J. Flarakos

发表

Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry.

G. V. Van Berkel, V. Kertész, M. Orcutt, 2017, Analytical chemistry.

Assessment of the absorption, metabolism and excretion of [14C]pasireotide in healthy volunteers using accelerator mass spectrometry

T. Lin, J. Flarakos, J. Mangold, 2013, Cancer Chemotherapy and Pharmacology.

Highly selective and sensitive LC-MS/MS quantification of a therapeutic protein in human serum using immunoaffinity capture enrichment.

J. Flarakos, Yunlin Fu, Wenkui Li, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

LC-MS/MS determination of a human mAb drug candidate in rat serum using an isotopically labeled universal mAb internal standard.

J. Flarakos, Yunlin Fu, Wenkui Li, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation, identification and impact assessment of abnormal internal standard response variability in regulated LC-MS bioanalysis.

F. Picard, J. Flarakos, Yunlin Fu, 2020, Bioanalysis.

Best Practices in LC‐MS Method Development and Validation for Dried Blood Spots

F. Tse, J. Flarakos, Jie Zhang, 2013 .

Quantitative analysis of factor P (Properdin) in monkey serum using immunoaffinity capturing in combination with LC-MS/MS.

F. Tse, J. Flarakos, C. Krantz, 2016, Bioanalysis.

Bioanalytical Challenges in Support of Complex Modalities of Antibody-Based Therapeutics

J. Glick, J. Flarakos, Liang Zhu, 2020, The AAPS Journal.

Development and validation of a LC-MS/MS method for the quantitative analysis of the adenosine A2a receptor antagonist NIR178 and its monohydroxy metabolite in human plasma: Application to clinical pharmacokinetics.

O. Heudi, F. K. Hurtado, F. Picard, 2020, Biomedical chromatography : BMC.

Application of tail vein serial microsampling for plasma or dried plasma spots (DPS) in toxicokinetic assessment in rats using acetaminophen as the model compound.

P. Devine, J. Flarakos, Katie Kubek, 2020, Biomedical chromatography : BMC.

Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and pediatric patients by liquid chromatography-mass spectrometry.

D. Svinarov, M. Aman, P. Vouros, 2004, Journal of chromatography. A.

LC‐MS Bioanalysis of Ester Prodrugs and Other Esterase Labile Molecules

J. Flarakos, Duxi Zhang, Yunlin Fu, 2013 .

Determination of tissue-specific ion suppression by liquid extraction surface analysis mass spectrometry.

J. Flarakos, James J Glick, Paul A Moench, 2016, Rapid communications in mass spectrometry : RCM.

Differential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma.

F. Tse, Yuan-qing Xia, J. Flarakos, 2016, Analytical chemistry.

Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

P. Jordaan, Priya Chandra, J. Flarakos, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.

K. Mansfield, S. Hintermann, Adam Bentley, 2016, Analytical chemistry.

Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections.

G. V. Van Berkel, V. Kertész, J. Flarakos, 2014, Bioanalysis.

A semi-automated LC-MS/MS method for the determination of LCI699, a steroid 11β-hydroxylase inhibitor, in human plasma.

F. Tse, S. Rebello, J. Flarakos, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study.

F. Tse, J. Flarakos, Wenkui Li, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of plasma microsampling for dried plasma spots (DPS) in quantitative LC-MS/MS bioanalysis using ritonavir as a model compound.

F. Tse, J. Flarakos, Wenkui Li, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

High-throughput solution-based medicinal library screening against human serum albumin.

Jimmy Flarakos, Paul Vouros, K. Morand, 2005, Analytical chemistry.

Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography-tandem mass spectrometry.

J. Flarakos, Yunlin Fu, Wenkui Li, 2018, Biomedical chromatography : BMC.

Mass balance, excretion and metabolism of [14C] ASA404 in cancer patients in a phase I trial

M. McKeage, P. Fong, H. Schran, 2012, Cancer Chemotherapy and Pharmacology.

An industry perspective on tiered approach to the investigation of metabolites in drug development.

J. Flarakos, J. Mangold, Wenkui Li, 2014, Bioanalysis.

Resea R ch aR ticle Mini Focus issue: tie R ed app R oach to bioanalysis

J. Flarakos, Wenkui Li, S. Huskey, 2014 .

Bioavailability of valsartan oral dosage forms

A. Mendonza, S. Neelakantham, G. Sunkara, 2014, Clinical pharmacology in drug development.

Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline

Imad Hanna, J. Flarakos, J. Mangold, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats

J. Flarakos, J. Mangold, Wenyu Hu, 2016, Antimicrobial Agents and Chemotherapy.

BEAMS Lab: Novel approaches to finding a balance between throughput and sensitivity

Chandra Prakash, Jimmy Flarakos, Christopher L. Shaffer, 2007 .

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent

J. Flarakos, Jin Zhang, J. Mangold, 2016, Drug Metabolism and Disposition.

Metabolomic analysis and signatures in motor neuron disease

S. Rozen, R. Kaddurah-Daouk, M. Beal, 2005, Metabolomics.

Integration of continuous-flow accelerator mass spectrometry with chromatography and mass-selective detection.

S. Tannenbaum, P. Skipper, J. Flarakos, 2008, Analytical chemistry.

Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma.

Steven R Tannenbaum, Jimmy Flarakos, L. Tremaine, 2007, Drug metabolism letters.

Abstract 751: Mass balance, excretion and metabolism of [14C] ASA404 in cancer patients in a phase I trial

M. McKeage, P. Fong, H. Schran, 2012 .

Roles of LC‐MS Bioanalysis in Drug Discovery, Development, and Therapeutic Drug Monitoring

F. Tse, S. Unger, J. Flarakos, 2013 .

1 ROLES OF LC-MS BIOANALYSIS IN DRUG DISCOVERY , DEVELOPMENT , AND THERAPEUTIC DRUG MONITORING

F. Tse, S. Unger, J. Flarakos, 2013 .

Dixon's Q-test and Student's t-test to assess analog internal standard response in nonregulated LC-MS/MS bioanalysis.

J. Glick, J. Flarakos, P. Hatsis, 2020, Bioanalysis.