D. Fourmy

L. Daulhac, A. Kowalski-Chauvel, L. Pradayrol, 2002, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Direct binding of p 85 to sst 2 somatostatin receptor reveals a novel mechanism for inhibiting PI 3 K pathway

B. Monsarrat, L. Pradayrol, C. Bousquet, 2013 .

Identification of a region of the N-terminal of the human CCKA receptor essential for the high affinity interaction with agonist CCK.

N. Vaysse, C. Escrieut, D. Fourmy, 1995, Biochemical and biophysical research communications.

Gastrin mediated cholecystokinin-2 receptor activation induces loss of cell adhesion and scattering in epithelial MDCK cells

A. Kowalski-Chauvel, L. Pradayrol, C. Seva, 2002, Oncogene.

Mutation of Asn-391 within the Conserved NPXXY Motif of the Cholecystokinin B Receptor Abolishes Gq Protein Activation without Affecting Its Association with the Receptor*

A. Kowalski-Chauvel, L. Pradayrol, N. Vaysse, 2000, The Journal of Biological Chemistry.

The CCKB/gastrin receptor is coupled to the regulation of enzyme secretion, protein synthesis and p70 S6 kinase activity in acinar cells from ElasCCKB transgenic mice.

P. Guilloteau, D. Fourmy, M. Dufresne, 1999, European journal of biochemistry.

Cholecystokinin-2 receptor modulates cell adhesion through β1-integrin in human pancreatic cancer cells

C. Seva, C. Bertrand, G. Portolan, 2006, Oncogene.

Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen‐induced preneoplastic lesions formation

L. Pradayrol, C. Seva, C. Bierkamp, 2005, International journal of cancer.

Id3 modulates cellular localization of bHLH Ptf1‐p48 protein

A. Couvelard, D. Fourmy, M. Dufresne, 2011, International journal of cancer.

Somatostatin 28 interacts with CCK receptor in brain and pancreas

N. Vaysse, J. Estève, C. Susini, 1991, Neuropeptides.

Targeted nanoscale magnetic hyperthermia: challenges and potentials of peptide-based targeting.

D. Fourmy, J. Carrey, V. Gigoux, 2015, Nanomedicine.

Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields

L. Motte, Y. Lalatonne, A. Hillion, 2021, Nanoscale advances.

Biologically Active Recombinant Human Progastrin6–80Contains a Tightly Bound Calcium Ion*

A. Paterson, G. Baldwin, A. Shulkes, 2001, The Journal of Biological Chemistry.

Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas.

N. Tarasova, R. Gomis, N. Vaysse, 1999, Diabetes.

Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

Bernard Maigret, B. Maigret, L. Pradayrol, 2003, Trends in pharmacological sciences.

Photoaffinity labeling of rat pancreatic cholecystokinin type A receptor antagonist binding sites demonstrates the presence of a truncated cholecystokinin type A receptor.

N. Vaysse, C. Escrieut, D. Fourmy, 1994, Molecular pharmacology.

Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion.

N. Vaysse, C. Escrieut, D. Fourmy, 1998, Gastroenterology.

The third intracellular loop of the rat and mouse cholecystokinin-A receptors is responsible for different patterns of gene activation.

S. Silvente-Poirot, C. Escrieut, D. Fourmy, 2000, Molecular pharmacology.

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development

P. Valet, R. Jockers, P. Cordelier, 2022, International journal of molecular sciences.

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor

L. Pradayrol, L. Buscail, M. Poirot, 2003, Oncogene.

Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors.

J. Reubi, B. Waser, D. Fourmy, 2012, The Journal of clinical endocrinology and metabolism.

Receptors for cholecystokinin and gastrin peptides display specific binding properties and are structurally different in guinea-pig and dog pancreas.

L. Pradayrol, D. Fourmy, A. Ribet, 1987, European journal of biochemistry.

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

M. Martín-Martínez, B. Maigret, M. García-López, 2005, Journal of medicinal chemistry.

Secretin Receptors in Human Pancreatic Membranes

L. Pradayrol, N. Vaysse, P. de Neef, 1988, Pancreas.

Reduction of stress responses in honey bees by synthetic ligands targeting an allatostatin receptor

J. Devaud, F. Busqué, D. Fourmy, 2022, Scientific Reports.

Pharmacological and biochemical characterization of cholecystokinin/gastrin receptors in developing rat pancreas

N. Vaysse, L. Moroder, D. Fourmy, 1992 .

Purification of A-subtype pancreatic cholecystokinin receptor by immunoaffinity chromatography.

N. Vaysse, D. Fourmy, M. Dufresne, 1992, Biochimie.

Cholecystokinin 1 receptor modulates the MEKK1‐induced c‐Jun trans‐activation: structural requirements of the receptor

Jean Martinez, C. Escrieut, D. Fourmy, 2006, British journal of pharmacology.

Cyclodextrin as Carrier of Peptide Hormones. Conformational and Biological Properties of β-Cyclodextrin/Gastrin Constructs

G. Müller, L. Moroder, C. Escrieut, 1998 .

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells.

A. Kowalski-Chauvel, C. Seva, A. Ferrand, 2006, World journal of gastroenterology.

125I-(Thr34, Nle37)- CCK31-39 a non oxidizable tracer for the characterization of CCK receptor on pancreatic acini and radio-immunoassay of C-terminal CCK peptides.

L. Pradayrol, N. Vaysse, C. Susini, 1984, Journal of immunoassay.

Gastrin‐induced DNA synthesis requires p38‐MAPK activation via PKC/Ca2+ and Src‐dependent mechanisms

L. Daulhac, A. Kowalski-Chauvel, L. Pradayrol, 2001, FEBS letters.

Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors.

G. Klebe, A. Schafferhans, G. Müller, 2000, Biopolymers.

Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist.

I. Tikhonova, C. Escrieut, D. Fourmy, 2013, Journal of the American Chemical Society.

5-(tryptophylamino)-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based cholecystokinin receptor antagonists: reversal of CCK1 receptor subtype selectivity toward CCK2 receptors.

M. García-López, D. Fourmy, M. Dufresne, 2004, Journal of medicinal chemistry.

New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R).

F. Gasparrini, A. Ciogli, E. Marco, 2011, Journal of medicinal chemistry.

Analysis of the interactions of sulfur‐containing amino acids in membrane proteins

Arnau Cordomí, Leonardo Pardo, Eduardo Mayol, 2016, Protein science : a publication of the Protein Society.

Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas

R. Gomis, C. Seva, L. Pénicaud, 2008, Regulatory Peptides.

Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas.

A. Kowalski-Chauvel, C. Seva, A. Ferrand, 2006, World journal of gastroenterology.

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/beta-tricalcium phosphate porous ceramics.

P. Swider, C. Rey, J. Salles, 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

Purification of Radio-Iodinated Cholecystokinin Peptides by Reverse Phase HPLC

L. Pradayrol, J. Estève, D. Fourmy, 1982 .

The peripheral cholecystokinin receptors.

N. Vaysse, S. Silvente-Poirot, D. Fourmy, 1993, European journal of biochemistry.

A new probe for affinity labelling pancreatic cholecystokinin receptor with minor modification of its structure.

N. Vaysse, L. Moroder, D. Fourmy, 1989, European journal of biochemistry.

Intrinsic photoaffinity labeling probes for cholecystokinin (CCK)-gastrin family receptors. D-Tyr-Gly-[Nle28,31,pNO2-Phe33)CCK-26-33).

L. Miller, D. Fourmy, H. Gaisano, 1988, The Journal of biological chemistry.

Study of the states and populations of the rat pancreatic cholecystokinin receptor using the full peptide antagonist JMV 179.

N. Vaysse, C. Escrieut, D. Fourmy, 1993, European journal of biochemistry.

Differential expression of A- and B-subtypes of cholecystokinin/gastrin receptors in the developing calf pancreas.

N. Vaysse, P. Guilloteau, D. Fourmy, 1993, Endocrinology.

Relationship of CCK/gastrin receptor binding to amylase release in dog pancreatic acini

L. Pradayrol, D. Fourmy, A. Ribet, 1984, Regulatory Peptides.

Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPER

D. Fourmy, V. Gigoux, 2013, Front. Endocrinol..

Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.

T. Wang, L. Pradayrol, C. Seva, 2005, Cancer research.

Real-Time Analysis of Magnetic Hyperthermia Experiments on Living Cells under a Confocal Microscope.

V. Connord, D. Fourmy, Daniel Fourmy, 2015, Small.

Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin.

A. Kowalski-Chauvel, L. Pradayrol, C. Seva, 2004, Experimental cell research.

mRNAs encoding CCKB but not CCKA receptors are expressed in human T lymphocytes and Jurkat lymphoblastoid cells.

P. Cuq, D. Fourmy, A. Gross, 1997, Life sciences.

Characterisation of gastrin receptors on a rat pancreatic acinar cell line (AR42J). A possible model for studying gastrin mediated cell growth and proliferation.

L. Pradayrol, C. Susini, D. Fourmy, 1987, Gut.

Interaction of [125I]-Tyr4-bombesin with specific receptors on normal human pancreatic membranes

L. Pradayrol, N. Vaysse, D. Fourmy, 1986, Regulatory Peptides.

Molecular cloning, developmental expression and pharmacological characterization of the CCKB/gastrin receptor in the calf pancreas.

H. Prats, N. Vaysse, P. Guilloteau, 1996, European journal of pharmacology.

Pharmacological and biochemical evidence for the simultaneous expression of CCKB/gastrin and CCKA receptors in the pig pancreas

E. Lhoste, L. Moroder, D. Fourmy, 1997, British journal of pharmacology.

Mapping of ligand binding sites of the cholecystokinin-B/gastrin receptor with lipo-gastrin peptides and molecular modeling.

G. Müller, H. Kessler, L. Moroder, 1997, Biopolymers.

Pancreatic secretory response to feeding in the calf: CCK-A receptors, but not CCK-B/gastrin receptors are involved.

P. Guilloteau, J. Chayvialle, I. Le Huërou-Luron, 2000, Canadian journal of physiology and pharmacology.

Immune recognition of affinity-labelled cholecystokinin receptor.

N. Vaysse, D. Fourmy, M. Dufresne, 1990, European journal of biochemistry.

Molecular properties of solubilized CCK receptor from guinea-pig pancreas

J. Darbon, L. Pradayrol, D. Fourmy, 1986, Regulatory Peptides.

Targeted Magnetic Intra‐Lysosomal Hyperthermia produces lysosomal reactive oxygen species and causes Caspase‐1 dependent cell death

D. Fourmy, B. Pipy, J. Carrey, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

Frédéric Lopez, Bernard Monsarrat, Julie Guillermet-Guibert, 2006, The EMBO journal.

A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway

S. Schulz, S. Najib, C. Bousquet, 2011, Molecular and Cellular Biology.

Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function.

Arnau Cordomí, J. C. Gómez-Tamayo, D. Fourmy, 2013, Trends in pharmacological sciences.

Molecular Mechanism Underlying Partial and Full Agonism Mediated by the Human Cholecystokinin-1 Receptor*

B. Maigret, L. Pradayrol, C. Seva, 2005, Journal of Biological Chemistry.

Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor.

Luis Moroder, Bernard Maigret, B. Maigret, 2005, Journal of medicinal chemistry.

Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients.

C. Dina, P. Froguel, S. Marchal-Victorion, 2002, Pharmacogenetics.

Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin

B. Maigret, E. Marco, I. Tikhonova, 2008, Regulatory Peptides.

Mechanism of Activation of a G Protein-coupled Receptor, the Human Cholecystokinin-2 Receptor*

E. Marco, I. Tikhonova, C. Escrieut, 2007, Journal of Biological Chemistry.

Partial Agonism, Neutral Antagonism, and Inverse Agonism at the Human Wild-Type and Constitutively Active Cholecystokinin-2 Receptors

Bernard Maigret, Irina G Tikhonova, B. Maigret, 2006, Molecular Pharmacology.

Evidence That Interspecies Polymorphism in the Human and Rat Cholecystokinin Receptor-2 Affects Structure of the Binding Site for the Endogenous Agonist Cholecystokinin*

Bernard Maigret, Irina G Tikhonova, B. Maigret, 2005, Journal of Biological Chemistry.

Biological Evaluation of JMV180 Cholecystokinin Analogs

M. Galas, D. Fourmy, M. Amblard, 1994, Annals of the New York Academy of Sciences.

Targeting a G-protein-coupled receptor overexpressed in endocrine tumors by magnetic nanoparticles to induce cell death.

B. Payre, V. Connord, D. Fourmy, 2014, ACS nano.

Cholecystokinin receptor parameters responsible for specific cellular signalling

Jean Martinez, D. Fourmy, D. Gagne, 1999 .

Gut hormone GPCRs: structure, function, drug discovery.

Arnau Cordomí, Irina G Tikhonova, I. Tikhonova, 2016, Current opinion in pharmacology.

An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.

A. Kowalski-Chauvel, C. Seva, F. Lopez, 2006, Biochimica et biophysica acta.

Evidence for a Direct and Functional Interaction between the Regulators of G Protein Signaling-2 and Phosphorylated C Terminus of Cholecystokinin-2 Receptor

J. Estève, L. Moroder, I. Tikhonova, 2009, Molecular Pharmacology.

Identification of Determinants of Glucose-Dependent Insulinotropic Polypeptide Receptor That Interact with N-Terminal Biologically Active Region of the Natural Ligand

T. Yaqub, I. Tikhonova, C. Escrieut, 2010, Molecular Pharmacology.

Probing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor.

Christophe Chipot, Jérôme Hénin, Bernard Maigret, 2006, Biophysical journal.

Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity

D. Fourmy, V. Gigoux, P. Clerc, 2018, Nanomaterials.

Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor.

A. Kowalski-Chauvel, L. Pradayrol, N. Vaysse, 2000, The Journal of biological chemistry.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

Gebhard F. X. Schertler, Christofer S. Tautermann, Philip C. Biggin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Regulation of Membrane Cholecystokinin-2 Receptor by Agonists Enables Classification of Partial Agonists as Biased Agonists*

P. Cordelier, C. Escrieut, D. Fourmy, 2010, The Journal of Biological Chemistry.

Bimodal regulation of pancreatic exocrine function in vitro by somatostatin-28.

L. Pradayrol, N. Vaysse, J. Estève, 1983, American Journal of Physiology.

Electric properties of photoaffinity-labelled pancreatic A-subtype cholecystokinin.

N. Vaysse, D. Fourmy, M. Dufresne, 1990, Journal of chromatography.

GIP receptor: Expression in neuroendocrine tumours, internalization, signalling from endosomes and structure-function relationship studies

J. Reubi, I. Tikhonova, D. Fourmy, 2019, Peptides.

Differential expression of the CCK‐A and CCK‐B/gastrin receptor genes in human cancers of the esophagus, stomach and colon

N. Vaysse, T. André, C. Escrieut, 1997, International journal of cancer.

Exogenous CCK and gastrin stimulate pancreatic exocrine secretion via CCK-A but also via CCK-B/gastrin receptors in the calf

D. Gully, L. Moroder, P. Guilloteau, 1999, Pflügers Archiv.

Use of RP-HPLC for Purification of a CCK-39 Radio-Ligand and of Its Photoactivable Derivative. Controls of Degradations

L. Pradayrol, D. Fourmy, A. Ribet, 1986 .

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors.

L. Pardo, C. Escrieut, D. Fourmy, 2015, Biochemical pharmacology.

Modeled structure of the whole regulator G-protein signaling-2.

I. Tikhonova, D. Fourmy, I. Langer, 2006, Biochemical and biophysical research communications.

Influence on cell death of high frequency motion of magnetic nanoparticles during magnetic hyperthermia experiments

D. Fourmy, Daniel Fourmy, Julian Carrey, 2016 .

The G‐protein‐coupled CCK2 receptor associates with phospholipase Cγ1

Luis Moroder, C. Seva, J. Estève, 2004 .

Purification of radioiodinated somatostatin-related peptides by reversed-phase high-performance liquid chromatography.

L. Pradayrol, J. Estève, D. Fourmy, 1984, Journal of chromatography.

[Internalized receptor for glucose-dependent insulinotropic peptide stimulates adenylyl cyclase on early endosomes].

D. Fourmy, V. Gigoux, Sadek Ismail, 2018, Biologie aujourd'hui.

A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway

S. Schulz, S. Najib, C. Bousquet, 2011, Molecular and Cellular Biology.

MINIREVIEW — COMPUTATIONAL ANALYSIS OF GPCRS Understanding Peptide Binding in Class A G Protein-Coupled Receptors

D. Fourmy, V. Gigoux, Irina G. Tikhonova, 2022 .

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

T. Ceska, P. Biggin, M. Bodkin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Gut hormone GPCRs: structure, function, drug discovery.

I. Tikhonova, D. Fourmy, A. Cordomí, 2016, Current opinion in pharmacology.

Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist

I. Tikhonova, D. Fourmy, V. Gigoux, 2015, Molecular and Cellular Endocrinology.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society)

P. Biggin, P. Sexton, C. Tautermann, 2018 .

Met-195 of the Cholecystokinin-A Receptor Interacts with the Sulfated Tyrosine of Cholecystokinin and Is Crucial for Receptor Transition to High Affinity State*

B. Maigret, N. Vaysse, S. Silvente-Poirot, 1998, The Journal of Biological Chemistry.

Biochemical characterization of a subtype pancreatic cholecystokinin receptor and of its agonist binding domain.

N. Vaysse, D. Fourmy, M. Dufresne, 1992, Journal of receptor research.

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.

Luis Moroder, Bernard Maigret, Céline Galés, 2003, Molecular pharmacology.

Linking Non-peptide Ligand Binding Mode to Activity at the Human Cholecystokinin-2 Receptor*

C. Escrieut, D. Fourmy, C. Low, 2008, Journal of Biological Chemistry.