D. Covey

发表

Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC

G. Akk, J. Bracamontes, A. Evers, 2018, The Journal of Biological Chemistry.

Chirality in Membranes: First Evidence that Enantioselective Interactions Between Cholesterol and Cell Membrane Lipids Can Be a Determinant of Membrane Physical Properties

K. Stine, S. Lalitha, D. Covey, 2001 .

Cholesterol Depletion Results in Site-specific Increases in Epidermal Growth Factor Receptor Phosphorylation due to Membrane Level Effects

Rhoderick E. Brown, L. Pike, D. Covey, 2003, Journal of Biological Chemistry.

Enantiospecific interactions between cholesterol and phospholipids.

P. Kinnunen, Xin Jiang, D. Covey, 2008, Langmuir : the ACS journal of surfaces and colloids.

Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands*

Jonathan C. Cohen, Helen H. Hobbs, Yuan Zhang, 2006, Journal of Biological Chemistry.

4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor

R. Zoncu, D. Nomura, D. Ory, 2021, Journal of lipid research.

4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor

R. Zoncu, D. Nomura, D. Ory, 2020, bioRxiv.

Side-Chain Oxysterols Modulate Cholesterol Accessibility through Membrane Remodeling

Nathan A. Baker, B. Olsen, P. Schlesinger, 2014, Biochemistry.

Oxysterols are allosteric activators of the oncoprotein Smoothened

P. Schlesinger, Sigrid Nachtergaele, R. Rohatgi, 2011, Nature chemical biology.

Oxysterols as non-genomic regulators of cholesterol homeostasis

P. Schlesinger, D. Ory, D. Covey, 2012, Trends in Endocrinology & Metabolism.

Neurosteroid analogues. 7. A synthetic route for the conversion of 5 beta-methyl-3-ketosteroids into 7(S)-methyl-substituted analogues of neuroactive benz[e]indenes.

D. Covey, C. Zeng, M. Han, 2000, The Journal of organic chemistry.

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.

María Queralt-Martín, Julian P Whitelegge, J. Whitelegge, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

Benjamin Bishop, Mark S. P. Sansom, Tomas Malinauskas, 2019, Nature Chemical Biology.

Structural basis for Smoothened regulation by its extracellular domains

M. Sansom, R. Rambo, C. Siebold, 2016, Nature.

Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann–Pick C disease

D. Kipnis, S. Gale, D. Ory, 2006, Proceedings of the National Academy of Sciences.

Kinetic analysis of voltage‐dependent potentiation and block of the glycine α3 receptor by a neuroactive steroid analogue

J. Steinbach, D. Covey, Xiaochun Jin, 2009, The Journal of physiology.

Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels

S. Philipp, F. Mohr, A. Drews, 2014, British journal of pharmacology.

Membrane dipole potential is sensitive to cholesterol stereospecificity: implications for receptor function.

H. Chakraborty, A. Chattopadhyay, D. Covey, 2014, Chemistry and physics of lipids.

Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol

D. Covey, Laurel K Mydock-McGrane, N. Rath, 2014, The Journal of organic chemistry.

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.

C. Zorumski, S. Mennerick, A. Evers, 2008, European journal of medicinal chemistry.

The Anesthetic Steroid (+)-3α-Hydroxy-5α-androstane-17β-carbonitrile Blocks N-, Q-, and R-Type, but Not L- and P-Type, High Voltage-Activated Ca2+ Current in Hippocampal and Dorsal Root Ganglion Neurons of the Rat

C. Lingle, S. Todorovic, D. Covey, 1998 .

The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury

K. A. Yamada, Yong Y. He, Kelvin A. Yamada, 1998, Annals of neurology.

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

David E Reichert, Yusuke Sugasawa, G. Akk, 2020, bioRxiv.

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

David E Reichert, Yusuke Sugasawa, G. Akk, 2020, eLife.

Multiple functional neurosteroid binding sites on GABAA receptors

David E Reichert, G. Akk, J. Bracamontes, 2018, bioRxiv.

Estrogen-Like Compounds for Ischemic Neuroprotection

J. Simpkins, Shao-Hua Yang, Ran Liu, 2004, Stroke.

Neurosteroids, stress and depression: Potential therapeutic opportunities

S. Paul, Y. Izumi, C. Zorumski, 2013, Neuroscience & Biobehavioral Reviews.

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2014, Psychopharmacology.

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ25–35 peptide-induced toxicity in vitro and in vivo in mice

K. Krishnan, D. Covey, J. Meunier, 2014, Psychopharmacology.

Modulation of the human ρ1 GABAA receptor by inhibitory steroids

G. Akk, D. Covey, Megan M. Eaton, 2013, Psychopharmacology.

Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain.

V. Jevtovic-Todorovic, S. Todorovic, K. Krishnan, 2020, British journal of anaesthesia.

Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats

V. Jevtovic-Todorovic, S. Todorovic, Y. H. Raol, 2021, British journal of anaesthesia.

Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain

V. Jevtovic-Todorovic, S. Todorovic, Y. H. Raol, 2019, British journal of pharmacology.

A novel mechanism of non-feminizing estrogens in neuroprotection

J. Simpkins, D. Covey, E. Engler-Chiurazzi, 2017, Experimental Gerontology.

Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo

J. Simpkins, Shao-Hua Yang, Ran Liu, 2005, Brain Research.

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking

S. Gale, D. Ory, J. Schaffer, 2019 .

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking[S]

S. Gale, D. Ory, J. Schaffer, 2019, Journal of Lipid Research.

Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains.

D. Piwnica-Worms, G. Luker, C. Pica, 2000, Biochemistry.

TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model

Y. Izumi, C. Zorumski, D. Covey, 2016, Neuropharmacology.

The Enantiomer of Cholesterol

D. Covey, E. J. Westover, Emily J. Westover, 2004, The Journal of Membrane Biology.

The sticky issue of neurosteroids and GABAA receptors

C. Zorumski, S. Mennerick, L. Eisenman, 2010, Trends in Neurosciences.

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog.

S. Wiley, R. Wen, J. Dykens, 2004, Biochemical pharmacology.

Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels

V. Jevtovic-Todorovic, S. Todorovic, K. Krishnan, 2020, Cells.

Inhibition of growth and appearance of estrogen-dependent rat mammary tumors by 10-propargylestr-4-ene-3,17-dione, an aromatase inhibitor

D. Puett, D. Covey, S. Zimniski, 2004, Breast Cancer Research and Treatment.

Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids

J. Freed, F. Maxfield, L. Ciani, 2004, Journal of Biological Chemistry.

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

Kevin A. Robertson, J. Haas, C. Glass, 2013, Immunity.

Inhibition of voltage-dependent sodium channels by the anticonvulsant gamma-aminobutyric acid type A receptor modulator, 3-benzyl-3-ethyl-2-piperidinone.

S. Rothman, D. Covey, M. Hill, 1998, The Journal of pharmacology and experimental therapeutics.

Neuroprotective Effects of a Novel Non–Receptor-Binding Estrogen Analogue: In Vitro and In Vivo Analysis

A. Day, J. Simpkins, S. Wu, 2002, Stroke.

Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione.

D. Covey, P. Sherwin, P. McMullan, 1989, Journal of medicinal chemistry.

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

D. Ory, Haowei Song, C. Semenkovich, 2016, Nature.

Nanomolar, noncovalent antagonism of hedgehog cholesterolysis: exception to the “irreversibility rule” for protein autoprocessing inhibition

Chunyu Wang, D. Covey, Andrew G. Wagner, 2021, bioRxiv.

The Estrogen Receptor Is Not Essential for All Estrogen Neuroprotection: New Evidence from a New Analog

S. Xia, S. Rothman, L. Thio, 2002, Neurobiology of Disease.

Localization of tolbutamide binding sites on human serum albumin using titration calorimetry and heteronuclear 2-D NMR.

D. Cistola, D. Covey, M. Jakoby, 1995, Biochemistry.

and Anesthetic Agents Adult Rat Sensory Neurons: Effects of Anticonvulsant Current in 2+ Pharmacological Properties of T-Type Ca

P. Barrett, Jung-Ha Lee, C. Lingle, 2015 .

Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiol.

R. Auchus, D. Covey, 1986, Biochemistry.

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.

D. Mangelsdorf, A. Ferguson, D. Covey, 2007, Journal of medicinal chemistry.

The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.

Steven Mennerick, C. Zorumski, S. Mennerick, 2009, Journal of neurophysiology.

A neurosteroid analogue with T‐type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain

J. Klawitter, V. Jevtovic-Todorovic, S. Todorovic, 2018, British journal of anaesthesia.

Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

C. Zorumski, S. Mennerick, G. Akk, 2014, Journal of medicinal chemistry.

Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids

J. Steinbach, C. Zorumski, S. Mennerick, 2010, Current neuropharmacology.

Potential clinical uses of neuroactive steroids.

K. Isenberg, C. Zorumski, S. Mennerick, 2000, Current opinion in investigational drugs.

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.

R. Schwabe, Xiaoming Yang, K. Guan, 2020, Cell metabolism.

Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents.

David E Reichert, S. Gale, D. Ory, 2021, ACS chemical biology.

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

R. Zoncu, D. Nomura, D. Ory, 2017, Science.

The assessment of non-feminizing estrogens for use in neuroprotection

J. Simpkins, Shao-Hua Yang, Ran Liu, 2011, Brain Research.

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Grace Brannigan, Mark J. Arcario, K. Krishnan, 2021, bioRxiv.

Pregnenolone Sulfate Modulates Inhibitory Synaptic Transmission by Enhancing GABAA Receptor Desensitization

C. Zorumski, S. Mennerick, D. Covey, 2000, The Journal of Neuroscience.

Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.

R. Strickler, D. Covey, B. Tobias, 1981, The Journal of biological chemistry.

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.

J. Xie, Chunyu Wang, D. Covey, 2020, Biochemistry.

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

M. Sansom, R. E. Woolley, C. Siebold, 2022, Science advances.

Synthesis of the enantiomer of the oxysterol-antagonist LY295427

D. Ory, D. Covey, Agata A. Bielska, 2011, Steroids.

Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.

Jay Liu, Catherine C. Y. Chang, Ta-Yuan Chang, 2005, The Biochemical journal.

Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans.

J. McGill, J. Stearns, R. Ostlund, 2002, American journal of physiology. Endocrinology and metabolism.

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

R. Zoncu, D. Nomura, R. Perera, 2022, Science.

Synthesis of ent-25-hydroxycholesterol

D. Covey, E. J. Westover, 2006, Steroids.

Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons

J. Ferrendelli, S. Rothman, D. Covey, 1990, Brain Research.

A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors

C. Zorumski, S. Mennerick, D. Covey, 2020, Neuropharmacology.

Mechanism of okadaic acid‐induced neuronal death and the effect of estrogens

J. Simpkins, D. Covey, K. D. Yi, 2009, Journal of neurochemistry.

Estrogen Receptor-Independent Neuroprotection via Protein Phosphatase Preservation and Attenuation of Persistent Extracellular Signal-Regulated Kinase 1/2 Activation

J. Simpkins, D. Covey, K. D. Yi, 2008, Journal of Pharmacology and Experimental Therapeutics.

Estrogen Receptor Independent Neuroprotection Via Protein Phosphatase Preservation and Attenuation of Persistent ERK 1 / 2 Activation

J. Simpkins, D. Covey, K. D. Yi, 2007 .

Metabolism of 19-methyl-substituted steroids by human placental aromatase.

H. L. Carrell, D. Covey, D. Beusen, 1987, Biochemistry.

Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.

C. Zorumski, S. Mennerick, G. Akk, 2008, Journal of medicinal chemistry.

Recent developments in structure–activity relationships for steroid modulators of GABAA receptors

C. Zorumski, S. Mennerick, R. Purdy, 2001, Brain Research Reviews.

A neurosteroid analogue photolabeling reagent labels the colchicine‐binding site on tubulin: A mass spectrometric analysis

Cheryl F. Lichti, David E Reichert, N. Akentieva, 2012, Electrophoresis.

Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.

J. Ferrendelli, D. Covey, K. D. Holland, 1990, The Journal of pharmacology and experimental therapeutics.

Physiological regulation of the picrotoxin receptor by gamma- butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons

J. Ferrendelli, S. Rothman, D. Covey, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.

W. Klunk, J. Ferrendelli, D. Covey, 1982, Molecular pharmacology.

Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones.

W. Klunk, J. Ferrendelli, D. Covey, 1982, Molecular pharmacology.

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders☆☆☆

D. Ory, W. Griffiths, Yuqin Wang, 2019, Free radical biology & medicine.

Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition.

Chunyu Wang, D. Covey, Andrew G. Wagner, 2021, Biochemistry.

Effects of 4-hydroxy-4-androstene-3,17-dione and 10-propargylestr-4-ene-3,17-dione on the metabolism of androstenedione in human breast carcinoma and breast adipose tissues

D. Killinger, D. Covey, S. Davis, 1981, Steroids.

Eliminating the Roughness in Cholesterol’s β-Face: Does it Matter?

P. F. Almeida, Minghui Wang, D. Covey, 2014, Langmuir : the ACS journal of surfaces and colloids.

A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase.

D. Covey, W. Hood, 1982, Cancer research.

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters Published, JLR Papers in Press, August 26, 2006.

R. Ostlund, D. Covey, E. J. Westover, 2006, Journal of Lipid Research.

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization

C. Zorumski, S. Mennerick, J. E. Huettner, 2019, Neuropharmacology.

Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina

T. Nakazawa, Y. Izumi, C. Zorumski, 2022, Neural regeneration research.

Cholesterol Tuning of BK Ethanol Response Is Enantioselective, and Is a Function of Accompanying Lipids

S. Treistman, L. Johnston, D. Covey, 2011, PloS one.

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

M. Rogawski, A. Dhir, K. Krishnan, 2014, Psychopharmacology.

Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs.

W. Klunk, J. Ferrendelli, D. Covey, 1982, Science.

Neuroprotective Effects of 17β-Estradiol and Nonfeminizing Estrogens against H2O2 Toxicity in Human Neuroblastoma SK-N-SH Cells

J. Simpkins, Shao-Hua Yang, Ran Liu, 2006, Molecular Pharmacology.

A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein.

D. Cistola, D. Covey, Gregory P. Tochtrop, 2004, Journal of the American Chemical Society.

Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein.

D. Cistola, D. Covey, Gregory P. Tochtrop, 2003, Biochemistry.

Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione.

D. Puett, D. Covey, S. Zimniski, 1988, Journal of steroid biochemistry.

Hydroperoxides as inactivators of aromatase: 10 beta-hydroperoxy-4-estrene-3,17-dione, crystal structure and inactivation characteristics.

H. L. Carrell, D. Covey, W. Hood, 1984, Biochemistry.

Selective inhibition of rat epididymal steroid Δ4-5α-reductase> by conjugated allenic 3-oxo-5,10-secosteroids

D. Covey, L. Ewing, C. Robinson, 1977 .

Lactone Modulation of the γ-Aminobutyric Acid A Receptor: Evidence for a Positive Modulatory Site

J. Ferrendelli, S. Rothman, J. Krause, 1997 .

Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.

J. Ferrendelli, S. Rothman, J. Krause, 1997, Molecular pharmacology.

Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIα at the trans-Golgi network

J. Hsuan, S. Minogue, M. Waugh, 2010, Journal of Lipid Research.

Enantiospecificity of Cholesterol Function in Vivo *

R. Ostlund, D. Covey, C. Crowder, 2001, The Journal of Biological Chemistry.

Bis ( guanylhydrazone ) by a Rat Prostate-derived Tumor C-labeled Polyamines and Methylglyoxal 14 Uptake of in Vivo-Difluoromethylornithine on the α Differential Effect of Updated Version

D. Kadmon, W. Heston, D. Covey, 2006 .

Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.

W. Fair, D. Kadmon, W. Heston, 1984, Cancer research.

ent-Steroids: Novel tools for studies of signaling pathways

D. Covey, 2009, Steroids.

Dual Potentiating and Inhibitory Actions of a Benz[e]indene Neurosteroid Analog on Recombinant α1β2γ2 GABAA Receptors

J. Steinbach, G. Akk, D. Covey, 2006, Molecular Pharmacology.

Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.

J. Steinbach, G. Akk, D. Covey, 2006, Molecular pharmacology.

Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats

G. Koob, M. Roberto, R. Purdy, 2005, Pharmacology Biochemistry and Behavior.

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5α-reduced neuroactive steroids

C. Zorumski, S. Mennerick, V. Jevtovic-Todorovic, 2005, Pain.

Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia.

C. Zorumski, A. Evers, D. Covey, 2000, The Journal of pharmacology and experimental therapeutics.

Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABAA receptors

W. Shen, C. Zorumski, S. Mennerick, 1999, Neuropharmacology.

Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.

C. Zorumski, D. Covey, K. R. Nilsson, 1998, Journal of medicinal chemistry.

The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.

R. Auchus, D. Covey, N. Rath, 2003, Archives of biochemistry and biophysics.

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

S. Paul, C. Zorumski, S. Mennerick, 2014, Neuropharmacology.

The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury

D. Stein, S. Hoffman, Jacob W. Vanlandingham, 2006, Neuropharmacology.

Differential interaction of the two cholesterol‐dependent, membrane‐damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol

M. Palmer, D. Covey, E. J. Westover, 2003, FEBS letters.

Comparison of the Anticonvulsant Activities of Ethosuximide, Valproate, and a New Anticonvulsant, Thiobutyrolactone

J. Ferrendelli, D. Covey, K. D. Holland, 1989, Epilepsia.

Enantioselectivity of α-Benzyl-α-methyl-γ-butyrolactone-Mediated Modulation of Anticonvulsant Activity and GABAA Receptor Function

J. Ferrendelli, D. Covey, G. Dillon, 2004, Journal of Pharmacology and Experimental Therapeutics.

Development of a bile acid–based newborn screen for Niemann-Pick disease type C

H. Runz, S. Gale, D. Ory, 2016, Science Translational Medicine.

Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.

J. Steinbach, G. Akk, J. Bracamontes, 2007, Molecular pharmacology.

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

B. Bembi, T. Butters, S. Mellon, 2008, Journal of cellular and molecular medicine.

Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH

V. Jevtovic-Todorovic, Tamara Timic Stamenic, S. Todorovic, 2022, Frontiers in Pharmacology.

Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid.

J. Klawitter, V. Jevtovic-Todorovic, S. Todorovic, 2022, British journal of anaesthesia.

Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Delta-androgens and their 18-nor-13,17-epoxide derivatives.

Cunde Wang, D. Covey, N. Rath, 2006, Tetrahedron letters.

Neurosteroid analogues. Part 13: Synthetic methods for the preparation of 2β-hydroxygonane derivatives as structural mimics of ent-3α-hydroxysteroid modulators of GABAA receptors

Cunde Wang, D. Covey, N. Rath, 2007 .

Neuroactive Steroids as Targets for Development of Novel Pain Therapies

C. Zorumski, V. Jevtovic-Todorovic, S. Todorovic, 2005 .

Potentiation and inhibition of GABAA receptor function by neuroactive steroids

C. Zorumski, S. Mennerick, L. Eisenman, 2003 .

Neurosteroid Analogs. 2. Total Synthesis and Electrophysiological Evaluation of Benz[e]indene Analogs of the Anesthetic Steroid Alphaxalone

C. Zorumski, D. Covey, Yuefei Hu, 1995 .

Mechanisms of neurosteroid interactions with GABA(A) receptors.

J. Steinbach, C. Zorumski, S. Mennerick, 2007, Pharmacology & therapeutics.

3β-Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABAA Receptor Antagonists

J. Steinbach, C. Zorumski, S. Mennerick, 2002, The Journal of Neuroscience.

5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2005, Pain.

Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons

K. Isenberg, J. Ferrendelli, S. Rothman, 1994, Neuron.

Relative Anticonvulsant Effects of GABAmimetic and GABA Modulatory Agents

J. Ferrendelli, D. Covey, D. Canney, 1992, Epilepsia.

Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.

D. Naritoku, J. Ferrendelli, D. Covey, 1987, Biochemical pharmacology.

Alkyl-substituted γ-butyrolactones as potential tools in the study and treatment of epilepsy

W. Klunk, J. Ferrendelli, D. Covey, 1983 .

Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action.

D. Covey, M. Dibas, J. Drewe, 2001, The Journal of pharmacology and experimental therapeutics.

Neurosteroid Analogues. 10. The Effect of Methyl Group Substitution at the C-6 and C-7 Positions on the GABA Modulatory and Anesthetic Actions of (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

C. Zorumski, S. Mennerick, A. Evers, 2005 .

3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents.

T. Latifi, J. Ferrendelli, S. Rothman, 1996, Journal of medicinal chemistry.

Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.

J. Ferrendelli, D. Covey, J. A. Levine, 1986, Journal of medicinal chemistry.

Inhibition of type a GABA receptors by L-type calcium channel blockers

P. Das, D. Covey, G. Dillon, 2004, Neuroscience.

Neurosteroid Analogues. 9. Conformationally Constrained Pregnanes: Structure−Activity Studies of 13,24-Cyclo-18,21-dinorcholane Analogues of the GABA Modulatory and Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

C. Zorumski, S. Mennerick, A. Evers, 2003 .

Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

C. Zorumski, S. Mennerick, A. Evers, 2003, Journal of medicinal chemistry.

Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

C. Zorumski, S. Mennerick, D. Covey, 2002, Neuropharmacology.

Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.

J. Ferrendelli, K. Xu, S. Rothman, 1994, Journal of medicinal chemistry.

Structure-activity studies of fluoroaljyl-substituted γ-butyrolactone and γ-thiobutyrolactone modulators of GABAA receptor function

J. Ferrendelli, S. Rothman, D. Covey, 1998 .

Convulsant and anticonvulsant cyclopentanones and cyclohexanones.

D. Naritoku, J. Ferrendelli, D. Covey, 1990, Molecular pharmacology.

Facile Synthesis of α, β, and/or γ-Alkyl-Substituted γ-Butyrolactones Using Readily Prepared Olefinic Esters

D. Covey, J. A. Levine, D. Canney, 1990 .

.beta.-Epimerization and .gamma.-hydrogen abstraction via homoenolate ions

J. E. Oliver, D. Covey, J. Lambert, 1976 .

Unusually facile bridgehead enolization. Locked boat forms in anti-Bredt olefins

D. Covey, A. Nickon, F. Huang, 1975 .

Carbon-13 nuclear magnetic resonance studies. XXV. Carbon-13 nuclear magnetic resonance as a monitor for anionic exchange processes. Remote epimerization via homoenolate ions and aryl D exchange

D. Covey, J. Lambert, A. Nickon, 1972 .

Title Structure and function of the smoothened extracellulardomain in vertebrate hedgehog signaling

P. Ingham, C. Siebold, Sigrid Nachtergaele, 2017 .

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

P. Ingham, C. Siebold, Sigrid Nachtergaele, 2013, eLife.

Difunctionalized brendanes via thallium triacetate cleavage of the cyclopropyl ring of triaxane

D. Covey, A. Nickon, 1977 .

Energetics by NMR: Site-specific binding in a positively cooperative system

D. Cistola, K. Richter, D. Covey, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Tracking the Subcellular Fate of 20(S)-Hydroxycholesterol with Click Chemistry Reveals a Transport Pathway to the Golgi*

P. Schlesinger, D. Ory, Sigrid Nachtergaele, 2014, The Journal of Biological Chemistry.

Regioselectivity and stereospecificity in homoketonizations. Control by thermodynamic and steric factors.

D. Covey, A. Nickon, J. Frank, 1975 .

ACID HOMOKETONIZATION WITH INVERSION OF CONFIGURATION, A DRAMATIC EFFECT OF WATER IN CONTROL OF STEREOCHEMISTRY

D. Covey, A. Nickon, J. Frank, 1974 .

Molecular structures of substrates and inhibitors of .DELTA.5-3-keto steroid isomerase and their relevance to the enzymic mechanism

H. L. Carrell, J. Glusker, D. Covey, 1978 .

Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon.

Xin Jiang, D. Covey, 2002, The Journal of organic chemistry.

CONJUGATED ALLENIC 3-OXO-5,10-SECOSTEROIDS. IRREVERSIBLE INHIBITORS OF Δ5-3-KETOSTEROID ISOMERASE

D. Covey, C. Robinson, 1976 .

Letter: Conjugated allenic 3-oxo-5,10-secosteroids. Irreversible inhibitors of delta 5-3-ketosteroid isomerase.

D. Covey, C. Robinson, 1976, Journal of the American Chemical Society.

The Δ5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition

P. Talalay, D. Covey, A. Benson, 1976 .

Neuroactive Steroids and Human Recombinant ρ1 GABA Receptors

J. Steinbach, D. Covey, Wenjun Li, 2007, Journal of Pharmacology and Experimental Therapeutics.

Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione.

D. Covey, W. Hood, 1982, Molecular pharmacology.

Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity.

D. Covey, W. Hood, 1981, Endocrinology.

10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

D. Covey, W. Hood, V. Parikh, 1981, The Journal of biological chemistry.

Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site.

R. Strickler, D. Covey, B. Tobias, 1980, Biochemistry.

Inactivation of Streptomyces hydrogenans 20 beta-hydroxysteroid dehydrogenase by an enzyme-generated ethoxyacetylenic ketone in the presence of a thiol.

D. Covey, W. Chien, P. McMullan, 1986, Biochemistry.

Inactivation of human placental 17 beta,20 alpha-hydroxysteroid dehydrogenase by 16-methylene estrone, an affinity alkylator enzymatically generated from 16-methylene estradiol-17 beta.

R. Strickler, D. Covey, J. Thomas, 1983, The Journal of biological chemistry.

Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase.

J. Pawlowski, D. M. Scolnick, T. Penning, 1994, Biochemistry.

Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers.

P. Kinnunen, D. Covey, J. Alakoskela, 2007, Biochimica et biophysica acta.

Inactivation of delta 5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids.

T. Penning, D. Covey, 1982, Journal of steroid biochemistry.

Synthesis of 1,10-seco-5α-estr-1 -ynes: potential mechanism-based inhibitors of 3α- and 3β-hydroxysteroid dehydrogenases

D. Covey, Yuefei Hu, 1993 .

Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase

H. L. Carrell, R. Auchus, D. Covey, 1989, Steroids.

Synthesis of 17β-[(1 S )-1-hydroxy-2-propynyl]- and 17β-[(1 R )-1-hydroxy-2-propynyl]androst-4--en-3-one. Potential suicide substrates of 20α- and 20β- hydroxysteroid dehydrogenases

D. Covey, 1979, Steroids.

Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol.

D. Covey, S. Lawate, 1990, Journal of medicinal chemistry.

Solid-state NMR observation of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase.

R. Auchus, J. Schaefer, D. Covey, 1988, The Journal of biological chemistry.

Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.

R. Strickler, D. Covey, B. Tobias, 1982, The Journal of biological chemistry.

Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer

D. Covey, Yuefei Hu, P. F. Sherwin, 1995, Steroids.

Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-16-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer

D. Covey, Yuefei Hu, P. F. Sherwin, 1995, Steroids.

Cytotoxic activity of a polyamine analogue, monoaziridinylputrescine, against the PC-3 human prostatic carcinoma cell line.

P. Russo, W. Heston, D. Covey, 1987, Cancer research.

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors

J. Steinbach, C. Zorumski, S. Mennerick, 2014, Psychopharmacology.

A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions.

D. Cistola, D. Covey, Gregory P. Tochtrop, 2002, Bioorganic & medicinal chemistry letters.

Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Cav3.2 T-Type Calcium Channels

P. Barrett, Jung-Ha Lee, V. Jevtovic-Todorovic, 2013, Diabetes.

Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice

Michael E. Levin, V. Jevtovic-Todorovic, S. Todorovic, 2009, Diabetes.

The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone.

D. Covey, N. Rath, Eva Stastna, 2011, Organic & biomolecular chemistry.

Synthesis of (5α)-17-azaandrostan-3-ols and (5α)-17-aza-D-homoandrostan-3-ols and their N-acylated derivatives

Jie Wang, D. Covey, Xin Jiang, 2001, Steroids.

Neurosteroid Analogues. Part 8. Structure—Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one.

D. Covey, 2000 .

Neurosteroid Analogues. 8. Structure−Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

S. Mennerick, A. Evers, D. Covey, 2000 .

A Practical and Facile Route for the Preparation of 18-Norandrostan-17-ones from Androstan-17-ones Using SmI2-Promoted Cyclization and Dehydroxylation.

Cunde Wang, D. Covey, Xin Jiang, 2000 .

A practical and facile route for the preparation of 18-norandrostan-17-ones from androstan-17-ones using SmI(2)-promoted cyclization and dehydroxylation.

D. Covey, C. Wang, Y. Hu, 2000, The Journal of organic chemistry.

The Nonfeminizing Enantiomer of 17b-Estradiol Exerts Protective Effects in Neuronal Cultures and a Rat Model of Cerebral Ischemia*

J. Simpkins, Shao-Hua Yang, P. Green, 2000 .

Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens.

J. Simpkins, D. Covey, M. Qian, 2016, Organic & biomolecular chemistry.

The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-related to Neurosteroids.

D. Covey, M. Qian, 2010, Advanced synthesis & catalysis.

Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems.

D. Covey, N. Rath, G. Dekoster, 2007, The Journal of organic chemistry.

Neuroprotective effects of estratriene analogs: structure‐activity relationships and molecular optimization

J. Simpkins, D. Covey, E. Perez, 2005 .

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

C. Zorumski, S. Mennerick, A. Evers, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of [3,4-13C2]-Enriched Bile Salts as NMR Probes of Protein−Ligand Interactions

D. Cistola, D. Covey, Gregory P. Tochtrop, 2002 .

Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors.

C. Zorumski, D. Covey, M. Han, 1996, Journal of medicinal chemistry.

Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.

C. Zorumski, A. Evers, D. Covey, 1996, Molecular pharmacology.

Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation

S. Rothman, D. Covey, M. Hill, 1999, Epilepsy Research.

Contribution of Subsaturating GABA Concentrations to IPSCs in Cultured Hippocampal Neurons

S. Rothman, D. Covey, M. Hill, 1998, The Journal of Neuroscience.

Neurosteroid Access to the GABAA Receptor

J. Steinbach, C. Zorumski, S. Mennerick, 2005, The Journal of Neuroscience.

Cytotoxic and non-cytotoxic N-alkyl derivatives of putrescine: effect on polyamine uptake and growth of prostatic cancer cells in vitro.

K. Watanabe, W. Heston, D. Covey, 1987, Biochemical pharmacology.

First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol

D. Covey, E. J. Westover, Emily J. Westover, 2003, Steroids.

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

C. Siebold, B. Bishop, R. Gilbert, 2021, Nature Communications.

Biological formation and reactions

D. Covey, C. Robinson, 2010 .

Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis

C. Henderson, M. Schumacher, N. Akentieva, 2007, Journal of Pharmacology and Experimental Therapeutics.

Identification and Characterization of Cholest-4-en-3-one , Oxime ( TRO 19622 ) , a Novel Drug Candidate for Amyotrophic Lateral Sclerosis

C. Henderson, M. Schumacher, N. Akentieva, 2007 .

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

C. Siebold, Sigrid Nachtergaele, R. Sircar, 2016, eLife.

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

C. Siebold, Sigrid Nachtergaele, R. Sircar, 2016, bioRxiv.

Characterization of Enantiomeric Bile Acid-induced Apoptosis in Colon Cancer Cell Lines*

S. Anant, D. Covey, Douglas F Covey, 2009, Journal of Biological Chemistry.

The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?

E. Baulieu, D. Covey, Y. Akwa, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Neuroactive steroids have multiple actions to potentiate GABAA receptors

J. Steinbach, G. Akk, J. Bracamontes, 2004, The Journal of physiology.

ent-Steroids Chemistry and Biology

D. Covey, 2006 .

Inhibition of testosterone 5 alpha-reductase by and antiandrogenicity of allenic 3-keto-5,10-secosteroids.

D. Covey, W. Voigt, C. Robinson, 1978, Acta endocrinologica.

Steroid Inhibition of Rat Neuronal Nicotinic α4β2 Receptors Expressed in HEK 293 Cells

J. Steinbach, C. Zorumski, K. Paradiso, 2000 .

Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.

J. Steinbach, C. Zorumski, K. Paradiso, 2000, Molecular Pharmacology.

Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.

J. Steinbach, J. Bracamontes, D. Covey, 2000, Molecular pharmacology.

Neurosteroid analogue photolabeling of a site in the TM 3 domain of the β 3 subunit of the GABAA receptor

David E Reichert, J. Steinbach, K. Fuchs, 2012 .

A Synthetic 18-Norsteroid Distinguishes between Two Neuroactive Steroid Binding Sites on GABAA Receptors

J. Steinbach, C. Zorumski, S. Mennerick, 2010, Journal of Pharmacology and Experimental Therapeutics.

Steroid structure and pharmacological properties determine the anti‐amnesic effects of pregnenolone sulphate in the passive avoidance task in rats

S. Heinrichs, W. Shen, M. Vallée, 2001, The European journal of neuroscience.

Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol*

D. Piwnica-Worms, G. Luker, D. Covey, 1999, The Journal of Biological Chemistry.

Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.

J. Ferrendelli, D. Covey, R. A. Gross, 1997, The Journal of pharmacology and experimental therapeutics.

Multiple mechanisms of picrotoxin block of GABA‐induced currents in rat hippocampal neurons.

D. Covey, K. Yoon, S. Rothman, 1993, The Journal of physiology.

The influence of the membrane on neurosteroid actions at GABAA receptors

Steven Mennerick, J. Steinbach, C. Zorumski, 2009, Psychoneuroendocrinology.

Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors.

C. Zorumski, S. Mennerick, L. Eisenman, 2008, Biophysical journal.

Synthesis of 13C, 15N‐enriched α‐dicarbonyl model adducts to determine the utility of 13c and 15N NMR for studying mechanism‐based inactivation of cytochromes P‐450 by substituted dichloroacetamides

S. Weiner, D. Covey, S. Holl, 1994 .

Dehydrogenase inactivation by an enzyme-generated acetylenic ketone: identification of a lysyl enaminone by 13C NMR

R. Auchus, D. Covey, 1987 .

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

G. Petsko, D. Holtzman, S. Paul, 2020, Journal of Neuroinflammation.

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

M. Akabas, D. Covey, M. Xu, 1995, Biophysical journal.

T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor

K. Sakimura, G. Homanics, A. Handforth, 2010, Neuropharmacology.

Correlation of the apparent affinities and efficacies of γ-aminobutyric acid(C) receptor agonists

D. S. Weiss, D. Covey, Yongchang Chang, 2000 .

Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists.

D. S. Weiss, D. Covey, Y. Chang, 2000, Molecular pharmacology.

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

J. Janetka, J. Abramson, A. Evers, 2017, Analytical chemistry.

Neurosteroid Analog Photolabeling of a Site in the Third Transmembrane Domain of the β3 Subunit of the GABAA Receptor

David E Reichert, J. Steinbach, K. Fuchs, 2012, Molecular Pharmacology.

subunit of the GABAA receptor

David E Reichert, K. Fuchs, W. Sieghart, 2012 .

Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

L. Cegelski, J. Schaefer, D. Covey, 2005 .

The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells.

P. Majerus, R. Auchus, D. Covey, 1985, Biochemical and biophysical research communications.

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

U. Andley, J. Gestwicki, K. Molnar, 2019, Investigative ophthalmology & visual science.

Slow Death of Postnatal Hippocampal Neurons by GABAA Receptor Overactivation

K. Isenberg, C. Zorumski, S. Mennerick, 2000, The Journal of Neuroscience.

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

S. Paul, C. Zorumski, S. Mennerick, 2019, Neurobiology of Stress.

A facile total synthesis of ent-17β-estradiol and structurally related analogues

D. Covey, Z. Cai, 2007, Steroids.

Metabolism of 19-methyl substituted steroids and a proposal for the third aromatase monooxygenation

H. L. Carrell, D. Covey, D. Beusen, 1987, Steroids.

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

C. Siebold, J. McDonald, R. Rohatgi, 2019, eLife.

Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease.

Y. Izumi, C. Zorumski, D. Covey, 2018, Neuropsychiatry.

Anticonvulsant Medications Extend Worm Life-Span

K. Evason, K. Kornfeld, D. Covey, 2005, Science.

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Y. Izumi, C. Zorumski, H. Kunikata, 2022, Frontiers in Pharmacology.

The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models

Y. Izumi, C. Zorumski, D. Covey, 2020, Autophagy.

Neurosteroids Enhance Spontaneous Glutamate Release in Hippocampal Neurons

D. A. Meyer, C. Valenzuela, M. Carta, 2002, The Journal of Biological Chemistry.

Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA‐A receptor potentiation

J. Steinbach, C. Zorumski, S. Mennerick, 2007, The Journal of physiology.

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol[S]

P. Schlesinger, F. Maxfield, S. Gale, 2015, Journal of Lipid Research.

Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein.

Vasanthanathan Poongavanam, J. Kongsted, D. Wüstner, 2020, Biochimica et biophysica acta. Biomembranes.

Structural design of intrinsically fluorescent oxysterols.

J. Kongsted, D. Wüstner, H. Khandelia, 2018, Chemistry and physics of lipids.

Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis

K. Krishnan, D. Covey, R. Cenedella, 2005, Lipids.

Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells

G. Schneider, D. Wüstner, S. Werner, 2021, Scientific Reports.

Inhibition of T‐type Calcium Current in the Reticular Thalamic Nucleus by a Novel Neuroactive Steroid

S. Todorovic, D. Covey, Pavle M. Joksovic, 2007, Annals of the New York Academy of Sciences.

General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2022, International journal of molecular sciences.

Slow Actions of Neuroactive Steroids at GABAA Receptors

Deepani Jinadasa, Steven Mennerick, C. Zorumski, 2004, The Journal of Neuroscience.

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol

S. Paul, A. Cashikar, Y. Izumi, 2021, The Journal of Neuroscience.

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1

Julian P. Whitelegge, J. Janetka, J. Whitelegge, 2017, The Journal of Biological Chemistry.

Side Chain Oxygenated Cholesterol Regulates Cellular Cholesterol Homeostasis through Direct Sterol-Membrane Interactions*

Xianlin Han, P. Schlesinger, S. Gale, 2009, Journal of Biological Chemistry.

Neurosteroids in Pain Management: A New Perspective on an Old Player

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2018, Front. Pharmacol..

Novel neurosteroid hypnotic blocks T‐type calcium channel‐dependent rebound burst firing and suppresses long‐term potentiation in the rat subiculum

Y. Izumi, C. Zorumski, V. Jevtovic-Todorovic, 2019, British journal of anaesthesia.

Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity.

C. Lingle, C. Zorumski, M. Prakriya, 1998, Molecular pharmacology.

Studies of the inactivation of human placentae aromatase by 17α-ethynyl-substituted 10β-hydroperoxy and related 19-nor steroids

D. Covey, W. Hood, P. McMullan, 1986 .

The Nonfeminizing Enantiomer of 17 b -Estradiol Exerts Protective Effects in Neuronal Cultures and a Rat Model of Cerebral Ischemia*

S. Yang, J. Simpkins, P. Green, 2000 .

Analysis of GABAA Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites

J. Steinbach, G. Akk, Daniel J. Shin, 2018, Molecular Pharmacology.

Mutations of the GABA-A Receptor α1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids

David E Reichert, J. Steinbach, G. Akk, 2008, Molecular Pharmacology.

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.

C. Zorumski, S. Mennerick, A. Evers, 2004, Molecular pharmacology.

Selective Antagonism of 5-Reduced Neurosteroid Effects at GABAA Receptors

C. Zorumski, S. Mennerick, A. Evers, 2004 .

Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR

D. Cistola, D. Covey, Á. Bencsura, 2016, The FEBS journal.

Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2006, Pain.

Neurosteroid enantiomers as potentially novel neurotherapeutics

Y. Izumi, C. Zorumski, S. Mennerick, 2023, Neuroscience & Biobehavioral Reviews.

Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2021, Journal of neuroendocrinology.

Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes.

T. McIntosh, R. McElhaney, Xin Jiang, 2003, Biophysical journal.

Enantiospecificity of sterol–lipid interactions: first evidence that the absolute configuration of cholesterol affects the physical properties of cholesterol–sphingomyelin membranes

K. Stine, S. Lalitha, D. Covey, 2001 .

A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons

C. Zorumski, S. Mennerick, D. Covey, 2018, Front. Neurosci..

Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative

D. Puett, D. Covey, S. Zimniski, 1987, Steroids.

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.

Yusuke Sugasawa, J. Bracamontes, A. Evers, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Convulsant and anti-convulsant gammabutyrolactones bind at the picrotoxinin/T-butylbicyclophosphorothionate (TBPS) receptor.

J. Ferrendelli, D. Covey, J. A. Levine, 1985, Biochemical pharmacology.

Alkyl-substituted γ-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex

J. Ferrendelli, D. Covey, M. Bouley, 1993, Brain Research.

5β-Reduced Neuroactive Steroids Are Novel Voltage-Dependent Blockers of T-Type Ca2+ Channels in Rat Sensory Neurons in Vitro and Potent Peripheral Analgesics in Vivo

C. Zorumski, V. Jevtovic-Todorovic, S. Todorovic, 2004, Molecular Pharmacology.

The structural basis of cholesterol accessibility in membranes.

Nathan A. Baker, Michael D. Daily, B. Olsen, 2013, Biophysical journal.

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

D. Marks, A. Manglik, J. Reiter, 2023, bioRxiv.

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

C. Zorumski, S. Mennerick, K. Krishnan, 2016, Neuropharmacology.

The Diazoxide Derivative 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide Augments AMPA- and GABA-Mediated Synaptic Responses in Cultured Hippocampal Neurons

Kelvin A. Yamada, D. Covey, Yuefei Hu, 1998, Neurobiology of Disease.

Comparative studies of aromatase inhibitors in cultured human breast cancer cells.

D. Covey, J. MacIndoe, L. Etre, 1982, Cancer research.

Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.

J. Ferrendelli, K. Xu, S. Rothman, 1998, Bioorganic & medicinal chemistry.

Enantioselective synthesis of cyclothiazide analogues: Novel probes of the stereospecific actions of benzothiadiazines at AMPA-type glutamate receptors

D. Chalmers, Kelvin A. Yamada, D. Covey, 1996 .

Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane

C. Siebold, R. Rohatgi, D. Covey, 2019, bioRxiv.

GABAergic neurosteroids mediate the effects of ethanol on long‐term potentiation in rat hippocampal slices

Y. Izumi, C. Zorumski, K. Krishnan, 2007, The European journal of neuroscience.

The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile☆

V. Jevtovic-Todorovic, Tamara Timic Stamenic, Simon Feseha, 2020, British journal of anaesthesia.

Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol.

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The molecular determinants of neurosteroid binding in the GABA(A) receptor

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Formation of stable vesicles from N- or 3-alkylindoles: possible evidence for tryptophan as a membrane anchor in proteins.

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Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases

M. Finel, K. Krishnan, D. Covey, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2009, Psychoneuroendocrinology.

Neuroprotection with non-feminizing estrogen analogues: An overlooked possible therapeutic strategy

J. Simpkins, T. Richardson, D. Covey, 2013, Hormones and Behavior.

Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol

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C. Zorumski, S. Mennerick, D. Covey, 1998, Synapse.

Characteristics of concatemeric GABAA receptors containing α4/δ subunits expressed in Xenopus oocytes

J. Steinbach, C. Zorumski, S. Mennerick, 2012, British journal of pharmacology.

Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.

B L Kalman, B. Kalman, W. Klunk, 1983, Molecular pharmacology.

Irreversible inactivation of delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct.

T. Penning, P. Talalay, D. Covey, 1981, The Journal of biological chemistry.

Racemic progesterone: predicted in silico and produced in the solid state.

P. Karamertzanis, S. Price, D. Covey, 2006, Chemical communications.

The Mechanism of Enantioselective Neurosteroid Actions on GABAA Receptors

G. Akk, J. Bracamontes, A. Evers, 2023, Biomolecules.

Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors

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11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors

J. Steinbach, C. Zorumski, S. Mennerick, 2014, Psychopharmacology.

Photoaffinity Labeling with a Neuroactive Steroid Analogue

J. Steinbach, S. Mennerick, G. Akk, 2003, The Journal of Biological Chemistry.

Neuroactive Steroid Interactions with Voltage-Dependent Anion Channels: Lack of Relationship to GABAA Receptor Modulation and Anesthesia

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Author response: Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

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Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.

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Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone.

K. Krishnan, D. Covey, Shirisha Komarapuri, 2008, Journal of labelled compounds & radiopharmaceuticals.

The Neurosteroids Dehydroepiandrosterone Sulfate and Pregnenolone Sulfate Inhibit the UNC-49 GABA Receptor through a Common Set of Residues

D. Covey, B. Bamber, Vernon D. Twede, 2007, Molecular Pharmacology.

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light

J. Steinbach, C. Zorumski, S. Mennerick, 2007, Nature Neuroscience.

Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.

C. Zorumski, S. Mennerick, A. Evers, 2006, Journal of medicinal chemistry.

Enantiomers of Neuroactive Steroids Support a Specific Interaction with the GABA-C Receptor as the Mechanism of Steroid Action

P. Kinnunen, J. Steinbach, D. Covey, 2006, Molecular Pharmacology.

Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission.

W. Shen, C. Zorumski, S. Mennerick, 2001, Molecular pharmacology.

Enantioselectivity of Pregnanolone-Induced γ-Aminobutyric AcidA Receptor Modulation and Anesthesia

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Neurosteroid Analogues. Part 5. Enantiomers of Neuroactive Steroids and Benz[e]indenes: Total Synthesis, Electrophysiological Effects on GABAA Receptor Function and Anesthetic Actions in Tadpoles.

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Effects of Neurosteroid and Benz[e]indene Enantiomers on GABAA Receptors in Cultured Hippocampal Neurons and Transfected HEK-293 Cells

K. Isenberg, C. Zorumski, D. Covey, 1996, Neuropharmacology.

Neurosteroid Analogues. Part 3. The Synthesis and Electrophysiological Evaluation of Benz(e)indene Congeners of Neuroactive Steroids Having the 5β‐Configuration.

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Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5 beta-configuration.

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Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles.

C. Zorumski, D. Covey, Y. Hu, 1993, Journal of Medicinal Chemistry.

Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes.

K. Isenberg, C. Zorumski, D. Covey, 1993, Journal of medicinal chemistry.

Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons.

K. Isenberg, C. Zorumski, D. Covey, 1992, Molecular pharmacology.

Photoaffinity Labeling with a Neuroactive Steroid Analogue 6-AZI-PREGNANOLONE LABELS VOLTAGE-DEPENDENT ANION CHANNEL-1 IN RAT BRAIN*

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Neurosteroid analogues. Part 5.1 Enantiomers of neuroactive steroids and benz[e]indenes: total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles

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Stereospecific requirement of cholesterol in the function of the serotonin1A receptor.

J. Ruysschaert, A. Chattopadhyay, D. Covey, 2014, Biochimica et biophysica acta.

Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity.

J. Simpkins, N. Agarwal, D. Covey, 2004, Free radical biology & medicine.

Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ22 steroids

D. Covey, David Brownholland, 2017, Steroids.

Blockade of Ba2+ current through human α1E channels by two steroid analogs, (+)-ACN and (+)-ECN

C. Lingle, T. Schneider, D. Covey, 1999, Neuropharmacology.

Molecular Neurosteroid Access to the GABAA Receptor

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Natural and Enantiomeric Etiocholanolone Interact with Distinct Sites on the Rat α1β2γ2L GABAA Receptor

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Natural and Enantiomeric Etiocholanolone Interact with Distinct Sites on the Rat (cid:1) 1 (cid:2) 2 (cid:3) 2L GABA A Receptor

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Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells.

J. Simpkins, Shao-Hua Yang, Ran Liu, 2006, Molecular pharmacology.

Hydrogen bonding between the 17β‐substituent of a neurosteroid and the GABAA receptor is not obligatory for channel potentiation

J. Steinbach, G. Akk, D. Covey, 2009, British journal of pharmacology.

Synthesis and Anticonvulsant Activities of 3,3-Dialkyl- and 3-Alkyl-3-benzyl-2-piperidinones (δ-Valerolactams) and Hexahydro-2H-azepin-2-ones (ε-Caprolactams)

T. Latifi, J. Ferrendelli, S. Rothman, 1997 .

Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).

T. Latifi, J. Ferrendelli, S. Rothman, 1997, Journal of Medicinal Chemistry.

Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

Y. Izumi, C. Zorumski, D. Covey, 2018, Scientific Reports.

Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.

J. Ferrendelli, D. Covey, J. A. Levine, 1991, Journal of medicinal chemistry.

NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue

C. Zorumski, S. Mennerick, L. Eisenman, 2009, The Journal of physiology.

Physiological comparison of α-ethyl-α-methyl-γ-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors

J. Ferrendelli, S. Rothman, D. Covey, 1996, Neuropharmacology.

α-Substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons

D. Clifford, C. Zorumski, J. Yang, 1988, Neuroscience Letters.

Identification and Characterization of TRO 19622 ( Cholest-4-en-3-One , Oxime ) , a Novel Drug Candidate for Amyotrophic Lateral Sclerosis

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Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis □ S

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Enantioselective Protein-Sterol Interactions Mediate Regulation of Both Prokaryotic and Eukaryotic Inward Rectifier K+ Channels by Cholesterol

C. Nichols, N. D'Avanzo, D. Covey, 2011, PloS one.

Identification and determination of certain N,N′-disubstituted p-phenylenediamine antiozonants in cured styrenebutadiene elastomers

D. Burns, D. Covey, E. W. Johnson, 1975 .

Palladium-Catalyzed Potassium Enoxyborate Alkylation of Enantiopure Hajos—Parrish Indenone to Construct Rearranged Steroid Ring Systems.

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Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions

C. Zorumski, S. Mennerick, D. Covey, 2007, British journal of pharmacology.

Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

C. Zorumski, S. Mennerick, A. Evers, 2005, Journal of medicinal chemistry.

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ25–35 peptide-induced toxicity in vitro and in vivo in mice

K. Krishnan, D. Covey, J. Meunier, 2014, Psychopharmacology.

Affinity labeling of human placental 3 beta-hydroxy-delta 5-steroid dehydrogenase and steroid delta-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity.

R. Strickler, D. Covey, J. Thomas, 1992, Biochemistry.

Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum

V. Jevtovic-Todorovic, S. Todorovic, P. Herson, 2023, Experimental biology and medicine.

Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.

David E Reichert, J. Steinbach, C. Zorumski, 2012, Journal of medicinal chemistry.

20 Pregnane X receptor (PXR) activation: A novel mechanism for neuroprotection in a mouse model of Niemann–Pick C disease

S. Gale, D. Ory, S. Walkley, 2007 .

Mapping Two Neursteroid Modulatory Sites in GLIC: A Prototypic Pentameric Ligand Gated Ion Channel

G. Akk, A. Evers, Melissa M. Budelier, 2018 .

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone

V. Jevtovic-Todorovic, S. Todorovic, D. Covey, 2014, Psychopharmacology.

Inhibition of Leydig tumor cell steroidogenesis by 10-propargylestr-4-ene-3,17-dione, an irreversible aromatase inhibitor.

D. Puett, D. Covey, M. H. Melner, 1985, Cancer research.

Natamycin interferes with ergosterol-dependent lipid phases in model membranes

D. Wüstner, H. Scheidt, D. Covey, 2023, BBA advances.

Side Chain Oxygenated Cholesterol Regulates Cellular Cholesterol Homeostasis through Direct Sterol-Membrane Interactions*

Xianlin Han, P. Schlesinger, S. Gale, 2009, Journal of Biological Chemistry.

Enantiospecific interactions between cholesterol and phospholipids.

P. Kinnunen, Xin Jiang, D. Covey, 2008, Langmuir : the ACS journal of surfaces and colloids.

The effects of in vivo administration of 10-propargylestr-4-ene-3,17-dione on rat ovarian aromatase and estrogen levels.

D. Covey, S. Zimniski, M. Brandt, 1990, Journal of enzyme inhibition.

Neurosteroid enantiomers as potentially novel neurotherapeutics

Y. Izumi, C. Zorumski, S. Mennerick, 2023, Neuroscience & Biobehavioral Reviews.

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Y. Izumi, C. Zorumski, A. Evers, 2023 .

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

C. Zorumski, S. Mennerick, K. Krishnan, 2016, Neuropharmacology.

Mutations of the GABA-A Receptor α1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids

David E Reichert, J. Steinbach, G. Akk, 2008, Molecular Pharmacology.

Stereospeci fi c requirement of cholesterol in the function of the serotonin 1 A receptor

J. Ruysschaert, A. Chattopadhyay, D. Covey, 2013 .

Characteristics of concatemeric GABAA receptors containing α4/δ subunits expressed in Xenopus oocytes

J. Steinbach, C. Zorumski, S. Mennerick, 2012, British journal of pharmacology.