H. Bräuner‐Osborne

发表

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.

A. A. Jensen, P. Wellendorph, H. Bräuner‐Osborne, 2007, Current drug targets.

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

David E. Gloriam, Hans Bräuner-Osborne, Kasper Harpsøe, 2015, Scientific Reports.

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB‐1893 and MPEP

J. M. Mathiesen, H. Bräuner‐Osborne, C. Thomsen, 2003, British journal of pharmacology.

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

U. Gether, H. Bräuner‐Osborne, Stine E. Jacobsen, 2017, Scientific Reports.

Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor.

Hans Bräuner-Osborne, David E Gloriam, D. Gloriam, 2011, Chemistry & biology.

The emerging role of promiscuous 7TM receptors as chemosensors for food intake.

P. Wellendorph, H. Bräuner‐Osborne, L. D. Johansen, 2010, Vitamins and hormones.

Molecular pharmacology of promiscuous 7 TM receptors sensing organic nutrients

P. Wellendorph, H. Bräuner‐Osborne, L. D. Johansen, 2009 .

Allosteric Modulation of the Calcium-Sensing Receptor

A. A. Jensen, H. Bräuner‐Osborne, A. Jensen, 2007, Current neuropharmacology.

mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

Christina Mølck, David E. Gloriam, Hans Bräuner-Osborne, 2014, Neurochemical Research.

Structure–Activity Relationships for Negative Allosteric mGluR5 Modulators

Christina Mølck, Hans Bräuner-Osborne, Kasper Harpsøe, 2012, ChemMedChem.

Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).

Hans Bräuner-Osborne, J. L. Hansen, A. A. Jensen, 2002, European journal of biochemistry.

Calcium-sensing receptor (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

E. Brown, D. Shoback, D. Ward, 2020 .

Calcium-sensing receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

E. Brown, D. Shoback, D. Ward, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Synthesis and pharmacological characterization at glutamate receptors of erythro-and threo-tricholomic acid and homologues thereof

G. Roda, A. Pinto, L. Tamborini, 2007 .

Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.

P. Krogsgaard‐Larsen, A. Kristensen, D. Pickering, 2003, Bioorganic & medicinal chemistry.

1,2,3-triazolyl amino acids as AMPA receptor ligands.

J. M. Mathiesen, D. S. Pedersen, A. Abell, 2010, Bioorganic & medicinal chemistry letters.

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.

Peter Naur, Hans Bräuner-Osborne, P. Naur, 2009, Journal of medicinal chemistry.

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.

J. Greenwood, S. Traynelis, K. Hansen, 2008, Journal of medicinal chemistry.

Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils.

David E. Gloriam, D. Gloriam, D. S. Pedersen, 2017, Journal of pharmacological and toxicological methods.

Transmembrane α-Helix 2 and 7 Are Important for Small Molecule-Mediated Activation of the GLP-1 Receptor

G. Peters, L. B. Knudsen, H. Bräuner‐Osborne, 2011, Pharmacology.

Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

K. Gregory, S. Foster, H. Bräuner‐Osborne, 2020, Molecular Pharmacology.

Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.

H. Bräuner‐Osborne, Martin Hansen, J. Kristensen, 2014, ACS chemical neuroscience.

Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites.

P. Wellendorph, B. Frølund, R. Clausen, 2010, Journal of medicinal chemistry.

Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

A. Hauser, D. Gloriam, P. Wellendorph, 2017, Scientific Reports.

Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors.

H. Bräuner‐Osborne, Lenea Nørskov-Lauritsen, 2015, European journal of pharmacology.

Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.

A. A. Jensen, H. Bräuner‐Osborne, A. Jensen, 2004, Biochemical pharmacology.

Strontium Is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells

Alex R. B. Thomsen, H. Bräuner‐Osborne, Markus Latta, 2012, Journal of Pharmacology and Experimental Therapeutics.

Identification of a novel scaffold for a small molecule GPR139 receptor agonist

D. Gloriam, S. Foster, P. R. Gentry, 2019, Scientific Reports.

G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology

Alex R. B. Thomsen, H. Bräuner‐Osborne, Lenea Nørskov-Lauritsen, 2014, International journal of molecular sciences.

GABAB-Agonistic Activity of Certain Baclofen Homologues

H. Bräuner‐Osborne, M. Attia, C. Herdeis, 2013, Molecules.

Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-d-Aspartate Receptor Antagonists

J. Snyder, Yuhong Du, S. Traynelis, 2010, Journal of Pharmacology and Experimental Therapeutics.

Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, P Krogsgaard-Larsen, 2000, Genomics.

Class C Orphans (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

E. Brown, D. Shoback, A. Conigrave, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor.

P. Krogsgaard‐Larsen, A. A. Jensen, H. Bräuner‐Osborne, 2001, European journal of pharmacology.

Pharmacological characterization of mouse GPRC6A, an L‐α‐amino‐acid receptor modulated by divalent cations

K. Hansen, P. Wellendorph, H. Bräuner‐Osborne, 2007, British journal of pharmacology.

Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay.

A. A. Jensen, H. Bräuner‐Osborne, Mette Strange, 2006, Combinatorial chemistry & high throughput screening.

Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.

J. Greenwood, A. A. Jensen, R. Clausen, 2007, Journal of medicinal chemistry.

The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH.

A. A. Jensen, H. Bräuner‐Osborne, Martin Hansen, 2020, Biochemical pharmacology.

Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359.

D. Gloriam, Xiao-Feng Xiong, K. Strømgaard, 2018, European journal of medicinal chemistry.

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

Kirsten B. Andersen, D. Gloriam, F. Björkling, 2016, Scientific Reports.

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway

U. Gether, K. Madsen, H. Bräuner‐Osborne, 2017, The Journal of Biological Chemistry.

G protein‐coupled receptor pharmacology—The next generation

M. Rosenkilde, D. Gloriam, U. Gether, 2020, Basic & clinical pharmacology & toxicology.

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

David E. Gloriam, Ariana C. Gavin, Ryan T. Strachan, 2019, Cell.

Label-free dynamic mass redistribution analysis of endogenous adrenergic receptor signaling in primary preadipocytes and differentiated adipocytes.

M. Seibel, H. Bräuner‐Osborne, Hong Zhou, 2019, Journal of pharmacological and toxicological methods.

Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline.

K. Bogeso, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 1999, Bioorganic & medicinal chemistry.

Novel approaches leading towards peptide GPCR de‐orphanisation

David E. Gloriam, A. Hauser, D. Gloriam, 2019, British journal of pharmacology.

The GABAB Receptor

B. Bettler, H. Bräuner‐Osborne, 2004 .

Calcium-sensing receptor in GtoPdb v.2021.3

E. Brown, D. Shoback, D. Ward, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa.

L. Rejnmark, B. Lanske, A. Juul, 2020, The Journal of clinical endocrinology and metabolism.

Calcium-Sensing Receptor Internalization Is β-Arrestin–Dependent and Modulated by Allosteric Ligands

S. Foster, H. Bräuner‐Osborne, Stine E. Jacobsen, 2019, Molecular Pharmacology.

l-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

B. Holst, A. Madsen, C. Clemmensen, 2011, Amino Acids.

Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements.

K. Hansen, H. Bräuner‐Osborne, J. Egebjerg, 2008, Combinatorial chemistry & high throughput screening.

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.

J. Kehler, P. Krogsgaard‐Larsen, R. Clausen, 2007, Bioorganic & medicinal chemistry.

Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

David E. Gloriam, J. M. Mathiesen, D. Gloriam, 2020, The Journal of Biological Chemistry.

Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias

K. Gregory, S. Foster, H. Bräuner‐Osborne, 2021, Molecular Pharmacology.

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, K. Hansen, 2003, Journal of medicinal chemistry.

Human GIP(3‐30)NH2 inhibits G protein‐dependent as well as G protein‐independent signaling and is selective for the GIP receptor with high‐affinity binding to primate but not rodent GIP receptors

M. Rosenkilde, B. Hartmann, A. Inoue, 2018, Biochemical pharmacology.

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP system

M. Rosenkilde, B. Hartmann, F. X. Smit, 2019, Basic & clinical pharmacology & toxicology.

A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

J. M. Mathiesen, H. Bräuner‐Osborne, Line Vedel, 2015, Journal of biomolecular screening.

Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.

R. Thakker, Xiao-Feng Xiong, A. Inoue, 2017, JCI insight.

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice.

B. Holst, A. Madsen, C. Clemmensen, 2013, The Journal of endocrinology.

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

B. Holst, A. Madsen, C. Clemmensen, 2012, Regulatory Peptides.

α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

J. Olsen, G. Knudsen, N. Absalom, 2012, Proceedings of the National Academy of Sciences.

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

J. Holst, P. Thams, P. Wellendorph, 2012, Amino Acids.

Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking*

S. M. Knudsen, M. Waldhoer, H. Bräuner‐Osborne, 2014, The Journal of Biological Chemistry.

Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

D. Gloriam, Zhi-jie Liu, Lijie Wu, 2021, Cell research.

N‐glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization

H. Bräuner‐Osborne, Lenea Nørskov-Lauritsen, S. Jørgensen, 2015, FEBS letters.

Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

J. M. Mathiesen, A. Secher, N. Kulahin, 2014, Molecular and Cellular Endocrinology.

Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling.

Alex R. B. Thomsen, H. Bräuner‐Osborne, S. Smajilovic, 2012, Current drug targets.

Biased agonism of the calcium-sensing receptor.

Alex R. B. Thomsen, H. Bräuner‐Osborne, Maja Hvidtfeldt, 2012, Cell calcium.

The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity.

P. O'Hara, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2000, European journal of pharmacology.

The use of Xenopus oocytes in drug screening

K. Hansen, H. Bräuner‐Osborne, T. Kvist, 2011, Expert opinion on drug discovery.

Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells

J. M. Mathiesen, P. R. Gentry, H. Bräuner‐Osborne, 2022, Basic & clinical pharmacology & toxicology.

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

E. Casanova, M. Gassmann, B. Bettler, 2008, Journal of molecular endocrinology.

Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.

J. Kehler, P. Krogsgaard‐Larsen, K. Hansen, 2007, Organic & biomolecular chemistry.

Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo.

E. Brown, Alex R. B. Thomsen, S. Quinn, 2013, American journal of physiology. Endocrinology and metabolism.

4-Alkylated homoibotenic acid (HIBO) analogues: Versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes

D. Pickering, H. Bräuner‐Osborne, U. Madsen, 2005, Neuropharmacology.

A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.

S. Nakanishi, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 1996, Journal of medicinal chemistry.

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.

J. Holst, T. Frimurer, M. Rosenkilde, 2021, ACS pharmacology & translational science.

Three Distinct Epitopes on the Extracellular Face of the Glucagon Receptor Determine Specificity for the Glucagon Amino Terminus*

B. Wulff, L. B. Knudsen, K. Madsen, 2003, Journal of Biological Chemistry.

Functional Importance of the Ala116–Pro136 Region in the Calcium-sensing Receptor

M. Brann, P. O'Hara, P. Krogsgaard‐Larsen, 2000, The Journal of Biological Chemistry.

Enhanced voluntary wheel running in GPRC6A receptor knockout mice

J. Wojtaszewski, C. Clemmensen, H. Bräuner‐Osborne, 2013, Physiology & Behavior.

Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).

G. Ecker, A. Schousboe, P. Wellendorph, 2017, Journal of medicinal chemistry.

Phenylacetic acids and the structurally related non‐steroidal anti‐inflammatory drug diclofenac bind to specific γ‐hydroxybutyric acid sites in rat brain

Christian Skonberg, P. Wellendorph, H. Bräuner‐Osborne, 2009, Fundamental & clinical pharmacology.

Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters.

L. Bunch, F. Couty, G. Evano, 2005, Organic & biomolecular chemistry.

Novel Cyclic γ-Hydroxybutyrate (GHB) Analogs with High Affinity and Stereoselectivity of Binding to GHB Sites in Rat Brain

J. Greenwood, P. Wellendorph, B. Frølund, 2005, Journal of Pharmacology and Experimental Therapeutics.

A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, B. Nielsen, 2000, European journal of pharmacology.

Arrestin-Dependent and -Independent Internalization of G Protein–Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling

H. Bräuner‐Osborne, Thor C. Møller, Ee Von Moo, 2021, Molecular Pharmacology.

Known regulators of nitric oxide synthase and arginase are agonists at the human G‐protein‐coupled receptor GPRC6A

P. Wellendorph, H. Bräuner‐Osborne, B. Christiansen, 2006, British journal of pharmacology.

The dance of the clams: twists and turns in the family C GPCR homodimer.

J. Greenwood, H. Bräuner‐Osborne, A. Jensen, 2002, Trends in pharmacological sciences.

The Anticonvulsant Gabapentin (Neurontin) Does Not Act through γ-Aminobutyric Acid-B Receptors

B. Bettler, B. Abrahamsen, K. Lingenhoehl, 2002 .

Activity of l-α-amino acids at the promiscuous goldfish odorant receptor 5.24

P. Wellendorph, H. Bräuner‐Osborne, B. Christiansen, 2006 .

Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids.

G. Höfner, H. Bräuner‐Osborne, U. Madsen, 2005, Chirality.

FLIPR assays of intracellular calcium in GPCR drug discovery.

K. Hansen, H. Bräuner‐Osborne, 2009, Methods in molecular biology.

A highly selective agonist for the metabotropic glutamate receptor mGluR2

J. Greenwood, P. Norrby, R. Clausen, 2011 .

Robust GLP‐1 secretion by basic L‐amino acids does not require the GPRC6A receptor

C. Clemmensen, H. Bräuner‐Osborne, S. Smajilovic, 2017, Diabetes, obesity & metabolism.

Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.

S. Woods, R. Seeley, Eric P. Smith, 2013, Endocrinology.

Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators

Christina Mølck, David E. Gloriam, Hans Bräuner-Osborne, 2012, Molecular Pharmacology.

Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization

H. Bräuner‐Osborne, Thor C. Møller, Ee Von Moo, 2022, The Journal of biological chemistry.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Arthur Christopoulos, Christopher Southan, Stephen PH Alexander, 2017, British journal of pharmacology.

Interactions of Muscarinic Receptors with the Heterotrimeric G Proteins Gq and G12: Transduction of Proliferative Signals

B. Conklin, M. Brann, H. Bräuner‐Osborne, 1997, Journal of neurochemistry.

Synthesis of Conformationally Constrained Glutamic Acid Homologues and Investigation of Their Pharmacological Profiles

A. Pinto, L. Tamborini, P. Conti, 2007, ChemMedChem.

The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay.

H. Bräuner‐Osborne, T. Kvist, B. Christiansen, 2009, Combinatorial chemistry & high throughput screening.

Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor

Alex R. B. Thomsen, P. Wellendorph, H. Bräuner‐Osborne, 2013, The Journal of Pharmacology and Experimental Therapeutics.

3-Substituted 2-phenyl-indoles: privileged structures for medicinal chemistry

David E. Gloriam, D. Gloriam, H. Bräuner‐Osborne, 2013 .

Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24.

P. Wellendorph, H. Bräuner‐Osborne, B. Christiansen, 2006, European journal of pharmacology.

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.

J. McCorvy, H. Bräuner‐Osborne, Martin Hansen, 2015, Bioorganic & medicinal chemistry.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Stephen P. H. Alexander, Leigh A. Stoddart, Kalyan C. Tirupula, 2021, British journal of pharmacology.

Novel Radioiodinated γ-Hydroxybutyric Acid Analogues for Radiolabeling and Photolinking of High-Affinity γ-Hydroxybutyric Acid Binding Sites

G. Knudsen, P. Wellendorph, B. Frølund, 2010, Journal of Pharmacology and Experimental Therapeutics.

Implementation of a fluorescence-based screening assay identifies histamine H 3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective NMDA receptor antagonists

J. Snyder, Yuhong Du, Katie M Vance, 2010 .

GABA and Glutamate Receptor Ligands and their Therapeutic Potential in CNS Disorders

T. Liljefors, J. Greenwood, P. Krogsgaard‐Larsen, 2010 .

Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients

P. Wellendorph, H. Bräuner‐Osborne, L. D. Johansen, 2009, Molecular Pharmacology.

Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids

J. Greenwood, K. Hansen, P. Wellendorph, 2005, Molecular Pharmacology.

Probing the existence of a metastable binding site at the β2-adrenergic receptor with homobivalent bitopic ligands.

David E. Gloriam, J. M. Mathiesen, D. Gloriam, 2019, Journal of medicinal chemistry.

Ligands for glutamate receptors: design and therapeutic prospects.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 2000, Journal of medicinal chemistry.

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.

F. Acher, K. Hansen, G. Roda, 2005, Journal of medicinal chemistry.

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.

A. Pinto, L. Tamborini, P. Conti, 2008, Journal of medicinal chemistry.

Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold.

D. Gloriam, H. Bräuner‐Osborne, H. Johansson, 2015, Journal of medicinal chemistry.

Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

S. Nakanishi, R. Duvoisin, R. Shigemoto, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 1998, Journal of medicinal chemistry.

Specific γ‐hydroxybutyrate‐binding sites but loss of pharmacological effects of γ‐hydroxybutyrate in GABAB(1)‐deficient mice

J. Cryan, B. Bettler, W. Froestl, 2003 .

Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA.

P. Wellendorph, H. Bräuner‐Osborne, G. V. van Woerden, 2022, Journal of pharmacological and toxicological methods.

Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.

E. Russo, G. De Sarro, P. Conti, 2003, Journal of medicinal chemistry.

Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors

L. Toma, G. Roda, P. Conti, 2003 .

Design of novel conformationally restricted analogues of glutamic acid

G. Vistoli, L. Toma, G. Roda, 2003 .

Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.

G. De Sarro, P. Conti, H. Bräuner‐Osborne, 1998, Journal of medicinal chemistry.

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists.

G. De Sarro, L. Toma, G. Roda, 2004, Journal of medicinal chemistry.

Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.

P. Krogsgaard‐Larsen, E. Falch, I. Mikkelsen, 2004, European journal of pharmacology.

Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).

T. Liljefors, A. Schousboe, J. Greenwood, 2003, Journal of medicinal chemistry.

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

R. Thakker, R. Mason, D. Ward, 2020, Pharmacological Reviews.

Arrestin-dependent and -independent internalization of GPCRs-methods, mechanisms and implications on cell signaling

H. Bräuner‐Osborne, Thor C. Møller, Ee Von Moo, 2021 .

Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches.

S. Foster, H. Bräuner‐Osborne, 2018, Handbook of experimental pharmacology.

Molecular basis for amino acid sensing by family C G‐protein‐coupled receptors

P. Wellendorph, H. Bräuner‐Osborne, 2009, British journal of pharmacology.

Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 1996 .

The Agonist-binding Domain of the Calcium-sensing Receptor Is Located at the Amino-terminal Domain*

P. O'Hara, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 1999, The Journal of Biological Chemistry.

Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.

P. Wellendorph, H. Bräuner‐Osborne, 2004, Gene.

Novel 3‐Carboxy‐ and 3‐Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

K. Hansen, A. Pinto, L. Tamborini, 2010, ChemMedChem.

Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile.

A. Schousboe, R. Clausen, H. Bräuner‐Osborne, 2013, Biochemical Pharmacology.

The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

J. Greenwood, K. Hansen, R. Clausen, 2004, European journal of pharmacology.

Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.

J. Greenwood, P. Krogsgaard‐Larsen, C. Sánchez, 2004, European journal of pharmacology.

Functional partial agonism at cloned human muscarinic acetylcholine receptors.

M. Brann, P. Krogsgaard‐Larsen, E. Falch, 1996, European journal of pharmacology.

Structure of a G-protein-coupling Domain of a Muscarinic Receptor Predicted by Random Saturation Mutagenesis (*)

M. Brann, D. Hill-Eubanks, H. Bräuner‐Osborne, 1996, The Journal of Biological Chemistry.

Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells.

M. Brann, H. Bräuner‐Osborne, 1996, European journal of pharmacology.

Agonists and Inverse Agonists for the Herpesvirus 8-encoded Constitutively Active Seven-transmembrane Oncogene Product, ORF-74*

Thomas N. Kledal, Mette M. Rosenkilde, T. Schwartz, 1999, The Journal of Biological Chemistry.

Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling

A. Irving, P. Davies, H. Bräuner‐Osborne, 2008, Pharmacogenetics and genomics.

3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.

P. Davies, H. Bräuner‐Osborne, A. Jensen, 2008, Trends in pharmacological sciences.

High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor

Hans Bräuner-Osborne, Paul A Davies, P. Davies, 2008, Proceedings of the National Academy of Sciences.

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

H. Bräuner‐Osborne, A. Jensen, K. Krzywkowski, 2007, Pharmacogenetics and genomics.

Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

K. Hansen, R. Clausen, H. Bräuner‐Osborne, 2017, Molecular Pharmacology.

Molecular pharmacology of human NMDA receptors

S. Traynelis, K. Hansen, H. Bräuner‐Osborne, 2012, Neurochemistry International.

Mutational Landscape of the Proglucagon-Derived Peptides

M. Rosenkilde, A. Hauser, H. Bräuner‐Osborne, 2021, Frontiers in Endocrinology.

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

M. Rossol, M. Pierer, C. Baerwald, 2012, Nature Communications.

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, B. Frølund, 2005, Bioorganic & medicinal chemistry.

Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 2000, European journal of medicinal chemistry.

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

Kirsten B. Andersen, A. Hauser, D. Gloriam, 2017, Neurochemistry International.

Synthesis of Novel N1‐Substituted Bicyclic Pyrazole Amino Acids and Evaluation of Their Interaction with Glutamate Receptors

G. Roda, A. Pinto, P. Conti, 2005, Chemistry & biodiversity.

Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

L. Toma, P. Conti, H. Bräuner‐Osborne, 2002, Farmaco.

Tweaking Agonist Efficacy at N-Methyl-d-aspartate Receptors by Site-Directed Mutagenesis

J. Greenwood, K. Hansen, E. Bjerrum, 2005, Molecular Pharmacology.

The rat GPRC6A: cloning and characterization.

P. Wellendorph, H. Bräuner‐Osborne, H. Schmale, 2007, Gene.

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

B. Bettler, B. Abrahamsen, K. Lingenhoehl, 2002, Molecular pharmacology.

Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

Hans Bräuner-Osborne, P. Wellendorph, B. Frølund, 2008, Journal of medicinal chemistry.

mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

J. M. Mathiesen, D. Gloriam, H. Bräuner‐Osborne, 2014, Neurochemical Research.

(R)-(3-Amino-2-fluoropropyl) Phosphinic Acid (AZD3355), a Novel GABAB Receptor Agonist, Inhibits Transient Lower Esophageal Sphincter Relaxation through a Peripheral Mode of Action

Jacobson, J. Dent, A. Page, 2009, Journal of Pharmacology and Experimental Therapeutics.

Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice

M. Seibel, H. Bräuner‐Osborne, Sylvia J. Gasparini, 2019, Scientific Reports.

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

P. Wellendorph, C. Clemmensen, H. Bräuner‐Osborne, 2014, British journal of pharmacology.

(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.

J. Brodie, A. Schousboe, C. Craft, 2012, Journal of medicinal chemistry.

Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.

T. Liljefors, J. Greenwood, P. Krogsgaard‐Larsen, 2003, The Journal of organic chemistry.

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.

D. Liotta, S. Traynelis, K. Hansen, 2010, Journal of medicinal chemistry.

Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.

P. Krogsgaard‐Larsen, B. Brodin, H. Bräuner‐Osborne, 2001, Biochimica et biophysica acta.

Structure-based discovery of antagonists for GluN3-containing N-methyl-d-aspartate receptors

J. Greenwood, S. Traynelis, K. Hansen, 2013, Neuropharmacology.

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

J. M. Mathiesen, M. Bouvier, H. Bräuner‐Osborne, 2020, Scientific Reports.

Xenopus oocyte electrophysiology in GPCR drug discovery.

K. Hansen, H. Bräuner‐Osborne, 2009, Methods in molecular biology.

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, K. Frydenvang, 2002, Bioorganic & medicinal chemistry.

Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, B. Nielsen, 1998, European journal of pharmacology.

Pharmacology of (S)‐homoquisqualic acid and (S)‐2‐amino‐5‐phosphonopentanoic acid [(S)‐AP5] at cloned metabotropic glutamate receptors

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, Povl Krogsgaard‐Larsen, 1998, British journal of pharmacology.

Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants

T. Oertner, R. Shigemoto, R. Luján, 2006, Neuron.

Mutation-induced Quisqualic Acid and Ibotenic Acid Affinity at the Metabotropic Glutamate Receptor Subtype 4

J. Greenwood, H. Bräuner‐Osborne, M. B. Hermit, 2004, Journal of Biological Chemistry.

The GABAB1a Isoform Mediates Heterosynaptic Depression at Hippocampal Mossy Fiber Synapses

M. Frotscher, R. Shigemoto, O. Kretz, 2009, The Journal of Neuroscience.

Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function*

T. Hansen, O. Pedersen, N. Grarup, 2016, The Journal of Biological Chemistry.

Different domains of the glucagon and glucagon‐like peptide‐1 receptors provide the critical determinants of ligand selectivity

B. Wulff, L. B. Knudsen, K. Madsen, 2003, British journal of pharmacology.

Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1).

A. Juul, H. Bräuner‐Osborne, M. Blomberg Jensen, 2020, The Journal of clinical endocrinology and metabolism.

l-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

B. Holst, C. Clemmensen, H. Bräuner‐Osborne, 2012, Amino Acids.

Synthesis and receptor binding affinity of new selective GluR5 ligands.

T. H. Johansen, P. Krogsgaard‐Larsen, L. Bunch, 2001, Bioorganic & medicinal chemistry.

Asymmetric activation of the calcium-sensing receptor homodimer

M. J. Robertson, J. M. Mathiesen, G. Skiniotis, 2021, Nature.

Structure–Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM‐254890

Xiao-Feng Xiong, K. Strømgaard, H. Bräuner‐Osborne, 2019, ChemMedChem.

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

J. Holst, P. Thams, P. Wellendorph, 2013, Amino Acids.

Pharmacology and physiological function of the orphan GPRC6A receptor.

H. Bräuner‐Osborne, C. Jørgensen, 2020, Basic & clinical pharmacology & toxicology.

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors.

D. Gloriam, Xiao-Feng Xiong, K. Strømgaard, 2016, Nature chemistry.

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor.

D. Rognan, T. Gorojankina, P. Dauban, 2009, Cell calcium.

Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3.

T. Gefflaut, L. Bunch, H. Bräuner‐Osborne, 2005, Journal of medicinal chemistry.

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

D. Gloriam, E. Kostenis, A. Inoue, 2019, The Journal of Biological Chemistry.

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

B. Ueberheide, C. Hill, B. Olivera, 2021, bioRxiv.

Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein

Xiao-Feng Xiong, K. Strømgaard, H. Bräuner‐Osborne, 2017, ChemMedChem.

Metabotropic glutamate receptors in GtoPdb v.2023.1 Metabotropic glutamate receptors in GtoPdb v.2023.1

S. Nakanishi, R. Duvoisin, R. Shigemoto, 2023 .

Metabotropic glutamate receptors in GtoPdb v.2021.3

S. Nakanishi, R. Duvoisin, R. Shigemoto, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.

P. Krogsgaard‐Larsen, E. Falch, I. Mikkelsen, 2003, Molecular pharmacology.

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.

J. Cryan, B. Bettler, W. Froestl, 2003, The European journal of neuroscience.

Calcium-sensing receptor in GtoPdb v.2023.1

E. Brown, D. Shoback, D. Ward, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.

M. Brann, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2000, The Journal of biological chemistry.

The orthosteric GABAA receptor ligand Thio‐4‐PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

U. Kristiansen, N. O. Dalby, J. Cryan, 2013, British journal of pharmacology.

Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist

J. Kehler, C. Bundgaard, J. McCorvy, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Ligand-directed bias of G protein signaling at the dopamine D2 receptor.

David E. Gloriam, A. Hauser, D. Gloriam, 2021, Cell chemical biology.

Characterisation of the Family C of G-protein Coupled Receptors

H. Bräuner‐Osborne, 2002 .

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

David E. Gloriam, Hans Bräuner-Osborne, Kasper Harpsøe, 2016, Bioinform..

Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice

M. Seibel, H. Bräuner‐Osborne, Sylvia J. Gasparini, 2019, Scientific Reports.

Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms

A. Inoue, H. Bräuner‐Osborne, Yufang Deng, 2023, FEBS letters.

Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3.

L. Bunch, H. Bräuner‐Osborne, B. Nielsen, 2006, Journal of medicinal chemistry.

Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.

J. Greenwood, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2004, Chirality.

Construction of a High Affinity Zinc Binding Site in the Metabotropic Glutamate Receptor mGluR1

H. Bräuner‐Osborne, P. Sheppard, L. Jensen, 2001, The Journal of Biological Chemistry.

Synthesis of the calcilytic ligand NPS 2143

H. Bräuner‐Osborne, H. Johansson, D. Sejer Pedersen, 2013, Beilstein journal of organic chemistry.

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

S. Foster, M. Bouvier, H. Bräuner‐Osborne, 2020, Neuropharmacology.

Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-d-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site*

J. Greenwood, J. Kastrup, M. Gajhede, 2013, The Journal of Biological Chemistry.

Molecular Mechanism of a Novel GluN 1 Glycine-Site Antagonist ! " ! ! Crystal Structure and Pharmacological Characterization of a Novel NMDA Receptor Antagonist at the GluN 1 Glycine Binding Site

J. Greenwood, J. Kastrup, M. Gajhede, 2013 .

cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors.

J. M. Mathiesen, H. Bräuner‐Osborne, Line Vedel, 2013, Methods in enzymology.

A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.

Dennis K. Taylor, E. Tiekink, J. M. Mathiesen, 2010, Bioorganic & medicinal chemistry.

New analogues of ACPD with selective activity for group II metabotropic glutamate receptors.

E. Mikiciuk-Olasik, H. Bräuner‐Osborne, U. Madsen, 1997, European journal of pharmacology.

Identification of the first surrogate agonists for the G protein-coupled receptor GPR132

A. Bender, D. Gloriam, H. Bräuner‐Osborne, 2015 .

Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, Povl Krogsgaard‐Larsen, 1999, British journal of pharmacology.

Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1)

P. Wellendorph, B. Frølund, R. Clausen, 2014, Neurochemical Research.

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

J. Greenwood, P. Wellendorph, B. Frølund, 2005, The Journal of pharmacology and experimental therapeutics.

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.

G. De Sarro, L. Toma, P. Conti, 1999, Journal of medicinal chemistry.

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, A. Jensen, 1999, Neuroreport.

Homology Modelling of the GABA Transporter and Analysis of Tiagabine Binding

O. Taboureau, F. Jørgensen, H. Bräuner‐Osborne, 2010, ChemMedChem.

Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139.

D. Gloriam, S. Foster, H. Bräuner‐Osborne, 2023, European journal of pharmacology.

Pharmacology and function of the orphan GPR139 G protein‐coupled receptor

David E. Gloriam, D. Gloriam, H. Bräuner‐Osborne, 2019, Basic & clinical pharmacology & toxicology.

Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, K. Frydenvang, 2002, Chirality.

Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, T. Stensbøl, 1997, European journal of pharmacology.

Class C Orphans in GtoPdb v.2023.1

D. Shoback, A. Conigrave, H. Bräuner‐Osborne, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site

Kirsten B. Andersen, J. Åqvist, H. Gutiérrez‐de‐Terán, 2017, Scientific Reports.

Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

D. Gloriam, H. Bräuner‐Osborne, T. Ulven, 2023, Basic & clinical pharmacology & toxicology.