T. Guinter

发表

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

M. Kubo, L. Hennighausen, A. Singer, 2010, Nature Immunology.

The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells

Jinghui Zhang, Qingrong Chen, D. Singer, 2012, Molecular and Cellular Biology.

Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors

A. Singer, T. Nakayama, X. Tai, 2016, Nature Immunology.

Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

A. Singer, S. Adoro, S. Sharrow, 2009, Immunity.

Coreceptor Signal Strength Regulates Positive Selection but Does Not Determine CD4/CD8 Lineage Choice in a Physiologic In Vivo Model1

A. Singer, B. Erman, A. Grinberg, 2006, The Journal of Immunology.

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

A. Singer, B. Erman, W. Ellmeier, 2005, Immunity.

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.

A. Singer, A. Bhandoola, S. Sharrow, 2000, Immunity.

Role of CD8β Domains in CD8 Coreceptor Function

J. Altman, A. Singer, T. Guinter, 2000 .

Positive selection of CD4+ T cells by TCR‐specific antibodies requires low valency TCR cross‐linking: implications for repertoire selection in the thymus

A. Singer, S. Koyasu, T. Guinter, 1998, European journal of immunology.

CD8 Coreceptor Extinction in Signaled CD4+CD8+ Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes

A. Singer, A. Bhandoola, S. Sharrow, 2000, Molecular and Cellular Biology.

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

C. Thompson, A. Singer, M. Kruhlak, 2012, Blood.

Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus

A. Singer, Xiongfong Chen, B. Erman, 2022, Nature Immunology.

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

A. Singer, B. Erman, T. Guinter, 2004, The Journal of experimental medicine.

Deﬁned (cid:2)(cid:3) T Cell Receptors with Distinct Ligand Speciﬁcities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

A. Singer, B. Erman, T. Guinter, 2004 .

E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex

A. Singer, Y. Zhuang, M. Kruhlak, 2019, The Journal of experimental medicine.

Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.

J. Altman, A. Singer, T. Guinter, 2000, Immunity.

Unraveling a Revealing Paradox: Why Major Histocompatibility Complex I–signaled Thymocytes Appear as CD4 (cid:2) 8 lo Transitional Cells During Positive Selection of CD8 (cid:2) T Cells

A. Singer, S. Sharrow, T. Guinter, 2003 .

IL-7 signaling must be intermittent, not continuous, during CD8 T cell homeostasis to promote cell survival instead of cell death

A. Singer, X. Tai, Jung-Hyun Park, 2012, Nature Immunology.

Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.

D. Singer, A. Singer, B. Erman, 2013, Immunity.

Let-7 miRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function

A. Singer, S. Sharrow, T. Guinter, 2015, Nature Immunology.

Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC

F. V. Laethem, A. Singer, X. Tai, 2007 .

αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.

A. Singer, Jinghua Lu, P. Sun, 2012, Immunity.

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

A. Singer, X. Tai, Jung-Hyun Park, 2007, Immunity.

Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire

F. V. Laethem, A. Singer, X. Tai, 2013, Cell.

Unraveling a Revealing Paradox

Susan O. Sharrow, A. Singer, S. Sharrow, 2003, The Journal of experimental medicine.

Identification of lineage-specifying cytokines that signal all CD8-cytotoxic lineage fate decisions in the thymus

A. Singer, B. Erman, T. Egawa, 2017, Nature Immunology.

How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion

Marco Craveiro, A. Singer, X. Tai, 2023, Nature Immunology.

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus

B. Engelhardt, A. Singer, Jinghua Lu, 2020, Frontiers in Immunology.