Jian Zhang

发表

Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors.

P. Zhan, Xinyong Liu, Han Ju, 2018, European journal of medicinal chemistry.

Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, P. Zhan, 2021, Bioorganic & medicinal chemistry.

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

Dongwei Kang, Boshi Huang, C. Pannecouque, 2018, ACS medicinal chemistry letters.

Overview of Recent Strategic Advances in Medicinal Chemistry.

Peng Zhan, Yuning Song, Dongwei Kang, 2019, Journal of medicinal chemistry.

Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics.

P. Zhan, Xinyong Liu, Jian Zhang, 2018, Drug discovery today.

Contemporary medicinal-chemistry strategies for discovery of blood coagulation factor Xa inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, Expert opinion on drug discovery.

Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives.

Dongwei Kang, Boshi Huang, P. Zhan, 2017, Journal of medicinal chemistry.

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.

P. Zhan, Xinyong Liu, Jianbo Ji, 2022, Journal of medicinal chemistry.

Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity.

P. Zhan, Xinyong Liu, A. Loregian, 2020, European journal of medicinal chemistry.

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

P. Zhan, Xinyong Liu, Jian Zhang, 2022, European journal of medicinal chemistry.

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

P. Zhan, Xinyong Liu, A. Loregian, 2022, Molecules.

Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2021, Molecular Diversity.

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2019, Bioorganic & medicinal chemistry.

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta Pharmaceutica Sinica B.

Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Bioorganic & medicinal chemistry.

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.

Lingzi Zhang, C. Pannecouque, P. Zhan, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.

P. Zhan, Xinyong Liu, Xiao Ding, 2019, European journal of medicinal chemistry.

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Design, synthesis, and evaluation of novel heteroaryldihydropyrimidine derivatives as non‐nucleoside hepatitis B virus inhibitors by exploring the solvent‐exposed region

P. Zhan, Xinyong Liu, Xiao Ding, 2020, Chemical biology & drug design.

Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.

E. De Clercq, Dongwei Kang, Boshi Huang, 2021, Journal of medicinal chemistry.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Peng Zhan, F. J. Luque, Ye Tian, 2019, Journal of medicinal chemistry.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Peng Zhan, Jian Zhang, F. J. Luque, 2019, Journal of medicinal chemistry.

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

P. Zhan, Xinyong Liu, A. Loregian, 2021, Acta pharmaceutica Sinica. B.

Efficient drug discovery by rational lead hybridization based on crystallographic overlay.

Jian Zhang, Peng Zhan, Shuo Zhang, 2019, Drug discovery today.

Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies.

Xinyong Liu, Jianbo Ji, Min Zhai, 2017, Bioorganic & medicinal chemistry letters.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2020–present)

P. Zhan, Xinyong Liu, E. D. da Silva-Júnior, 2022, Expert opinion on therapeutic patents.

Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.

P. Zhan, Xinyong Liu, Waleed A Zalloum, 2020, European journal of medicinal chemistry.

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update).

Dongwei Kang, Zengjun Fang, P. Zhan, 2019, Future medicinal chemistry.

A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

P. Zhan, Xinyong Liu, A. Loregian, 2023, Journal of enzyme inhibition and medicinal chemistry.