B. Priest

发表

Ion Channels as Drug Targets: The Next GPCRs

O. McManus, G. Kaczorowski, B. Priest, 2008, The Journal of general physiology.

Tetrodotoxin-Resistant Sodium Channels in Sensory Neurons Generate Slow Resurgent Currents That Are Enhanced by Inflammatory Mediators

E. Nisenbaum, T. Cummins, B. Priest, 2014, The Journal of Neuroscience.

Imidazopyridines: a novel class of hNav1.7 channel blockers.

V. Warren, K. Lyons, G. Kaczorowski, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.

M. Fisher, K. Lyons, M. Wyvratt, 2006, Bioorganic & medicinal chemistry letters.

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III–IV linker

E. Nisenbaum, T. Cummins, B. Priest, 2014, FEBS letters.

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.

S. Kash, D. Macintyre, P. Liberator, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter’s Syndrome Type II Phenotype

J. Metzger, G. Kaczorowski, B. Priest, 2016, The Journal of Pharmacology and Experimental Therapeutics.

The therapeutic potential of targeting the Kir1.1 (renal outer medullary K+) channel.

B. Priest, A. Pasternak, 2017, Future medicinal chemistry.

Cardiac ion channels

B. Priest, J. Mcdermott, J. McDermott, 2015, Channels.

Phenotypic screening in the 21st century

G. Erdemli, B. Priest, 2014, Front. Pharmacol..

ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.

K. Blumenthal, V. Warren, B. Priest, 2007, Toxicon : official journal of the International Society on Toxinology.

Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes.

F. Ujjainwalla, E. Sherer, R. Nargund, 2016, Bioorganic & medicinal chemistry letters.

A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.

V. Warren, K. Lyons, G. Kaczorowski, 2013, Bioorganic & medicinal chemistry letters.

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.

Jun Liang, J. W. Tarpley, M. Fisher, 2005, Bioorganic & medicinal chemistry letters.

ShK, a Pharmacological Tool for Studying Kv3.2 Channels

Ethan M. Goldberg, B. Rudy, J. Herrington, 2005 .

Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

S. Xu, B. Priest, P. Morissette, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.

J. Metzger, A. Swensen, M. Forrest, 2016, ACS medicinal chemistry letters.

Substituted biaryl pyrazoles as sodium channel blockers.

V. Warren, Sanjeev Kumar, M. Fisher, 2010, Bioorganic & medicinal chemistry letters.

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

K. Lyons, A. Weber, G. Kaczorowski, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.

V. Warren, Sanjeev Kumar, M. Fisher, 2010, Bioorganic & medicinal chemistry letters.

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.

Jun Liang, J. W. Tarpley, M. Fisher, 2005, Bioorganic & medicinal chemistry letters.

The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.

J. Metzger, K. Maloney, E. Joshi, 2017, Bioorganic & medicinal chemistry letters.

Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis

A. Swensen, K. Hoagland, G. Kaczorowski, 2014, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.

D. Macintyre, V. Warren, K. Lyons, 2007, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.

D. Macintyre, V. Warren, M. Fisher, 2007, Bioorganic & medicinal chemistry letters.

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

V. Warren, Y. S. Tang, K. Wafford, 2004, Biochemistry.

Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.

A. Swensen, G. Kaczorowski, B. Priest, 2013, Bioorganic & medicinal chemistry letters.

The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.

L. Kiss, G. Kaczorowski, B. Priest, 2012, Assay and drug development technologies.

Ion channel drug discovery: challenges and future directions.

G. Erdemli, A. Wickenden, B. Priest, 2012, Future medicinal chemistry.

Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.

G. Kaczorowski, B. Priest, W. Martin, 2007, The journal of pain : official journal of the American Pain Society.

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

F. Ujjainwalla, E. Sherer, A. Howard, 2016, ACS medicinal chemistry letters.

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

Martin Koltzenburg, Timothy Bailey, M. Koltzenburg, 2008, Molecular Pharmacology.

Future potential and status of selective sodium channel blockers for the treatment of pain.

B. Priest, Birgit T Priest, 2009, Current opinion in drug discovery & development.

Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats

O. McManus, J. W. Tarpley, Z. Ali, 2006, Molecular Pharmacology.

On the Process of Finding Novel and Selective Sodium Channel Blockers for the Treatment of Diseases

B. Priest, 2008 .

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

Clare London, Joseph L Duffy, Y. S. Tang, 2007, Biochemistry.

Voltage-gated Na+ currents in human dorsal root ganglion neurons

M. Gold, I. Belfer, B. Priest, 2017, eLife.

Role of hERG potassium channel assays in drug development

B. Priest, I. M. Bell, M. García, 2008, Channels.

BgK, a disulfide-containing sea anemone toxin blocking K+ channels, can be produced in Escherichia coli cytoplasm as a functional tagged protein.

G. Mourier, A. Ménez, J. Boulain, 2004, Protein expression and purification.

Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay

E. Nisenbaum, E. Sher, J. Watson, 2017, Molecular pain.

Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels

Ethan M. Goldberg, B. Rudy, J. Herrington, 2005, Molecular Pharmacology.

Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.

O. McManus, V. Garsky, Yun-ping Zhou, 2006, Diabetes.

Inflammatory mediator-induced modulation of GABAA currents in human sensory neurons

M. Gold, I. Belfer, B. Priest, 2015, Neuroscience.

Non-GABAergic Vestibular Nucleus Neurons Resurgent Na Currents in GABAergic and Similar Properties of Transient, Persistent, and

E. Nisenbaum, I. Raman, T. Cummins, 2015 .

Blocking sodium channels to treat neuropathic pain

G. Kaczorowski, B. Priest, 2007, Expert opinion on therapeutic targets.

Revealing the molecular determinants of neurotoxin specificity for calcium-activated versus voltage-dependent potassium channels.

B. Priest, W. Schmalhofer, Maria L. Garcia, 2007, Biochemistry.

Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.

M. Bednarek, G. Kaczorowski, B. Priest, 2006, Biochemistry.

Biophysical and pharmacological properties of the voltage‐gated potassium current of human pancreatic β‐cells

O. McManus, J. Herrington, B. Priest, 2005, The Journal of physiology.

Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

V. Warren, G. Kaczorowski, B. Priest, 2004, Assay and drug development technologies.

Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.

E. Sher, B. Eastwood, B. Priest, 2019, Assay and drug development technologies.

A Variable Residue in the Pore of Kv1 Channels Is Critical for the High Affinity of Blockers from Sea Anemones and Scorpions*

B. Roux, M. Eriksson, A. Ménez, 2005, Journal of Biological Chemistry.

Optimization of a High-Throughput Assay for Calcium Channel Modulators on IonWorks Barracuda.

B. Priest, Baolin Li, K. Burris, 2016, Assay and drug development technologies.

A high-throughput assay for modulators of ligand-gated chloride channels.

D. Cully, M. Hamelin, B. Priest, 2005, Assay and drug development technologies.

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.

V. Warren, Sanjeev Kumar, M. Fisher, 2010, Bioorganic & medicinal chemistry letters.

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

G. Kaczorowski, B. Priest, H. Knaus, 2006, Assay and drug development technologies.

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

K. Lyons, A. Weber, G. Kaczorowski, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.

K. Lyons, A. Weber, G. Kaczorowski, 2009, Bioorganic & medicinal chemistry letters.

3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.

V. Warren, M. Fisher, K. Lyons, 2008, Bioorganic & medicinal chemistry letters.

Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.

M. Fisher, K. Lyons, M. Wyvratt, 2005, Bioorganic & medicinal chemistry letters.

Subtype-selective sodium channel blockers promise a new era of pain research

G. Kaczorowski, B. Priest, 2007, Proceedings of the National Academy of Sciences.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis

A. Swensen, K. Hoagland, G. Kaczorowski, 2014, The Journal of Pharmacology and Experimental Therapeutics.