C. Hop

发表

Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/tandem mass spectrometric quantitation.

L. Romanyshyn, P. R. Tiller, C. Hop, 2000, Rapid communications in mass spectrometry : RCM.

Protonation of Ferrocene in the Gas Phase

C. Hop, T. Mcmahon, T. McMahon, 1994, Journal of the American Society for Mass Spectrometry.

Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone

Yuan Chen, Cornelis E C A Hop, Jialin Mao, 2015, Drug Metabolism and Disposition.

Role of ADME Studies in Selecting Drug Candidates: Dependence of ADME Parameters on Physicochemical Properties

C. Hop, 2012 .

Prediction of drug distribution in subcutaneous xenografts of human tumor cell lines and healthy tissues in mouse: application of the tissue composition-based model to antineoplastic drugs.

B. Liederer, S. Gould, C. Hop, 2015, Journal of pharmaceutical sciences.

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Jin Y. Jin, Yuan Chen, S. Girish, 2014, Clinical Pharmacokinetics.

Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs.

S. Haddad, C. Hop, P. Poulin, 2012, Journal of pharmaceutical sciences.

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

W. Humphreys, X. Chu, Caroline A. Lee, 2018, Drug Metabolism and Disposition.

Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

Harvey Wong, Xiling Song, Cornelis E C A Hop, 2010, Drug Metabolism and Disposition.

A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance

W. Humphreys, R. Obach, C. Prakash, 2018, Drug Metabolism and Disposition.

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

E. Choo, C. Hop, J. Halladay, 2016, Drug Metabolism and Disposition.

Drug Metabolizing Enzymes

H. Wong, C. Hop, S. C. Khojasteh, 2011 .

Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib

J. Lyssikatos, H. Wong, C. Hop, 2014, Drug Metabolism and Disposition.

A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834

Jeffrey P. Jones, Donald S Kirkpatrick, Jasleen K Sodhi, 2015, Drug Metabolism and Disposition.

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor

John C. Davis, P. Kuebler, J. Lubach, 2011, Drug Metabolism and Disposition.

Use of the Cassette-Dosing Approach to Assess Brain Penetration in Drug Discovery

Xingrong Liu, B. Liederer, C. Hop, 2012, Drug Metabolism and Disposition.

Use of Cassette Dosing Approach to Assess Brain Penetration in Drug Discovery

B. Liederer, C. Hop, G. Deshmukh, 2012 .

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

David Q. Liu, C. Hop, G. Doss, 2004, Drug Metabolism and Disposition.

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. I. ROLE OF CYTOCHROME P450, METHYLTRANSFERASES, FLAVIN MONOOXYGENASES, AND ESTERASES

David Q. Liu, D. Dean, C. Hop, 2004, Drug Metabolism And Disposition.

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.

Kevin A Ford, J. Driscoll, C. Hop, 2011, Chemical research in toxicology.

A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation

S. Heyward, W. Humphreys, X. Chu, 2019, Drug Metabolism and Disposition.

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities

Xingrong Liu, L. Di, K. Nagapudi, 2019, Drug Metabolism and Disposition.

Method for internal standard introduction for quantitative analysis using on-line solid-phase extraction LC-MS/MS.

Y. Alnouti, A. Gusev, C. Hop, 2006, Analytical chemistry.

Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice

Hong Wang, P. Dragovich, C. Hop, 2016, Drug Metabolism and Disposition.

Electrospray mass spectrometry of borane salts: The electrospray needle as an electrochemical cell

C. Hop, D. Saulys, D. Gaines, 1995, Journal of the American Society for Mass Spectrometry.

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of G-856 (Cur-61414) in human plasma using semi-automated solid phase extraction.

C. Hop, Y. Shin, B. Dean, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp

Xingrong Liu, J. Lyssikatos, C. Hop, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947

J. Lubach, Xingrong Liu, C. Hop, 2020, Drug Metabolism and Disposition.

IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

Yue Chen, C. Hop, T. O’Connell, 2005, Drug Metabolism and Disposition.

Ultra-fast gradient vs. fast isocratic chromatography in bioanalytical quantification by liquid chromatography/tandem mass spectrometry.

L. Romanyshyn, C. Hop, P. Tiller, 2001, Rapid communications in mass spectrometry : RCM.

Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues

P. Dragovich, C. Hop, Donglu Zhang, 2019, Drug Metabolism and Disposition.

Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates

P. Dragovich, C. Hop, Donglu Zhang, 2018, Molecular Cancer Therapeutics.

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates

P. Dragovich, C. Hop, H. Erickson, 2016, Drug Metabolism and Disposition.

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

R. Evers, S. Ambudkar, S. Shukla, 2014, Drug Metabolism and Disposition.

Quantitative transporter proteomics by LC-MS/MS: addressing methodological issues of plasma membrane isolation and expression-activity relationship

R. Evers, J. Unadkat, L. Salphati, 2014 .

An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

A. Zakharov, Dac-Trung Nguyen, A. Simeonov, 2016, Drug Metabolism and Disposition.

Assessment of the hepatic CYP reductase null mouse model and its potential application in drug discovery.

E. Choo, J. Boggs, K. West, 2014, Molecular pharmaceutics.

BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

F. Lombardo, Z. Hendsch, A. Kalgutkar, 2005, Drug Metabolism and Disposition.

Current Technology and Limitation of LC‐MS

C. Hop, 2012 .

Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib

H. Wong, C. Hop, M. Wright, 2022, Drug Metabolism and Disposition.

Determination of bond dissociation energies via energy-resolved collision induced dissociation in a fourier transform ion cyclotron resonance spectrometer

C. Hop, G. Willett, T. Mcmahon, 1990 .

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

I. Chang, C. Hop, Y. Shin, 2011, Drug Metabolism and Disposition.

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound

Yuan Chen, J. Mao, C. Hop, 2017, Pharmaceutical Research.

Charge reversal of the hydrogen dichloride anion, [ClHCl]−

C. Hop, J. Holmes, 1988 .

Interference peaks in collisional activation mass spectra: the loss of CH3 from [C13H9] ions

P. Burgers, J. K. Terlouw, C. Hop, 1986 .

1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9

C. Hop, J. Halladay, S. Mukadam, 2014, Drug Metabolism and Disposition.

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

E. Choo, J. Boggs, C. Hop, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry.

S. Reuschel, M. Meng, C. Hop, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947

J. Lubach, Xingrong Liu, C. Hop, 2020, Drug Metabolism and Disposition.

A solid phase extraction-liquid chromatographic-tandem mass spectrometry method for determination of concentrations of GDC-0941, a small molecule class I phosphatidylinositide 3-kinase inhibitor, to support clinical development.

J. Ware, S. Reuschel, M. Meng, 2012, Journal of pharmaceutical and biomedical analysis.

Do we need to optimize plasma protein and tissue binding in drug discovery?

Xingrong Liu, C. Hop, Cuiping Chen, 2011, Current topics in medicinal chemistry.

The elusive methene ylides CH2CIH, CH2FH and CH2OH2

J. K. Terlouw, C. Hop, J. Holmes, 1988 .

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0834 and its metabolite in human plasma using semi-automated 96-well protein precipitation.

H. Wong, C. Hop, Y. Shin, 2012, Biomedical chromatography : BMC.

Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis.

J. Ware, P. LoRusso, W. Fairbrother, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Strategy for Determining the Free Fraction of Labile Covalent Modulators in Plasma Using Equilibrium Dialysis.

Zhengyin Yan, C. Hop, J. Kenny, 2020, Journal of pharmaceutical sciences.

Rational use of plasma protein and tissue binding data in drug design.

Xingrong Liu, C. Hop, M. Wright, 2014, Journal of medicinal chemistry.

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

Parallel extraction columns and parallel analytical columns coupled with liquid chromatography/tandem mass spectrometry for on-line simultaneous quantification of a drug candidate and its six metabolites in dog plasma.

C. Hop, S. Vincent, Y. Xia, 2001, Rapid communications in mass spectrometry : RCM.

Homocysteine thiolactone and protein homocysteinylation: mechanistic studies with model peptides and proteins.

C. Hop, R. Bakhtiar, 2002, Rapid communications in mass spectrometry : RCM.

A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib

Priya Chandra, C. Hop, R. Graham, 2016, Cancer Chemotherapy and Pharmacology.

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction.

J. Ware, H. Wong, C. Hop, 2013, Biomedical chromatography : BMC.

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening

H. Wong, C. Hop, M. Reynolds, 2011, Drug Metabolism and Disposition.

Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification.

David Q. Liu, M. Beconi, C. Hop, 2001, Rapid communications in mass spectrometry : RCM.

p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.

A. Woods, D. Zaller, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

Translational energy spectroscopy of collisional neutralization-reionization processes

J. Bordas-Nagy, C. Hop, J. Holmes, 1989 .

keV collisions of methonium ions: The properties of CH5 and [CH5]2+ and the generation of high-rydberg fragments therefrom

J. Bordas-Nagy, C. Hop, J. Holmes, 1988 .

The ionization of fast neutrals by electron impact in the second field-free region of a mass spectrometer of reversed geometry

A. Mommers, C. Hop, J. Holmes, 1988 .

The mass spectrometry of neutral species produced from mass-selected ions by collision and by charge exchange. Experiments with tandem collision gas cells

J. K. Terlouw, A. Mommers, C. Hop, 1986 .

Elucidation of fragmentation mechanisms involving transfer of three hydrogen atoms using a quadrupole time-of-flight mass spectrometer.

C. Hop, R. Singh, X. Yu, 2001, Journal of mass spectrometry : JMS.

OBSERVATION OF A WEAKLY BOUND MN(CO)5+/CH4 COMPLEX

C. Hop, T. McMahon, 1991 .

Unravelling seemingly complex chemistry of reactions using electrospray ionization mass spectrometry

C. Hop, R. Bakhtiar, 1999 .

Metastable and collision-induced fragmentation of selected C3H6S+· isomers; evidence for extensive isomerization

C. Hop, 1995 .

An introduction to electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry: Essential tools in a modern biotechnology environment

Ray Bakhtiar, Cornelis E. C. A. Hop, C. Hop, 1997 .

The unanticipated loss of SO2 from sulfonamides in collision-induced dissociation.

T. Baillie, C. Hop, Mi-Sook Kim, 2003, Rapid communications in mass spectrometry : RCM.

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

Yuan Chen, C. Hop, J. Halladay, 2017, Drug Metabolism and Disposition.

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

F. V. Heuveln, J. Wieling, C. Hop, 2015 .

A study of the complexation between dimethyl-beta-cyclodextrin and steroid hormones using electrospray ionization mass spectrometry.

C. Hop, R. Bakhtiar, 1997, Rapid communications in mass spectrometry : RCM.

Gas phase ion chemistry of methyl acetate, methyl propanoate and their enolic tautomers. An experimental approach

P. Burgers, J. K. Terlouw, C. Hop, 1986 .

The stability of [CCl4]+·, [Cl2CClCl]+·, their dications, and neutral counterparts

J. K. Terlouw, C. Hop, J. Holmes, 1988 .

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction

Yuan Chen, H. Wong, J. Mao, 2016, Clinical Pharmacokinetics.

Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry.

J. Ware, Yuan Chen, J. Mao, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Fragmentation characteristics of the unstable [CH3 CO] radicals generated by neutralization of [CH3CO]+ cations

C. Hop, J. Holmes, 1991 .

Does the unimolecular dissociation of ionized methyl acetate produce CH3O˙ OR CH2OH radicals?

J. K. Terlouw, C. Hop, J. Holmes, 1986 .

Neutralization-reionization mass spectrometry: Efficiency of the charge-exchange process

C. Hop, J. Holmes, 1991 .

Neutralization-reionization of CH4+•: At which stage does fragmentation occur?

L. Radom, M. W. Wong, C. Hop, 1989 .

Neutralization-reionization experiments; a simple metal vapour cell for VG analytical ZAB-2F mass spectrometers

J. Bordas-Nagy, J. K. Terlouw, A. Mommers, 1988 .

The isomeric [C2H6O2].cntdot.+ hydrogen-bridged radical cations [CH2-O(H).cntdot..cntdot..cntdot.H.cntdot..cntdot..cntdot.O:CH2].cntdot.+, [CH3-O.cntdot..cntdot..cntdot.H.cntdot..cntdot..cntdot.O:CH2].cntdot.+, and [CH3-O(H).cntdot..cntdot..cntdot.H.cntdot..cntdot..cntdot.O:CH].cntdot.+: theory and

P. Burgers, P. J. Ruttink, J. K. Terlouw, 1987 .

Do the aminopyridine molecular ions display aniline‐ or pyridine‐type behaviour?

C. Hop, J. Holmes, M. Dakubu, 1988 .

Theory and experiment in concert: the [MeOC:O]+ ion and its isomers.

P. J. Ruttink, J. K. Terlouw, C. Hop, 1986, Journal of the American Chemical Society.

[HCNO]+⋅, [HNCO]+⋅ and their neutral counterparts studied by mass spectrometry

J. K. Terlouw, C. Hop, J. Holmes, 1987 .

Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches.

David Q. Liu, C. Hop, 2005, Journal of pharmaceutical and biomedical analysis.

Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary

C. Prakash, F. Tse, S. Surapaneni, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods.

S. Haddad, C. Hop, P. Poulin, 2012, Journal of pharmaceutical sciences.

Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins

H. Wong, C. Hop, M. Wright, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

A. Robichaud, T. Baillie, R. Anari, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs.

Y. Lai, C. Hop, Donglu Zhang, 2021, Journal of medicinal chemistry.

The Isomeric (C2H6O2)·+ Hydrogen-Bridged Radical Cations (CH2-O(H)...H...O=CH2)·+, (CH3-O...H...O=CH2)·+, and (CH3-O(H)...H...O=CH)·+: Theory and Experiment.

P. Burgers, P. J. Ruttink, J. K. Terlouw, 1988 .

Protonation of isomeric methoxyhexenes. Effects of double bond⋯H+⋯OCH3 interaction

S. Shaffer, F. Tureček, M. Sadílek, 1997 .

New [C2, H3, N, O]+˙ isomers: A metastable and collision-induced fragmentation study†

C. Hop, D. F. Snyder, 1993 .

a compact high pressure ion source for high and low energy collision-induced dissociation studies of cluster ions on a VG analytical ZAB-2FQ

J. Szulejko, A. G. Harrison, A. Young, 1992, Journal of the American Society for Mass Spectrometry.

Strong hydrogen bonding in gas-phase ions. A high-pressure mass spectrometric study of the proton affinity, proton transfer kinetics, and hydrogen-bonding capability of iron pentacarbonyl

J. Szulejko, C. Hop, T. Mcmahon, 1991 .

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics

Bhagwat Prasad, Yurong Lai, Jashvant D Unadkat, 2019, Clinical pharmacology and therapeutics.

Low-energy fragmentations of five isomeric [H3, C, N, O2] +· ions

C. Hop, J. Holmes, M. Sirois, 1990 .

Isomeric [C,H3,N,O]+˙ ions and their neutral counterparts

P. J. Ruttink, C. Hop, J. Holmes, 1991 .

The isomeric ions produced by the gas phase protonation of HNCO and HCNO

P. J. Ruttink, J. K. Terlouw, C. Hop, 1989 .

[HNCO]•+, [HCNO]•+, and [CNOH]•+ and their neutral counterparts studied by mass spectrometry

J. K. Terlouw, C. Hop, J. Holmes, 1989 .

Franck-Condon Dominated Chemistry. Formation and Dissociations of Tetrahydroxyphosphoranyl Radicals Following Femtosecond Reduction of Their Cations in the Gas Phase

M. Gu, C. Hop, F. Tureček, 1995 .

Franck-Condon Dominated Chemistry. Dissociations of Silicon-Centered Radicals Prepared by Femtosecond Reduction of Their Cations in the Gas Phase

S. Shaffer, F. Tureček, C. Hop, 1995 .

Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics

X. Chu, R. Evers, J. Unadkat, 2015, Drug Metabolism and Disposition.

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

Harvey Wong, Cornelis E C A Hop, F. Theil, 2012, Clinical Cancer Research.

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Sanjeev Kumar, C. Hop, G. Doss, 2003, Drug metabolism and disposition: the biological fate of chemicals.

A NOVEL P 450-CATALYZED TRANSFORMATION OF THE 2 , 2 , 6 , 6-TETRAMETHYL PIPERIDINE MOIETY TO A 2 , 2-DIMETHYL PYRROLIDINE IN HUMAN LIVER MICROSOMES : CHARACTERIZATION BY HIGH RESOLUTION QUADRUPOLE-TIME-OF-FLIGHT MASS SPECTROMETRY AND 1 H-NMR

Sanjeev Kumar, C. Hop, G. Doss, 2003 .

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Xi Chen, Karthik Venkatakrishnan, Matthew Troutman, 2005, Drug Metabolism and Disposition.

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.

C. Hop, R. Franklin, Jianmei Pang, 2005, Journal of pharmaceutical and biomedical analysis.

Microsoft Word-54693261-file00

F. Theil, H. Wong, C. Hop, 2010 .

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects.

M. Borin, I. Chang, C. Hop, 2012, British journal of clinical pharmacology.

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma

Yuan Chen, C. Khojasteh, J. Mao, 2016, Pharmaceutical Research.

Comparison of metabolic soft spot predictions of CYP3A4, CYP2C9 and CYP2D6 substrates using MetaSite and StarDrop.

Hoa Le, Young G Shin, Cornelis E C A Hop, 2011, Combinatorial chemistry & high throughput screening.

Biotransformation and Bioactivation

H. Wong, C. Hop, S. C. Khojasteh, 2011 .

A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.

A. Kalgutkar, J. Boyd, M. Cole, 2006, Chemical research in toxicology.

p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.

D. Zaller, S. O'keefe, Sanjeev Kumar, 2006, Bioorganic & medicinal chemistry letters.

Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Jill Barber, Bhagwat Prasad, Amin Rostami-Hodjegan, 2019, Clinical pharmacology and therapeutics.

For a series of methylindole analogs, reactive metabolite formation is a poor predictor of intrinsic cytotoxicity in human hepatocytes

C. Hop, D. Misner, J. Halladay, 2014 .

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

P. Dragovich, B. Liederer, C. Hop, 2014, Bioanalysis.

Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A

Mark Muzi, Yurong Lai, Laigao Chen, 2019, Clinical pharmacology and therapeutics.

Surrogate analyte approach for quantitation of endogenous NAD(+) in human acidified blood samples using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Liling Liu, C. Hop, Xiaorong Liang, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Use of nano-electrospray for metabolite identification and quantitative absorption, distribution, metabolism and excretion studies.

C. Hop, 2006, Current drug metabolism.

Uniformity of ionization response of structurally diverse analytes using a chip-based nanoelectrospray ionization source.

Cornelis E C A Hop, Yue Chen, C. Hop, 2005, Rapid communications in mass spectrometry : RCM.

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates

Liling Liu, Yichin Liu, P. Dragovich, 2019, Drug Metabolism and Disposition.

Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis.

Zhengyin Yan, C. Hop, J. Kenny, 2019, Journal of pharmaceutical sciences.

New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry.

Zhengyin Yan, C. Hop, J. Kenny, 2023, Analytical chemistry.

Mechanism of RF plasma induced fragmentation of SiCl4 and surface functionalization of polymeric substrates from SiClx species

R. Young, F. Denes, C. Hop, 1996 .

Structure and properties of tin‐containing polymers deposited from tetramethyltin HF plasma

F. Denes, C. Hop, A. Sarmadi, 1995 .

High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening.

Xingrong Liu, B. Liederer, C. Hop, 2013, Rapid communications in mass spectrometry : RCM.

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma

Yuan Chen, C. Khojasteh, J. Mao, 2016, Pharmaceutical Research.

Signal suppression/enhancement in HPLC-ESI-MS/MS from concomitant medications.

A. Gusev, C. Hop, M. J. Avery, 2007, Biomedical chromatography : BMC.

Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis

W. Ouyang, H. Wong, C. Hop, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.

P. Dragovich, C. Hop, J. Wai, 2016, ACS medicinal chemistry letters.

Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.

B. Vollmar, BinQing Wei, P. Dragovich, 2018, Bioconjugate chemistry.

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics

W. Humphreys, X. Chu, R. Evers, 2018, Drug Metabolism and Disposition.

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics

Li Wang, Carol Collins, Cornelis E. C. A. Hop, 2016, Drug Metabolism and Disposition.

Compound Attrition at the Preclinical Phase

C. Hop, 2015 .

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.

A. Kalgutkar, A. Vaz, C. Hop, 2005, Chemico-biological interactions.

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.

J. Driscoll, C. Hop, Shuguang Ma, 2016, Drug metabolism letters.

Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach

S. Heyward, W. Humphreys, X. Chu, 2020, Drug Metabolism and Disposition.

Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship

Bhagwat Prasad, Jashvant D Unadkat, Cornelis E C A Hop, 2014, Drug Metabolism and Disposition.

C ] Cobimetinib , a MEK Inhibitor , in Humans

Isabelle, E. Choo, C. Hop, 2015 .

Importance of Early Assessment of Bioactivation in Drug Discovery

A. Kalgutkar, C. Hop, J. Soglia, 2006 .

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

R. Mortishire-Smith, U. Gerhard, Sanjeev Kumar, 2002, Drug Metabolism And Disposition.

In Vitro Metabolism of MK-0767, a PPAR alpha/delta Agonist. I. Role of Cytochrome P450, Methyltransferases, Flavin Monooxygenases and Esterases

David Q. Liu, D. Dean, C. Hop, 2004 .

An unusual fragmentation mechanism involving the transfer of a methyl group.

P. R. Tiller, C. Hop, C. Raab, 2001, Journal of mass spectrometry : JMS.

Generation of high molecular weight cluster ions by electrospray ionization : Implications for mass calibration

C. Hop, 1996 .

A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR / AGONIST . II . IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

David Q. Liu, C. Hop, G. Doss, 2004 .

Influence of the compound selection process on the performance of human clearance prediction methods.

F. Theil, H. Wong, C. Hop, 2012, Journal of pharmaceutical sciences.

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound

Yuan Chen, J. Mao, C. Hop, 2017, Pharmaceutical Research.

Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing

K. Scearce-Levie, Xingrong Liu, J. Lyssikatos, 2013, Drug Metabolism and Disposition.

Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition

A. Zakharov, Ruili Huang, M. Xia, 2021 .

Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition

Ruili Huang, M. Xia, S. Sakamuru, 2021, Drug Metabolism and Disposition.

Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist

A. Tolcher, W. Fairbrother, E. Kadel, 2013, Drug Metabolism and Disposition.

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp

Xingrong Liu, J. Lyssikatos, C. Hop, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats

Xingrong Liu, C. Hop, Shuguang Ma, 2014, Drug Metabolism and Disposition.

“[Cp*CoCoCp*]” is a Hydride

A. Rheingold, C. Hop, K. Theopold, 1992 .

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0879 and its metabolite in dog plasma using solid phase extraction.

M. Meng, C. Hop, Y. Shin, 2012, Journal of pharmaceutical and biomedical analysis.

Abstract A11: Antitumor activity of targeted and cytotoxic agents in xenograft models correlates with clinical response: A pharmacokinetic-pharmacodynamic analysis.

L. Friedman, H. Wong, E. Choo, 2011 .

Opportunities and challenges using artificial intelligence in ADME/Tox

Sean Ekins, Guido Lanza, W Patrick Walters, 2019, Nature Materials.

Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening.

C. Hop, C E Hop, Z Wang, 1998, Journal of pharmaceutical sciences.

High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models.

David B Duignan, John S Janiszewski, Theodore E Liston, 2008, Current drug metabolism.

Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-Amino-1,2,3-Thiadiazole

J. Ware, J. Lyssikatos, H. Wong, 2013, Drug Metabolism and Disposition.

Correlation of tissue-plasma partition coefficients between normal tissues and subcutaneous xenografts of human tumor cell lines in mouse as a prediction tool of drug penetration in tumors.

B. Liederer, L. Salphati, C. Hop, 2013, Journal of pharmaceutical sciences.

Microsoft Word-93038660-file00

C. Hop, S. C. Khojasteh, A. Deese, 2014 .

Characterization of Anti-Neovascularization Activity and Ocular Pharmacokinetics of PI3K/mTOR Inhibitor GNE-947

C. Hop, S. Shahidi-Latham, J. Nonomiya, 2020 .

Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling

Yuan Chen, Cornelis E. C. A. Hop, Jialin Mao, 2018, CPT: pharmacometrics & systems pharmacology.

Translational energy dependence of gas-phase reactions of halides with halogenated alkanes

C. Hop, T. McMahon, 1991 .

Metabolism-Based Drug Interactions

H. Wong, C. Hop, S. C. Khojasteh, 2011 .

Metastable and collision-induced fragmentation studies of all C4H12Si+ isomers; a systematic study of structure-reactivity relations

C. Hop, D. Saulys, D. Gaines, 1994, Journal of the American Society for Mass Spectrometry.

Advances in Bioanalysis as It Relates to ADME

H. Wong, C. Hop, S. C. Khojasteh, 2011 .

Strategies of Drug Transporter Quantitation by LC-MS: Importance of Peptide Selection and Digestion Efficiency

Yuan Chen, J. Payandeh, Liling Liu, 2017, The AAPS Journal.

ADME Properties and Their Dependence on Physicochemical Properties

H. Wong, C. Hop, S. C. Khojasteh, 2011 .