S. Espitia

发表

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Brian M. Smith, F. Menzaghi, P. Dosa, 2008, Journal of medicinal chemistry.

1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites

J. Hawkinson, S. Espitia, J. Keana, 1996 .

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists.

J. Hawkinson, S. Espitia, E. R. Whittemore, 2001, Bioorganic & medicinal chemistry.

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

Brian M. Smith, F. Menzaghi, Michael Martin, 2008, Journal of Pharmacology and Experimental Therapeutics.

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.

S. Espitia, L. Wise, E. R. Whittemore, 2001, Journal of medicinal chemistry.

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

J. Hawkinson, S. Espitia, S. Cai, 1997, Journal of medicinal chemistry.

5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.

J. Hawkinson, S. Espitia, S. Cai, 1997, Journal of medicinal chemistry.

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.

J. Hawkinson, S. Espitia, E. R. Whittemore, 2003, Bioorganic & medicinal chemistry.

Opioid activity profiles indicate similarities between the nociceptin/orphanin FQ and opioid receptors.

J. Hawkinson, S. Espitia, J E Hawkinson, 2000, European journal of pharmacology.

Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding.

J. Hawkinson, S. Espitia, 1997, European journal of pharmacology.

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

J. Hawkinson, J. E. Huettner, S. Espitia, 1996, Journal of medicinal chemistry.

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

J. Hawkinson, S. Espitia, L. Wise, 1999, Journal of medicinal chemistry.

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Brian M. Smith, F. Menzaghi, P. Dosa, 2008, Journal of medicinal chemistry.