K. Mikušová

发表

Sequences Human Induced Pluripotent Stem Cells Free of Vector and Transgene

S. Cole, S. Waddell, P. Butcher, 2012 .

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

H. Erlandsen, Jana Korduláková, Carolyn Shoen, 2019, Cell chemical biology.

Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis.

P. Brennan, V. Ferrières, T. Lowary, 2010, Chemistry & biology.

Development of Macozinone for TB treatment: An Update

V. Makarov, K. Mikušová, 2020, Applied Sciences.

Learning from the past for TB drug discovery in the future.

S. Ekins, K. Mikušová, 2017, Drug discovery today.

Identification of aminopyrimidine‐sulfonamides as potent modulators of Wag31‐mediated cell elongation in mycobacteria

G. Knott, G. Kéri, S. Cole, 2017, Molecular microbiology.

V. Makarov, O. Riabova, A. Kaprelyants, 2018, Metallomics : integrated biometal science.

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.

S. Cole, T. Smutny, P. Pávek, 2016, Journal of medicinal chemistry.

Truncated Structural Variants of Lipoarabinomannan in Ethambutol Drug-resistant Strains of Mycobacterium smegmatis

G. Besra, K. Khoo, P. Azadi, 1996, The Journal of Biological Chemistry.

Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan in Mycobacterium tuberculosis*

G. Larrouy-Maumus, P. Brennan, B. Gicquel, 2010, The Journal of Biological Chemistry.

A Small Multidrug Resistance-like Transporter Involved in the Arabinosylation of Arabinogalactan and Lipoarabinomannan in Mycobacteria*

G. Larrouy-Maumus, A. Villela, P. Brennan, 2012, The Journal of Biological Chemistry.

Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster.

P. Brennan, M. Jackson, Jana Korduláková, 2011, General physiology and biophysics.

Polymerization of Mycobacterial Arabinogalactan and Ligation to Peptidoglycan*

P. Brennan, D. Crick, S. Mahapatra, 2003, Journal of Biological Chemistry.

Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

T. Blundell, C. Abell, Jana Korduláková, 2019, Journal of medicinal chemistry.

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK

S. Ekins, S. Cole, J. Lelièvre, 2018, Scientific Reports.

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.

Jana Korduláková, M. Krátký, J. Vinšová, 2018, European journal of medicinal chemistry.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

S. Ekins, R. Fani, S. Cole, 2015, Chemistry & biology.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

S. Cole, A. Lucarelli, P. Alzari, 2010, Molecular microbiology.

Interaction of human mannose-binding protein with Mycobacterium avium.

K. Joiner, J. Belisle, V. Polotsky, 1997, The Journal of infectious diseases.

An ethA-ethR-Deficient Mycobacterium bovis BCG Mutant Displays Increased Adherence to Mammalian Cells and Greater Persistence In Vivo, Which Correlate with Altered Mycolic Acid Composition

M. Wenk, G. Shui, A. Bendt, 2014, Infection and Immunity.

Assembling of the Mycobacterium tuberculosis Cell Wall Core*

Q. Gao, D. Ronning, P. Brennan, 2016, The Journal of Biological Chemistry.

Definition of the First Mannosylation Step in Phosphatidylinositol Mannoside Synthesis

Brigitte Gicquel, Patrick J Brennan, Mary Jackson, 2002, The Journal of Biological Chemistry.

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

Joel S. Freundlich, S. Ekins, N. Connell, 2018, Tuberculosis.

Biosynthesis of the Linkage Region of the Mycobacterial Cell Wall (*)

G. Besra, P. Brennan, K. Mikušová, 1996, The Journal of Biological Chemistry.

Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2

K. Mikušová, M. Baráth, S. Kozmon, 2020, Beilstein journal of organic chemistry.

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization.

S. Cole, Jana Korduláková, J. Neres, 2015, ACS chemical biology.

Synthesis of alkyl and cycloalkyl alpha-d-mannopyranosides and derivatives thereof and their evaluation in the mycobacterial mannosyltransferase assay.

L. Petruš, K. Mikušová, M. Beláňová, 2010, Carbohydrate research.

Decaprenylphosphoryl Arabinofuranose, the Donor of the d-Arabinofuranosyl Residues of Mycobacterial Arabinan, Is Formed via a Two-Step Epimerization of Decaprenylphosphoryl Ribose

P. Brennan, M. Holsters, D. Crick, 2005, Journal of bacteriology.

Protein Separation and Enzyme Purification by Preparative Capillary Isotachophoresis

R. Bodor, K. Mikušová, M. Beláňová, 2013, Chromatographia.

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Stewart T. Cole, Claudia Sala, Vadim Makarov, 2009, Science.

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-D-ribofuranose 2'-Oxidase.

P. Pávek, K. Vávrová, A. Hrabálek, 2019, Journal of medicinal chemistry.

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis

V. Mizrahi, P. Baráth, C. Nacy, 2017, Antimicrobial Agents and Chemotherapy.

Synthesis of the Arabinose Donor .beta.-D-Arabinofuranosyl-1-monophosphoryldecaprenol, Development of a Basic Arabinosyl-Transferase Assay, and Identification of Ethambutol as an Arabinosyl Transferase Inhibitor

G. Besra, P. Brennan, K. Mikušová, 1995 .

University of Birmingham Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Peter G. Schultz, Morad Hassani, Feng Wang, 2013 .

Time-adjusted Analysis Shows Weak Associations Between BCG Vaccination Policy and COVID-19 Disease Progression

Broňa Brejová, T. Vinař, K. Mikušová, 2020, medRxiv.

An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria

M. Tesařová, P. Baráth, Jana Korduláková, 2021, Proceedings of the National Academy of Sciences.

Recognition of multiple effects of ethambutol on metabolism of mycobacterial cell envelope

P. Brennan, M. McNeil, K. Mikušová, 1995, Antimicrobial agents and chemotherapy.

Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria*

P. Alzari, D. Giganti, B. Gicquel, 2007, Journal of Biological Chemistry.

Galactosyl Transferases in Mycobacterial Cell Wall Synthesis

Patrick J. Brennan, P. Brennan, T. Lowary, 2007, Journal of bacteriology.

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside.

P. Baráth, M. Jackson, Jana Korduláková, 2014, Protein expression and purification.

Novel synthetic (1 → 6)-α-D-mannodisaccharide substrates support processive mannosylation catalysed by the mycobacterial cell envelope enzyme fraction

H. Perreault, K. Mikušová, E. Lattová, 2013 .

Biogenesis of the mycobacterial cell wall and the site of action of ethambutol

G. Besra, P. Brennan, R. Slayden, 1995, Antimicrobial agents and chemotherapy.

Biosynthesis of Galactan in Mycobacterium tuberculosis as a Viable TB Drug Target?

K. Mikušová, S. Kozmon, Zuzana Konyariková, 2020, Antibiotics.

The complex mechanism of antimycobacterial action of 5-fluorouracil.

V. Mizrahi, J. Blackburn, D. Warner, 2015, Chemistry & biology.

The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.

G. Besra, J. Belisle, P. Brennan, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the Required Acyltransferase Step in the Biosynthesis of the Phosphatidylinositol Mannosides of Mycobacterium Species*

P. Brennan, B. Gicquel, G. Puzo, 2003, Journal of Biological Chemistry.

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents.

L. Chiarelli, K. Mikušová, Chunhua Qiao, 2021, Journal of medicinal chemistry.

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.

L. Chiarelli, A. Oliver, S. Franzblau, 2016, ACS medicinal chemistry letters.

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.

S. Cole, K. Johnsson, V. Makarov, 2012, Journal of the American Chemical Society.

Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents.

L. Chiarelli, M. Fumagalli, K. Mikušová, 2020, European journal of medicinal chemistry.

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

S. Cole, V. Makarov, R. Hartkoorn, 2015, Antimicrobial Agents and Chemotherapy.

DprE1--from the discovery to the promising tuberculosis drug target.

V. Makarov, J. Neres, K. Mikušová, 2013, Current pharmaceutical design.

Identification of a Novel Galactosyl Transferase Involved in Biosynthesis of the Mycobacterial Cell Wall

P. Brennan, D. Crick, Jana Korduláková, 2006, Journal of bacteriology.

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

E. Sancho-Vaello, J. Cifuente, P. Bonnet, 2016, Nature Communications.

New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053.

L. Chiarelli, F. Gosetti, E. Marengo, 2019, ACS infectious diseases.

Biosynthesis of the Galactan Component of the Mycobacterial Cell Wall*

G. Besra, P. Brennan, D. Crick, 2000, The Journal of Biological Chemistry.

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK

S. Ekins, S. Cole, J. Lelièvre, 2018, Scientific Reports.

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis

Luciano A. Abriata, Matteo Dal Peraro, Stewart T. Cole, 2015, Journal of bacteriology.

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library.

G. Kéri, S. Cole, V. Nagaraja, 2015, Tuberculosis.

Identification of promoters recognized by RNA polymerase containing Mycobacterium tuberculosis stress-response sigma factor σF

D. Homerova, J. Kormanec, K. Mikušová, 2007, Archives of Microbiology.

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo

S. Cole, G. Palù, N. Dhar, 2014, Journal of bacteriology.

2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.

V. Spiwok, S. Bősze, Jiří Janoušek, 2023, European journal of medicinal chemistry.

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

T. Blundell, C. Abell, Jana Korduláková, 2020, Journal of Medicinal Chemistry.

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.

S. Ekins, J. Lelièvre, David Barros, 2017, ACS infectious diseases.

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds.

R. Liu, S. Franzblau, Marvin J. Miller, 2021, RSC medicinal chemistry.

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

S. Cole, S. Waddell, P. Butcher, 2009, Science.

Side Chain-Modified Benzothiazinone Derivatives with Anti-Mycobacterial Activity

L. Chiarelli, V. Makarov, O. Riabova, 2023, Biomedicines.

University of Birmingham Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

P. Schultz, G. Besra, W. Jacobs, 2013 .

A Small Multidrug Resistance-like Transporter Involved in the Arabinosylation of Arabinogalactan and Lipoarabinomannan in Mycobacteria*

G. Larrouy-Maumus, A. Villela, P. Brennan, 2012, The Journal of Biological Chemistry.