R. Donnelly

H. Dickensheets, R. Donnelly, S. Freeman, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Interleukin-10 upregulates tumor necrosis factor receptor type-II (p75) gene expression in endotoxin-stimulated human monocytes.

H. Dickensheets, R. Donnelly, S. Freeman, 1997, Blood.

Inhibition of IL‐4‐inducible gene expression in human monocytes by type I and type II interferons

H. Dickensheets, R. Donnelly, 1999, Journal of leukocyte biology.

Gene Expression in Endotoxin-Stimulated Human Monocytes Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75)

H. Dickensheets, R. Donnelly, Michael F. Smith, 2010 .

Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.

N. Ilyushina, Z. Ye, R. Donnelly, 2017, Virus research.

Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes.

R. Donnelly, S. Freeman, M. Hayes, 1995, Journal of immunology.

Differential responses of human monocytes and macrophages to IL‐4 and IL‐13

P. Hart, J. Finlay-Jones, H. Dickensheets, 1999, Journal of leukocyte biology.

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

N. Ilyushina, William L. Ince, Eric Donaldson, 2019, Virology Journal.

General Nature of the STAT3-Activated Anti-Inflammatory Response1

W. Alexander, D. Hilton, A. Smith, 2006, The Journal of Immunology.

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

David K. Finlay, Kevin T. Liou, C. Biron, 2014, The Journal of Immunology.

mTORC 1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function

David K. Finlay, Kevin T. Liou, C. Biron, 2014 .

A novel role for IL-22R1 as a driver of inflammation.

W. Wilson, S. Pittaluga, S. Anderson, 2011, Blood.

Involvement of the IL-2 receptor gamma-chain (gammac) in the control by IL-4 of human monocyte and macrophage proinflammatory mediator production.

P. Hart, J. Finlay-Jones, H. Dickensheets, 1998, Journal of immunology.

Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

S. Pestka, S. Kotenko, G. Gallagher, 2000, Genes and Immunity.

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain

A. Murphy, G. Yancopoulos, T. Wynn, 2008, Nature Immunology.

Involvement of the IL-2 Receptor γ-Chain (γc) in the Control by IL-4 of Human Monocyte and Macrophage Proinflammatory Mediator Production

P. Hart, J. Finlay-Jones, H. Dickensheets, 1998, The Journal of Immunology.

IL-4 Engagement of the Type I IL-4 Receptor Complex Enhances Mouse Eosinophil Migration to Eotaxin-1 In Vitro

A. Keegan, S. Constant, R. Donnelly, 2012, PloS one.

IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability.

R. Donnelly, S. Freeman, M. Hayes, 1995, Cytokine.

Tuning sensitivity to IL-4 and IL-13: diff erential expression of IL-4R (cid:2) , IL-13R (cid:2) 1, and (cid:3) c regulates relative cytokine sensitivity

M. Meier-Schellersheim, W. Paul, H. Yamane, 2008 .

Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts.

E. Remmers, L. Crofford, M. Fenton, 1993, Journal of immunology.

The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4

S. Gordon, L. Helming, H. Dickensheets, 2015, Journal of Innate Immunity.

Regulation of the dephosphorylation of Stat 6 : Participation of Y 713 in the IL-4 R α , the tyrosine phosphatase SHP-1 , and the proteasome

A. Keegan, E. Hanson, H. Dickensheets, 2002 .

Anti-Inflammatory Response General Nature of the STAT3-Activated

D. Hilton, M. Myers, D. Kaushal, 2013 .

Diminished responses to IL‐13 by human monocytes differentiated in vitro: role of the IL‐13Rα1 chain and STAT6

P. Hart, J. Finlay-Jones, H. Dickensheets, 1999, European journal of immunology.

Inhibition of interleukin-2-induced T-cell proliferation by sera from patients with the acquired immune deficiency syndrome

G. Galbraith, R. Donnelly, K. Tsang, 2004, Journal of Clinical Immunology.

Kinetic analysis of the immunopotentiating effect of the hypoxanthine analogue, NPT-15392, on the interleukin-2 production potential of human lymphocytes.

L. Bishop, R. Donnelly, K. Tsang, 1986, International journal of immunopharmacology.

Howard A. Young: Always Willing to Lend a Helping Hand.

R. Donnelly, 2022, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Effect of isoprinosine on sialylation of interleukin-2.

P. Arnaud, R. Donnelly, K. Tsang, 1986, Immunology letters.

Pleiotropic Effects of Influenza H1, H3, and B Baloxavir-Resistant Substitutions on Replication, Sensitivity to Baloxavir, and Interferon Expression

R. Webby, N. Ilyushina, William L. Ince, 2022, Antimicrobial agents and chemotherapy.

IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4.

J. Kaufman, M. Fenton, R. Donnelly, 1991, Journal of immunology.

IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling

L. Prokunina-Olsson, O. Onabajo, Reed S Shabman, 2017, The Journal of Immunology.

Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus

J. Renauld, R. Rabin, M. Roederer, 2006, Journal of Virology.

Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model

N. Ilyushina, N. Mohan, Yukinori Endo, 2022, Journal of Virus Eradication.

Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

Xiaojing Ma, Fang Wei, Na Li, 2015, F1000Research.

Glucose, glycolysis and lymphocyte responses.

D. Finlay, R. Donnelly, 2015, Molecular immunology.

Dietary ascorbic acid and resistance to experimental renal candidiasis.

R. Donnelly, T. Rogers, K. O'Day, 1983, The Journal of nutrition.

Induction of immunosuppressive B-lymphocytes with components of Candida albicans.

C. Cuff, A. Cassone, T. Rogers, 1988, Advances in experimental medicine and biology.

IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

A. Lewis-Antes, S. Kotenko, G. Gallagher, 2003, Nature Immunology.

Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function

R. Donnelly, 2016 .

Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling

J. Ryan, P. Murray, H. Dickensheets, 2007, Genes and Immunity.

Comparison of the Antiviral Activity of Remdesivir, Chloroquine, and Interferon-β as Single or Dual Agents Against the Human Beta-Coronavirus OC43

N. Ilyushina, Brady T. Hickerson, R. Donnelly, 2023, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Aberrant regulation of IL-1 expression in macrophages from young autoimmune-prone mice.

J. Levine, M. Fenton, G. Frendl, 1990, Journal of immunology.

Inhibitors of prostaglandin synthesis block the induction of staphylococcal enterotoxin B-activated T-suppressor cells.

T. Rogers, R. Donnelly, 1983, Cellular immunology.

Interferon-lambda: a new addition to an old family.

S. Kotenko, R. Donnelly, 2010, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Distinct and overlapping genomic profiles and antiviral effects of Interferon‐λ and ‐α on HCV‐infected and noninfected hepatoma cells

R. Lempicki, Jun Yang, H. Masur, 2012, Journal of viral hepatitis.

Interferon-lambda and therapy for chronic hepatitis C virus infection.

T. O'Brien, H. Dickensheets, R. Donnelly, 2011, Trends in immunology.

Characterization of the mouse IFN-λ ligand-receptor system: IFN-λs exhibit antitumor activity against B16 melanoma

S. Smirnov, A. Lewis-Antes, S. Kotenko, 2006 .

Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma.

S. Smirnov, A. Lewis-Antes, S. Kotenko, 2006, Cancer research.

The expanded family of class II cytokines that share the IL‐10 receptor‐2 (IL‐10R2) chain

S. Kotenko, H. Dickensheets, R. Donnelly, 2004, Journal of leukocyte biology.

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.

A. Lewis-Antes, S. Kotenko, G. Gallagher, 2003, Nature immunology.

IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity.

S. Maher, D. Baker, R. Donnelly, 2008, Cancer biology & therapy.

Hurdles and Leaps for Protein Therapeutics

R. Donnelly, S. Kozlowski, B. Cherney, 2009, Annals of the New York Academy of Sciences.

Interferon‐lambda (IFN‐λ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes

B. Gao, H. Dickensheets, R. Donnelly, 2013, Journal of leukocyte biology.

Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses.

M. Boniotto, G. Gallagher, J. Eskdale, 2002, International immunopharmacology.

Identification, Cloning, and Characterization of a Novel Soluble Receptor That Binds IL-22 and Neutralizes Its Activity1 2

S. Pestka, S. Kotenko, L. Izotova, 2001, The Journal of Immunology.

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages

S. Vogel, H. Dickensheets, R. Donnelly, 2014, Journal of leukocyte biology.

Impact of Influenza A Virus Infection on the Proteomes of Human Bronchoepithelial Cells from Different Donors.

M. Eichelberger, N. Ilyushina, G. Fantoni, 2017, Journal of proteome research.

Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.

A. Miyajima, A. Yamada, Taketomo Kido, 2009, American journal of respiratory cell and molecular biology.

Differential Regulation of IL-12 and IL-10 Gene Expression in Macrophages by the Basic Leucine Zipper Transcription Factor c-Maf Fibrosarcoma1

P. L. Bergsagel, Xiaojing Ma, I. Ho, 2002, The Journal of Immunology.

Maf Fibrosarcoma Basic Leucine Zipper Transcription Factor Gene Expression in Macrophages by the Differential Regulation of IL-12 and IL-10

P. L. Bergsagel, Xiaojing Ma, I. Ho, 2002 .

Melanoma s Exhibit Antitumor Activity against B 16 λ System : IFN-Ligand-Receptor λ Characterization of the Mouse IFN-Updated

S. Smirnov, A. Lewis-Antes, S. Kotenko, 2006 .

Srebp-controlled glucose metabolism is essential for NK cell functional responses

David K. Finlay, P. Oefner, K. Dettmer, 2017, Nature Immunology.

Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro.

L. Bishop, G. Galbraith, R. Donnelly, 1985, The Journal of clinical investigation.

Immunosuppression induced by staphylococcal enterotoxin B.

T. Rogers, R. Donnelly, 1982, Cellular immunology.

Interleukin-10 inhibits interferon-gamma-induced intercellular adhesion molecule-1 gene transcription in human monocytes.

A. Finnegan, K. Roebuck, R. Donnelly, 1997, Blood.

IFN-gamma down-regulates Secretoglobin 3A1 gene expression.

R. Kamijo, Baohong Zhao, M. Takami, 2009, Biochemical and biophysical research communications.

Induction of Uteroglobin-Related Protein 2 (Ugrp2) Gene Expression by the Th2 Cytokines IL-4 and IL-131

F. DeMayo, A. Keegan, A. Yamada, 2005, The Journal of Immunology.

IFN-λ4: the paradoxical new member of the interferon lambda family.

L. Prokunina-Olsson, T. O'Brien, R. Donnelly, 2014, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

Barbara Rehermann, Raymond P Donnelly, Ruth M Pfeiffer, 2013, Nature Genetics.

Weak Induction of Interferon Expression by Severe Acute Respiratory Syndrome Coronavirus 2 Supports Clinical Trials of Interferon-λ to Treat Early Coronavirus Disease 2019

L. Prokunina-Olsson, T. O'Brien, David L. Thomas, 2020, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America.

Weak Induction of Interferon Expression by SARS-CoV-2 Supports Clinical Trials of Interferon Lambda to Treat Early COVID-19.

L. Prokunina-Olsson, T. O'Brien, David L. Thomas, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A variant upstream of IFNL 3 ( IL 28 B ) creating a novel interferon gene IFNL 4 is associated with impaired clearance of hepatitis C virus

L. Prokunina-Olsson, T. O'Brien, H. Bonkovsky, 2012 .

Cytokines 2022: 10th Annual Meeting of the International Cytokine & Interferon Society.

R. Donnelly, 2023, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells

A. Lewis-Antes, S. Kotenko, J. Dai, 2012, The Journal of Immunology.

Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

U. Schindler, H. Dickensheets, R. Donnelly, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.

H. Dickensheets, R. Donnelly, D. Finbloom, 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20 Receptor 1 and IL-10 Receptor 2 1

S. Smirnov, J. Renauld, A. Lewis-Antes, 2004, The Journal of Immunology.

Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

S. Pestka, S. Kotenko, L. Izotova, 2001, The Journal of Biological Chemistry.

Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

L. Prokunina-Olsson, T. O'Brien, H. Young, 2019, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

IFN-α and IFN-λ differ in their antiproliferative effects and duration of JAK/STAT signaling activity

S. Maher, D. Baker, R. Donnelly, 2008 .

Interleukin-26: an IL-10-related cytokine produced by Th17 cells.

H. Young, R. Savan, H. Dickensheets, 2010, Cytokine & growth factor reviews.

Adaptation of influenza B virus by serial passage in human airway epithelial cells.

N. Ilyushina, N. Bovin, R. Donnelly, 2020, Virology.

Leishmania donovani-Induced Expression of Suppressor of Cytokine Signaling 3 in Human Macrophages: a Novel Mechanism for Intracellular Parasite Suppression of Activation

S. Bertholet, H. Dickensheets, R. Donnelly, 2003, Infection and Immunity.

INTERFERON LAMBDA MEETING Meeting Overview: Interferon Lambda—Disease Impact and Therapeutic Potential

L. Prokunina-Olsson, T. O'Brien, H. Young, 2019 .

A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis.

T. Veenstra, S. Maher, Ming Zhou, 2007, Molecular biology of the cell.

Suppression of B-cell and T-cell responses by the prostaglandin-induced T-cell-derived suppressor (PITS). II. Resolution of multiple PITS beta factors.

J. Dehaven, T. Rogers, R. Donnelly, 1984, Cellular immunology.

IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes.

H. Dickensheets, R. Donnelly, 1997, Journal of immunology.

The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability

S. J. Schrieber, C. Agarabi, K. Brorson, 2020, Scientific Reports.

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

S. Beyaz, A. Tavakkoli, L. Dyck, 2018, Nature Immunology.

Generation and characterization of interferon-lambda 1-resistant H1N1 influenza A viruses

N. Ilyushina, N. Bovin, R. Donnelly, 2017, PloS one.

Title A variant upstream of IFNL 3 ( IL 28 B ) creating a novel interferon gene IFNL 4 is associated with impaired clearance of hepatitis C virus

L. Prokunina-Olsson, T. O'Brien, H. Bonkovsky, 2013 .

Amino Acids in Hemagglutinin Antigenic Site B Determine Antigenic and Receptor Binding Differences between A(H3N2)v and Ancestral Seasonal H3N2 Influenza Viruses

M. Eichelberger, N. Ilyushina, N. Bovin, 2016, Journal of Virology.

Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm

Luis V. Santana-Quintero, Konstantinos Karagiannis, Trent J Bosma, 2019, PloS one.

Suppression of B-cell and T-cell responses by the prostaglandin-induced T-cell-derived suppressors (PITS)--III. Production of PITS beta factors from T-cell hybridomas.

J. Dehaven, T. Rogers, R. Donnelly, 1985, International journal of immunopharmacology.

Specificity of anti-lymphocyte antibodies in sera from patients with AIDS-related complex (ARC) and healthy homosexuals.

R. Donnelly, R. Q. Warren, K. Tsang, 1988, Clinical and experimental immunology.

Neutralizes Its Activity IL-22 of a Novel Soluble Receptor That Binds Identification , Cloning , and Characterization

S. Pestka, S. Kotenko, L. Izotova, 2001 .

and Neutralizes Its Activity IL-22 of a Novel Soluble Receptor That Binds Identification, Cloning, and Characterization

S. Pestka, S. Kotenko, L. Izotova, 2001 .

Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility

N. Ilyushina, William L. Ince, Brady T. Hickerson, 2023, Journal of virology.

Lymphokine-independent induction of macrophage membrane IL-1 by autoreactive T cells recognizing either class I or class II MHC determinants.

M. Wasik, R. Donnelly, D. Beller, 1988, Journal of immunology.

Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations

B. Aryal, D. Verthelyi, Melissa A. Pegues, 2021, Pharmaceutical Research.

Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1.

J. Vivian, P. Hertzog, H. Dickensheets, 2023, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Interleukin-26: an IL-10-related cytokine produced by Th17 cells.

H. Young, R. Savan, H. Dickensheets, 2010, Cytokine & growth factor reviews.

IFN-λ4: the paradoxical new member of the interferon lambda family.

L. Prokunina-Olsson, T. O'Brien, R. Donnelly, 2014, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Amino Acids in Hemagglutinin Antigenic Site B Determine Antigenic and Receptor Binding Differences between A(H3N2)v and Ancestral Seasonal H3N2 Influenza Viruses

M. Eichelberger, N. Ilyushina, N. Bovin, 2016, Journal of Virology.

Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS).

G. Galbraith, R. Donnelly, K. Tsang, 1986, International journal of immunopharmacology.

In vitro anti-influenza A activity of interferon (IFN)-λ1 combined with IFN-β or oseltamivir carboxylate.

N. Ilyushina, R. Donnelly, 2014, Antiviral Research.

Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors.

N. Ilyushina, R. Donnelly, V. Lugovtsev, 2019, Antiviral research.

Defining Your Product Profile and Maintaining Control Over It , Part 1 Session One of the WCBP CMC Strategy Forum , 19 – 20 July 2004

Heather Simmerman, R. Donnelly, Raymond P. Donnelly, 2005 .

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages

S. Vogel, H. Dickensheets, R. Donnelly, 2014, Journal of leukocyte biology.

Type III Interferons: The Interferon‐λ Family

S. Kotenko, R. Donnelly, 2006 .

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity

W. Paul, H. Yamane, H. Dickensheets, 2008, The Journal of experimental medicine.

Receptor 1 and IL-10 Receptor 2 Receptor Complex Composed of IL-20 Cutting Edge : IL-26 Signals through a Novel Kotenko

S. Smirnov, J. Renauld, Shubha Anantha, 2004 .