O. Francone

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The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding Published, JLR Papers in Press, October 9, 2008.

O. Francone, M. Tu, L. Royer, 2009, Journal of Lipid Research.

Relationship between Expression Levels and Atherogenesis in Scavenger Receptor Class B, Type I Transgenics*

E. Rubin, E. Gong, O. Francone, 2000, The Journal of Biological Chemistry.

The Development of Subcutaneous Sarcomas in Rodents Exposed to Peroxisome Proliferators Agonists

Y. Will, D. Amacher, O. Francone, 2012, Toxicologic pathology.

Pulmonary abnormalities due to ABCA1 deficiency in mice.

O. Francone, G. Rothblat, J. Tao, 2005, American journal of physiology. Lung cellular and molecular physiology.

A Mouse Model with Features of Familial Combined Hyperlipidemia

A. Tall, J. Breslow, I. Goldberg, 1997, Science.

Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived choleste

C. Fielding, A. Gurakar, O. Francone, 1989, The Journal of biological chemistry.

In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice.

J. Parks, O. Francone, J. Furbee, 2002, Journal of lipid research.

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels.

A. Tall, X. Jiang, M. Lin, 1999, The Journal of clinical investigation.

Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake*

Xiang-An Li, O. Francone, Xuewei Zhu, 2015, The Journal of Biological Chemistry.

Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha

A. Kalgutkar, R. Walsky, B. Feng, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger receptor B-I.

A. Tall, X. Jiang, H. Oliveira, 1999, Journal of lipid research.

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH

A. Seymour, D. Lamppu, J. Ellsworth, 2020, Molecular therapy. Methods & clinical development.

Identification and characterization of rodent ABCA1 in isolated type II pneumocytes.

M. Reilly, E. Favari, O. Francone, 2003, American journal of physiology. Lung cellular and molecular physiology.

Molecular Characterization of Novel and Selective Peroxisome Proliferator-Activated Receptor (cid:1) Agonists with Robust Hypolipidemic Activity in Vivo □ S

P. Zagouras, O. Francone, L. Royer, 2009 .

Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

A. Tall, J. Breslow, A. Walsh, 1996, The Journal of clinical investigation.

Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters.

K. Feingold, C. Fielding, C. Grunfeld, 1995, Journal of lipid research.

Increased Cholesterol Deposition, Expression of Scavenger Receptors, and Response to Chemotactic Factors in Abca1-Deficient Macrophages

O. Francone, L. Royer, D. Brees, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.

A. Tall, A. Walsh, N. Moatti, 1995, The Journal of clinical investigation.

Increased prebeta-HDL levels, cholesterol efflux, and LCAT-mediated esterification in mice expressing the human cholesteryl ester transfer protein (CETP) and human apolipoprotein A-I (apoA-I) transgenes.

O. Francone, L. Royer, M. Haghpassand, 1996, Journal of lipid research.

Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPARalpha.

O. Francone, C. Kane, Kimberly A. Stevens, 2006, Gene.

A Selective Peroxisome Proliferator-Activated Receptor α Agonist, CP-900691, Improves Plasma Lipids, Lipoproteins, and Glycemic Control in Diabetic Monkeys

O. Francone, L. Royer, B. Auerbach, 2010, Journal of Pharmacology and Experimental Therapeutics.

A critical role for peroxisomal proliferator-activated receptor-alpha nuclear receptors in the development of cardiomyocyte degeneration and necrosis.

O. Francone, L. Royer, C. Kane, 2006, The American journal of pathology.

Aldosterone production in human adrenocortical cells is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2).

W. Rainey, O. Francone, L. Royer, 2011, Endocrinology.

Effects of Enrichment of Fibroblasts with Unesterified Cholesterol on the Efflux of Cellular Lipids to Apolipoprotein A-I*

W. J. Johnson, P. Holvoet, O. Francone, 2002, The Journal of Biological Chemistry.

SR-BI: a new player in an old game.

O. Francone, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Disruption of the Murine Lecithin:Cholesterol Acyltransferase Gene Causes Impairment of Adrenal Lipid Delivery and Up-regulation of Scavenger Receptor Class B Type I*

E. Rubin, T. Forte, O. Francone, 1997, The Journal of Biological Chemistry.

Distribution of cell-derived cholesterol among plasma lipoproteins: a comparison of three techniques.

C. Fielding, P. Fielding, O. Francone, 1990, Journal of lipid research.

Identification and characterization of rodent ABCA 1 in isolated type II pneumocytes

M. Reilly, E. Favari, O. Francone, 2003 .

Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism.

E. Rubin, E. Gong, C. Fielding, 1995, The Journal of clinical investigation.

Initial steps in reverse cholesterol transport: the role of short-lived cholesterol acceptors.

C. Fielding, O. Francone, 1990, European heart journal.

Enhanced efflux of cholesterol from ABCA1-expressing macrophages to serum from type IV hypertriglyceridemic subjects.

J. Paul, N. Fournier, M. Cambillau, 2003, Atherosclerosis.

Modification of the cholesterol efflux properties of human serum by enrichment with phospholipid.

O. Francone, L. Royer, G. Rothblat, 1997, Journal of lipid research.

Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse.

A. Rigotti, F. Nervi, D. Cohen, 2007, Biochimica et biophysica acta.

Secretion of lecithin:cholesterol acyltransferase by brain neuroglial cell lines.

C. Fielding, F. Besnard, O. Francone, 1999, Biochemical and biophysical research communications.

Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice.

L. Guey, J. Uitto, D. Keene, 2015, The Journal of investigative dermatology.

Efficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitus.

C. Contant, S. Terra, A. Lewin, 2008, The American journal of cardiology.

Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

A. Kalgutkar, T. Maurer, S. Winter, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Effect of a high-fat diet on the incorporation of stored triacylglycerol into hepatic VLDL.

O. Francone, A. Kalopissis, G. Griffaton, 1992, The American journal of physiology.

Contribution of cytoplasmic storage triacylglycerol to VLDL-triacylglycerol in isolated rat hepatocytes.

O. Francone, A. Kalopissis, G. Griffaton, 1989, Biochimica et biophysica acta.

Lecithin-cholesterol acyltransferase: effects of mutagenesis at N-linked oligosaccharide attachment sites on acyl acceptor specificity.

C. Fielding, O. Francone, L. Evangelista, 1993, Biochimica et biophysica acta.

Effects of site-directed mutagenesis at residues cysteine-31 and cysteine-184 on lecithin-cholesterol acyltransferase activity.

C. Fielding, O. Francone, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT.

J. Parks, O. Francone, J. Furbee, 2001, Journal of lipid research.

Lower Plasma Levels and Accelerated Clearance of High Density Lipoprotein (HDL) and Non-HDL Cholesterol in Scavenger Receptor Class B Type I Transgenic Mice*

E. Rubin, E. Gong, O. Francone, 1999, The Journal of Biological Chemistry.

Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia

S. Eyheramendy, R. Uauy, A. Rigotti, 2019, Lipids in Health and Disease.

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.

C. Gabel, J. Mcneish, G. Chimini, 2000, Proceedings of the National Academy of Sciences of the United States of America.

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.

Paul T. Tarr, M. Fishbein, P. Edwards, 2005, Cell metabolism.

The Correlation of ATP-binding Cassette 1 mRNA Levels with Cholesterol Efflux from Various Cell Lines*

J. Mcneish, O. Francone, L. Royer, 2000, The Journal of Biological Chemistry.

Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15

Huei-Mei Chen, Johnf . Thompson, A. Seymour, 2020, PloS one.

Molecular Characterization of Novel and Selective Peroxisome Proliferator-Activated Receptor α Agonists with Robust Hypolipidemic Activity in Vivo

P. Zagouras, O. Francone, L. Royer, 2009, Molecular Pharmacology.

Structure-function relationships in human lecithin:cholesterol acyltransferase. Site-directed mutagenesis at serine residues 181 and 216.

C. Fielding, O. Francone, 1991, Biochemistry.

ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

B. McManus, M. Hayden, C. Wellington, 2002, Laboratory Investigation.

Adrenal cell aldosterone production is stimulated by very-low-density lipoprotein (VLDL).

J. Apolzan, W. Bollag, W. Rainey, 2012, Endocrinology.

Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels

A. Burlingame, J. Kane, O. Francone, 2011, Journal of Lipid Research.

Binding and functional effects of transcription factors Sp1 and Sp3 on the proximal human lecithin:cholesterol acyltransferase promoter.

O. Francone, K. L. Hoppe, 1998, Journal of lipid research.

Expression of human lecithin:cholesterol acyltransferase in transgenic mice: effects on cholesterol efflux, esterification, and transport.

J. Mcneish, O. Francone, L. Royer, 1997, Journal of lipid research.

ATVB In Focus Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport

O. Francone, D. Brees, R. Aiello, 2003 .

ATVB In Focus Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport

O. Francone, D. Brees, R. Aiello, 2003 .

Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels.

O. Francone, P. Bourassa, R. Aiello, 2001, The Journal of clinical investigation.

Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease.

Christian Zellner, Prakash Deedwania, L. Guey, 2011, The American journal of cardiology.

Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages

O. Francone, L. Royer, T. Coskran, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1 Published, JLR Papers in Press, February 23, 2009.

Johnf . Thompson, C. Pullinger, J. Kane, 2009, Journal of Lipid Research.

The PPARα Agonists Fenofibrate and CP-778875 Cause Increased β-Oxidation, Leading to Oxidative Injury in Skeletal and Cardiac Muscle in the Rat

D. Amacher, O. Francone, W. Ballinger, 2012, Toxicologic pathology.

Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis

S. Young, H. Mertens, M. Ploug, 2018, Proceedings of the National Academy of Sciences.

Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1.

P. Subbaiah, A. van Tol, O. Francone, 2003, Biochemistry.

Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression[S]

S. Grosskurth, M. Kuhn, D. Ziemek, 2012, Journal of Lipid Research.

Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection[S]

G. Karam, I. Wang, J. Boyd, 2010, Journal of Lipid Research.

Intestinal very-low-density lipoprotein secretion in the genetically obese Zucker rat.

O. Francone, A. Kalopissis, G. Griffaton, 1988, Biochimica et biophysica acta.

Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility

A. Kalgutkar, X. Hu, B. Lefker, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Post-heparin plasma hepatic triglyceride lipase and monoglyceride hydrolase activities in hyperlipemia induced by a sucrose rich diet.

O. Francone, M. Basílico, Y. Lombardo, 1983, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Effects of carboxy-terminal truncation on human lecithin:cholesterol acyltransferase activity.

C. Fielding, O. Francone, L. Evangelista, 1996, Journal of lipid research.

Structure of the lipoprotein lipase GPIHBP1 complex that mediates plasma triglyceride hydrolysis

S. Young, H. Mertens, M. Ploug, 2018 .