J. Hothersall

发表

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic

Christopher M Thomas, R. Cox, Daisuke Fukuda, 2011, PloS one.

Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens

Georgios S. Vernikos, Julian Parkhill, Konstantinos Mavromatis, 2009, Genome Biology.

Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586.

Christopher M Thomas, J. Hothersall, C M Thomas, 2001, Microbiology.

Tandemly Duplicated Acyl Carrier Proteins, Which Increase Polyketide Antibiotic Production, Can Apparently Function Either in Parallel or in Series*

Christopher M Thomas, Ayesha Rahman, T. J. Simpson, 2005, Journal of Biological Chemistry.

Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production

Christopher M Thomas, P. Williams, G. Campbell, 2011, Applied Microbiology and Biotechnology.

High quality genome annotation and expression visualisation of a mupirocin-producing bacterium

Christopher M Thomas, S. Kendrew, A. Haines, 2022, PloS one.

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

Christopher M Thomas, T. J. Simpson, J. Hothersall, 2003, Chemistry & biology.

Phosphopantetheinylation and Specificity of Acyl Carrier Proteins in the Mupirocin Biosynthetic Cluster

Christopher M Thomas, Ayesha Rahman, T. J. Simpson, 2010, Chembiochem : a European journal of chemical biology.

Mutational Analysis Reveals That All Tailoring Region Genes Are Required for Production of Polyketide Antibiotic Mupirocin by Pseudomonas fluorescens

Christopher M Thomas, R. Cox, Ayesha Rahman, 2007, Journal of Biological Chemistry.

Activation by NarL at the Escherichia coli ogt promoter

S. Busby, D. Browning, David J Lee, 2020, The Biochemical journal.

University The PAR promoter expression system: modified lac promoters for controlled recombinant protein production in Escherichia coli

Tim W. Overton, S. Busby, D. Browning, 2021 .

Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.

Christopher M Thomas, R. Cox, T. J. Simpson, 2007, Chemical communications.

New Vectors for Urea-Inducible Recombinant Protein Production.

Tim W. Overton, S. Busby, D. Browning, 2022, New biotechnology.

Inexpensive protein overexpression driven by the NarL transcription activator protein

Tim W. Overton, S. Busby, D. Browning, 2022, Biotechnology and bioengineering.

In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the “Leaky Hosepipe” Mechanism

Christopher M Thomas, R. Cox, Ayesha Rahman, 2008, Chembiochem : a European journal of chemical biology.

A conserved motif flags Acyl Carrier Proteins for β-branching in polyketide synthesis

Christopher M Thomas, P. Winn, R. Cox, 2013, Nature chemical biology.

Polyketide Antibiotics of Pseudomonas

Christopher M Thomas, J. Hothersall, 2004 .

The PAR promoter expression system: modified lac promoters for controlled recombinant protein production in Escherichia coli.

Tim W. Overton, S. Busby, D. Browning, 2021, New biotechnology.

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

Christopher M Thomas, R. Cox, Ayesha Rahman, 2005, Chemistry & biology.

Resistance to and synthesis of the antibiotic mupirocin

Christopher M Thomas, T. J. Simpson, J. Hothersall, 2010, Nature Reviews Microbiology.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

David H Sherman, Kristina Håkansson, Christopher M Thomas, 2008, Chemistry & biology.

Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586

Christopher M Thomas, P. Winn, Amber Wilson, 2019, Scientific Reports.

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Christopher M Thomas, P. Winn, R. Cox, 2017, Angewandte Chemie.

Biosynthesis of mupirocin by Pseudomonas fluorescens NCIMB 10586 involves parallel pathways.

Christopher M Thomas, R. Cox, T. J. Simpson, 2014, Journal of the American Chemical Society.

Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390

Christopher M Thomas, R. Cox, Daisuke Fukuda, 2014 .

Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudoalteromonas SANK73390.

Daisuke Fukuda, Christopher M Thomas, R. Cox, 2011, Angewandte Chemie.

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.

Christopher M Thomas, R. Cox, W. Laosripaiboon, 2005, Chemical communications.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

Christopher M Thomas, D. Sherman, K. Håkansson, 2008, Chemistry & biology.

University of Birmingham Activation by NarL at the Escherichia coli ogt promoter

S. Busby, D. Browning, J. Hothersall, 2020 .