E. Shepard

发表

Insights into [FeFe]-hydrogenase structure, mechanism, and maturation.

J. W. Peters, M. Posewitz, P. King, 2011, Structure.

[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation.

J. W. Peters, P. King, E. Boyd, 2015, Biochimica et biophysica acta.

Biosynthesis of complex iron-sulfur enzymes.

J. W. Peters, E. Boyd, J. Broderick, 2011, Current opinion in chemical biology.

Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate.

D. Dooley, L. Sayre, E. Shepard, 2006, Journal of the American Chemical Society.

Radical SAM Enzymes and Their Roles in Complex Cluster Assembly

J. Broderick, E. Shepard, J. Betz, 2015 .

Radical S-Adenosyl-l-methionine Chemistry in the Synthesis of Hydrogenase and Nitrogenase Metal Cofactors*

J. W. Peters, A. Byer, J. Broderick, 2014, The Journal of Biological Chemistry.

The Radical SAM enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed During Substrate-Free Turnover.

B. Hoffman, J. Broderick, E. Shepard, 2020, Journal of the American Chemical Society.

EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii.

J. W. Peters, A. Byer, P. King, 2013, Journal of the American Chemical Society.

Hydrogenase cluster biosynthesis: organometallic chemistry nature's way.

J. W. Peters, David W. Mulder, J. Broderick, 2009, Dalton transactions.

Natural selection based on coordination chemistry: computational assessment of [4Fe–4S]-maquettes with non-coded amino acids

S. McGlynn, E. Shepard, R. Szilagyi, 2019, Interface Focus.

Using xenon as a probe for dioxygen-binding sites in copper amine oxidases.

A. Cohen, A. Duff, J. Guss, 2004, Journal of molecular biology.

Understanding the Molecular Factors Governing Inhibitor Potency and Oxygen Activation in Copper Amine Oxidases

E. Shepard, 2006 .

HydG, the "dangler" iron, and catalytic production of free CO and CN-: implications for [FeFe]-hydrogenase maturation.

J. W. Peters, A. Byer, J. Broderick, 2021, Dalton transactions.

Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation

A. Byer, J. Broderick, S. Eaton, 2017, Biochemistry.

A Redox Active [2Fe-2S] Cluster on the Hydrogenase Maturase HydF.

J. W. Peters, A. Byer, J. Broderick, 2016, Biochemistry.

[FeFe]-hydrogenase maturation.

J. W. Peters, A. Byer, J. Broderick, 2014, Biochemistry.

[FeFe]‐Hydrogenase Cofactor Assembly

J. W. Peters, A. Byer, E. Boyd, 2013 .

Iron–sulfur cluster coordination in the [FeFe]‐hydrogenase H cluster biosynthetic factor HydF

J. W. Peters, A. Byer, J. Broderick, 2012, FEBS letters.

Radical AdoMet enzymes in complex metal cluster biosynthesis.

J. W. Peters, E. Boyd, J. Broderick, 2012, Biochimica et biophysica acta.

Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor

J. W. Peters, E. Boyd, J. Broderick, 2009, Journal of bacteriology.

Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical.

B. Hoffman, J. Broderick, E. Shepard, 2019, Journal of the American Chemical Society.

Proteomic Analysis of Methanococcus voltae Grown in the Presence of Mineral and Nonmineral Sources of Iron and Sulfur

J. Broderick, B. Bothner, E. Shepard, 2022, Microbiology spectrum.

[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

J. W. Peters, E. Boyd, P. Roach, 2010, Angewandte Chemie.

Radical S-adenosylmethionine maquette chemistry: Cx3Cx2C peptide coordinated redox active [4Fe–4S] clusters

V. Copié, J. Broderick, Jacquelyn Miller, 2019, JBIC Journal of Biological Inorganic Chemistry.

Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes.

B. Hoffman, J. Broderick, E. Shepard, 2020, Journal of the American Chemical Society.

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

A. Byer, B. Hoffman, J. Broderick, 2017, Journal of the American Chemical Society.

H-cluster assembly intermediates built on HydF by the radical SAM enzymes HydE and HydG

A. Byer, P. King, J. Broderick, 2019, JBIC Journal of Biological Inorganic Chemistry.

Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis.

Doreen E. Brown, D. Dooley, J. Broderick, 2019, Journal of the American Chemical Society.

Decarboxylation involving a ferryl, propionate, and a tyrosyl group in a radical relay yields heme b

Arianna I. Celis, E. Shepard, G. Lukat-Rodgers, 2018, The Journal of Biological Chemistry.

Towards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases.

D. Dooley, J. Kuchar, L. Sayre, 2002, European journal of biochemistry.

Inhibition and oxygen activation in copper amine oxidases.

D. Dooley, E. Shepard, 2015, Accounts of chemical research.

HydF as a scaffold protein in [FeFe] hydrogenase H‐cluster biosynthesis

Mark A. Winslow, J. W. Peters, M. Posewitz, 2008, FEBS letters.

[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide.

J. W. Peters, P. Roach, J. Broderick, 2010, Journal of the American Chemical Society.

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

L. Scott, A. Byer, K. Yokoyama, 2018, Journal of the American Chemical Society.

S-Adenosyl-l-ethionine is a Catalytically Competent Analog of S-Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG.

B. Hoffman, J. Broderick, E. Shepard, 2021, Angewandte Chemie.

Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct.

J. Broderick, E. Shepard, E. Zilinskas, 2009, Journal of the American Chemical Society.

Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase

J. Broderick, D. Gardenghi, S. Naik, 2014, JBIC Journal of Biological Inorganic Chemistry.

3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases.

D. Dooley, L. Sayre, R. Silverman, 2002, Journal of the American Chemical Society.

Catalytic turnover of substrate benzylamines by the quinone-dependent plasma amine oxidase leads to H2O2-dependent inactivation: evidence for generation of a cofactor-derived benzoxazole.

D. Dooley, L. Sayre, E. Shepard, 2001, Biochemistry.

Intramolecular electron transfer rate between active-site copper and TPQ in Arthrobacter globiformis amine oxidase

D. Dooley, E. Shepard, 2006, JBIC Journal of Biological Inorganic Chemistry.

Kinetics and spectroscopic evidence that the Cu(I)-semiquinone intermediate reduces molecular oxygen in the oxidative half-reaction of Arthrobacter globiformis amine oxidase.

D. Dooley, E. Shepard, Kristina M. Okonski, 2008, Biochemistry.

Amine Oxidase and Galactose Oxidase

Doreen E. Brown, D. Dooley, E. Shepard, 2011 .

Cyanide as a copper and quinone-directed inhibitor of amine oxidases from pea seedlings (Pisum sativum) and Arthrobacter globiformis: evidence for both copper coordination and cyanohydrin derivatization of the quinone cofactor

D. Dooley, L. Sayre, E. Shepard, 2004, JBIC Journal of Biological Inorganic Chemistry.

Inhibition of six copper-containing amine oxidases by the antidepressant drug tranylcypromine.

D. Dooley, E. Shepard, G. Juda, 2003, Biochimica et biophysica acta.

Inner-sphere mechanism for molecular oxygen reduction catalyzed by copper amine oxidases.

A. Mukherjee, Doreen E. Brown, D. Dooley, 2008, Journal of the American Chemical Society.

A comparative study of the binding and inhibition of four copper-containing amine oxidases by azide: implications for the role of copper during the oxidative half-reaction.

D. Dooley, Bradley O. Elmore, E. Shepard, 2006, Biochemistry.

Radical S-Adenosylmethionine Enzymes

J. Broderick, E. Shepard, Benjamin R. Duffus, 2014, Chemical reviews.

Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold

Mark A. Winslow, J. W. Peters, J. Broderick, 2010, Proceedings of the National Academy of Sciences.

[FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis.

Eyal Akiva, Gemma L. Holliday, Patricia C Babbitt, 2015, Biochemistry.

Examining Pathways of Iron and Sulfur Acquisition, Trafficking, Deployment, and Storage in Mineral-Grown Methanogen Cells

E. Boyd, M. Young, J. Broderick, 2021, Journal of bacteriology.

S -Adenosylmethionine and Iron–Sulfur Clusters in Biological Radical Reactions: The Radical SAM Superfamily

J. Broderick, E. Shepard, 2010 .

Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG.

J. W. Peters, P. Roach, J. Broderick, 2013, Biochemistry.

Biochemical and kinetic characterization of radical AdoMet enzyme HydG

J. W. Peters, P. Roach, J. Broderick, 2022 .

17 Origin and evolution of Fe-S proteins and enzymes

E. Boyd, M. Adams, J. Broderick, 2017 .

Structure and inhibition of human diamine oxidase.

J Mitchell Guss, J. Guss, Doreen E. Brown, 2009, Biochemistry.

[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis.

B. Hoffman, J. Broderick, E. Shepard, 2022, Angewandte Chemie.

[FeFe]-Hydrogenase In Vitro Maturation.

J. Broderick, E. Shepard, Adrien Pagnier, 2022, Angewandte Chemie.

Secondary structure analysis of peptides with relevance to iron–sulfur cluster nesting

Rebecca Hanscam, Eric M. Shepard, Joan B. Broderick, 2018, J. Comput. Chem..

The B12-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine.

J. Broderick, E. Shepard, M. Villanueva, 2021, Journal of inorganic biochemistry.

H-Cluster assembly during maturation of the [FeFe]-hydrogenase

J. W. Peters, A. Byer, J. Broderick, 2014, JBIC Journal of Biological Inorganic Chemistry.

The crystal structure of Pichia pastoris lysyl oxidase.

A. Cohen, A. Duff, J. Guss, 2003, Biochemistry.

A C-terminal disulfide bond in the copper-containing amine oxidase from pea seedlings violates the twofold symmetry of the molecular dimer.

A. Duff, J. Guss, D. Dooley, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.

A. Duff, J. Guss, D. Dooley, 2004, Biochemistry.

Compositional and structural insights into the nature of the H-cluster precursor on HydF.

A. Byer, P. King, David W. Mulder, 2018, Dalton transactions.

Semisynthetic maturation of [FeFe]-hydrogenase using [Fe2(μ-SH)2(CN)2(CO)4]2-: key roles for HydF and GTP.

J. Broderick, Michael T. Mock, E. Shepard, 2023, Chemical communications.

Decarboxylation involving a ferryl, propionate, and a tyrosyl group in a radical relay yields heme

Arianna I. Celis, E. Shepard, G. Lukat-Rodgers, 2018 .

[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

J. W. Peters, E. Boyd, P. Roach, 2010, Angewandte Chemie.