C. Fernandes

发表

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

A. King, R. Copeland, P. Tummino, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

A. D. Rodrigues, E S Walsh, J B Gibbs, 2001, Journal of medicinal chemistry.

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.

J. Shipman, N. Kohl, L. Sepp-Lorenzino, 2006, Bioorganic & medicinal chemistry letters.

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

J. Davide, R. Lobell, C. Buser, 2002, Bioorganic & medicinal chemistry letters.

Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.

D. Heimbrook, J. Shipman, N. Kohl, 2004, Journal of medicinal chemistry.

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

A. W. Shaw, T. Ciccarone, L. Beese, 2003, Journal of medicinal chemistry.

Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.

R. Lehr, G. V. Van Aller, P. Tummino, 2008, Analytical biochemistry.

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding.

W. F. Hoffman, C. Buser, B. Wong, 2004, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.

W. F. Hoffman, Youwei Yan, L. Kuo, 2006, Bioorganic & medicinal chemistry letters.

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

A. D. Rodrigues, J Christopher Culberson, Ronald Robinson, 2002, Journal of medicinal chemistry.

RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Peter S. Linsley, Michael Carleton, P. Linsley, 2006, Molecular and Cellular Biology.

High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.

C. Buser, C. Fernandes, K. Koblan, 2001, Analytical biochemistry.

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.

J. Davide, R. Lobell, J. Gibbs, 2002, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.

W. F. Hoffman, Youwei Yan, P. Coleman, 2006, Bioorganic & medicinal chemistry letters.