E. Scott

发表

Mapping the Pathways for O2 Entry Into and Exit from Myoglobin*

Q. Gibson, J. Olson, E. Scott, 2001, The Journal of Biological Chemistry.

Crystal Structure of Histamine Dehydrogenase from Nocardioides simplex*

G. Lushington, Yan Xia, T. Reed, 2010, The Journal of Biological Chemistry.

Evaluation of Inhibition Selectivity for Human Cytochrome P450 2A Enzymes

E. Scott, Eva S. Stephens, A. Walsh, 2012, Drug Metabolism and Disposition.

Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine

K. Battaile, E. Scott, Eva S. Stephens, 2012, The FEBS journal.

p-dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/vis-MS/MS identification of indoles.

T. Williams, E. Scott, P. Porubsky, 2008, Archives of biochemistry and biophysics.

A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function.

J. Halpert, E. Scott, M. Spatzenegger, 2001, Archives of biochemistry and biophysics.

Targeting Drug-Metabolizing Enzymes for Effective Chemoprevention and Chemotherapy

David E. Williams, D. Waxman, V. Njar, 2010, Drug Metabolism and Disposition.

Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design

E. Scott, S. Brixius-Anderko, 2021, Hypertension.

Functional characterization of CYP2A13 polymorphisms.

S. Murphy, E. Scott, B. Smith, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

A1. X-RAY STRUCTURE OF HUMAN CYTOCHROME P450 1A1 AND INSIGHTS INTO FUNCTION FROM DOCKING STUDIES

G. Szklarz, E. Scott, A. Walsh, 2012 .

Inhibition of polymorphonuclear leucocyte phagocytosis by Porphyromonas gingivalis culture products in patients with adult periodontitis.

T. J. Hurst, E. Scott, J. Wilton, 1993, Archives of oral biology.

Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin

E. Scott, S. Brixius-Anderko, 2021, The Journal of biological chemistry.

Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands

E. Scott, A. Bart, 2018, The Journal of Biological Chemistry.

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.

J. Aubé, Kelin Li, E. Scott, 2018, Journal of medicinal chemistry.

Structural and Functional Evaluation of Clinically-Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1 (CYP17A1)

J. Aubé, E. Scott, S. Rogers, 2017 .

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

James R. Halpert, Eric F. Johnson, J. Halpert, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Structural insights into the function of steroidogenic cytochrome P450 17A1

E. Scott, D. F. Estrada, R. Yadav, 2017, Molecular and Cellular Endocrinology.

Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7

E. Scott, M. P. Godamudunage, Annemarie Grech, 2018, Drug Metabolism and Disposition.

Endogenous insertion of non-native metalloporphyrins into human membrane cytochrome P450 enzymes

E. Scott, R. Yadav, 2018, The Journal of Biological Chemistry.

The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes

H. Carlson, E. Scott, Jinghan Liu, 2022, The Journal of biological chemistry.

Expression, purification, crystallization and preliminary X-ray studies of a prolyl-4-hydroxylase protein from Bacillus anthracis.

E. Scott, J. Limburg, M. A. Miller, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor.

K. Thewlis, G. Riley, G. Stemp, 1998, Bioorganic & medicinal chemistry letters.

A novel series of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor

K. Thewlis, G. Riley, Christopher N. Johnson, 1997 .

2-[(substituted)phenyl]-5-[1-(2-phenylazacycloheptyl)methyl]-1H-pyrroles with high affinity and selectivity for the dopamine D3 receptor

G. Riley, Stephen A. Smith, Christopher N. Johnson, 1997 .

Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D3 receptor : N-benzyl modifications

G. Riley, Stephen A. Smith, Christopher N. Johnson, 1997 .

N-(SUBSTITUTED-PHENYL) PIPERAZINES : ANTAGONISTS WITH HIGH BINDING AND FUNCTIONAL SELECTIVITY FOR DOPAMINE D4 RECEPTORS

G. Riley, Stephen A. Smith, G. Stemp, 1996 .

Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond

J. Halpert, J. Stevens, A. Roberts, 2022, Drug Metabolism and Disposition.

Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.

C. Turro, E. Scott, B. Callahan, 2017, Chemical communications.

Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors

L. Olsen, F. Jørgensen, B. Styrishave, 2016, Scientific Reports.

Stabilizing bound O2 in myoglobin by valine68 (E11) to asparagine substitution.

S. Krzywda, M. Jaskólski, A. Wilkinson, 1998, Biochemistry.

POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION

Weihua Li, Frauke Gräter, Hualiang Jiang, 2005, Drug Metabolism and Disposition.

Waterproofing the Heme Pocket

E. Liong, J. Olson, G. Phillips, 2001, The Journal of Biological Chemistry.

Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1.

M. McLeish, E. Scott, G. L. Grunewald, 2020, Journal of medicinal chemistry.

Effects of fluorine substitution on substrate conversion by cytochromes P450 17A1 and 21A2.

J. Aubé, E. Scott, Rahul Yadav, 2021, Organic & biomolecular chemistry.

Structures of cytochrome P 450 17 A 1 with prostate cancer drugs abiraterone and TOK-001

E. Scott, N. DeVore, 2012 .

Correlating Structure and Function of Drug-Metabolizing Enzymes: Progress and Ongoing Challenges

Eric F. Johnson, M. Desai, J. Laurence, 2014, Drug Metabolism and Disposition.

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

P. Loadman, E. Scott, K. Pors, 2021, Drug Metabolism and Disposition.

Human Cytochrome P450 2E1 Structures with Fatty Acid Analogs Reveal a Previously Unobserved Binding Mode*

K. Battaile, E. Scott, P. Porubsky, 2010, The Journal of Biological Chemistry.

Cytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMR*

J. Laurence, E. Scott, D. F. Estrada, 2015, The Journal of Biological Chemistry.

Substrate-modulated Cytochrome P450 17A1 and Cytochrome b5 Interactions Revealed by NMR*

J. Laurence, E. Scott, D. F. Estrada, 2013, The Journal of Biological Chemistry.

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism*

G. Szklarz, E. Scott, A. Walsh, 2013, The Journal of Biological Chemistry.

Human Cytochrome P450 17A1 Conformational Selection

J. Laurence, Andria L. Skinner, E. Scott, 2014, The Journal of Biological Chemistry.

Steroidogenic cytochrome P450 17A1 structure and function

E. Scott, S. Burris-Hiday, Sarah Burris-Hiday, 2021, Molecular and Cellular Endocrinology.

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

Jeffrey P. Jones, K. Berka, M. Otyepka, 2016, Drug Metabolism and Disposition.

Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates*

E. Scott, P. Porubsky, N. DeVore, 2014, The Journal of Biological Chemistry.

CYTOCHROME P450 17A1 STRUCTURES WITH PROSTATE CANCER DRUGS ABIRATERONE AND TOK-001

E. Scott, Natasha M. DeVore, Emily E. Scott, 2011, Nature.

Structural and functional effects of cytochrome b5 interactions with human cytochrome P450 enzymes

E. Scott, A. Bart, 2017, The Journal of Biological Chemistry.

The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.

J. Halpert, E. Scott, Y. He, 2001, Archives of biochemistry and biophysics.

Structures of Human Cytochrome P-450 2E1

E. Scott, Emily E. Scott, P. Porubsky, 2008, Journal of Biological Chemistry.

Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability

K. L. Harris, E. Gillam, E. Scott, 2020, The Journal of Biological Chemistry.

Expression, purification, crystallization and preliminary X-ray studies of histamine dehydrogenase from Nocardioides simplex.

T. Reed, E. Scott, H. Hirakawa, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway

A. Swart, E. Scott, R. Yadav, 2020, The Journal of Steroid Biochemistry and Molecular Biology.

The stabilities of mammalian apomyoglobins vary over a 600-fold range and can be enhanced by comparative mutagenesis.

J. Olson, E. Scott, E. V. Paster, 2000, The Journal of biological chemistry.

Apoglobin stability and ligand movements in mammalian myoglobins

E. Scott, 1998 .

Nicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 Enzymes*

E. Scott, Emily E Scott, Natasha M DeVore, 2012, The Journal of Biological Chemistry.

A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5*

J. Halpert, Hong Liu, Santosh Kumar, 2003, The Journal of Biological Chemistry.

Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users

J. Aubé, F. Schoenen, E. Scott, 2013, Pharmaceutical Research.

and Xenobiotic Metabolism and Utility in Understanding Drug and Human Cytochrome P 450 1 A 1 Structure Protein Structure and Folding

Grazyna D. Szklarz, G. Szklarz, E. Scott, 2013 .

Human CYP 1 A 1 Structure and Use in Understanding Metabolism 1 Human Cytochrome P 450 1 A 1 Structure and Utility In Understanding Drug and Xenobiotic Metabolism *

G. Szklarz, E. Scott, A. Walsh, 2013 .

Structure of the Human Lung Cytochrome P450 2A13*

C. Stout, G. Lushington, E. Scott, 2007, Journal of Biological Chemistry.

Crystal structure of prolyl 4-hydroxylase from Bacillus anthracis.

E. Scott, J. Limburg, M. A. Culpepper, 2010, Biochemistry.

Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design

E. Scott, S. Brixius-Anderko, 2018, The Journal of Biological Chemistry.

Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1

Jeffrey Aubé, J. Aubé, E. Scott, 2017, Drug Metabolism and Disposition.

Ligand migration in sperm whale myoglobin.

Q H Gibson, Q. Gibson, E. Scott, 1997, Biochemistry.

Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents

L. Olsen, F. Jørgensen, F. Björkling, 2020, International journal of molecular sciences.

ω- versus (ω-1)-hydroxylation: Cytochrome P450 4B1 sterics make the call

E. Scott, 2017, The Journal of Biological Chemistry.

Key Residues Controlling Binding of Diverse Ligands to Human Cytochrome P450 2A Enzymes

G. Lushington, J. L. Wang, E. Scott, 2009, Drug Metabolism and Disposition.

Key Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A Enzymes

E. Scott, Brian D. Smith, N. DeVore, 2008, Drug Metabolism and Disposition.

Functional role of residues in the helix B' region of cytochrome P450 2B1.

Weihua Li, J. Halpert, Hong Liu, 2005, Archives of biochemistry and biophysics.

Structure of Mammalian Cytochrome P450 2B4 Complexed with 4-(4-Chlorophenyl)imidazole at 1.9-Å Resolution

Eric F. Johnson, J. Halpert, C. Stout, 2004, Journal of Biological Chemistry.

Structures of cytochrome P450 3A4.

J. Halpert, E. Scott, James R Halpert, 2005, Trends in biochemical sciences.

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix.

Hong Liu, J. Halpert, E. Scott, 2004, Archives of biochemistry and biophysics.

Structure of mammalian cytochrome P450 2B4

Eric F. Johnson, J. Halpert, C. Stout, 2000 .

Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate

E. Scott, Ryan H Takahashi, Xiaojing Wang, 2019, Drug Metabolism and Disposition.

Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site

R. Auchus, E. Scott, A. Bart, 2023, The Journal of biological chemistry.

Redox partner adrenodoxin alters cytochrome P450 11B1 ligand binding and inhibition.

E. Scott, S. Brixius-Anderko, Cara L Loomis, 2022, Journal of inorganic biochemistry.

Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

J. Halpert, E. Scott, James R Halpert, 2002, Chemical research in toxicology.

Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate

S. Kandel, E. Scott, J. Lampe, 2023, The Journal of biological chemistry.

Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281

E. Scott, F. Yoshimoto, Jinghan Liu, 2023, The Journal of biological chemistry.

Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists.

J. Hagan, D. Middlemiss, G. Riley, 1996, Journal of medicinal chemistry.

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain

E. Scott, Sarah D. Burris-Hiday, 2023, The Journal of biological chemistry.

Advances in the study of drug metabolism – symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX)

W. Humphreys, V. Lauschke, M. Segall, 2020, Drug metabolism reviews.