T. Wilkinson

发表

Current advances in the development of high-throughput purification strategies for the generation of therapeutic antibodies

J. Spooner, T. Wilkinson, B. Kemp, 2015 .

Parallel, high‐throughput purification of recombinant antibodies for in vivo cell assays

L. Jermutus, T. Wilkinson, D. Bannister, 2006, Biotechnology and bioengineering.

Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope “tags”

T. Wilkinson, B. Kemp, T. Vaughan, 2014, mAbs.

Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening.

Neera Borkakoti, Stephen D Pickett, N. Borkakoti, 2003, Bioorganic & medicinal chemistry letters.

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

J. Debreczeni, R. Woods, U. Sivars, 2017, mAbs.

Protein engineering and preclinical development of a GM‐CSF receptor antibody for the treatment of rheumatoid arthritis

R. Minter, L. Fabri, L. Jermutus, 2013, British journal of pharmacology.

Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays

R. Howes, T. Wilkinson, T. Vaughan, 2016, Journal of biomolecular screening.

Structure of IL-17A in complex with a potent, fully human neutralizing antibody.

S. Tuske, Y. Hamuro, D. Hargreaves, 2009, Journal of molecular biology.

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

E. Briend, Hongwei Guo, B. Wang, 2014, mAbs.

Development of a Homogeneous High-Throughput Screening Assay for Biological Inhibitors of Human Rhinovirus Infection

R. Dunmore, M. Sleeman, T. Wilkinson, 2013, Journal of biomolecular screening.

Use of the Site-Specific Retargeting Jump-In Platform Cell Line to Support Biologic Drug Discovery

Ling Huang, T. Wilkinson, N. Tigue, 2015, Journal of biomolecular screening.

Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies

T. Wilkinson, D. Schofield, R. Dodd, 2018, BioDrugs.

Development of therapeutic antibodies to G protein‐coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseases

T. Mustelin, T. Wilkinson, J. Douthwaite, 2017, Pharmacology & therapeutics.

Discovery of functional monoclonal antibodies targeting G-protein-coupled receptors and ion channels.

T. Wilkinson, 2016, Biochemical Society transactions.

Discovery of Functional Antibodies Targeting Ion Channels

T. Wilkinson, M. Gardener, Wendy A Williams, 2015, Journal of biomolecular screening.

Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1

J. Hakulinen, M. Sleeman, T. Sjögren, 2014, mAbs.

Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies.

T. Wilkinson, D. Schofield, R. Dodd, 2020, Methods.

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.

I. Chessell, Y. Shibata, A. Snijder, 2019, Pain.

Affinity Maturation Approaches for Antibody Lead Optimization

T. Wilkinson, T. Vaughan, D. Lowe, 2011 .

Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.

D. Hargreaves, R. Pauptit, Malcolm A. Anderson, 2011, Journal of molecular biology.

A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions

M. Grütter, L. Jermutus, M. Mccourt, 2008, Proceedings of the National Academy of Sciences.

Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges

M. Parmentier, J. Steyaert, J. Pin, 2017, mAbs.

Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids

S. Sridharan, T. Wilkinson, T. Vaughan, 2016, PloS one.

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2.

J. Breed, R. Minter, B. Popovic, 2017, Journal of molecular biology.

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1

T. Lundqvist, J. Huntington, L. Murray, 2019, Scientific Reports.

Spherical-supported membranes as platforms for screening against membrane protein targets

S. Baldwin, S. Rawson, S. Muench, 2018, Analytical biochemistry.

Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies

T. Wilkinson, D. Schofield, R. Dodd, 2018, BioDrugs.

Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics.

R. Faggioni, J. Campbell, S. Cruwys, 2011, Journal of molecular biology.

Screening Strategies for the Discovery of Ion Channel Monoclonal Antibodies

T. Wilkinson, Elizabeth England, J. Linley, 2018, Current protocols in pharmacology.

Engineering the expression of an anti-interleukin-13 antibody through rational design and mutagenesis

Suzanne J Gibson, T. Slidel, S. Gibson, 2017, Protein engineering, design & selection : PEDS.

Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines.

J. Carrell, M. Marelli, Herren Wu, 2018, Protein engineering, design & selection : PEDS.

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

E. Briend, Hongwei Guo, B. Wang, 2014, mAbs.

Use of the Site-Specific Retargeting Jump-In Platform Cell Line to Support Biologic Drug Discovery

Ling Huang, T. Wilkinson, N. Tigue, 2015, Journal of biomolecular screening.