhibitors.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.

M. Dwyer, A. Nomeir, R. Mazzola, 2016, Bioorganic & medicinal chemistry letters.

Discovery of an irreversible HCV NS5B polymerase inhibitor.

J. Gesell, J. Duca, F. G. Njoroge, 2013, Bioorganic & medicinal chemistry letters.

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:

Weiying Yang, Zhuyan Guo, Andrea Hart, 2006, Journal of medicinal chemistry.

Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants.

E. Asante-Appiah, C. Coburn, S. Agrawal, 2016, Journal of medicinal chemistry.

Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.

Sony Agrawal, Charles A. Lesburg, Gerald W. Shipps, 2010, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.

Rebecca T. Ruck, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.

S. Tamura, S. Kemp, M. Lim-Wilby, 2006, Journal of medicinal chemistry.

Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core.

E. Asante-Appiah, S. Agrawal, Laura R Rokosz, 2019, Bioorganic & medicinal chemistry letters.

Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.

J. Duca, F. G. Njoroge, S. Agrawal, 2013, Bioorganic & medicinal chemistry.

Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors.

Robert Chase, Sony Agrawal, X. Tong, 2008, Biochemical pharmacology.

In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A

E. Asante-Appiah, F. Lahser, S. Agrawal, 2018, Antimicrobial Agents and Chemotherapy.

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

F. G. Njoroge, S. Agrawal, S. Ruan, 2006, Bioorganic & medicinal chemistry letters.

Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4 Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.

Scott T. Harrison, M. Rudd, F. Monsma, 2020, Journal of medicinal chemistry.

Interferon in Replicon Cells Enhances the Antiviral Activity of Alpha Suppresses Polyprotein Maturation and of Hepatitis C Virus NS 3 Protease , SCH 503034 , a Mechanism-Based Inhibitor

F. Gheyas, X. Tong, C. Jiang, 2005 .

Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.

Andrea Hart, Robert Chase, Sony Agrawal, 2009, Journal of medicinal chemistry.

Imaging-Based Assay for Identification and Characterization of Inhibitors of CXCR4-Tropic HIV-1 Envelope-Dependent Cell-Cell Fusion

S. Kramer, S. Agrawal, R. Ralston, 2011, Journal of biomolecular screening.

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.