Young-Guen Kwon

Hong-Hee Kim, Young-Guen Kwon, Siyoung Yang, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production.

Bo-Jeong Pyun, Young-Guen Kwon, Young-Myeong Kim, 2009, Blood.

Y. M. Lee, Soo-Young Lee, Yongwon Choi, 2002, The Journal of Biological Chemistry.

Promotion of direct angiogenesis in vitro and in vivo by Puerariae flos extract via activation of MEK/ERK‐, PI3K/Akt/eNOS‐, and Src/FAK‐dependent pathways

M. Won, K. Ha, Young-Guen Kwon, 2010, Phytotherapy Research.

Hepatocyte Growth Factor Suppresses Vascular Endothelial Growth Factor–Induced Expression of Endothelial ICAM-1 and VCAM-1 by Inhibiting the Nuclear Factor- (cid:1) B Pathway

Jeong Hun Kim, Soo Young Lee, Y. Gho, 2005 .

Hepatocyte Growth Factor Suppresses Vascular Endothelial Growth Factor–Induced Expression of Endothelial ICAM-1 and VCAM-1 by Inhibiting the Nuclear Factor-&kgr;B Pathway

Y. Gho, G. Oh, Soo-Young Lee, 2005 .

The WNT antagonist Dickkopf 2 promotes angiogenesis in rodent and human endothelial cells

Chulhee Choi, C. Yun, B. Koo, 2011 .

The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.

Chulhee Choi, C. Yun, B. Koo, 2011, The Journal of clinical investigation.

Homeobox D1 regulates angiogenic functions of endothelial cells via integrin β1 expression.

D. Hwang, Minhyung Kim, Young-Guen Kwon, 2011, Biochemical and biophysical research communications.

CU06-1004 modulates the adenosine monophosphate (AMP)-associated protein kinase (AMPK) signaling pathway and inhibits lipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obese mice.

Young-Guen Kwon, Cho-Rong Bae, Cho‐Rong Bae, 2022, Life sciences.

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma

K. Bae, Sang Chul Lee, H. Hong, 2015, Oncotarget.

Telmisartan Inhibits TNFα-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells

S. Jo, Young-Guen Kwon, Jungjin Kim, 2020, Biomolecules & therapeutics.

Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways.

K. Ha, S. Namkoong, Seon-Jin Lee, 2006, American journal of physiology. Heart and circulatory physiology.

Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy.

Y. Suh, Kyeojin Kim, Young-Guen Kwon, 2011, European journal of pharmacology.

Effects of Transient Cerebral Ischemia on the Expression of DNA Methyltransferase 1 in the Gerbil Hippocampal CA1 Region

J. Park, M. Won, D. Jeoung, 2012, Neurochemical Research.

Hepatitis B virus X protein induces TNF-α expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2

G. Jung, Young-Guen Kwon, Y. Yi, 2003 .

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation

S. Ha, Weontae Lee, N. Mochizuki, 2015, The Journal of cell biology.

Korean Red Ginseng protects endothelial cells from serum-deprived apoptosis by regulating Bcl-2 family protein dynamics and caspase S-nitrosylation

M. Won, H. M. Kwon, Young-Guen Kwon, 2013, Journal of ginseng research.

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

K. Yoo, J. Park, I. Hwang, 2014, Neurochemical Research.

Vascular Endothelial Growth Factor Up-regulates Expression of Receptor Activator of NF-κB (RANK) in Endothelial Cells

Y. Kong, Y. Gho, Eok-Cheon Kim, 2003, Journal of Biological Chemistry.

20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway.

Shin-Jeong Lee, Jeong-Hill Park, Bo-Jeong Pyun, 2006, Biochemical and biophysical research communications.

Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation.

M. Won, Eok-Cheon Kim, I. Yoo, 2004, Biochemical and biophysical research communications.

Ischemic preconditioning protects hippocampal pyramidal neurons from transient ischemic injury via the attenuation of oxidative damage through upregulating heme oxygenase-1.

K. Yoo, J. Park, I. Hwang, 2015, Free radical biology & medicine.

Neuroprotection of ischemic preconditioning is mediated by thioredoxin 2 in the hippocampal CA1 region following a subsequent transient cerebral ischemia

J. Park, M. Won, Soo‐Young Choi, 2016, Brain pathology.

Endostatin binds to the catalytic domain of matrix metalloproteinase‐2

Young-Guen Kwon, Seung-Taek Lee, Jin-wook Jang, 2002, FEBS letters.

4-O-methylgallic acid down-regulates endothelial adhesion molecule expression by inhibiting NF-kappaB-DNA-binding activity.

K. Ha, S. Namkoong, Young-Guen Kwon, 2006, European journal of pharmacology.

Nestin expression during differentiation of fetal endothelial progenitor cells and hypoxic culture of human umbilical vein endothelial cells

Young-Guen Kwon, Y. Park, Yong-Sun Maeng, 2008, Acta obstetricia et gynecologica Scandinavica.

Late expression of Na+/H+ exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia

K. Yoo, I. Hwang, M. Won, 2008, Experimental Neurology.

Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis

Yoon Kyung Choi, M. Won, K. Ha, 2017, Experimental & Molecular Medicine.

Detection and measurement for the modification and inactivation of caspase by nitrosative stress in vitro and in vivo.

T. Billiar, K. Ha, Young-Guen Kwon, 2008, Methods in Enzymology.

Aqueous extract of unripe Rubus coreanus fruit attenuates atherosclerosis by improving blood lipid profile and inhibiting NF-κB activation via phase II gene expression.

M. Won, K. Ha, D. Jeoung, 2013, Journal of ethnopharmacology.

Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs

K. Hoe, M. Won, Seung-Hae Kwon, 2018, Experimental & Molecular Medicine.

p-Hydroxybenzyl alcohol-containing biodegradable nanoparticle improves functional blood flow through angiogenesis in a mouse model of hindlimb ischemia.

P. Kang, K. Ha, Dongwon Lee, 2015, Biomaterials.

REDD‐1 aggravates endotoxin‐induced inflammation VIA atypical NF‐κB activation

Yoon Kyung Choi, M. Won, T. Billiar, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage.

K. Yoo, I. Hwang, M. Won, 2010, Free radical biology & medicine.

Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2.

M. Kibbe, T. Billiar, Young-Guen Kwon, 2008, BMB reports.

REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression

M. Won, Young-Guen Kwon, Young-Myeong Kim, 2021, Experimental & Molecular Medicine.

Interactive relations between nitric oxide (NO) and carbon monoxide (CO): heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation.

Young-Guen Kwon, Hun-taeg Chung, Byung-Min Choi, 2008, Methods in enzymology.

Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway

Ho Min Kim, H. Park, J. Ock, 2018, Diabetes.

Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation

M. Won, K. Ha, Young-Guen Kwon, 2017, BMB reports.

CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.

K. Ha, Seon-Jin Lee, Young-Guen Kwon, 2008, Biochemical pharmacology.

N-Terminal modification of the tetrapeptide Arg-Leu-Tyr-Glu, a VEGFR-2 antagonist, improves anti-tumor activity by increasing its stability against serum peptidases

Ha, M. Won, D. Jeoung, 2019 .

The tetrapeptide Arg-Leu-Tyr-Glu inhibits VEGF-induced angiogenesis.

Cheol‐Hee Kim, M. Won, K. Ha, 2015, Biochemical and biophysical research communications.

Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling.

Hyangkyu Lee, Jeong-Han Kim, Myung-Shin Jeon, 2010, Free radical biology & medicine.

Astaxanthin Inhibits Nitric Oxide Production and Inflammatory Gene Expression by Suppressing IκB Kinase-dependent NF-κB Activation

K. Ha, S. Yim, J. Han, 2003, Molecules and Cells.

Combined effect of vascular-leakage-blocker Sac-1004 and antiangiogenic drug sunitinib on tumor angiogenesis.

Y. Suh, Kyeojin Kim, Young-Guen Kwon, 2014, Biochemical and biophysical research communications.

Expression and changes of endogenous insulin-like growth factor-1 in neurons and glia in the gerbil hippocampus and dentate gyrus after ischemic insult

K. Yoo, I. Hwang, M. Won, 2004, Neurochemistry International.

Decreased Endothelial Progenitor Cells in Umbilical Cord Blood in Severe Preeclampsia

J. Kwon, Young-Guen Kwon, Y. Park, 2007, Gynecologic and Obstetric Investigation.

B Activation k -Dependent NF-ras Expression through Suppression of p21 Down-Regulation of Inflammatory Gene Collagen-Induced Arthritis by Inhibition of Farnesyltransferase Prevents

K. Ha, Seon-Jin Lee, Young-Guen Kwon, 2004 .

Hypothyroid state does not protect but delays neuronal death in the hippocampal CA1 region following transient cerebral ischemia: Focus on oxidative stress and gliosis

K. Yoo, I. Hwang, M. Won, 2010, Journal of neuroscience research.

Difference in serum nephrin expression between normal and preeclamptic pregnancies: A preliminary study

Young Han Kim, J. Choi, Myung-Hwa Kang, 2012 .

Could circulating progenitor cell count be a barometer for coronary artery disease progression?

J. Park, Young-Guen Kwon, 2010, Circulation journal : official journal of the Japanese Circulation Society.

Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3.

M. Won, K. Ha, D. Jeoung, 2014, Antioxidants & redox signaling.

Specific Activation of Insulin-like Growth Factor-1 Receptor by Ginsenoside Rg5 Promotes Angiogenesis and Vasorelaxation*

M. Won, D. Jeoung, Dong-Hyun Kim, 2014, The Journal of Biological Chemistry.

Aspirin prevents TNF‐&agr;‐induced endothelial cell dysfunction by regulating the NF‐&kgr;B‐dependent miR‐155/eNOS pathway: Role of a miR‐155/eNOS axis in preeclampsia

Yoon Kyung Choi, M. Won, D. Jeoung, 2017, Free radical biology & medicine.

Senescence of fetal endothelial progenitor cell in pregnancy with idiopathic fetal growth restriction

Young Han Kim, J. Kwon, Young-Guen Kwon, 2012, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil

K. Yoo, I. Hwang, M. Won, 2007, Journal of neuroscience research.

Changes in immunoreactivity of HSP60 and its neuroprotective effects in the gerbil hippocampal CA1 region induced by transient ischemia

K. Yoo, I. Hwang, M. Won, 2007, Experimental Neurology.

Hydroquinone Strongly Alleviates Focal Ischemic Brain Injury via Blockage of Blood-Brain Barrier Disruption in Rats.

K. Yoo, M. Won, S. Her, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway.

Y. Suh, Kyeojin Kim, Young-Guen Kwon, 2013, Biochemical and biophysical research communications.

Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress

K. Yoo, J. Park, I. Hwang, 2011, Experimental Neurology.

Melatonin's protective action against ischemic neuronal damage is associated with up‐regulation of the MT2 melatonin receptor

K. Yoo, I. Hwang, M. Won, 2010, Journal of neuroscience research.

Arg-Leu-Tyr-Glu tetrapeptide inhibits tumor progression by suppressing angiogenesis and vascular permeability via VEGF receptor-2 antagonism

M. Won, K. Ha, D. Jeoung, 2016, Oncotarget.

Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia

M. Won, K. Ha, Young-Guen Kwon, 2020, Cells.

MicroRNA-148a/b-3p regulates angiogenesis by targeting neuropilin-1 in endothelial cells

Hyejeong Kim, Young-Guen Kwon, Young-Myeong Kim, 2019, Experimental & Molecular Medicine.

Catalytic and regulatory domains of doublecortin kinase-1.

Sandip K. Nandy, A. Edelman, D. Lawrence, 2003, Biochemistry.

Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Jong-Wha Jung, Y. Suh, Kyeojin Kim, 2012, Archives of pharmacal research.

REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation

Ji Hyun Lee, Young-Guen Kwon, Joohwan Kim, 2022, Nature Communications.

New GABAergic Neurogenesis in the Hippocampal CA1 Region of a Gerbil Model of Long‐Term Survival after Transient Cerebral Ischemic Injury

K. Yoo, J. Park, I. Hwang, 2016, Brain pathology.

Comparison of the immunoreactivities of NMDA receptors between the young and adult hippocampal CA1 region induced by experimentally transient cerebral ischemia

J. Park, M. Won, Young-Guen Kwon, 2013, Journal of the Neurological Sciences.

Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia

K. Yoo, I. Hwang, M. Won, 2010, Journal of the Neurological Sciences.

Na+/Ca2+ exchanger 1 alters in pyramidal cells and expresses in astrocytes of the gerbil hippocampal CA1 region after ischemia

K. Yoo, I. Hwang, M. Won, 2006, Brain Research.

Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization.

M. Won, K. Ha, D. Jeoung, 2012, Biochemical and biophysical research communications.

Cyclic AMP prolongs graft survival by suppressing apoptosis and inflammatory gene expression in acute cardiac allograft rejection

K. Ha, Young-Guen Kwon, Young-Myeong Kim, 2010, Experimental & Molecular Medicine.

TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p–dependent down-regulation of cGMP-dependent kinase 1

M. Won, K. Ha, Young-Guen Kwon, 2018, The Journal of Biological Chemistry.

Low-dose metronomic doxorubicin inhibits mobilization and differentiation of endothelial progenitor cells through REDD1-mediated VEGFR-2 downregulation

Ji Yoon Kim, Young-Guen Kwon, Young-Myeong Kim, 2021, BMB reports.

The effect of nicotine on the production of soluble fms‐like tyrosine kinase‐1 and soluble endoglin in human umbilical vein endothelial cells and trophoblasts

C. Kim, J. A. Linton, S. Bai, 2010, Acta obstetricia et gynecologica Scandinavica.

Co‐localization of inducible nitric oxide synthase and phosphorylated Akt in the lesional skins of patients with melasma

K. Ha, H. Jo, Young-Guen Kwon, 2009, The Journal of dermatology.

Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner

K. Hoe, M. Won, B. Jeon, 2018, Journal of the American Heart Association.

The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.

M. Won, Tae-Hyoung Kim, K. Ha, 2017, Free radical biology & medicine.

NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function

M. Won, K. Ha, Young-Guen Kwon, 2020, Experimental & Molecular Medicine.

Interleukin-4 inhibits the vascular endothelial growth factor- and basic fibroblast growth factor-induced angiogenesis in vitro.

Young-Guen Kwon, Jinkoo Kim, J. Choe, 2002, Molecules and cells.

Receptor Activator of Nuclear Factor &kgr;B Ligand Is a Novel Inducer of Tissue Factor in Macrophages

J. Park, Young-Guen Kwon, Young-Myeong Kim, 2010, Circulation research.

Angiogenic activity of sesamin through the activation of multiple signal pathways.

K. Ha, D. Jeoung, Jung Joon Lee, 2010, Biochemical and biophysical research communications.

Expanding Roles in Angiogenesis

N. Mochizuki, Young-Guen Kwon, 2008 .

Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation

Shin-Jeong Lee, Young-Guen Kwon, Young-Myeong Kim, 2009, Experimental & Molecular Medicine.

Microscopic technique for the detection of nitric oxide-dependent angiogenesis in an animal model.

K. Ha, S. Namkoong, Young-Guen Kwon, 2008, Methods in enzymology.

The Wnt pathway and the roles for its antagonists, DKKS, in angiogenesis

Young-Guen Kwon, H. Choi, Heon-Woo Lee, 2012, IUBMB life.

Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligand.

Y. Kong, Y. Gho, Eok-Cheon Kim, 2003, The Journal of biological chemistry.

Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc 2 kinase

P. Greengard, A. Nairn, Soo Young Lee, 1997 .

TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions

Yoon Kyung Choi, M. Won, G. Koh, 2013, Angiogenesis.

Carbohydrate-binding protein CLEC14A regulates VEGFR-2– and VEGFR-3–dependent signals during angiogenesis and lymphangiogenesis

N. Mochizuki, In-kyu Lee, G. Koh, 2016, The Journal of clinical investigation.

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

Paul Greengard, Jonathan Goldberg, Angus C. Nairn, 1995, Nature.

Glucal-conjugated sterols as novel vascular leakage blocker: structure-activity relationship focusing on the C17-side chain.

Y. Suh, Kyeojin Kim, Young-Guen Kwon, 2014, European journal of medicinal chemistry.

Definition of Optimal Substrate Recognition Motifs of Ca2+-Calmodulin-dependent Protein Kinases IV and II Reveals Shared and Distinctive Features*

D S Lawrence, A. Edelman, D. Lawrence, 1998, The Journal of Biological Chemistry.

Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1α-Independent VEGF Expression via an AMPKα/SIRT1-Mediated PGC-1α/ERRα Axis.

Yoon Kyung Choi, M. Won, K. Ha, 2017, Antioxidants & redox signaling.

[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo.

Shin-Jeong Lee, Hyun-Ok Yang, Eok-Cheon Kim, 2005, Biochemical and biophysical research communications.

β-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-κB activation

K. Ha, J. Han, Seon-Jin Lee, 2005, Experimental & Molecular Medicine.

The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish

K. Kawakami, K. Alitalo, N. Mochizuki, 2013, Development.

Regulation of Caspases by Nitric Oxide

Young-Guen Kwon, Young-Myeong Kim, Hun-taeg Chung, 2002, Annals of the New York Academy of Sciences.

Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells

M. Won, K. Ha, Young-Guen Kwon, 2012, Experimental & Molecular Medicine.

Recruitment of monocytes/macrophages in different tumor microenvironments.

S. Ha, Kyung-Tae Lee, Young-Guen Kwon, 2013, Biochimica et biophysica acta.

Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells.

M. Won, K. Ha, M. Dong, 2008, Biochemical and biophysical research communications.

Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/&bgr;-Catenin and Protein Kinase C&agr;

E. R. Andersson, E. Arenas, Kang-Yell Choi, 2009, Circulation research.

Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation.

K. Ha, J. Han, Young-Guen Kwon, 2003, Toxicology and applied pharmacology.

Heterochromatin Protein 1 Alpha (HP1α: CBX5) is a Key Regulator in Differentiation of Endothelial Progenitor Cells to Endothelial Cells

J. Kwon, Young-Guen Kwon, Yong-Sun Maeng, 2015, Stem cells.

CU06-1004 (endothelial dysfunction blocker) ameliorates astrocyte end-feet swelling by stabilizing endothelial cell junctions in cerebral ischemia/reperfusion injury

Young-Guen Kwon, Haiying Zhang, Cho-Rong Bae, 2020, Journal of Molecular Medicine.

Nitric oxide prevents 6‐hydroxydopamine‐induced apoptosis in PC12 cells through cGMP‐dependent PI3 kinase/Akt activation

T. Billiar, K. Ha, Young-Guen Kwon, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

Hyejeong Kim, Young-Guen Kwon, Haiying Zhang, 2023, Fluids and Barriers of the CNS.

Desmethylanhydroicaritin inhibits NF-kappaB-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway.

M. Won, K. Ha, J. Choi, 2009, European journal of pharmacology.

Desmethylanhydroicaritin inhibits NF-κ B-regulated in fl ammatory gene expression by modulating the redox-sensitive PI 3 K / PTEN / Akt pathway

M. Won, K. Ha, J. Choi, 2009 .

Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

K. Ha, S. Yim, J. Han, 2003, Molecules and cells.

N-Terminal Modification of the Tetrapeptide Arg-Leu-Tyr-Glu, a Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Antagonist, Improves Antitumor Activity by Increasing its Stability against Serum Peptidases

M. Won, D. Jeoung, Young-Guen Kwon, 2019, Molecular Pharmacology.

A miRNA-101-3p/Bim axis as a determinant of serum deprivation-induced endothelial cell apoptosis

M. Won, K. Ha, Young-Guen Kwon, 2017, Cell Death & Disease.

Hippo-YAP/TAZ signaling in angiogenesis

J. Park, Young-Guen Kwon, 2018, BMB reports.

Carbon Monoxide Promotes VEGF Expression by Increasing HIF-1α Protein Level via Two Distinct Mechanisms, Translational Activation and Stabilization of HIF-1α Protein*

Yoon Kyung Choi, K. Ha, D. Jeoung, 2010, The Journal of Biological Chemistry.

Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein

S. Morrison, M. Penichet, K. Webster, 2005, Molecular Cancer Therapeutics.

Capsaicin Inhibits in Vitro and in Vivo Angiogenesis

Y. Gho, O. Kim, Eok-Cheon Kim, 2004, Cancer Research.

Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

J. Park, I. Hwang, M. Won, 2017, Journal of Neuroinflammation.

Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide

Jia Yu, K. Yoo, I. Hwang, 2010, Journal of the Neurological Sciences.

Indole‐3‐propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus

In Koo Hwang, Ki-Yeon Yoo, Jung Hoon Choi, 2009, Journal of neuroscience research.

Polyphosphate blocks tumour metastasis via anti-angiogenic activity.

Y. Gho, Yoon-Keun Kim, Young-Guen Kwon, 2007, The Biochemical journal.

Increased senescence and reduced functional ability of fetal endothelial progenitor cells in pregnancies complicated by preeclampsia without intrauterine growth restriction.

Young-Guen Kwon, Han-Sung Hwang, Yong-Sun Maeng, 2007, American journal of obstetrics and gynecology.

Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity.

Sun Choi, Yoonji Lee, Jeong-Han Kim, 2008, Cancer research.

Regulation of ROS Production and Vascular Function by Carbon Monoxide

Yoon Kyung Choi, Young-Guen Kwon, Young-Myeong Kim, 2012, Oxidative medicine and cellular longevity.

Primaquine Diphosphate, a Known Antimalarial Drug, Blocks Vascular Leakage Acting Through Junction Stabilization

Hyejeong Kim, Young-Guen Kwon, Young-Myeong Kim, 2021, Frontiers in Pharmacology.

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.

D. Lim, Y. Kubota, G. Koh, 2017, The Journal of clinical investigation.

Differences in Doublecortin Immunoreactivity and Protein Levels in the Hippocampal Dentate Gyrus Between Adult and Aged Dogs

K. Yoo, I. Hwang, M. Won, 2007, Neurochemical Research.

Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization*

T. Billiar, K. Ha, Seon-Jin Lee, 2002, The Journal of Biological Chemistry.

Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway

M. Won, K. Ha, Young-Guen Kwon, 2020, Journal of ginseng research.

Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells.

Kyu-Won Kim, Kyu-Sil Choi, M. Yoo, 2008, Biochimica et biophysica acta.

Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice.

N. Mochizuki, G. Oh, J. H. Kim, 2007, Blood.

Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells

K. Ha, J. Han, S. Namkoong, 2005, Experimental & Molecular Medicine.

Isolation and Characterization of PNUTS, a Putative Protein Phosphatase 1 Nuclear Targeting Subunit*

P. Greengard, A. Nairn, P. Allen, 1998, The Journal of Biological Chemistry.

Regulation of apoptosis by nitrosative stress.

Young-Guen Kwon, Young-Myeong Kim, P. K. Kim, 2002, Journal of biochemistry and molecular biology.

Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression

In-kyu Lee, J. Park, Young-Guen Kwon, 2015, PLoS genetics.

BMP9 Induces Cord Blood–Derived Endothelial Progenitor Cell Differentiation and Ischemic Neovascularization via ALK1

D. Hwang, Minhyung Kim, J. Kwon, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.

H. Kwon, K. Ha, S. Namkoong, 2007, Biological & pharmaceutical bulletin.

Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation.

J. Park, Young-Guen Kwon, Young-Myeong Kim, 2012, Biochemical and biophysical research communications.

Inhibition of B16BL6 tumor progression by coadministration of recombinant angiostatin K1-3 and endostatin genes with cationic liposomes

Hong-Sung Kim, Y. Park, Keun-Sik Kim, 2004, Cancer Gene Therapy.

Stabilization of Intrinsically Disordered DKK2 Protein by Fusion to RNA-Binding Domain

B. Seong, Y. Byun, Young-Guen Kwon, 2019, International journal of molecular sciences.

Computational Analysis of Tumor Angiogenesis Patterns Using a Two-dimensional Model

Eun Bo Shim, E. Shim, Young-Guen Kwon, 2005, Yonsei medical journal.

SALM4 regulates angiogenic functions in endothelial cells through VEGFR2 phosphorylation at Tyr1175

Eunjoon Kim, J. Park, Young-Guen Kwon, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Nitric Oxide Inhibition of Homocysteine-induced Human Endothelial Cell Apoptosis by Down-regulation of p53-dependent Noxa Expression through the Formation of S-Nitrosohomocysteine*

K. Ha, J. Han, S. Namkoong, 2005, Journal of Biological Chemistry.

DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis

Young-Guen Kwon, Young-Myeong Kim, Haiying Zhang, 2022, BMC biology.

CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation

M. Won, Hyejeong Kim, Young-Guen Kwon, 2020, Journal of neuroinflammation.

CU06-1004 Alleviates Experimental Colitis by Modulating Colonic Vessel Dysfunction

Young-Guen Kwon, Haiying Zhang, Sunghye Lee, 2020, Frontiers in Pharmacology.

Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1.

Y. Suh, Kyeojin Kim, Young-Guen Kwon, 2010, Bioorganic & medicinal chemistry letters.

The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal Pathways

Yoon Kyung Choi, M. Won, K. Ha, 2010, Molecular Pharmacology.

The Farnesyltransferase Inhibitor LB 42708 Suppresses VEGF-induced Angiogenesis by Inhibiting Ras-dependent MAPK and PI 3 K / Akt Signal Pathways

M. Won, K. Ha, Young-Guen Kwon, 2010 .

Comparison of Trophic Factors Changes in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia

K. Yoo, J. Park, M. Won, 2012, Cellular and Molecular Neurobiology.

Roles of HIF-1α, VEGF, and NF-κB in Ischemic Preconditioning-Mediated Neuroprotection of Hippocampal CA1 Pyramidal Neurons Against a Subsequent Transient Cerebral Ischemia

J. Park, M. Won, Soo‐Young Choi, 2017, Molecular Neurobiology.

Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke

K. Yoo, J. Park, I. Hwang, 2016, Neurorehabilitation and neural repair.

Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury

Ho Min Kim, J. Ock, Young-Guen Kwon, 2017, Scientific Reports.

Antioxidant enzymes are differently changed in experimental ischemic hippocampal CA1 region following repeated restraint stress

K. Yoo, J. Park, I. Hwang, 2011, Journal of the Neurological Sciences.

beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation.

K. Ha, J. Han, Seon-Jin Lee, 2005, Experimental & molecular medicine.

Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.

Hansoo Lee, K. Ha, J. Han, 2005, Biochemical and biophysical research communications.

Hepatocyte growth factor suppresses vascular endothelial growth factor-induced expression of endothelial ICAM-1 and VCAM-1 by inhibiting the nuclear factor-kappaB pathway.

Y. Gho, G. Oh, Soo-Young Lee, 2005, Circulation research.

Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury

N. Mochizuki, Dongyeop Kim, Hyejeong Kim, 2023, Journal of Inflammation.

Correction: The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice

Young-Guen Kwon, Haiying Zhang, Cho-Rong Bae, 2021, PloS one.

CU06-1004-Induced Vascular Normalization Improves Immunotherapy by Modulating Tumor Microenvironment via Cytotoxic T Cells

S. Ha, Hyejeong Kim, J. Oh, 2021, Frontiers in Immunology.

Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

J. Park, I. Hwang, M. Won, 2017, Journal of Neuroinflammation.

Folic acid deficiency increases delayed neuronal death, DNA damage, platelet endothelial cell adhesion molecule‐1 immunoreactivity, and gliosis in the hippocampus after transient cerebral ischemia

Young Sup Kim, K. Yoo, I. Hwang, 2008, Journal of neuroscience research.

The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination.

In-kyu Lee, Kyu-Sung Choi, J. Park, 2016, Cellular signalling.

Time course of changes in pyridoxal 5′-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage

K. Yoo, I. Hwang, M. Won, 2007, Experimental Neurology.

Human plasminogen-derived N-acetyl-Arg-Leu-Tyr-Glu antagonizes VEGFR-2 to prevent blood-retinal barrier breakdown in diabetic mice.

K. Ha, Young-Guen Kwon, Young-Myeong Kim, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Rk1, a Ginsenoside, Is a New Blocker of Vascular Leakage Acting through Actin Structure Remodeling

Jeong-Hill Park, Young-Guen Kwon, Yong-Sun Maeng, 2013, PloS one.

Ginseng Berry Extract Prevents Atherogenesis via Anti-Inflammatory Action by Upregulating Phase II Gene Expression

K. Ha, Young-Guen Kwon, Young-Myeong Kim, 2012, Evidence-based complementary and alternative medicine : eCAM.

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

S. Ha, M. Won, G. Koh, 2014, Oncotarget.

Carbon monoxide stimulates astrocytic mitochondrial biogenesis via L-type Ca2+ channel-mediated PGC-1α/ERRα activation.

Yoon Kyung Choi, J. Park, M. Won, 2016, Biochemical and biophysical research communications.

Preparation and characterization of recombinant protein phosphatase 1.

P. Greengard, A. Nairn, E. F. da Cruz e Silva, 2003, Methods in enzymology.

Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression.

Jongjin Park, Nayoung Kim, K. Bae, 2015, Journal of hepatology.

Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation

K. Hoe, M. Won, Young-Guen Kwon, 2018, Yonsei medical journal.

Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling

Young-Guen Kwon, H. Choi, 2015, BMB reports.

NF-κB-responsive miR-155 induces functional impairment of vascular smooth muscle cells by downregulating soluble guanylyl cyclase

M. Won, K. Ha, S. Kang, 2019, Experimental & Molecular Medicine.

Protein kinase C‐δ regulates the stability of hypoxia‐inducible factor‐1α under hypoxia

C. Jeong, Kwang-Hoon Chun, Seung-Ki Lee, 2007 .

Extract of Moutan radicis cortex and Cinnamomi ramulus ameliorates laser-induced choroidal neovascularization in Brown-Norway rats.

Young-Guen Kwon, Haiying Zhang, Jin Sook Kim, 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA.

Yoon Kyung Choi, M. Won, K. Ha, 2012, Free radical biology & medicine.

Chronological alterations of neurofilament 150 immunoreactivity in the gerbil hippocampus and dentate gyrus after transient forebrain ischemia

Seon-Gil Do, K. Yoo, I. Hwang, 2004, Brain Research.

Molecular Basis for the Substrate Specificity of a Serine/Threonine-Specific Protein Kinase

D. Lawrence, Young-Guen Kwon, Tae Ryong Lee, 1993 .

The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo.

Juyeon Jung, H. Hong, Young-Guen Kwon, 2011, Oncology reports.

Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke

K. Yoo, J. Park, I. Hwang, 2013, PLoS ONE.

Regulation of programmed cell death in neuronal cells by nitric oxide.

K. Ha, Young-Guen Kwon, Young-Myeong Kim, 2004, In vivo.

Function and mode of action of NO in biological system

Young-Guen Kwon, Young-Myeong Kim, Hun-taeg Chung, 2009 .

Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells.

D. Hwang, Minhyung Kim, J. Kwon, 2010, Biochemical and biophysical research communications.

Integrative analysis of DNA methylation and mRNA expression during differentiation of umbilical cord blood derived mononuclear cells to endothelial cells.

Sanghyuk Lee, Kyu-Sung Choi, J. Park, 2017, Gene.

Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB‐dependent mechanisms in macrophages

M. Won, K. Ha, D. Jeoung, 2015, FEBS letters.

Extracellular taurine induces angiogenesis by activating ERK-, Akt-, and FAK-dependent signal pathways.

Hansoo Lee, Moo-Ho Won, Dooil Jeoung, 2012, European journal of pharmacology.

Distinct roles of DKK1 and DKK2 in tumor angiogenesis

C. Yun, J. Yoo, Young-Guen Kwon, 2013, Angiogenesis.

Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway

M. Won, J. H. Kim, Jin Hyoung Kim, 2019, Biomolecules & therapeutics.

K. Yoo, I. Hwang, M. Won, 2008, Neurochemical Research.

TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions

Yoon Kyung Choi, M. Won, K. Ha, 2013, Angiogenesis.

Wnt 5 a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt /-Catenin and Protein Kinase C

E. R. Andersson, E. Arenas, Kang-Yell Choi, 2009 .

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

K. Yoo, J. Park, I. Hwang, 2014, Neurochemical Research.

Anti‐angiogenic activity of thienopyridine derivative LCB03‐0110 by targeting VEGFR‐2 and JAK/STAT3 Signalling

M. Cui, Sun Choi, Yoonji Lee, 2015, Experimental dermatology.

Mineralocorticoid and glucocorticoid receptor expressions in astrocytes and microglia in the gerbil hippocampal CA1 region after ischemic insult

K. Yoo, I. Hwang, M. Won, 2006, Neuroscience Research.

The cAMP-Dependent Protein Kinase Discriminates between Prochiral Hydroxyl Groups

D. Lawrence, Young-Guen Kwon, S. Pluskey, 1993 .

Effects of Transient Cerebral Ischemia on the Expression of DNA Methyltransferase 1 in the Gerbil Hippocampal CA1 Region

J. Park, M. Won, D. Jeoung, 2012, Neurochemical Research.

The stress-responsive protein REDD1 and its pathophysiological functions

Young-Guen Kwon, Ji-Yon Kim, Young-Myeong Kim, 2023, Experimental & molecular medicine.

M. Won, D. Jeoung, Young-Guen Kwon, 2019, Molecular Pharmacology.

Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation

K. Ha, D. Jeoung, S.-J. Lee, 2004, Cell Death and Differentiation.

Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptides.

P. Greengard, A. Nairn, J. Girault, 1995, Biochemical and biophysical research communications.

Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway.

H. Kwon, K. W. Kim, O. Lee, 2000, Biochemical and biophysical research communications.

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis.

M. Won, P. Suh, Y. Kim, 2009, Blood.

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC (cid:1) 2 axis

M. Won, P. Suh, Kyu-Sil Choi, 2008 .

N-/C-terminal deleted mutant of human endostatin efficiently acts as an anti-angiogenic and anti-tumorigenic agent.

Y. M. Lee, Kyu-Won Kim, Young-Guen Kwon, 2004, Oncology reports.

15-lipoxygenase-1 in the vasculature: expanding roles in angiogenesis.

N. Mochizuki, Young-Guen Kwon, 2008, Circulation research.

Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation

M. Won, K. Ha, Young-Guen Kwon, 2017, BMB reports.

Hepatocyte Growth Factor Suppresses Vascular Endothelial Growth Factor–Induced Expression of Endothelial ICAM-1 and VCAM-1 by Inhibiting the Nuclear Factor-&kgr;B Pathway

Y. Gho, G. Oh, Soo-Young Lee, 2005, Circulation research.

Multiple paracrine factors secreted by mesenchymal stem cells contribute to angiogenesis.

M. Won, Yong-Man Kim, H. M. Kwon, 2014, Vascular pharmacology.

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

Kyu-Sung Choi, Young-Guen Kwon, Young-Myeong Kim, 2015, Nature Communications.