A. Grottick

发表

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Brian M. Smith, F. Menzaghi, P. Dosa, 2008, Journal of medicinal chemistry.

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

F. Du, C. Sage, Albert S. Ren, 2012, Bioorganic & medicinal chemistry letters.

A new family of H3 receptor antagonists based on the natural product Conessine.

V. Santora, J. Knudsen, C. Sage, 2008, Bioorganic & medicinal chemistry letters.

Novel H3 receptor antagonists with improved pharmacokinetic profiles.

V. Santora, John Covel, Albert S. Ren, 2008, Bioorganic & medicinal chemistry letters.

Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia

R. Luthringer, C. Anderson, Michael E. Morgan, 2010, Journal of Pharmacology and Experimental Therapeutics.

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays.

C. Sage, Albert S. Ren, Michael E. Morgan, 2019, Bioorganic & medicinal chemistry letters.

Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor.

Albert S. Ren, K. Whelan, A. Grottick, 2021, Bioorganic & medicinal chemistry letters.

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor.

C. Sage, Albert S. Ren, K. Whelan, 2016, Bioorganic & medicinal chemistry letters.

Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat

C. Sage, Michael E. Morgan, K. Whelan, 2014, Psychopharmacology.

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

C. Sage, B. Fioravanti, Albert S. Ren, 2011, Bioorganic & medicinal chemistry letters.

Diet‐Induced Models of Obesity (DIO) in Rodents

K. Whelan, A. Grottick, D. Behan, 2012, Current protocols in neuroscience.

Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.

K. Whelan, A. Grottick, Konrad Feichtinger, 2012, Bioorganic & medicinal chemistry letters.

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain.

I. Gaidarov, A. Grottick, Robert M. Jones, 2017, ACS medicinal chemistry letters.

&agr;2‐Adrenoceptor antagonism is neither sufficient nor necessary for the distinctive action of atypical neuroleptics on intracranial self‐stimulation in the rat

A. Grottick, L. J. Herberg, A. Montgomery, 2003, Behavioural pharmacology.

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

Brian M. Smith, F. Menzaghi, Michael Martin, 2008, Journal of Pharmacology and Experimental Therapeutics.

Editorial: Dopaminergic Alterations in Schizophrenia

C. Tamminga, P. Llorca, M. Tricklebank, 2021, Frontiers in Neuroscience.

Rapid Recovery of Self-Stimulation from Depression Produced by the Atypical Neuroleptic Risperidone is not Prevented by 5-HT2 Receptor Stimulation

A. Grottick, L. J. Herberg, A. Montgomery, 1997, Pharmacology Biochemistry and Behavior.

Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia.

P. Dosa, K. Whelan, A. Grottick, 2010, Journal of medicinal chemistry.

Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.

William Thomsen, B. Fioravanti, Albert S. Ren, 2008, Journal of medicinal chemistry.

Nitric oxide synthesis, epileptic seizures and kindling

A. Grottick, L. J. Herberg, I. C. Rose, 1995, Psychopharmacology.

Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists

Shigeru Okuyama, William Thomsen, S. Chaki, 2005, Journal of Pharmacology and Experimental Therapeutics.

Neurotransmission- and cellular stress-related gene expression associated with prepulse inhibition in mice.

Y. Hakak, J. McDonald, A. Grottick, 2005, Brain research. Molecular brain research.

Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D1 but not nicotinic agonist

A. Grottick, S. Barnes, Chris Carroll, 2021, Psychopharmacology.

Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D1 but not nicotinic agonist

A. Grottick, S. Barnes, Chris Carroll, 2021, Psychopharmacology.

Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands

G. Higgins, A. Grottick, M. Haman, 2003, Neuropsychopharmacology.

Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants

G. Higgins, A. Grottick, 2002, Psychopharmacology.

The potential use of selective 5-HT2C agonists in treating obesity

Brian M. Smith, A. Grottick, W. Thomsen, 2006, Expert opinion on investigational drugs.

Phencyclidine Exacerbates Attentional Deficits in a Neurodevelopmental Rat Model of Schizophrenia

G. Higgins, J. Moreau, A. Grottick, 2003, Neuropsychopharmacology.

Neurotransmitter System Interactions Revealed by Drug-Induced Changes in Motivated Behavior

A. Grottick, A. Montgomery, 1999, Pharmacology Biochemistry and Behavior.

Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat

C. Sage, Michael E. Morgan, K. Whelan, 2014, Psychopharmacology.

Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

P. Fletcher, G. Higgins, A. Grottick, 2002, Neuropsychopharmacology.

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

P. Fletcher, G. Higgins, A. Grottick, 2000, The Journal of pharmacology and experimental therapeutics.

Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

G. Higgins, A. Grottick, P. Malherbe, 2000, The Journal of pharmacology and experimental therapeutics.

Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.

S. Chaki, M. Casper, D. Sengupta, 2009, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Brian M. Smith, F. Menzaghi, P. Dosa, 2008, Journal of medicinal chemistry.