E. Rial

发表

The coordinate regulation of multiple terminal oxidases by the Pseudomonas putida ANR global regulator.

F. Rojo, H. Williams, A. Ugidos, 2008, Environmental microbiology.

Fractionation of rat liver mitochondrial components after short treatments with Triton X-100.

F. Goñi, J. Gurtubay, J. Otamendi, 1982, The International journal of biochemistry.

The distinct bioenergetic properties of the human UCP1.

E. Rial, Leonor Rodríguez-Sánchez, 2017, Biochimie.

A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier.

D. Georgellis, L. A. Luévano‐Martínez, D. Araiza-Olivera, 2012, The Biochemical journal.

Lipotoxicity, fatty acid uncoupling and mitochondrial carrier function.

E. Rial, Leonor Rodríguez-Sánchez, E. Gallardo-Vara, 2010, Biochimica et biophysica acta.

Yeast cultures with UCP1 uncoupling activity as a heating device.

A. Moya, J. Urchueguía, J. Peretó, 2009, New biotechnology.

Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1.

E. Rial, P. Zaragoza, M. González-Barroso, 2006, Biochimica et biophysica acta.

Evolutionarily distinct residues in the uncoupling protein UCP1 are essential for its characteristic basal proton conductance.

R. Zardoya, E. Rial, P. Zaragoza, 2006, Journal of molecular biology.

Brown-adipose-tissue mitochondria: the regulation of the 32000-Mr uncoupling protein by fatty acids and purine nucleotides.

D. Nicholls, E. Rial, A. Poustie, 1983, European journal of biochemistry.

Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.

M. Redondo-Horcajo, C. Lourenço, J. Enríquez, 2010, Cardiovascular research.

Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells.

R. Brandes, J. Enríquez, F. Rodríguez-Pascual, 2014, Biochimica et biophysica acta.

The Uncoupling Protein UCP1 Does Not Increase the Proton Conductance of the Inner Mitochondrial Membrane by Functioning as a Fatty Acid Anion Transporter*

D. Nicholls, C. Fleury, E. Rial, 1998, The Journal of Biological Chemistry.

A History of the First Uncoupling Protein, UCP1

D. Nicholls, E. Rial, 1999, Journal of bioenergetics and biomembranes.

The characterization and energetic potential of brown adipose tissue in man.

D. Hopwood, D. Nicholls, R. Jung, 1985, Clinical science.

A novel regulatory mechanism for the brown-fat uncoupling protein?

D. Nicholls, E. Rial, 2016, Nature Structural &Molecular Biology.

Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2.

E. Rial, M. González-Barroso, Eduardo Rial, 2001, Biochimica et biophysica acta.

The uncoupling protein from brown adipose tissue mitochondria.

D. Nicholls, E. Rial, 1987, Revisiones sobre biologia celular : RBC.

The acute regulation of mitochondrial proton conductance in cells and mitochondria from the brown fat of cold-adapted and warm-adapted guinea pigs.

D. Nicholls, E. Rial, R. Locke, 1982, European journal of biochemistry.

Leptin administration to cold-acclimated rats reduces both food intake and brown adipose tissue thermogenesis

E. Rial, A. Ledesma, M. Abelenda, 2003 .

Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

B. Guillen-Guio, E. Rial, E. de Blas, 2014, PloS one.

2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways.

M. L. Mena, M. Gómez-Gómez, E. Rial, 2012, Biochemical pharmacology.

Capacitation promotes a shift in energy metabolism in murine sperm

Ester Sansegundo, M. Tourmente, E. Rial, 2022, bioRxiv.

Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria.

D. Nicholls, E. Rial, I. Scott, 1982, European journal of biochemistry.

The mechanism for the ATP-induced uncoupling of respiration in mitochondria of the yeast Saccharomyces cerevisiae.

S. Prieto, E. Rial, F. Bouillaud, 1995, The Biochemical journal.

Activation by ATP of a proton-conducting pathway in yeast mitochondria.

S. Prieto, E. Rial, D. Ricquier, 1992, European journal of biochemistry.

Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity

V. Cachofeiro, E. Rial, M. Nieto, 2018, Disease Models & Mechanisms.

Cysteine residues are not essential for uncoupling protein function.

B. Miroux, I. Arechaga, S. Prieto, 1993, The Biochemical journal.

The mitochondrial uncoupling protein from guinea-pig brown adipose tissue. Synchronous increase in structural and functional parameters during cold-adaptation.

D. Nicholls, E. Rial, 1984, The Biochemical journal.

The regulation of the proton conductance of brown fat mitochondria

D. Nicholls, E. Rial, 1983, FEBS letters.

Differences in ATP Generation Via Glycolysis and Oxidative Phosphorylation and Relationships with Sperm Motility in Mouse Species*

E. Roldan, M. Tourmente, E. Rial, 2015, The Journal of Biological Chemistry.

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2

D. Sanchís, C. Fleury, E. Rial, 1999, The EMBO journal.

L. Casteilla, I. Arechaga, E. Rial, 1994, The EMBO journal.

The nature and regulation of the ATP-induced anion permeability in Saccharomyces cerevisiae mitochondria.

S. Prieto, E. Rial, F. Bouillaud, 1996, Archives of biochemistry and biophysics.

The landscape of mitochondrial small non-coding RNAs in the PGCs of male mice, spermatogonia, gametes and in zygotes

J. Del Mazo, E. Larriba, E. Rial, 2018, BMC Genomics.

Permeabilization of the mitochondrial inner membrane by short cecropin-A-melittin hybrid peptides.

D. Andreu, S. Prieto, L. Rivas, 1994, European journal of biochemistry.

The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans.

C. Nombela, R. Alonso-Monge, J. Pla, 2009, Microbiology.

The Hog 1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans

C. Nombela, R. Alonso-Monge, J. Pla, 2009 .

The structure and function of the brown fat uncoupling protein UCP1: current status

C. Fleury, E. Rial, F. Bouillaud, 1998, BioFactors.

Activation of the uncoupling protein by fatty acids is modulated by mutations in the C-terminal region of the protein.

I. Arechaga, C. Fleury, E. Rial, 1996, European journal of biochemistry.

Glucagon Regulation of Oxidative Phosphorylation Requires an Increase in Matrix Adenine Nucleotide Content through Ca2+ Activation of the Mitochondrial ATP-Mg/Pi Carrier SCaMC-3*

Margarita Fernández, J. Satrústegui, E. Rial, 2013, The Journal of Biological Chemistry.

Effect of hydrophobic sulphydryl reagents on the uncoupling protein and inner-membrane anion channel of brown-adipose-tissue mitochondria.

D. Nicholls, I. Arechaga, E. Rial, 1989, European journal of biochemistry.

Catabolic Pathways Polarization through Modulation of Glucose Reshaping of Human Macrophage

J. Joven, Á. Corbí, E. Rial, 2015 .

Physiological state of submitochondrial particles and their susceptibility to Triton X-100

F. Goñi, J. Valpuesta, J. Gurtubay, 1984, Experientia.

Role of UCP2 in the Energy Metabolism of the Cancer Cell Line A549

E. Rial, J. Segalés, M. Martín-Ruíz, 2022, bioRxiv.

Effect of the nonionic detergent Triton X-100 on mitochondrial succinate-oxidizing enzymes.

F. Goñi, J. Valpuesta, J. Gurtubay, 1984, Archives of biochemistry and biophysics.

UCP2 Deficiency Helps to Restrict the Pathogenesis of Experimental Cutaneous and Visceral Leishmaniosis in Mice

G. Domínguez-Bernal, E. Rial, J. Carrión, 2013, PLoS neglected tropical diseases.

Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism.

E. Rial, A. Ledesma, Jesús Jiménez-Jiménez, 2004, Biochimica et biophysica acta.

ReviewBrown fat mitochondria

D. Nicholls, E. Rial, 1984 .

The antiandrogenic vinclozolin induces differentiation delay of germ cells and changes in energy metabolism in 3D cultures of fetal ovaries

J. Del Mazo, M. Brieño-Enríquez, E. Rial, 2020, Scientific Reports.

A Ca2+-Dependent Mechanism Boosting Glycolysis and OXPHOS by Activating Aralar-Malate-Aspartate Shuttle, upon Neuronal Stimulation

J. Molgó, J. Satrústegui, E. Rial, 2022, The Journal of Neuroscience.

Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore.

C. Fleury, E. Rial, F. Bouillaud, 1997, Biochemistry.

Zebrafish Models for Human Acute Organophosphorus Poisoning

Demetrio Raldúa, Francesc Padrós, Natàlia Garcia-Reyero, 2015, Scientific Reports.

Expression and regulation of mitochondrial uncoupling protein 1 from brown adipose tissue in Leishmania major promastigotes.

L. Rivas, E. Rial, L. Ruiz-Pérez, 1998, Molecular and biochemical parasitology.

POSTCOPULATORY SEXUAL SELECTION INCREASES ATP CONTENT IN RODENT SPERMATOZOA

M. Gomendio, M. Rowe, M. Tourmente, 2013, Evolution; international journal of organic evolution.

Development of chromanes as novel inhibitors of the uncoupling proteins.

M. Redondo-Horcajo, A. Viso, E. Rial, 2011, Chemistry & biology.

Chemical modification of the brown-fat-mitochondrial uncoupling protein with tetranitromethane and N-ethylmaleimide. A cysteine residue is implicated in the nucleotide regulation of anion permeability.

D. Nicholls, E. Rial, 1986, European journal of biochemistry.

Chemical modification of the brown fat mitochondrial uncoupling protein with tetranitromethane

D. Nicholls, E. Rial, 1986, FEBS letters.

Modeling the Transmembrane Arrangement of the Uncoupling Protein UCP1 and Topological Considerations of the Nucleotide-Binding Site

I. Arechaga, E. Rial, A. Ledesma, 2002, Journal of bioenergetics and biomembranes.

The Mitochondrial Uncoupling Protein UCP1: A Gated Pore

I. Arechaga, E. Rial, A. Ledesma, 2001, IUBMB life.

Molecular Studies of the Mitochondrial Uncoupling Protein

B. Miroux, L. Casteilla, S. Klaus, 1994 .

The uncoupling protein from brown adipose tissue mitochondria. The environment of the tryptophan residues as revealed by quenching of the intrinsic fluorescence.

F. Goñi, A. Viguera, E. Rial, 1992, European journal of biochemistry.

Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation.

M. Redondo-Horcajo, E. Rial, Leonor Rodríguez-Sánchez, 2012, Biochimica et biophysica acta.

Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats

M. Lorenzo, R. Hernández, T. Teruel, 2005, Diabetologia.

Identification of the mitochondrial carrier that provides Yarrowia lipolytica with a fatty acid-induced and nucleotide-sensitive uncoupling protein-like activity.

S. Uribe-Carvajal, E. Rial, E. Moyano, 2010, Biochimica et biophysica acta.

Infrared spectroscopic studies of detergent-solubilized uncoupling protein from brown-adipose-tissue mitochondria.

F. Goñi, A. Muga, J. Valpuesta, 1990, European journal of biochemistry.

Reproductive senescence impairs the energy metabolism of human luteinized granulosa cells.

G. Cecchino, E. Rial, J. García-Velasco, 2021, Reproductive biomedicine online.

REPRODUCTIVE SENESCENCE IMPAIRS THE ENERGY METABOLISM OF HUMAN GRANULOSA CELLS

G. Cecchino, E. Rial, J. García-Velasco, 2021, bioRxiv.

Pten positively regulates brown adipose function, energy expenditure, and longevity.

A. Efeyan, Á. Valverde, F. Mulero, 2012, Cell metabolism.

c‐Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor‐β‐Induced Epithelial–Mesenchymal Transition and Regulates Cell Phenotypic Switch

S. Thorgeirsson, W. Mikulits, V. Factor, 2019, Stem cells.

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

B. Viollet, Xiaoling Li, M. Foretz, 2015, PLoS pathogens.

Performance of Rodent Spermatozoa Over Time Is Enhanced by Increased ATP Concentrations: The Role of Sperm Competition1

E. Roldan, M. Tourmente, María Varea-Sánchez, 2015, Biology of reproduction.

The mitochondrial uncoupling proteins

E. Rial, A. Ledesma, Mario García de Lacoba, 2002, Genome Biology.

Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1–13C)-Glucose

S. Cerdán, Laura Contreras, J. Satrústegui, 2016, Neurochemical Research.

Bioenergetic changes in response to sperm capacitation and two-way metabolic compensation in a new murine model

Ester Sansegundo, M. Tourmente, E. Rial, 2022, Cellular and Molecular Life Sciences.

Mitochondrial respiratory states and rates

Sharma, Whiejong M. Han, Duchen, 2019 .

“A feed-forward Ca2+-dependent mechanism boosting glycolysis and OXPHOS by activating Aralar-malate-aspartate shuttle, upon neuronal stimulation”

J. Molgó, J. Satrústegui, E. Rial, 2021, bioRxiv.

Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways

S. Fernández-Arroyo, J. Joven, Á. Corbí, 2015, The Journal of Immunology.

Oxidative stress, thermogenesis and evolution of uncoupling proteins

R. Zardoya, E. Rial, 2009, Journal of biology.

Activation by retinoids of the uncoupling protein UCP1.

R. Chandraratna, E. Rial, P. Zaragoza, 2004, Biochimica et biophysica acta.

Structural and functional study of a conserved region in the uncoupling protein UCP1: the three matrix loops are involved in the control of transport.

A. Romero, M. Jiménez, C. Fleury, 1999, Journal of molecular biology.

Regulation of Death Induction and Chemosensitizing Action of 3-Bromopyruvate in Myeloid Leukemia Cells: Energy Depletion, Oxidative Stress, and Protein Kinase Activity Modulation

E. Rial, R. Brea, E. de Blas, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels.

E. Rial, M. González-Barroso, A. Anedda, 2008, The Journal of endocrinology.

Isolation and bioenergetic characterization of mitochondria from Pichia pastoris

S. Lepper, E. Rial, P. Zaragoza, 2006, Yeast.

Uncoupling Protein 2 ( UCP 2 ) Function in the Brain as Revealed by the Cerebral Metabolism of ( 1 – 13 C )-Glucose

S. Cerdán, Laura Contreras, J. Satrústegui, 2016 .

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

M. Malumbres, P. Boya, María Salazar-Roa, 2015, Nature Cell Biology.

Carrier and Channel Properties of the Mitochondrial Transporters: Physiology and Pathology?

E. Rial, A. Ledesma, 2004, Toxicology mechanisms and methods.

The uncoupling protein from brown-adipose-tissue mitochondria. Chymotrypsin-induced structural and functional modifications.

D. Nicholls, E. Rial, M. Fernández, 1987, European journal of biochemistry.