R. Nishimura

T. Yoneda, M. Nomizu, R. Nishimura, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5

N. Fukui, A. Matsuda, R. Nishimura, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Dlx5 and Mef2 Regulate a Novel Runx2 Enhancer for Osteoblast‐Specific Expression

H. Komori, Wenguang Liu, T. Komori, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A novel role for TGF-[beta]1 in bone remodeling

R. Nishimura, 2009 .

C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis.

Paul J. Williams, T. Yoneda, G. Mundy, 2003, Cancer research.

Regulation of bone and cartilage development by network between BMP signalling and transcription factors.

T. Yoneda, R. Nishimura, T. Matsubara, 2012, Journal of biochemistry.

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

S. Takeda, U. Chung, Y. Omatsu, 2022, Nature Communications.

BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation*

H. Aburatani, T. Yoneda, A. Yamaguchi, 2008, Journal of Biological Chemistry.

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

Anne E Carpenter, Mark-Anthony Bray, Andrea Califano, 2014, Cell reports.

Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice

T. Abe, T. Komori, M. Kawaguchi, 2021, Communications Biology.

Transcriptional network systems in cartilage development and disease

R. Nishimura, K. Hata, T. Murakami, 2018, Histochemistry and Cell Biology.

Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice.

T. Yoneda, S. Hino, A. Wanaka, 2011, Bone.

Activation of NFAT Signal In Vivo Leads to Osteopenia Associated with Increased Osteoclastogenesis and Bone-Resorbing Activity1

T. Yoneda, S. Reddy, F. Ikeda, 2006, The Journal of Immunology.

Osteoclastogenesis and Bone-Resorbing Osteopenia Associated with Increased Activation of NFAT Signal In Vivo Leads to Hata

S. Reddy, F. Ikeda, R. Nishimura, 2006 .

The Effect of the Bisphosphonate Ibandronate on Breast Cancer Metastasis to Visceral Organs

Paul J. Williams, T. Yoneda, G. Mundy, 2002, Breast Cancer Research and Treatment.

Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice.

L. Bonewald, T. Yoneda, G. Mundy, 1991, The Journal of clinical investigation.

G protein subunit β1 is an important mediator of the late stage of endochondral ossification.

R. Nishimura, K. Hata, T. Murakami, 2020, Biochemical and biophysical research communications.

Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation

Masafumi Takahashi, Hiroaki Okae, S. Taniguchi, 2019, The Journal of Immunology.

Indian Hedgehog Signaling Regulates Transcription and Expression of Collagen Type X via Runx2/Smads Interactions*

B. Lanske, R. Nishimura, K. Amano, 2014, The Journal of Biological Chemistry.

Insulin‐like Growth Factor‐1 Rescues the Mutated FGF Receptor 3 (G380R) Expressing ATDC5 Cells From Apoptosis Through Phosphatidylinositol 3‐Kinase and MAPK

Hiroyuki Tanaka, Y. Seino, R. Nishimura, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Occurrence of hypercalcemia and leukocytosis with cachexia in a human squamous cell carcinoma of the maxilla in athymic nude mice: a novel experimental model of three concomitant paraneoplastic syndromes.

T. Yoneda, G. Mundy, R. Nishimura, 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

Sakae Tanaka, T. Yoneda, A. Rao, 2004 .

Combination of Interleukin‐6 and Soluble Interleukin‐6 Receptors Induces Differentiation and Activation of JAK‐STAT and MAP Kinase Pathways in MG‐63 Human Osteoblastic Cells

T. Yoneda, K. Moriyama, G. Mundy, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Activation and Function of NLRP3 Inflammasome in Bone and Joint-Related Diseases

R. Nishimura, K. Hata, T. Murakami, 2022, International journal of molecular sciences.

The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival

Y. Yamaguchi, T. Inubushi, F. Irie, 2021, bioRxiv.

Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis

R. Nishimura, K. Hata, T. Murakami, 2022, International journal of molecular sciences.

A CCAAT/Enhancer Binding Protein β Isoform, Liver-Enriched Inhibitory Protein, Regulates Commitment of Osteoblasts and Adipocytes

T. Yoneda, A. Yamaguchi, F. Ikeda, 2005, Molecular and Cellular Biology.

RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation.

S. Reddy, Kumaran Sundaram, R. Nishimura, 2007, Experimental cell research.

Role of interleukin-1 and inflammasomes in oral disease.

R. Nishimura, K. Hata, T. Murakami, 2020, Journal of oral biosciences.

Cbp recruitment of Csk into lipid rafts is critical to c‐Src kinase activity and bone resorption in osteoclasts

T. Yoneda, M. Okada, F. Ikeda, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cadherin-6 Mediates the Heterotypic Interactions between the Hemopoietic Osteoclast Cell Lineage and Stromal Cells in a Murine Model of Osteoclast Differentiation

T. Yoneda, S. Reddy, Di Chen, 1998, The Journal of cell biology.

Critical role of cortactin in actin ring formation and osteoclastic bone resorption

T. Yoneda, H. Yoshikawa, F. Ikeda, 2006, Journal of Bone and Mineral Metabolism.

Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases

R. Nishimura, K. Hata, T. Murakami, 2020, International journal of molecular sciences.

Retinoic acid regulates commitment of undifferentiated mesenchymal stem cells into osteoblasts and adipocytes

T. Yoneda, R. Nishimura, T. Matsubara, 2012, Journal of Bone and Mineral Metabolism.

JNK/c‐Jun Signaling Mediates an Anti‐Apoptotic Effect of RANKL in Osteoclasts

T. Yoneda, F. Ikeda, R. Nishimura, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Growth hormone stimulates ad ipogenesis of 3 T 3L 1 cells through activation of the Stat 5 A / 5 B-PPAR g pathway

M. Makishima, Y. Etani, K. Ozono, 2007 .

Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2

H. Kiyonari, T. Komori, R. Nishimura, 2021, Communications Biology.

Smoc1 and Smoc2 regulate bone formation as novel downstream molecules of Runx2

H. Kiyonari, T. Komori, R. Nishimura, 2021 .

Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes

H. Nakano, S. Toyosawa, K. Ebina, 2022, Science Signaling.

PTHrP Rescues ATDC5 Cells From Apoptosis Induced by FGF Receptor 3 Mutation

Hiroyuki Tanaka, Y. Seino, R. Nishimura, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription

M. Kogo, T. Yoneda, A. Matsuda, 2011, Molecular biology of the cell.

Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling.

S. Teitelbaum, F. Ross, L. Avioli, 2000, The Journal of biological chemistry.

Frequency of the hypercalcemia‐leukocytosis syndrome in oral malignancies

T. Yoneda, I. Kato, R. Nishimura, 1991, Cancer.

SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins

S. Takada, Y. Hasegawa, R. Nishimura, 2020, Molecular Reproduction and Development.

Transcriptional regulation of FRZB in chondrocytes by Osterix and Msx2

S. Murakami, R. Nishimura, K. Hata, 2022, Journal of Bone and Mineral Metabolism.

Transcriptional network systems in cartilage development and disease

R. Nishimura, K. Hata, T. Murakami, 2018, Histochemistry and Cell Biology.

Generation of orthotopically functional salivary gland from embryonic stem cells

O. Ohara, K. Mishima, I. Saito, 2018, Nature Communications.

Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.

M. Kogo, T. Yoneda, Yoko Takigawa, 2009, Molecular biology of the cell.

Reciprocal Roles of Msx2 in Regulation of Osteoblast and Adipocyte Differentiation*

H. Yatani, T. Yoneda, T. Komori, 2004, Journal of Biological Chemistry.

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

Hiroshi Sekiya, Shinichi Kondo, Atsushi Saito, 2009, Nature Cell Biology.

Carbonic anhydrase II regulates differentiation of ameloblasts via intracellular pH‐dependent JNK signaling pathway

Y. Miyamoto, R. Kamijo, Baohong Zhao, 2010, Journal of cellular physiology.

Sox9 regulates the luminal stem/progenitor cell properties of salivary glands.

M. Azuma, H. Akiyama, K. Mishima, 2019, Experimental cell research.

Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

C. Yoshida, H. Komori, T. Komori, 2018, Scientific Reports.

Signal transduction and transcriptional regulation during mesenchymal cell differentiation

T. Yoneda, M. Wada, F. Ikeda, 2008, Journal of Bone and Mineral Metabolism.

Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5.

T. Yoneda, S. Harris, F. Ikeda, 2002, Bone.

A Bone‐Seeking Clone Exhibits Different Biological Properties from the MDA‐MB‐231 Parental Human Breast Cancer Cells and a Brain‐Seeking Clone In Vivo and In Vitro

Paul J. Williams, T. Yoneda, R. Nishimura, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer

T. Yoneda, S. Toyosawa, R. Nishimura, 2022, Scientific Reports.

Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2

T. Yoneda, T. Komori, M. Nakanishi, 2021, Communications Biology.

Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2

T. Yoneda, T. Komori, S. Takenoshita, 2021, Communications biology.

Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification*

H. Kiyonari, T. Yoneda, H. Akiyama, 2012, The Journal of Biological Chemistry.

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.

Hiroyuki Tanaka, Y. Seino, T. Morishima, 2007, Bone.

Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma

T. Yoneda, Y. Yura, M. Nakanishi, 2015, Clinical & Experimental Metastasis.

Phenotypic Analysis of Dlx5 Overexpression in Post-natal Bone

R. Nishimura, T. Yoneda, Q. Tu, 2008, Journal of dental research.

Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.

T. Yoneda, A. Matsuda, F. Ikeda, 2008, The Journal of clinical investigation.

Transforming Growth Factor-β Up-regulates the β5Integrin Subunit Expression via Sp1 and Smad Signaling*

Su‐Li Cheng, S. Teitelbaum, F. Ross, 2000, The Journal of Biological Chemistry.

The transcription factor Foxc1 is necessary for Ihh–Gli2-regulated endochondral ossification

T. Yoneda, S. Iseki, T. Takano-Yamamoto, 2015, Nature Communications.

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

H. Kiyonari, O. Takeuchi, T. Kishimoto, 2013, Proceedings of the National Academy of Sciences.

Marked hypercalcemia and leukocytosis in a patient with squamous cell carcinoma of the tongue and metastases to rib and lumbar bone

T. Yoneda, I. Kato, R. Nishimura, 1987 .

A clinical course of the patient with epidermoid carcinoma of the maxilla associated with marked leukocytosis and an establishment of experimental model in nude mice

T. Yoneda, I. Kato, K. Fujimoto, 1988 .

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

Shinichi Kondo, Atsushi Saito, T. Yoneda, 2009, Nature Cell Biology.

[Studies on the pathophysiology of paraneoplastic syndromes: both cancer cells and host immune cells are responsible for the pathophysiology of leukocytosis associated with oral cancer].

R. Nishimura, 1990, [Osaka Daigaku shigaku zasshi] The journal of Osaka University Dental Society.

Three cases of oral squamous cancer associated with leukocytosis, hypercalcemia, or both.

I. Kato, R. Nishimura, M. Sakuda, 1989, Oral surgery, oral medicine, and oral pathology.

Squamous cell carcinoma of the mandible associated with humoral hypercalcemia of malignancy (HHM) and an establishment of experimental animal model in nude mice

T. Yoneda, R. Nishimura, M. Sakuda, 1988 .

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.

Sakae Tanaka, T. Yoneda, A. Rao, 2004, The Journal of clinical investigation.

Msx2 Stimulates Chondrocyte Maturation by Controlling Ihh Expression*

M. Kogo, T. Yoneda, M. Wada, 2008, Journal of Biological Chemistry.

PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.

Y. Okada, A. Yoshimura, Y. Toyama, 2009, Blood.

Bone and Cartilage Biology

R. Nishimura, 2023, International Journal of Molecular Sciences.

Functional Gene Screening System Identified TRPV4 as a Regulator of Chondrogenic Differentiation*

K. Tashiro, S. Kuhara, S. Sugano, 2007, Journal of Biological Chemistry.

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

S. Harris, Di Chen, G. Mundy, 2002, The Journal of cell biology.

Decreased sensory nerve excitation and bone pain associated with mouse Lewis lung cancer in TRPV1-deficient mice

M. Tominaga, T. Yoneda, H. Wakabayashi, 2018, Journal of Bone and Mineral Metabolism.

[Bone and Stem Cells. Regulation of chondrocyte differentiation from mesenchymal stem cells].

R. Nishimura, K. Hata, Eriko Nakamura, 2014, Clinical calcium.

[Regulation of osteoblasts and chondrocytes by Wnt signaling.]

R. Nishimura, K. Hata, Jumpei Kida, 2019, Clinical calcium.

Induction of salivary gland-like cells from epithelial tissues transdifferentiated from mouse embryonic fibroblasts.

K. Mishima, R. Nishimura, T. Shirota, 2021, Biochemical and biophysical research communications.

Generation of orthotopically functional salivary gland from embryonic stem cells

O. Ohara, K. Mishima, I. Saito, 2018, Nature Communications.

Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function.

Masaki Noda, Akira Yamaguchi, Fumiyo Ikeda, 2007, Molecular biology of the cell.

Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma

T. Yoneda, Y. Yura, M. Nakanishi, 2015, Clinical & Experimental Metastasis.

Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis.

R. Nishimura, K. Hata, T. Murakami, 2020, Current molecular pharmacology.

osteoclast precursors and indirectly via osteoblasts PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in

Y. Okada, A. Yoshimura, Y. Toyama, 2013 .

SLC26A2-mediated sulfate metabolism is essential for the tooth development

T. Inubushi, R. Nishimura, P. Papagerakis, 2023, bioRxiv.

Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a

R. Nishimura, K. Hata, T. Murakami, 2018, Scientific Reports.