C. Owen

发表

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

James D. Firth, Hanna F. Klein, M. Noble, 2020, Nature Communications.

SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19)

D. Stuart, D. Hall, F. von Delft, 2020 .

Streptococcus oralis subsp. dentisani Produces Monolateral Serine-Rich Repeat Protein Fibrils, One of Which Contributes to Saliva Binding via Sialic Acid

R. Wilson, S. McGrath, V. Magrini, 2019, Infection and Immunity.

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation

John Walshaw, Louise E. Tailford, W. D. de Vos, 2015, Nature Communications.

Fucosidases from the human gut symbiont Ruminococcus gnavus

S. Monaco, N. Juge, J. Angulo, 2020, Cellular and Molecular Life Sciences.

Elucidation of a unique sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

Jan Claesen, G. Thomas, N. Juge, 2019, Nature Microbiology.

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

A. Varki, G. Taylor, S. Monaco, 2017, Nature Communications.

Accelerating Inhibitor Discovery for Multiple SARS-CoV-2 Targets with a Single, Sequence-Guided Deep Generative Framework

Samuel C. Hoffman, D. Stuart, A. Mojsilovic, 2022, ArXiv.

xia2.multiplex: a multi-crystal data-analysis pipeline

P. Lukacik, P. Aller, R. Owen, 2021, bioRxiv.

Accelerating Inhibitor Discovery With A Deep Generative Foundation Model: Validation for SARS-CoV-2 Drug Targets

Samuel C. Hoffman, A. Mojsilovic, J. Crain, 2022, 2204.09042.

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

E. Salah, C. Schofield, A. Tumber, 2022, Journal of medicinal chemistry.

Effect on CD4 T-cell count of replacing protease inhibitors in patients with successful HIV suppression: a meta-analysis

F. Kazim, A. Badley, C. Owen, 2004, AIDS.

SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19).

D. Stuart, D. Hall, F. von Delft, 2020 .

Streptococcus pneumoniae NanC

G. Taylor, P. Lukacik, M. Walsh, 2015, The Journal of Biological Chemistry.

Sialidases from gut bacteria: a mini-review

L. Tailford, N. Juge, C. Owen, 2016, Biochemical Society transactions.

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

S. Monaco, N. Juge, J. Angulo, 2021, PLoS biology.

Modulation of apoptosis by HIV protease inhibitors

A. Badley, C. Owen, B. Phenix, 2002, Apoptosis.

Biochemical and structural basis of sialic acid utilization by gut microbes

N. Juge, E. Severi, C. Owen, 2023, The Journal of biological chemistry.

Development and Validation of a Western Blot Method to Quantify Mini-Dystrophin in Human Skeletal Muscle Biopsies

C. Owen, S. Moore, D. Gifondorwa, 2022, The AAPS Journal.

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

E. Salah, C. Schofield, M. Carroll, 2023, Journal of medicinal chemistry.

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors† †Electronic supplementary information (ESI) available: Experimental details and inhibition data. See DOI: 10.1039/d0cc06870e

E. Salah, Z. Rao, C. Schofield, 2021, Chemical communications.

Structure and function of microbial α-l-fucosidases: a mini review

N. Juge, C. Owen, Haiyang Wu, 2023, Essays in biochemistry.

An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

G. Oliva, R. Chalk, A. Godoy, 2023, Nature Communications.

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

R. Owens, P. Biggin, C. Robinson, 2021, PloS one.

Accelerating Inhibitor Discovery for Multiple SARS-CoV-2 Targets with a Single, Sequence-Guided Deep Generative Framework

Samuel C. Hoffman, D. Stuart, A. Mojsilovic, 2022, ArXiv.

Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding

Helen M. Deeks, Rebecca K. Walters, Rebecca M. Twidale, 2021, bioRxiv.

Accelerating drug target inhibitor discovery with a deep generative foundation model

Samuel C. Hoffman, A. Mojsilovic, G. Screaton, 2023, Science advances.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

M. Swindells, D. Stuart, A. Hopkins, 2021, Scientific Reports.

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

T. Katoh, E. Salah, C. Schofield, 2023, Nature Chemistry.

CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells

N. Cowieson, Y. Chaban, C. Owen, 2022, Nano Research.

AI-Driven Discovery of SARS-CoV-2 Main Protease Fragment-like Inhibitors with Antiviral Activity In Vitro

P. Lukacik, C. Strain-Damerell, M. Walsh, 2023, J. Chem. Inf. Model..

A standard data format for 3DED/MicroED.

C. Owen, D. Waterman, G. Winter, 2023, Structure.

Experimental phasing opportunities for macromolecular crystallography at very long wavelengths

E. Mancini, J. Grimes, M. Renner, 2023, Communications chemistry.

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

F. von Delft, J. Prilusky, N. London, 2021, Cell Chemical Biology.