J. Bryans

发表

Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes

C. Withers-Martinez, F. Hackett, M. Blackman, 2007, Cell.

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7.

Chris D. Edlin, K. Ansell, J. Bryans, 2008, Bioorganic & medicinal chemistry letters.

Are academic drug discovery efforts receiving more recognition with declining industry efficiency?

J. Bryans, C. Kettleborough, R. Solari, 2019, Expert opinion on drug discovery.

Crowd sourcing in drug discovery

K. Asadullah, M. Lessl, J. Bryans, 2011, Nature Reviews Drug Discovery.

Isolation of an intermediate in clavulanic acid biosynthesis

M. D. Lloyd, C. Schofield, J. Bryans, 1990 .

Isolation of dihydroclavaminic acid, an intermediate in the biosynthesis of clavulanic acid

M. D. Lloyd, C. Schofield, J. Bryans, 1991 .

Enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase

M. D. Lloyd, C. Schofield, J. Bryans, 1992 .

Academia–industry partnerships in drug discovery

J. Bryans, C. Kettleborough, Debbie Taylor, 2006, Expert opinion on drug discovery.

New anti-tuberculosis agents amongst known drugs.

R. Buxton, S. Osborne, J. Bryans, 2009, Tuberculosis.

3‐Substituted GABA analogs with central nervous system activity: A review

J. Bryans, D. Wustrow, 1999, Medicinal research reviews.

Evaluation of a Low Molecular Weight Modulator of Human Plasminogen Activator Inhibitor-1 Activity

P. Charlton, S. Machin, J. Bryans, 1996, Thrombosis and Haemostasis.

Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp.

S. Trew, P. Charlton, J. Bryans, 1996, The Journal of antibiotics.

Efficient tin hydride-mediated radical cyclisation of secondary amides. Part 1. Synthesis of a variety of substituted pyrrolidinones

J. Bryans, J. Large, A. Parsons, 1999 .

Chiral synthesis of 5-hydroxy-(L)-pipecolic acids from (L)-glutamic acid

J. Bryans, P. Bailey, 1988 .

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

C. Pritchard, L. Howells, M. MacFarlane, 2020, British Journal of Cancer.

Stereoselective synthesis of functionalised triol units by SnCl4 promoted allylation of α-benzyloxyaldehydes: crucial role of the stoichiometry of the Lewis acid

B. Tinant, J. Bryans, J. Declercq, 2004 .

Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam

J. Bryans, A. Parsons, F. Ghelfi, 2003 .

Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

T. Ryckmans, J. Bryans, T. Peakman, 2011 .

Chemo-enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase

M. D. Lloyd, C. Schofield, J. Bryans, 1997 .

The synthesis of functionalised β- and γ-lactams by cyclisation of enamides using copper(I) or ruthenium(II)

J. Bryans, A. Parsons, F. Ghelfi, 2001 .

Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.

S. Osborne, J. Bryans, D. Blakemore, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of highly substituted 2,6-anti-configured tetrahydropyrans. First steps towards an efficient access to amphidinol 3 ring system

J. Bryans, I. Markó, C. Dubost, 2005 .

Stereoselective Synthesis of Functionalized Triol Units by SnCl4 Promoted Allylation of α-Benzyloxyaldehydes: Crucial Role of the Stoichiometry of the Lewis Acid.

B. Tinant, J. Bryans, J. Declercq, 2004 .

Efficient tin hydride-mediated radical cyclisation of secondary amides leading to substituted pyrrolidinones. Part 2. Application to the synthesis of aromatic kainic acid analogues

J. Bryans, J. Large, A. Parsons, 1999 .

An in vitro investigation into conformational aspects of gabapentin.

J. Rubin, J. Bryans, D. Horwell, 1999, Bioorganic & medicinal chemistry.

Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents

J. Bryans, V. U. Dissanayake, N. Gee, 1998 .

Part 1: N-alkylated glycines as potent α2δ ligands.

J. Bryans, D. Blakemore, G. Maw, 2011, Bioorganic & Medicinal Chemistry Letters.

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

S. Smerdon, T. J. Nott, R. Buxton, 2011, Tuberculosis.

Synthesis and in vivo evaluation of bicyclic gababutins.

S. Osborne, J. Bryans, D. Blakemore, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and in vivo evaluation of 3-substituted gababutins.

S. Osborne, J. Bryans, D. Blakemore, 2010, Bioorganic & medicinal chemistry letters.

Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.

J. Bryans, V. U. Dissanayake, N. Gee, 1998, Journal of medicinal chemistry.

Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists.

G. McMurray, G. Whitlock, A. Stobie, 2008, Bioorganic & medicinal chemistry letters.

Isolation of Dihydroclavaminic Acid (I), an Intermediate in the Biosynthesis of Clavulanic Acid

M. D. Lloyd, C. Schofield, J. Bryans, 1991 .

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry.

V. Avery, Chris D. Edlin, J. Bryans, 2012, ACS medicinal chemistry letters.

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

C. Pritchard, L. Howells, M. MacFarlane, 2020, British Journal of Cancer.

The Fundamental Characteristics of a Translational Scientist.

Christopher P. Austin, Julia White, Florence Bietrix, 2019, ACS pharmacology & translational science.

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.

P. Cohen, J. Arthur, J. Bryans, 2012, Bioorganic & medicinal chemistry letters.

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

S. Smerdon, T. J. Nott, R. Buxton, 2011, Tuberculosis.