I. Kursula

发表

Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism

Aurora Martínez, J. Jänis, K. Toska, 2021, iScience.

The importance of the conserved Arg191–Asp227 salt bridge of triosephosphate isomerase for folding, stability, and catalysis

Inari Kursula, R. Wierenga, A. Lambeir, 2002, FEBS letters.

The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase.

J. Nielsen, R. Wierenga, V. Filimonov, 2000, European journal of biochemistry.

Two independently folding units of Plasmodium profilin suggest evolution via gene fusion

A. Torda, P. Kursula, J. Kallio, 2015, Cellular and Molecular Life Sciences.

Recombinant production, purification and crystallization of the Toxoplasma gondii coronin WD40 domain.

J. Kallio, I. Kursula, 2014, Acta crystallographica. Section F, Structural biology communications.

Structure of Toxoplasma gondii coronin, an actin‐binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress

W. Daher, D. Soldati-Favre, J. Kallio, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Crystallization and preliminary structural characterization of the two actin isoforms of the malaria parasite.

I. Kursula, S. P. Bhargav, J. Vahokoski, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Towards a molecular understanding of the apicomplexan actin motor: on a road to novel targets for malaria remedies?

I. Kursula, E. Kumpula, 2015, Acta crystallographica. Section F, Structural biology communications.

Rapid cadmium SAD phasing at the standard wavelength (1 Å)

A. Meents, I. Kursula, A. Burkhardt, 2017, Acta crystallographica. Section D, Structural biology.

Structure of an atypical homodimeric actin capping protein from the malaria parasite

P. Kursula, I. Kursula, Á. Bendes, 2020, bioRxiv.

Structural and Functional Characterization of Human Peripheral Nervous System Myelin Protein P2

E. Polverini, F. Natali, P. Kursula, 2010, PloS one.

Lipid membrane association of myelin proteins and peptide segments studied by oriented and synchrotron radiation circular dichroism spectroscopy.

A. Ulrich, P. Kursula, J. Bürck, 2013, The journal of physical chemistry. B.

Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase.

J. Sun, R. Wierenga, M. Salin, 2004, Protein engineering, design & selection : PEDS.

Structure and function of an atypical homodimeric actin capping protein from the malaria parasite

P. Kursula, I. Kursula, Á. Bendes, 2021, Cellular and Molecular Life Sciences.

Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers

S. Makumire, I. Kursula, A. Shonhai, 2020, PloS one.

Crystallographic Analysis of the Reaction Cycle of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family

Huijong Han, P. Kursula, I. Kursula, 2013, Journal of Molecular Biology.

Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B

U. Bergmann, J. Molloy, Yu-Fu Hung, 2022, The Journal of biological chemistry.

Characterization of Plasmodium falciparum myosin B in complex with the calmodulin-like domain of its light chain MLC-B

U. Bergmann, J. Molloy, Yu-Fu Hung, 2022, bioRxiv.

Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability

S. Raunser, I. Kursula, J. Vahokoski, 2017, Proceedings of the National Academy of Sciences.

Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organizing protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers

S. Makumire, I. Kursula, A. Shonhai, 2019, bioRxiv.

Crystal structure of the SH3 domain from S. cerevisiae Myo3

M. Wilmanns, P. Kursula, Y. Song, 2005 .

The sulfonylpiperazine MMV020291 prevents red blood cell invasion by the malaria parasite Plasmodium falciparum through interference with actin-1/profilin dynamics

Christopher J. Tonkin, Danny W. Wilson, G. McFadden, 2022, bioRxiv.

Structure and function of Plasmodium actin II in the parasite mosquito stages

Calder, P. Rosenthal, U. Bergmann, 2022, bioRxiv.

Two independently folding units of Plasmodium profilin suggest evolution via gene fusion

A. Torda, P. Kursula, J. Kallio, 2015, Cellular and Molecular Life Sciences.

Iron Binding at Specific Sites within the Octameric HbpS Protects Streptomycetes from Iron-Mediated Oxidative Stress

D. Ortiz de Orué Lucana, Ina Wedderhoff, I. Kursula, 2013, PloS one.

Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein (TgARO)

N. Klages, D. Soldati-Favre, J. Kallio, 2017 .

Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein

N. Klages, D. Soldati-Favre, J. Kallio, 2016, Journal of Cell Science.

An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion.

R. Tewari, Huijong Han, Yu-Fu Hung, 2016, Cell host & microbe.

Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332

M. Wahlgren, Qijun Chen, Ning Jiang, 2011, Malaria research and treatment.

Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates

C. Klotz, N. Langeland, J. Kallio, 2019, Infection and drug resistance.

Determinants of ligand binding and catalytic activity in the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase

P. Kursula, M. Moulin, M. Härtlein, 2015, Scientific Reports.

The N‐terminal domain of the myelin enzyme 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase: direct molecular interaction with the calcium sensor calmodulin

G. Lubec, K. Itoh, P. Kursula, 2012, Journal of neurochemistry.

Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility

S. Howell, A. Holder, D. Brady, 2017, The Journal of Biological Chemistry.

Crystallographic studies on the structure-function relationships in triosephosphate isomerase

I. Kursula, 2003 .

Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.

H. Schüler, I. Kursula, Julia M. Sattler, 2011, The Journal of biological chemistry.

Juxtanodin is an intrinsically disordered F-actin-binding protein

Petri Kursula, Inari Kursula, P. Kursula, 2012, Scientific Reports.

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress

M. Blackman, V. Heussler, B. Maco, 2017, Science.

The XBI BioLab for life science experiments at the European XFEL

Janos Hajdu, Petra Fromme, Poul Nissen, 2021, Journal of applied crystallography.

Structural Differences Explain Diverse Functions of Plasmodium Actins

F. Frischknecht, C. Sachse, S. Lepper, 2014, PLoS pathogens.

Structure of Toxoplasma gondii glideosome-associated connector suggests a role as an elastic element in actomyosin force generation for gliding motility

P. Rosenthal, Yu-Fu Hung, I. Kursula, 2022, bioRxiv.

A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replication.

H. Pospiech, L. Malkas, M. Vihinen-Ranta, 1999, Nucleic acids research.

Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation

Huijong Han, I. Kursula, E. Kumpula, 2019, PLoS biology.

Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and phosphate release

Huijong Han, I. Kursula, E. Kumpula, 2018, bioRxiv.

High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.

M. Wilmanns, W. Witke, P. Kursula, 2008, Journal of molecular biology.

Apicomplexan actin polymerization depends on nucleation

U. Bergmann, I. Kursula, J. Vahokoski, 2017, Scientific Reports.

Crystal structure of the LMAN1‐CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII

Y. Lindqvist, J. Guy, J. Bourhis, 2010, FEBS letters.

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2

M. Simons, Satyan Sharma, R. Yadav, 2013, Acta crystallographica. Section D, Biological crystallography.

High-resolution structures of malaria parasite actomyosin and actin filaments

P. Rosenthal, J. Molloy, L. Calder, 2020, bioRxiv.

Crystal structure of the PB1 domain of NBR1

M. Wilmanns, I. Kursula, S. Müller, 2006, FEBS letters.

The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity

J. Haavik, R. Loris, Peter D Szigetvari, 2018, Journal of neurochemistry.

A function of profilin in force generation during malaria parasite motility that is independent of actin binding

N. Tolia, R. Wade, F. Frischknecht, 2020, Journal of Cell Science.

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

Christopher J. Tonkin, Danny W. Wilson, G. McFadden, 2023, PLoS biology.

Apicomplexan actin polymerization depends on nucleation

U. Bergmann, I. Kursula, J. Vahokoski, 2017, Scientific Reports.

A unique profilin-actin interface is important for malaria parasite motility

R. Wade, F. Frischknecht, J. Spatz, 2017, PLoS pathogens.

The Lasso Segment Is Required for Functional Dimerization of the Plasmodium Formin 1 FH2 Domain

P. Kursula, I. Kursula, A. Ignatev, 2012, PloS one.

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.

K. Matuschewski, S. Panjikar, Markus Ganter, 2008, Structure.

Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase.

R. Yadav, P. Kursula, I. Kursula, 2011, Journal of molecular biology.

Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases

L. Scapozza, D. Soldati-Favre, I. Kursula, 2018, The EMBO journal.

Structural determinants for ligand binding and catalysis of triosephosphate isomerase.

R. Wierenga, A. Lambeir, I. Kursula, 2001, European journal of biochemistry.

Crystal Structure of Triosephosphate Isomerase Complexed with 2-Phosphoglycolate at 0.83-Å Resolution*

Inari Kursula, R. Wierenga, I. Kursula, 2003, The Journal of Biological Chemistry.

Functional homo- and heterodimeric actin capping proteins from the malaria parasite.

P. Kursula, I. Kursula, Á. Bendes, 2020, Biochemical and biophysical research communications.

P. Kursula, I. Kursula, A. Raasakka, 2017, BMC Biochemistry.

Crystal Structure of Triosephosphate Isomerase Complexed with 2-Phosphoglycolate at 0.83-Å Resolution*

R. Wierenga, I. Kursula, 2003, The Journal of Biological Chemistry.

Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding

I. Kursula, B. Haug, Fahimeh Khorsand, 2023, bioRxiv.

Crystal Structures Explain Functional Differences in the Two Actin Depolymerization Factors of the Malaria Parasite*

H. Schüler, I. Kursula, Julia M. Sattler, 2011, The Journal of Biological Chemistry.

Crystal structure of Anopheles gambiae actin depolymerizing factor explains high affinity to monomeric actin

I. Kursula, Devaki Lasiwa, 2024, bioRxiv.

Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite.

H. Schüler, I. Kursula, S. P. Bhargav, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.