F. Ekström

发表

Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase.

C. Akfur, F. Ekström, Anna-Karin Tunemalm, 2006, Biochemistry.

The Nature of Activated Non-classical Hydrogen Bonds: A Case Study on Acetylcholinesterase-Ligand Complexes.

C. D. Andersson, A. Linusson, B. Mishra, 2016, Chemistry.

Evaluation of novel carbamate insecticides for neurotoxicity to non-target species

J. Bloomquist, P. Carlier, F. Ekström, 2013 .

Changes in dynamics of α-chymotrypsin due to covalent inhibitors investigated by elastic incoherent neutron scattering.

C. D. Andersson, A. Linusson, N. Martinez, 2017, Physical chemistry chemical physics : PCCP.

Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6

A. Linusson, A. Allgardsson, C. Akfur, 2016, Proceedings of the National Academy of Sciences.

Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.

A. Linusson, S. Knutsson, F. Ekström, 2016, Journal of medicinal chemistry.

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.

M. Froment, P. Masson, O. Lockridge, 2008, Journal of the American Chemical Society.

Crystallization and X-ray analysis of a bacterial non-haem iron-containing phenylalanine hydroxylase from the Gram-negative opportunistic pathogen Pseudomonas aeruginosa.

U. Sauer, G. Stier, J. Eaton, 2003, Acta Crystallographica Section D: Biological Crystallography.

Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase.

J. Bloomquist, P. Carlier, F. Ekström, 2013, Pesticide biochemistry and physiology.

In Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design

A. Linusson, Tomas Bergström, M. Hedenström, 2020, Angewandte Chemie.

In situ assembly of choline acetyltransferase ligands by a hydrothiolation reaction reveals key determinants for inhibitor design.

A. Linusson, M. Hedenström, T. Bergström, 2020, Angewandte Chemie.

Insights into phase transitions and magnetism of MnBi crystals synthesized from self-flux

K. Gunnarsson, P. Svedlindh, S. Shafeie, 2019, Journal of Alloys and Compounds.

Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures

F. Ekström, M. Catto, L. Pisani, 2022, ACS medicinal chemistry letters.

Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency.

C. Lindgren, A. Linusson, S. Knutsson, 2018, Journal of medicinal chemistry.

N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.

A. Linusson, S. Knutsson, D. Nikjoo, 2017, European journal of medicinal chemistry.

Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues

A. Linusson, S. Knutsson, F. Ekström, 2015, PloS one.

Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

S. Brimijoin, Y. Pang, Sandeep Rana, 2009, PloS one.

Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad.

Y. Pang, F. Ekström, E. Artursson, 2010, Biochemical pharmacology.

An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet

A. Linusson, A. Allgardsson, C. Akfur, 2017, Molecules.

Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.

Anna Linusson, Fredrik Ekström, Lotta Berg, 2013, Journal of medicinal chemistry.

C. D. Andersson, A. Linusson, P. Wittung-Stafshede, 2012, Angewandte Chemie.

Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis.

Franz Worek, Fredrik Ekström, Christine Akfur, 2009, Toxicology.

S 024 Partial unfolding of insect acetylcholinesterase : Steps toward cysteine-targeting insecticides

M. Bolognesi, K. Kuča, I. Silman, 2018 .

Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity.

A. Linusson, P. Andersson, C. Akfur, 2013, Biochemical pharmacology.

Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

Anna Linusson, Fredrik Ekström, Lotta Berg, 2011, PloS one.

Structure of HI-6•Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design

G. Schneider, Y. Pang, F. Ekström, 2009, PloS one.

Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state.

F. Ekström, Anna-Karin Tunemalm, A. Hörnberg, 2007, Biochemistry.

Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates.

Yuan-Ping Pang, Malin Boman, Fredrik Ekström, 2006, Biochemical pharmacology.

Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering.

C. D. Andersson, A. Linusson, A. Allgardsson, 2018, The journal of physical chemistry. B.

Crystallization of the actin-binding domain of human alpha-actinin: analysis of microcrystals of SeMet-labelled protein.

U. Sauer, G. Stier, F. Ekström, 2003, Acta crystallographica. Section D, Biological crystallography.

X-ray characterization of PaPheOH, a bacterial phenylalanine hydroxylase.

F. Ekström, 2003 .

Benefits of statistical molecular design, covariance analysis, and reference models in QSAR: a case study on acetylcholinesterase

C. David Andersson, Anna Linusson, Cecilia M. Lindgren, 2014, Journal of Computer-Aided Molecular Design.

Physical Mechanisms Governing Substituent Effects on Arene–Arene Interactions in a Protein Milieu

C. D. Andersson, A. Linusson, B. Mishra, 2020, The journal of physical chemistry. B.

Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic.

D. A. Baker, A. Malavalli, K. Vandegriff, 2008, Biophysical journal.

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.

Y. Pang, F. Ekström, F. Worek, 2010, Biochemical pharmacology.

Structure–Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes

A. Linusson, S. Kitur, L. Kamau, 2023, Journal of medicinal chemistry.

Novel Nerve‐Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun‐Conjugated Acetylcholinesterase in Complex with Antidotes

Y. Pang, F. Ekström, C. Åstot, 2007, Clinical pharmacology and therapeutics.

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

A. Linusson, C. Akfur, F. Ekström, 2022, Chemistry.