B. Hughes

发表

Journal of Steroid Biochemistry and Molecular Biology

G. Lavery, C. Shackleton, P. Stewart, 2022 .

Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1

G. Reynolds, L. Gathercole, G. Lavery, 2012, Endocrinology.

Residual adrenal function in autoimmune Addison's disease: improvement after tetracosactide (ACTH1-24) treatment.

R. Quinton, S. Pearce, P. Perros, 2014, The Journal of clinical endocrinology and metabolism.

Reduced glucocorticoid production rate, decreased 5α-reductase activity and adipose tissue insulin sensitization following weight loss

P. Stewart, B. Hughes, J. Tomlinson, 2008, Diabetes.

Hyperandrogenemia Predicts Metabolic Phenotype in Polycystic Ovary Syndrome: The Utility of Serum Androstenedione

N. Crabtree, P. Stewart, B. Hughes, 2014, The Journal of clinical endocrinology and metabolism.

Abnormal low-density lipoprotein subfraction profile in patients with untreated hypertension.

M. Landray, G. Lip, M. Kendall, 2002, QJM : monthly journal of the Association of Physicians.

Cortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum

S. Rogers, J. Blissett, B. Hughes, 2016, Clinical endocrinology.

Accurate non‐invasive diagnosis and staging of non‐alcoholic fatty liver disease using the urinary steroid metabolome

Michael Biehl, P. Newsome, L. V. Van Gaal, 2020, Alimentary pharmacology & therapeutics.

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo

B. Keevil, L. Hodson, N. Nikolaou, 2020, The Journal of endocrinology.

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype.

N. Crabtree, C. Shackleton, P. Stewart, 2014, European journal of endocrinology.

Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.

M. McCarthy, S. Franks, T. Barber, 2009, The Journal of clinical endocrinology and metabolism.

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.

A. Grüters, S. Wiegand, C. Strasburger, 2007, European journal of endocrinology.

Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.

S. Rogers, J. Blissett, K. Smart, 2014, The Journal of clinical endocrinology and metabolism.

Human Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency and steroid metabolism

P. Clayton, C. Shackleton, P. Stewart, 2008, Steroids.

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

W. Dunn, L. Hodson, N. Nikolaou, 2015, The Journal of clinical endocrinology and metabolism.

The corticosteroid metabolic profile of the mouse

G. Lavery, E. Walker, B. Hughes, 2008, Steroids.

Biomarkers of hypothalamic–pituitary–adrenal axis activity in mice lacking 11β-HSD1 and H6PDH

G. Lavery, P. Stewart, B. Hughes, 2012, The Journal of endocrinology.

Hepatic 11beta‐HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis

C. Strasburger, H. Lochs, M. Pirlich, 2009, Clinical endocrinology.

TNFα regulates cortisol metabolism in vivo in patients with inflammatory arthritis

M. Cooper, I. McInnes, P. Taylor, 2014, Annals of the rheumatic diseases.

Dyslipidaemia in patients with malignant-phase hypertension.

G. Lip, D. Beevers, B. Hughes, 2001, QJM : monthly journal of the Association of Physicians.

17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

C. Shackleton, P. Stewart, B. Hughes, 2008, Steroids.

The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure.

R. Murray, N. Crabtree, L. Behan, 2015, European journal of endocrinology.

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

L. Gathercole, G. Mastorakos, N. Krone, 2015, Endocrinology.

Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells

S. Kliewer, D. Mangelsdorf, R. Auchus, 2016, Molecular endocrinology.

Altered cortisol metabolism in individuals with HNF1A-MODY.

M. McCarthy, K. Owen, B. Hughes, 2020, Clinical endocrinology.

PAPSS2 Deficiency Causes Androgen Excess via Impaired DHEA Sulfation—In Vitro and in Vivo Studies in a Family Harboring Two Novel PAPSS2 Mutations

A. Uitterlinden, A. Verkerk, M. Losekoot, 2015, The Journal of clinical endocrinology and metabolism.

11β-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function*

M. Cooper, J. Chou, G. Lavery, 2007, Journal of Biological Chemistry.

Dual-5 (cid:2) -Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

W. Dunn, L. Hodson, N. Nikolaou, 2015 .

The urinary steroid metabolome as a non-invasive tool to stage non-alcoholic fatty liver disease

Michael Biehl, L. Gaal, M. Armstrong, 2016 .

Urine steroid metabolomics as a diagnostic tool in primary aldosteroinism

Michael Biehl, F. Beuschlein, S. Hahner, 2015 .

Prenatal Diagnosis of Congenital Adrenal Hyperplasia Caused by P450 Oxidoreductase Deficiency

O. Abdul-Rahman, R. Harrison, E. Blair, 2013, Journal of Clinical Endocrinology and Metabolism.

Prenatal Diagnosis of Congenital Adrenal Hyperplasia Caused by P450 Oxidoreductase Deficiency

O. Abdul-Rahman, R. Harrison, E. Blair, 2013, The Journal of clinical endocrinology and metabolism.

Remission of hypertension and electrolyte abnormalities following renal transplantation in a patient with apparent mineralocorticoid excess well documented throughout childhood

M. New, C. Shackleton, B. Hughes, 2014, Journal of pediatric endocrinology & metabolism : JPEM.

Genotype-Phenotype Analysis in Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency

M. Dattani, P. Hindmarsh, M. Kempers, 2011, The Journal of clinical endocrinology and metabolism.

Mitotane therapy in adrenocortical cancer induces CYP 3 A 4 and inhibits 5-reductase , explaining the need for personalized glucocorticoid and androgen replacement

F. Beuschlein, J. Bertherat, X. Bertagna, 2012 .

Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.

M. Dowsett, R. Auchus, J. D. de Bono, 2012, The Journal of clinical endocrinology and metabolism.

The Journal of Steroid Biochemistry and Molecular Biology

G. Lavery, C. Shackleton, N. Krone, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)

G. Lavery, C. Shackleton, P. Stewart, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

University of Birmingham Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia

C. M. Jones, N. Nikolaou, A. Mallappa, 2017 .

Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study

N. Crabtree, L. Gathercole, C. Shackleton, 2019, Clinical Endocrinology.

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

M. van de Bunt, L. Hodson, J. Ryan, 2019, Metabolism: clinical and experimental.

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1

G. Lavery, E. Walker, P. Stewart, 2011, Proceedings of the National Academy of Sciences.

Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors

Michael Biehl, Martin Fassnacht, David J. Smith, 2011, The Journal of clinical endocrinology and metabolism.

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

Michael Biehl, Martin Reincke, Jonathan J. Deeks, 2017, JCI insight.

The effect of spironolactone upon corticosteroid hormone metabolism in patients with early stage chronic kidney disease

J. Townend, R. Steeds, C. Ferro, 2010, Clinical Endocrinology.

Is Metoprolol CR/ZOK More Selective Than Conventional Metoprolol and Atenolol?

M. Kendall, B. Hughes, B. Hughes, 1990, Journal of clinical pharmacology.

Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging.

Zaki K Hassan-Smith, Jeremy W Tomlinson, G. Lavery, 2015, The Journal of clinical endocrinology and metabolism.

Dual 5-[alpha] reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

W. Dunn, L. Hodson, N. Nikolaou, 2015 .

Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Δ7-sterol reductase (Dhcr7), the enzyme associated with Smith–Lemli–Opitz syndrome

Shailendra B. Patel, C. Shackleton, B. Hughes, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

Journal of Steroid Biochemistry and Molecular Biology

R. Tukey, J. Fiet, O. Barbier, 2022 .

Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?

A. V. van Beek, P. Murray, S. Rauz, 2010, The Journal of clinical endocrinology and metabolism.

Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

P. Stewart, B. Hughes, J. Tomlinson, 2008, Diabetes.

1 and H6PDH 2

G. Lavery, B. Hughes, N. Semjonous, 2012 .

Hyperandrogenaemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione

N. Crabtree, P. Stewart, B. Hughes, 2014 .

University of Birmingham Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome : the utility of serum androstenedione

N. Crabtree, P. Stewart, B. Hughes, 2014 .

Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.

J. Bertherat, X. Bertagna, M. Fassnacht, 2013, The Journal of clinical endocrinology and metabolism.

11 -Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function*

M. Cooper, J. Chou, G. Lavery, 2007 .

Prenatal Diagnosis of Congenital Adrenal Hyperplasia Caused by P450 Oxidoreductase Deficiency

O. Abdul-Rahman, R. Harrison, E. Blair, 2013, The Journal of clinical endocrinology and metabolism.

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

L. Hodson, N. Nikolaou, M. Armstrong, 2015, The Journal of clinical endocrinology and metabolism.

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

L. Gathercole, G. Mastorakos, N. Krone, 2015, Endocrinology.