S. Mesiano

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Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.

M. Chance, B. Jacobsson, L. Muglia, 2016, Human molecular genetics.

Myometrial Transcriptional Signatures of Human Parturition

M. Chance, Mehmet Koyutürk, R. Romero, 2019, Front. Genet..

Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor.

D M Shames, T. Helbich, M. Wendland, 2000, American journal of obstetrics and gynecology.

Estrogen receptor (ER) expression and function in the pregnant human myometrium: estradiol via ERα activates ERK1/2 signaling in term myometrium.

H. Tan, S. Mesiano, T. Zakar, 2012, The Journal of endocrinology.

Estrogen Receptor Expression and Function in the Pregnant Human

H. Tan, S. Mesiano, Toni N Welsh, 2011 .

Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling

S. Lye, O. Shynlova, S. Mesiano, 2017, Scientific Reports.

Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor†,‡

M. Chance, Sean Maxwell, Douglas K. Brubaker, 2018, Biology of Reproduction.

Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism

J. Sugimoto, H. Bernstein, S. Mesiano, 2012, The Journal of Immunology.

Novel thoughts on preterm birth research proceedings of the 13th annual preterm birth international collaborative (PREBIC) meeting.

Scott M. Williams, Siobhan M. Dolan, R. Menon, 2017, Seminars in perinatology.

Developmental and functional biology of the primate fetal adrenal cortex.

S. Mesiano, R. Jaffe, 1997, Endocrine reviews.

The Comparative Physiology of Parturition in Mammals: Hormones and Parturition in Mammals

G. Shaw, M. Renfree, Roger Smith, 2011 .

Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells.

R. Smith, E. Chan, S. Mesiano, 1998, The Journal of clinical endocrinology and metabolism.

Roles of estrogen and progesterone in human parturition.

S. Mesiano, 2001, Frontiers of hormone research.

Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland.

S. Mellon, S. Mesiano, R. Jaffe, 1993, The Journal of clinical endocrinology and metabolism.

Hypophysectomy of the fetal lamb leads to a fall in the plasma concentration of insulin-like growth factor I (IGF-I), but not IGF-II.

I. R. Young, S. Mesiano, C. Browne, 1989, Endocrinology.

In an in‐vitro model using human fetal membranes, 17‐&agr; hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening

Robert M. Moore, J. Mansour, C. Lockwood, 2017, American journal of obstetrics and gynecology.

Progesterone inhibits in vitro fetal membrane

Robert M. Moore, J. Mansour, C. Lockwood, 2015 .

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.

N. Ferrara, S. Mesiano, R. Jaffe, 1994, The Journal of clinical endocrinology and metabolism.

Agonist-Dependent Downregulation of Progesterone Receptors in Human Cervical Stromal Fibroblasts

D. Kniss, C. Lockwood, S. Mesiano, 2016, Reproductive Sciences.

Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term

S. Drăghici, L. Lipovich, R. Romero, 2010, Journal of perinatal medicine.

Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches.

G. Peters, S. Mesiano, F. van den Akker, 2019, Placenta.

The Endocrine Control of Human Pregnancy

S. Mesiano, K. Kuo, D. Hackney, 2018 .

Rationale for current and future progestin-based therapies to prevent preterm birth.

S. Mesiano, Megan Weatherborn, 2018, Best practice & research. Clinical obstetrics & gynaecology.

Progesterone inhibits in vitro fetal membrane weakening.

Robert M. Moore, J. Mansour, C. Lockwood, 2015, American journal of obstetrics and gynecology.

PROGESTERONE AND THE CONTROL OF HUMAN PREGNANCY AND PARTURITION

S. Mesiano, Toni N Welsh, Toni N. Welsh, 2009 .

Superovulation with gonadotropin-releasing hormone agonist or chorionic gonadotropin for ovulation trigger differentially affects leukocyte populations in the peri-implantation mouse uterus.

R. Redline, S. Mesiano, V. Libby, 2021, F&S science.

Proteoglycans in Leiomyoma and Normal Myometrium

James H. Liu, A. Caplan, H. Tan, 2016, Reproductive Sciences.

Amnion epithelial cell–derived exosomes induce inflammatory changes in uterine cells

Robert N. Taylor, G. Saade, R. Menon, 2018, American journal of obstetrics and gynecology.

Fetal-Maternal Endocrinology and Parturition

L. Muglia, S. Mesiano, H. Jones, 2021 .

Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

L. Muglia, A. Rokas, Ge Zhang, 2020, eLife.

Effect of Inflammatory Signals on Progesterone Production at the Maternal-Fetal Interface

S. Mesiano, D. Kumar, R. Moore, 2021, Medical Research Archives.

A Standardized Template for Clinical Studies in Preterm Birth

Scott M. Williams, C. Pennell, S. Lye, 2012, Reproductive Sciences.

Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling

R. Menon, S. Yellon, S. Mesiano, 2019, Reproductive Sciences.

Insulin-like growth factors augment steroid production and expression of steroidogenic enzymes in human fetal adrenal cortical cells: implications for adrenal androgen regulation.

J. Y. Lee, S. Mesiano, R. Jaffe, 1997, The Journal of clinical endocrinology and metabolism.

Preterm birth update in Australasia: A report of the international symposium of Preterm Birth International Collaborative-Australasia branch

R. Menon, C. Qiao, S. Mesiano, 2022, Frontiers in Pediatrics.

U0126, an Inhibitor of MEK1/2, Increases Tumor Necrosis Factor-α-Induced Apoptosis, but not Interleukin-6 Induced Apoptosis in C-28/I2 Human Chondrocytes.

S. Mesiano, C. Malemud, Yelenna Skomorovska-Prokvolit, 2015, Journal of autoimmune disorders.

Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells.

J. Y. Lee, S. Mesiano, R. Jaffe, 1999, The Journal of clinical endocrinology and metabolism.

Molecular evidence of functional progesterone withdrawal in human myometrium

S. Lye, O. Shynlova, E. Matysiak-Zablocki, 2016, Nature Communications.

Detection of endogenous epidermal growth factor-like activity in the developing chick embryo.

S. Mesiano, C. Browne, G. Thorburn, 1985, Developmental biology.

Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium.

K. Kwek, E. Chan, Roger Smith, 2002, The Journal of clinical endocrinology and metabolism.

Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism

J. Sugimoto, H. Bernstein, S. Mesiano, 2012, The Journal of Immunology.

This information is current as Immunomodulatory Mechanism Cytokine Production : A Novel Innate Magnesium Decreases Inflammatory

C. Ramírez, J. Sugimoto, S. Mesiano, 2012 .

Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition.

A. Caplan, S. Mesiano, W. Hurd, 2012, The Biochemical journal.

Myometrial progesterone responsiveness.

S. Mesiano, 2007, Seminars in reproductive medicine.

Tofacitinib Inhibits STAT Phosphorylation and Matrix Metalloproteinase-3, -9 and -13 Production by C28/I2 Human Juvenile Chondrocytes

S. Mesiano, C. Malemud, Rachel A. Wilson, 2022, Open access rheumatology : research and reviews.

Placental Production of Peptide, Steroid, and Lipid Hormones

J. Strauss, S. Mesiano, 2020 .

Progesterone signaling in myometrial cells: role in human pregnancy and parturition

S. Mesiano, Rachel A. Wilson, 2020 .

Progesterone, the maternal immune system and the onset of parturition in the mouse†

Mark R. Johnson, D. MacIntyre, S. Waddington, 2018, Biology of Reproduction.

Inflammatory Stimuli Increase Progesterone Receptor-A Stability and Transrepressive Activity in Myometrial Cells

G. Peters, H. Tan, S. Mesiano, 2016, Endocrinology.

Serum adipocytokines and adipose weight gain: a pilot study in adolescent females initiating depot medroxyprogesterone acetate.

E. Hade, S. Mesiano, A. Bonny, 2015, Contraception.

Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling.

J. Y. Lee, S. Mesiano, R. Jaffe, 1999, The Journal of clinical endocrinology and metabolism.

The regulation and role of fetal adrenal development in human pregnancy.

S. Mesiano, R. Smith, R. Jaffe, 1998, Endocrine research.

Interaction of insulin-like growth factor-II and estradiol directs steroidogenesis in the human fetal adrenal toward dehydroepiandrosterone sulfate production.

S. Mesiano, R. Jaffe, 1993, The Journal of clinical endocrinology and metabolism.

Growth hormone and testosterone can independently stimulate the growth of hypophysectomized prepubertal lambs without any alteration in circulating concentrations of insulin-like growth factors.

I. R. Young, R. Hintz, S. Mesiano, 1989, The Journal of endocrinology.

Pathophysiology of preterm labor with intact membranes.

A. Talati, S. Mesiano, D. Hackney, 2017, Seminars in perinatology.

The selective progesterone receptor modulator, Promegestone, delays term parturition and prevents systemic inflammation-mediated preterm birth in mice.

S. Lye, O. Shynlova, S. Mesiano, 2021, American journal of obstetrics and gynecology.

Progesterone and cAMP synergize to inhibit responsiveness of myometrial cells to pro-inflammatory/pro-labor stimuli

Junye Wang, H. Tan, S. Mesiano, 2019, Molecular and Cellular Endocrinology.

Human Parturition Involves Phosphorylation of Progesterone Receptor-A at Serine-345 in Myometrial Cells.

G. Peters, Junye Wang, H. Tan, 2016, Endocrinology.

Functional maturation of the primate fetal adrenal in vivo. II. Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3 beta-hydroxysteroid dehydrogenase/isomerase.

J. Mason, S. Mesiano, C. Voytek, 1996, Endocrinology.

Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells

S. Way, L. Xin, S. Mesiano, 2022, iScience.

Intracrine Control of Estrogen Action in Human Gestational Tissues at Parturition

K. Kwek, Roger Smith, G. Yeo, 2004, The Journal of the Society for Gynecologic Investigation: JSGI.

Hormone trajectories leading to human birth

Roger Smith, S. Mesiano, S. McGrath, 2002, Regulatory Peptides.

Corticotropin-releasing hormone stimulates P450 17alpha-hydroxylase/17,20-lyase in human fetal adrenal cells via protein kinase C.

S. Mesiano, R. Jaffe, A. Chakravorty, 1999, The Journal of clinical endocrinology and metabolism.

Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17, 20-lyase, and 3 beta-hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of functional zonation.

S. Mesiano, R. Jaffe, C. Coulter, 1993, The Journal of clinical endocrinology and metabolism.

Role of growth factors in the developmental regulation of the human fetal adrenal cortex

S. Mesiano, R. Jaffe, 1997, Steroids.

Functional maturation of the primate fetal adrenal in vivo: I. Role of insulin-like growth factors (IGFs), IGF-I receptor, and IGF binding proteins in growth regulation.

V. Han, S. Mesiano, C. Voytek, 1996, Endocrinology.

Effect of hypophysectomy with and without thyroxine replacement on growth and circulating concentrations of insulin-like growth factors I and II in the fetal lamb.

R. Baxter, I. R. Young, R. Hintz, 1987, Endocrinology.

Control of Progesterone Receptor-A Transrepressive Activity in Myometrial Cells: Implications for the Control of Human Parturition

G. Peters, Junye Wang, H. Tan, 2018, Reproductive Sciences.

Blastocyst Vitrification and Trophectoderm Biopsy Cumulatively Alter Embryonic Gene Expression in a Mouse Model

M. Cameron, S. Mesiano, B. Richardson, 2021, Reproductive Sciences.

Superovulation with human chorionic gonadotropin (hCG) trigger and gonadotropin releasing hormone agonist (GnRHa) trigger differentially alter essential angiogenic factors in the endometrium in a mouse ART model†

G. Peters, Junye Wang, S. Mesiano, 2020, Biology of Reproduction.

Separation of Bioactive Prostaglandins and their Metabolites by Reversed-Phase Thin-Layer Chromatography

P. Zarzycki, S. Mesiano, T. Zakar, 2003, JPC – Journal of Planar Chromatography – Modern TLC.

Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition.

Sam Mesiano, Robert N. Taylor, Ramkumar Menon, 2016, Human reproduction update.

Endocrinology of Human Pregnancy and Fetal-Placental Neuroendocrine Development

S. Mesiano, 2019, Yen and Jaffe's Reproductive Endocrinology.

Chapter 12 – The Endocrinology of Human Pregnancy and Fetal-Placental Neuroendocrine Development

S. Mesiano, 2014 .

Basic fibroblast growth factor expression is regulated by corticotropin in the human fetal adrenal: a model for adrenal growth regulation.

D. Gospodarowicz, S. Mellon, S. Mesiano, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Chapter 42 – Parturition

S. Mesiano, 2015 .

Growth Hormone and Fetal Growth: Historical Perspective

I. R. Young, S. Mesiano, C. Browne, 1988 .

Hormone ontogeny in the ovine fetus. XXVI. A sex difference in the effect of castration on the hypothalamic-pituitary gonadotropin unit in the ovine fetus.

S. Mesiano, M. Grumbach, S. Kaplan, 1991, Endocrinology.

Progesterone Receptors in the Human Pregnancy Uterus

E. Norwitz, S. Mesiano, Yuguang Wang, 2010, Reproductive Sciences.

Nuclear Progesterone Receptor Expression in the Human Fetal Membranes and Decidua at Term Before and After Labor

B. Mercer, S. Mesiano, T. Zakar, 2009, Reproductive Sciences.

Role of nuclear progesterone receptor isoforms in uterine pathophysiology.

S. Mesiano, M. Bedaiwy, B. Patel, 2015, Human reproduction update.

Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization.

N. Ferrara, S. Mesiano, R. Jaffe, 1998, The American journal of pathology.

Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A.

B. Mercer, H. Tan, S. Mesiano, 2007, The Journal of clinical endocrinology and metabolism.

Steroid hormone control of myometrial contractility and parturition.

S. Mesiano, Toni N Welsh, Toni N. Welsh, 2007, Seminars in cell & developmental biology.

Localization and regulation of corticotropin receptor expression in the midgestation human fetal adrenal cortex: implications for in utero homeostasis.

J. Y. Lee, V. Fujimoto, S. Mesiano, 1996, The Journal of clinical endocrinology and metabolism.

Vascular endothelial growth factor localization in human ovary and fallopian tubes: possible role in reproductive function and ovarian cyst formation.

C. Zaloudek, S. Mesiano, R. Jaffe, 1996, The Journal of clinical endocrinology and metabolism.

Matrix Metalloproteinase-9 Production by Immortalized Human Chondrocyte Lines

S. Mesiano, C. Malemud, Yelenna Skomorovska-Prokvolit, 2016, Journal of clinical & cellular immunology.

Expression of progesterone receptor isoforms -a and -b in adenomyosis

James H. Liu, T. Falcone, S. Mesiano, 2013 .

Programmed Fetal Membrane Senescence and Exosome-Mediated Signaling: A Mechanism Associated With Timing of Human Parturition

Robert N. Taylor, R. Menon, S. Mesiano, 2017, Front. Endocrinol..

A dynamical systems model of progesterone receptor interactions with inflammation in human parturition

Mark R. Chance, Alethea Barbaro, Sam Mesiano, 2016, BMC Systems Biology.

Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal.

S. Mesiano, T. Zakar, B. Sanborn, 2004, The Journal of clinical endocrinology and metabolism.

Progesterone – Historical perspective

S. Mesiano, 2022, The Journal of Steroid Biochemistry and Molecular Biology.

Natural Selection Has Differentiated the Progesterone Receptor among Human Populations.

G. Shaw, M. Snyder, D. Stevenson, 2018, American journal of human genetics.

Prostaglandin H2 synthase‐1 and ‐2 expression in guinea pig gestational tissues during late pregnancy and parturition

W. Walters, S. Mesiano, C. Mitchell, 2005, The Journal of physiology.

Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells.

N. Ferrara, S. Mesiano, R. Jaffe, 1998, The Journal of clinical endocrinology and metabolism.

Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells.

S. Mesiano, J. Rabinovici, R. Jaffe, 1992, The Journal of clinical investigation.

A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging

D. Kalman, Anusmita Sahoo, S. Mesiano, 2023, Science advances.

Activin expression by cultured human retinal pigment epithelial cells.

G. Jaffe, G. Lui, S. Mesiano, 1994, Investigative ophthalmology & visual science.

Labour classified by cervical dilatation & fetal membrane rupture demonstrates differential impact on RNA-seq data for human myometrium tissues

Qiye Li, Mark R. Johnson, S. Mesiano, 2021, PloS one.

Inflammatory Aetiology of Human Myometrial Activation Tested Using Directed Graphs

Roger Smith, Andrew M. Bisits, Sam Mesiano, 2005, PLoS Comput. Biol..

Pro‐inflammatory signals induce 20α‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal

S. Lye, O. Shynlova, S. Mesiano, 2021, Journal of cellular and molecular medicine.

Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

Günter P. Wagner, Hannah C. Zierden, J. Hanes, 2021, Science Translational Medicine.

Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition.

H. Tan, S. Mesiano, N. Rote, 2012, The Journal of clinical endocrinology and metabolism.

Tofacitinib Inhibits STAT Phosphorylation and Matrix Metalloproteinase-3, -9 and -13 Production by C28/I2 Human Juvenile Chondrocytes

S. Mesiano, C. Malemud, Rachel A. Wilson, 2022 .

Blockade of recombinant human IL-6 by tocilizumab suppresses matrix metalloproteinase-9 production in the C28/I2 immortalized human chondrocyte cell line.

S. Mesiano, C. Malemud, Evan C. Meszaros, 2015, Integrative molecular medicine.

Effects of Metformin on Cellular Proliferation and Steroid Hormone Receptors in Patient-Derived, Low-Grade Endometrial Cancer Cell Lines

A. Difeo, S. Mesiano, G. Collins, 2018, Reproductive Sciences.

Steroid Hormone Levels in Recipient Amniotic Fluid in Twin–Twin Transfusion Syndrome and Their Association with Preterm Delivery

E. Thom, R. Papanna, L. Mann, 2019, American Journal of Perinatology.

Interplay of transcriptional signaling by progesterone, cyclic AMP, and inflammation in myometrial cells: implications for the control of human parturition.

M. Chance, Mehmet Koyutürk, Junye Wang, 2019, Molecular human reproduction.

Myometrial Progesterone responsiveness and the Control of Human Parturition

S. Mesiano, 2004, The Journal of the Society for Gynecologic Investigation: JSGI.

Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants

James H. Liu, T. Falcone, S. Mesiano, 2015, Reproductive Sciences.

How does progesterone relax the uterus in pregnancy?

S. Mesiano, T. Zakar, 2011, The New England journal of medicine.

Failure of acid-ethanol treatment to prevent interference by binding proteins in radioligand assays for the insulin-like growth factors.

I. R. Young, S. Mesiano, C. Browne, 1988, The Journal of endocrinology.

Advancing human health in the decade ahead: pregnancy as a key window for discovery

N. Price, R. Freathy, D. Wildman, 2020, American Journal of Obstetrics and Gynecology.

Progesterone withdrawal and parturition

S. Mesiano, 2022, The Journal of Steroid Biochemistry and Molecular Biology.

Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract

Linden J. Gearing, P. Hertzog, S. Mesiano, 2022, JCI insight.

Progesterone Receptor or Cytoskeletal Protein?

D. MacIntyre, S. Mesiano, G. Madsen, 2007, Reproductive Sciences.

Corrigendum: Myometrial Transcriptional Signatures of Human Parturition

M. Chance, Mehmet Koyutürk, R. Romero, 2019, Frontiers in Genetics.

15-Hydroxyprostaglandin Dehydrogenase Expression and Localization in Guinea Pig Gestational Tissues During Late Pregnancy and Parturition

J. Paul, S. Mesiano, T. Zakar, 2012, Reproductive Sciences.

Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling

S. Lye, O. Shynlova, S. Mesiano, 2017, Scientific Reports.

Superovulation with different trigger agents differentially alter essential angiogenic factors in the endometrium in a mouse model.

G. Peters, Junye Wang, S. Mesiano, 2020, Biology of reproduction.

CHAPTER 11 – The Endocrinology of Human Pregnancy and Fetoplacental Neuroendocrine Development

S. Mesiano, 2009 .

Chapter 42 – Parturition

S. Mesiano, 2015 .

Reply to “Diversity is essential for good science and Reproductive science is no different: A response to the recent formulation of the Burroughs Welcome Fund Pregnancy Think-Tank”

R. Freathy, A. Mahadevan-Jansen, L. Muglia, 2020 .

Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism

J. Sugimoto, H. Bernstein, S. Mesiano, 2012, The Journal of Immunology.

Effects of Metformin on Cellular Proliferation and Steroid Hormone Receptors in Patient-Derived, Low-Grade Endometrial Cancer Cell Lines

A. Difeo, S. Mesiano, G. Collins, 2018, Reproductive Sciences.

The regulation of human parturition

E. Chan, V. Clifton, S. Mesiano, 2005 .

Human IFNε: Spaciotemporal expression, hormone regulation and innate immunity in the female reproductive tract

Linden J. Gearing, P. Hertzog, S. Mesiano, 2018, bioRxiv.