J. Ke

发表

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Garth J. Williams, Graham M. West, K. Diederichs, 2014, Nature.

Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion

N. Rosen, G. V. Vande Woude, H. Xu, 2011, Proceedings of the National Academy of Sciences.

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

L. Miller, H. Xu, B. Williams, 2017, Genes & development.

Distinct oligomeric structures of the YoeB–YefM complex provide insights into the conditional cooperativity of type II toxin–antitoxin system

Baolin Sun, L. Niu, J. Ke, 2020, Nucleic acids research.

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

P. Griffin, H. Xu, K. Melcher, 2017, The Journal of Biological Chemistry.

Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.

B. Caleb, N. Larsen, Tuong-Vi Nguyen, 2020, ACS medicinal chemistry letters.

Structural assembly of the nucleic-acid-binding Thp3–Csn12–Sem1 complex functioning in mRNA splicing

Jiong Hong, L. Niu, J. Ke, 2022, Nucleic acids research.

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1

Lifu Wang, C. Link, Sanjeev Kumar, 2020, Oncotarget.

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

C. Dann, H. Xu, L. Matherly, 2016, Journal of medicinal chemistry.

c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells.

Roger G. Chui, A. K. Karuppannan, J. Ke, 2005, Blood.

Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway.

J. Bolin, S. Seah, L. Eltis, 2006, Biochemistry.

Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response

Karl J. Dykema, E. Hudson, K. Dykema, 2011, Science Signaling.

Structural basis for molecular recognition of folic acid by folate receptors

Chen Chen, H. Xu, X. E. Zhou, 2013, Nature.

Structural basis for RNA recognition by a dimeric PPR-protein complex

Chen Chen, Jian‐Kang Zhu, H. Xu, 2013, Nature Structural &Molecular Biology.

Structure of a PLS-class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition

Jian‐Kang Zhu, H. Xu, X. E. Zhou, 2013, The Journal of Biological Chemistry.

Lipid modification in Wnt structure and function

H. Xu, B. Williams, J. Ke, 2013, Current opinion in lipidology.

A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex

Yonghong Wang, Jiayang Li, H. Xu, 2017, Science Advances.

Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth

L. Lekakis, V. Sindhava, J. Ke, 2009, Molecular Cancer.

Structural insights into alternative splicing-mediated desensitization of jasmonate signaling

G. Howe, S. He, H. Xu, 2017, Proceedings of the National Academy of Sciences.

The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity

M. Warmuth, Peter G. Smith, P. Zhu, 2019, The Journal of Biological Chemistry.

Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.

Shouyong Peng, P. Zhu, Lihua Yu, 2020, Cell chemical biology.

LRP5 and LRP6 in development and disease

H. Xu, B. Williams, J. Ke, 2013, Trends in Endocrinology & Metabolism.

Structural basis of JAZ repression of MYC transcription factors in jasmonate signaling

P. Griffin, S. He, H. Xu, 2015, Nature.

Structural basis of AMPK regulation by adenine nucleotides and glycogen

H. Xu, Donghai Wu, X. E. Zhou, 2014, Cell Research.

Structural and Functional Study of d-Glucuronyl C5-epimerase*

H. Xu, Yi Jiang, K. Melcher, 2015, The Journal of Biological Chemistry.

The Role of MAPKs in B Cell Receptor-induced Down-regulation of Egr-1 in Immature B Lymphoma Cells*

A. Simmons, J. Monroe, D. Wiest, 2006, Journal of Biological Chemistry.

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Jiayang Li, H. Xu, K. Melcher, 2015, Science Advances.

Characterization of a C—C Bond Hydrolase from Sphingomonas wittichii RW1 with Novel Specificities towards Polychlorinated Biphenyl Metabolites

S. Seah, C. Whiting, L. Eltis, 2007, Journal of bacteriology.

Structural basis of the Norrin-Frizzled 4 interaction

H. Xu, Wenqing Xu, G. Shen, 2015, Cell Research.

Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex

Chen Chen, L. Miller, H. Xu, 2013, Genes & development.

Modulation of β-Catenin Signaling by Glucagon Receptor Activation

L. Miller, H. Xu, B. Williams, 2012, PloS one.

Structure and function of Norrin in assembly and activation of a Frizzled 4 – Lrp 5 / 6 complex

L. Miller, H. Xu, B. Williams, 2013 .

Structural basis of AMPK regulation by adenine nucleotides and glycogen

H. Xu, Donghai Wu, X. E. Zhou, 2015, Cell Research.

The C-terminus of ubiquitin plays a critical role in deamidase Lpg2148 recognition.

M. Teng, L. Niu, Xiaowu Li, 2018, Biochemical and biophysical research communications.