I. Nishimura

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Increased Prevalence of Bisphosphonate-Related Osteonecrosis of the Jaw with Vitamin D Deficiency in Rats

J. Sayre, E. C. Sung, A. Hokugo, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genetic Networks in Osseointegration

I. Nishimura, I Nishimura, 2013, Journal of dental research.

Recombinant collagen polypeptide as a versatile bone graft biomaterial

I. Nishimura, Hideo Fushimi, Takahiro Hiratsuka, 2020, Communications Materials.

Effect of osseointegrated implants on the coordination of masticatory muscles: a pilot study.

H. Weber, I. Nishimura, J. L. Gartner, 2000, The Journal of prosthetic dentistry.

Precursor tissue analogs as a tissue-engineering strategy.

Stanley Osher, Marc Hedrick, Ichiro Nishimura, 2003, Tissue engineering.

Tissue-specific forms of type IX collagen-proteoglycan arise from the use of two widely separated promoters.

B. Olsen, Y. Muragaki, I. Nishimura, 1989, The Journal of biological chemistry.

The alpha 1 (IX) collagen gene gives rise to two different transcripts in both mouse embryonic and human fetal RNA.

B. Olsen, Y. Muragaki, Y. Ninomiya, 1990, Proceedings of the National Academy of Sciences of the United States of America.

A local pathophysiologic mechanism of the resorption of residual ridges: prostaglandin as a mediator of bone resorption.

E. Flynn, I. Nishimura, G. Szabó, 1988, The Journal of prosthetic dentistry.

Animal model for evaluating the effect of systemic estrogen deficiency on residual ridge resorption.

I. Nishimura, R. Hosokawa, D. Atwood, 1995, The Journal of prosthetic dentistry.

Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes.

I. Nishimura, T. Ogawa, 2003, The International journal of oral & maxillofacial implants.

A new animal model for molecular biological analysis of the implant-tissue interface: spatial expression of type XII collagen mRNA around a titanium oral implant.

N. Karimbux, H. Weber, I. Nishimura, 1995, The Journal of oral implantology.

Biomechanical Evaluation of Osseous Implants Having Different Surface Topographies in Rats

C. Sukotjo, I. Nishimura, J. Yang, 2000, Journal of dental research.

Genes Differentially Expressed in Titanium Implant Healing

I. Nishimura, T. Ogawa, 2006, Journal of dental research.

Altered bone remodeling pattern of the residual ridge in ovariectomized rats.

I. Nishimura, X. Li, 1994, The Journal of prosthetic dentistry.

Antifungal activity of Polymethyl Methacrylate/Si3N4 composites against Candida albicans.

W. Zhu, E. Marin, G. Pezzotti, 2021, Acta biomaterialia.

Novel Strategy to Expand Super-Charged NK Cells with Significant Potential to Lyse and Differentiate Cancer Stem Cells: Differences in NK Expansion and Function between Healthy and Cancer Patients

K. Kaur, I. Nishimura, So-Hyun Park, 2017, Front. Immunol..

Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.

Rajan P Kulkarni, Rajan P. Kulkarni, T. Hsiai, 2018, American journal of physiology. Heart and circulatory physiology.

Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism.

C. Colwell, Y. Tahara, A. Hokugo, 2019, Biomaterials.

Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-related Osteonecrosis of the Jaw*

K. Kaur, W. McBride, A. Hokugo, 2016, The Journal of Biological Chemistry.

The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: the effect of doxycycline and chemically modified tetracycline.

L. Golub, N. Karimbux, I. Nishimura, 1998, Journal of periodontology.

Bisphosphonates and Dental Implant Treatment

I. Nishimura, Sil Park, 2013 .

Effect of ovariectomy on the local residual ridge remodeling.

L. Jahangiri, I. Nishimura, A. Kim, 1997, The Journal of prosthetic dentistry.

The knife-edge tendency in mandibular residual ridges in women.

I. Nishimura, R. Hosokawa, D. Atwood, 1992, The Journal of prosthetic dentistry.

Ovariectomy hinders the early stage of bone-implant integration: histomorphometric, biomechanical, and molecular analyses.

R. Nishimura, C. Sukotjo, I. Nishimura, 2002, Bone.

Neuronal PAS Domain 2 (Npas2)‐Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction

A. Hokugo, I. Nishimura, H. Okawa, 2020, Anatomical record.

Neuronal Differentiation of Bone Marrow-derived Stromal Stem Cells Involves Suppression of Discordant Phenotypes through Gene Silencing*

F. Schweizer, H. Egusa, I. Nishimura, 2005, Journal of Biological Chemistry.

Molecular Cloning of Wound Inducible Transcript (wit 3.0) Differentially Expressed in Edentulous Oral Mucosa Undergoing Tooth Extraction Wound-healing

C. Sukotjo, I. Nishimura, T. Ogawa, 2002, Journal of dental research.

Circadian Rhythm and Cartilage Extracellular Matrix Genes in Osseointegration: A Genome-Wide Screening of Implant Failure by Vitamin D Deficiency

C. Colwell, F. Mussano, I. Nishimura, 2011, PloS one.

Temporal and Spatial Expressions of Type XII Collagen in the Remodeling Periodontal Ligament during Experimental Tooth Movement

I. Nishimura, N. Karimbux, 1995, Journal of dental research.

Site-specific Expression of Collagen I and XII mRNAs in the Rat Periodontal Ligament at Two Developmental Stages

N. Rosenblum, N. Karimbux, I. Nishimura, 1992, Journal of dental research.

Bioresorbable Bone Graft Composed of an RGD-Enriched Recombinant Human Collagen Polypeptide Induced Neovascularization and Regeneration of Mature Bone Tissue

I. Nishimura, Hideo Fushimi, Takahiro Hiratsuka, 2020 .

Effects of cortical bone perforation on experimental guided bone regeneration.

K. Ooya, Y. Shimizu, I. Nishimura, 2004, Clinical oral implants research.

Vitamin D and bone physiology: demonstration of vitamin D deficiency in an implant osseointegration rat model.

I. Nishimura, C. Wang, Sil Park, 2009, Journal of prosthodontics : official journal of the American College of Prosthodontists.

Embryonic chicken cornea and cartilage synthesize type IX collagen molecules with different amino-terminal domains.

B. Olsen, K. Svoboda, Y. Ninomiya, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

E. C. Sung, A. Hokugo, V. John, 2021, medRxiv.

Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice.

A. Hokugo, C. McKenna, I. Nishimura, 2019, Bone.

Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

A. Hokugo, V. John, C. McKenna, 2022, Communications Medicine.

Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation

K. Kaur, C. McKenna, I. Nishimura, 2015, Oncotarget.

Modulated bone matrix-related gene expression is associated with differences in interfacial strength of different implant surface roughness.

C. Sukotjo, I. Nishimura, T. Ogawa, 2002, Journal of prosthodontics : official journal of the American College of Prosthodontists.

Tissue‐Specific Expression of Type IX Collagen a

B. Olsen, Y. Muragaki, Y. Ninomiya, 1990, Annals of the New York Academy of Sciences.

A Role of Oral Bacteria in Bisphosphonate-induced Osteonecrosis of the Jaw

T. Kawai, S. Woo, I. Nishimura, 2011, Journal of dental research.

Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats.

A. Hokugo, C. McKenna, I. Nishimura, 2013, Bone.

Developmental Stages Site-specific Expression of Collagen I and XII mRNAs in the Rat Periodontal Ligament at Two

I. Nishimura, 2011 .

A short isoform of Col9a1 supports alveolar bone repair.

B. Olsen, I. Nishimura, K. Ting, 1999, The American journal of pathology.

Two distinct cystatin species in rice seeds with different specificities against cysteine proteinases. Molecular cloning, expression, and biochemical studies on oryzacystatin-II.

S. Arai, K. Abe, Y. Emori, 1990, The Journal of biological chemistry.

Maintenance of regional histodifferentiation patterns and a spatially restricted expression of type X collagen in rat Meckel's cartilage explants in vitro.

I. Nishimura, K. Chung, 1999, Archives of oral biology.

Differential effect of ionizing radiation exposure on multipotent and differentiation‐restricted bone marrow mesenchymal stem cells

P. Zuk, F. Mussano, S. Carossa, 2010, Journal of cellular biochemistry.

The role of titanium implant surface modification with hydroxyapatite nanoparticles in progressive early bone-implant fixation in vivo.

I. Nishimura, C. Wang, J. Kelly, 2009, The International journal of oral & maxillofacial implants.

Implant interface to bone tissue: biomimetic surface functionalization through nanotechnology

I. Nishimura, 2010 .

Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells

C. Colwell, Y. Tahara, P. Langfelder, 2017, PloS one.

Current perspectives in residual ridge remodeling and its clinical implications: a review.

L. Jahangiri, I. Nishimura, K. Ting, 1998, The Journal of prosthetic dentistry.

Osteonecrosis of the Jaw Developed in Mice

J. Sayre, K. Kaur, I. Nishimura, 2015, The Journal of Biological Chemistry.

Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons.

Y. Tabata, I. Spigelman, I. Nishimura, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Discrete deposition of hydroxyapatite nanoparticles on a titanium implant with predisposing substrate microtopography accelerated osseointegration

Yuhong Huang, F. Butz, I. Nishimura, 2007 .

Three-dimensional bone-implant integration profiling using micro-computed tomography.

Ichiro Nishimura, F. Butz, I. Nishimura, 2006, The International journal of oral & maxillofacial implants.

Resorption of Residual Ridges (RRR) in Rats

I. Nishimura, P. J. Damiani, D. Atwood, 1987, Journal of dental research.

Ontogenetic transition in fetal wound transforming growth factor-beta regulation correlates with collagen organization.

M. Longaker, H. Lorenz, E. Freymiller, 2003, The American journal of pathology.

The identification of novel wound-healing genes through differential display.

E. Freymiller, I. Nishimura, K. Ting, 2002, Plastic and reconstructive surgery.

In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing

A. Hokugo, I. Nishimura, R. Jarrahy, 2023, Frontiers in Medicine.

Knife-edge residual ridges: a clinical report.

I. Nishimura, D. Atwood, 1994, The Journal of prosthetic dentistry.

Ceramics in dentistry: historical roots and current perspectives.

S. Campbell, I. Nishimura, J R Kelly, 1996, The Journal of prosthetic dentistry.

Impact of Human Genome Project on treatment of frail and edentulous patients.

N. Garrett, I. Nishimura, 2004, Gerodontology.

Effect of Calcium Ion Supplementation on Oral Microbial Composition and Biofilm Formation In Vitro

R. Lux, I. Nishimura, Takeru Kondo, 2022, Microorganisms.

Relationship of Axonal Voltage-gated Sodium Channel 1.8 (NaV1.8) mRNA Accumulation to Sciatic Nerve Injury-induced Painful Neuropathy in Rats*

I. Spigelman, S. Ruangsri, I. Nishimura, 2011, The Journal of Biological Chemistry.

Aberrant plasticity of peripheral sensory axons in a painful neuropathy

Wei Li, I. Spigelman, Zheng Xia, 2017, Scientific Reports.

Downregulation of extracellular matrix-related gene clusters during osteogenic differentiation of human bone marrow- and adipose tissue-derived stromal cells.

M. Hedrick, P. Zuk, Min Zhu, 2007, Tissue engineering.

Tissue Healing with Doxycycline and Chemically Modified Tetracycline Treatments in Rats with Porphyromonas gingivalis—induced Periodontitis a

L. Golub, I. Nishimura, N. Ramamurthy, 1994, Annals of the New York Academy of Sciences.

Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control

Xianting Ding, Ichiro Nishimura, Yoshitomo Honda, 2013, Scientific Reports.

Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol: a case report.

E. C. Sung, N. Garrett, I. Nishimura, 2012, Oral surgery, oral medicine, oral pathology and oral radiology.

2 Methodology of microarray data analysis

Xiaofeng Zhou, Ichiro Nishimura, Hiroshi Egusa, 2005 .

Gene expression profiling by DNA microarray technology.

Ichiro Nishimura, Keisuke Iida, I. Nishimura, 2002, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

Gene expression profiling by DNA microarray technology.

I. Nishimura, K. Iida, 2002, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity

Y. Gwack, M. Kang, I. Nishimura, 2021, Journal of dentistry research.

Cartilage type IX collagen-proteoglycan contains a large amino-terminal globular domain encoded by multiple exons.

B. Olsen, G. Vasios, Y. Ninomiya, 1988, The Journal of biological chemistry.

ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities.

J. Nadeau, T. Drake, A. Lusis, 2003, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

Altered cartilage phenotype expressed during intramembranous bone formation

I. Nishimura, K. Ting, Lee Ann Petropulos, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Implications of the circadian clock in implant dentistry.

H. Egusa, I. Nishimura, H. Okawa, 2020, Dental materials journal.

Molecular cloning of the complementary DNA encoding for the hamster TGF- α mmature peptide

D. Wong, M. Chou, J. McBride, 1991 .

Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model.

E. Richard, A. Hokugo, C. McKenna, 2021, Bioconjugate chemistry.

Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs

K. Kaur, I. Nishimura, So-Hyun Park, 2018, Oncoimmunology.

Craniofacial abnormalities in mice carrying a dominant interference mutation in type X collagen

I. Nishimura, O. Jacenko, B. Olsen, 1997, Developmental Dynamics.

Animal model of radiogenic bone damage to study mandibular osteoradionecrosis.

J. Beumer, M. Steinberg, E. Abemayor, 2011, American journal of otolaryngology.

Modulated expression of type X collagen in Meckel's cartilage with different developmental fates.

H. Takita, S. Apte, I. Nishimura, 1995, Developmental biology.

Craniosynostosis in transgenic mice overexpressing Nell-1.

M. Longaker, R. Moats, K. Tanizawa, 2002, The Journal of clinical investigation.

Intravascular tissue reactions induced by various types of bioabsorbable polymeric materials: correlation between the degradation profiles and corresponding tissue reactions

Benjamin M. Wu, H. Vinters, I. Yuki, 2010, Neuroradiology.

A Genetic Association Study of Single Nucleotide Polymorphisms in FGFR1OP2/wit3.0 and Long-Term Atrophy of Edentulous Mandible

J. Sinsheimer, H. Devlin, N. Garrett, 2011, PloS one.

Craniomaxillofacial Disorders and Solutions in Humans and Animals

B. Arzi, F. Verstraete, I. Nishimura, 2018, Journal of dental research.

Genetic Background of Implant Failure

I. Nishimura, 2013 .

A case report of leiomyoma of the mesentery.

I. Nishimura, N. Baba, T. Kuei, 1987 .

Thrombus organization and healing in the swine experimental aneurysm model. Part I. A histological and molecular analysis.

Benjamin M. Wu, H. Vinters, I. Yuki, 2007, Journal of neurosurgery.

Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Weixian Xi, T. Segura, C. Hamad, 2021, Nature Communications.

Epithelial and Mesenchymal Cell Biology Small Cytoskeleton-Associated Molecule , Fibroblast Growth Factor Receptor 1 Oncogene Partner 2 / Wound Inducible Transcript-3 . 0 ( FGFR 1 OP 2 / wit 3 . 0 ) , Facilitates Fibroblast-Driven Wound Closure

Ichiro Nishimura, Audrey Lin, A. Hokugo, 2010 .

Wound closure and wound management

A. Hokugo, I. Nishimura, Audrey Lin, 2010, Cell adhesion & migration.

Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat.

J. Fiorellini, N. Karimbux, I. Nishimura, 2003, Journal of periodontology.

Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery

A. Hokugo, V. John, I. Nishimura, 2017, Journal of drug delivery.

Erratum: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation

K. Kaur, C. McKenna, I. Nishimura, 2015, Oncotarget.

Alteration of collagen three-dimensional architecture in noncompliant human urinary bladder.

C. Sukotjo, K. Eilber, I. Nishimura, 2003, Advances in experimental medicine and biology.

Trabecular Bone Deterioration in col9a1+/− Mice Associated With Enlarged Osteoclasts Adhered to Collagen IX–Deficient Bone

A. Hokugo, H. Egusa, I. Nishimura, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

A. Hokugo, I. Nishimura, R. Jarrahy, 2021, bioRxiv.

Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity

Y. Gwack, M. Kang, I. Nishimura, 2021, Journal of dental research.

Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains the pharmacokinetics and osteonecrosis of the jaw in rats

A. Hokugo, C. McKenna, I. Nishimura, 2013 .

Structural variation of type XII collagen at its carboxyl-terminal generated by tissue specific alternative splicing

B. Olsen, N. Karimbux, I. Nishimura, 1997 .

The Molecular Biology of Collagens with Short Triple-Helical Domains

G. Vasios, P. Castagnola, Y. Muragaki, 1990 .

A new dimension in the extracellular matrix.

B. Olsen, Y. Ninomiya, I. Nishimura, 1989, Connective tissue research.

Efficacy and cytotoxicity of cationic-agent-mediated nonviral gene transfer into osteoblasts.

Y. Tabata, I. Nishimura, T. Ogawa, 2004, Journal of biomedical materials research. Part A.

Molecular Fingerprint Imaging to Identify Dental Caries Using Raman Spectroscopy

E. Marin, G. Pezzotti, I. Nishimura, 2020, Materials.

Collagen XII Mutation Disrupts Matrix Structure of Periodontal Ligament and Skin

C. Sukotjo, B. Olsen, I. Nishimura, 2000, Journal of dental research.

In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

K. Akiyoshi, E. Marin, G. Pezzotti, 2020, Materials.

Standardized Analysis of Mandibular Osteoradionecrosis in a Rat Model

J. Beumer, M. Steinberg, E. Abemayor, 2011, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Brachytherapy-mediated bone damage in a rat model investigating maxillary osteoradionecrosis.

J. Beumer, M. Steinberg, E. Abemayor, 2012, Archives of otolaryngology--head & neck surgery.

Mathematical filtering minimizes metallic halation of titanium implants in MicroCT images.

S. Osher, I. Nishimura, J. Ha, 2013, Journal - California Dental Association.

Oral Fibroblast Expression of wound-inducible transcript 3.0 (wit3.0) Accelerates the Collagen Gel Contraction in Vitro*

C. Sukotjo, I. Nishimura, Ben M. Wu, 2003, Journal of Biological Chemistry.

Interfacial shear strength of endosseous implants.

F. Butz, I. Nishimura, T. Ogawa, 2011, The International journal of oral & maxillofacial implants.

Molecular cloning of the complementary DNA encoding for the hamster TGF-alpha mature peptide.

D. Wong, M. Chou, I. Nishimura, 1991, Carcinogenesis.

Collagen XII Mutation Disrupts Matrix Structure of Periodontal Ligament and Skin

C. Sukotjo, N. Karimbux, I. Nishimura, 2000 .

Pilot study of the heterogeneous patterns of masticatory muscle coordination in nonpatient population.

I. Nishimura, K. Mushimoto, E. Mushimoto, 1995, The Journal of prosthetic dentistry.

Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy

I. Spigelman, S. Ruangsri, I. Nishimura, 2009, Molecular pain.

K. Kaur, I. Nishimura, So-Hyun Park, 2018, Oncoimmunology.

High throughput screening of biologically functional small molecules for modulating the expression of FGFR1OP2/wit3.0 in fibroblasts.

I. Nishimura, William Cheng, 2012, Journal of the California Dental Association.

during Experimental Tooth Movement Temporal and Spatial Expressions of Type XII Collagen in the Remodeling Periodontal Ligament

I. Nishimura, 2011 .

Differential effect of ionizing radiation exposure on multipotent and differentiation‐restricted bone marrow mesenchymal stem cells

P. Zuk, F. Mussano, S. Carossa, 2010, Journal of cellular biochemistry.