L. Lad

发表

High-Throughput Kinetic Screening of Hybridomas to Identify High-Affinity Antibodies Using Bio-Layer Interferometry

N. Pagratis, L. Lad, Sheila Clancy, 2015, Journal of biomolecular screening.

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

J. R. Somoza, Melanie H. Wong, W. Tse, 2015, Biochemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & Medicinal Chemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & medicinal chemistry.

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

Iron: Heme Proteins, Peroxidases, Catalases & Catalase‐Peroxidases

T. Poulos, B. Bhaskar, L. Lad, 2006 .

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.

J. D. Elliott, Nicholas D. Adams, X. Qian, 2010, ACS medicinal chemistry letters.

Substrate binding and catalytic mechanism in ascorbate peroxidase: evidence for two ascorbate binding sites.

M. Mewies, L. Lad, E. Raven, 2002, Biochemistry.

The characterization of idelalisib binding to PI3Kδ 1 Structural, biochemical and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta*

J. R. Somoza, Melanie H. Wong, M. Mcgrath, 2015 .

Kinetic analysis of Mad2-Cdc20 formation: conformational changes in Mad2 are catalyzed by a C-Mad2-ligand complex.

K. Wood, S. Lichtsteiner, L. Lad, 2009, Biochemistry.

Regiospecificity Determinants of Human Heme Oxygenase

T. Poulos, L. Lad, P. D. de Montellano, 2005, Journal of Biological Chemistry.

Mechanism of inhibition of human KSP by ispinesib.

Latesh Lad, Robert A Copeland, K. Wood, 2008, Biochemistry.

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.

J. Chandrasekhar, M. Mcgrath, G. Phillips, 2017, Journal of medicinal chemistry.

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage.

P. Ortiz de Montellano, T. Poulos, L. Lad, 2005, Journal of inorganic biochemistry.

Crystal structures of the G139A, G139A–NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity

T. Poulos, L. Lad, P. O. D. Montellano, 2005, JBIC Journal of Biological Inorganic Chemistry.

Defining substrate specificity and catalytic mechanism in ascorbate peroxidase.

M. Mewies, P. Moody, L. Lad, 2004, Biochemical Society symposium.

Clinical targeting of HIV capsid protein with a long-acting small molecule

J. R. Somoza, W. Sundquist, Xiaohong Liu, 2020, Nature.

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Neysa Nevins, W. D. Cornwell, R. Annan, 2010, Proceedings of the National Academy of Sciences.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Neysa Nevins, R. Annan, D. Mcnulty, 2007, Nature chemical biology.

The role of Ala134 in controlling substrate binding and reactivity in ascorbate peroxidase.

K. Carr, P. Moody, L. Lad, 2017, Journal of inorganic biochemistry.

Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes*

T. Poulos, D. Alvarez, Liusheng Huang, 2004, Journal of Biological Chemistry.

Comparison of the Heme-free and -bound Crystal Structures of Human Heme Oxygenase-1*

D. J. Schuller, P. Ortiz de Montellano, T. Poulos, 2003, The Journal of Biological Chemistry.

Role of histidine 42 in ascorbate peroxidase. Kinetic analysis of the H42A and H42E variants.

Jaswir Basran, Nigel S Scrutton, Latesh Lad, 2002, European journal of biochemistry.

Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle

M. Morar, L. Lad, G. Magombedze, 2022, Scientific reports.

Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.

M. Gross, Melanie H. Wong, S. Wise, 2019, Biochemistry.

Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa.

T. Poulos, Huiying Li, A. Wilks, 2004, Biochemistry.

Synthesis of chiral half-sandwich rhodium oxazoline complexes and their use as asymmetric Diels–Alder catalysts

J. Fawcett, L. Lad, D. Russell, 1997 .

Synthesis of Chiral Half-Sandwich Rhodium Oxazoline Complexes and Their Use as Asymmetric Diels—Alder Catalysts.

J. Fawcett, L. Lad, D. Davies, 1998 .

Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications.

Latesh Lad, P. Ortiz de Montellano, T. Poulos, 2003, Journal of Molecular Biology.

Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro

M. Massari, G. Pedrazzi, P. Lampertico, 2023, Gut.

Crystal Structures of the NO- and CO-bound Heme Oxygenase from Neisseriae meningitidis

T. Poulos, Huiying Li, A. Wilks, 2003, Journal of Biological Chemistry.

Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1

T. Poulos, L. Lad, P. O. D. Montellano, 2005 .

Lipid-Sensing High-Throughput ApoA-I Assays

Xiaohong Liu, J. W. Chisholm, N. Pagratis, 2012, Journal of biomolecular screening.

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

J. R. Somoza, Melanie H. Wong, W. Tse, 2015, Biochemistry.

Regiospecificity Determinants of Human Heme Oxygenase

T. Poulos, L. Lad, P. D. de Montellano, 2005, Journal of Biological Chemistry.

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Neysa Nevins, W. D. Cornwell, R. Annan, 2010, Proceedings of the National Academy of Sciences.

Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ*

Latesh Lad, Mary E. McGrath, J. R. Somoza, 2015, The Journal of Biological Chemistry.

Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase (cid:2) *

J. R. Somoza, Giuseppe A. Papalia, L. Lad, 2020 .

N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor

R. Neve, R. Mackman, K. Babaoglu, 2019 .