Zhiwu Lin

发表

The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding Published, JLR Papers in Press, October 9, 2008.

O. Francone, M. Tu, L. Royer, 2009, Journal of Lipid Research.

Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor

A. Kalgutkar, T. Goosen, M. Tu, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibits Cytochrome c Release From Mitochondria and Protects Against Hypoxia-Induced Apoptosis in Heart-Derived H 9 c 2 Cells

M. Crow, G. Núñez, F. Brosius, 1999 .

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

G. Lu, J. Pfefferkorn, M. Harris, 2007, Bioorganic & medicinal chemistry letters.

Evaluation of Drugs With Speciﬁc Organ Toxicities in Organ-Speciﬁc Cell Lines

Y. Will, Zhiwu Lin, 2012 .

Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.

Yuntao Song, Bruce Auerbach, Lisa Dillon, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.

Bo Feng, David B Duignan, Bruce Auerbach, 2011, Bioorganic & medicinal chemistry letters.

Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.

Yuntao Song, Bruce Auerbach, Lisa Dillon, 2008, Bioorganic & medicinal chemistry letters.

Evaluation of drugs with specific organ toxicities in organ-specific cell lines.

Yvonne Will, Y. Will, Zhiwu Lin, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis (*)

M. Tewari, V. Dixit, R. Noelle, 1995, The Journal of Biological Chemistry.

Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney.

Tianxin Yang, J. Schnermann, J. Briggs, 1999, American journal of physiology. Renal physiology.

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

A. Kalgutkar, T. Goosen, Zhiwu Lin, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome

Jeffrey R. Chabot, A. Kalgutkar, L. Buckbinder, 2017, Drug Metabolism and Disposition.

Investigation of CYP3A induction by PF‐05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response

T. Goosen, Zhiwu Lin, Jian Lin, 2022, Clinical and translational science.

Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.

Bruce Auerbach, Lisa Dillon, Jeffrey A Pfefferkorn, 2008, Journal of medicinal chemistry.

ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells.

M. Crow, G. Núñez, F. Brosius, 1999, Circulation research.

The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding Published, JLR Papers in Press, October 9, 2008.

O. Francone, M. Tu, L. Royer, 2009, Journal of Lipid Research.