J. Hyttel

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Selective dopamine D1 and D2 receptor antagonists.

J. Hyttel, J. Arnt, M. Van den Berghe, 1989, Psychopharmacology series.

The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters.

J. Larsen, J. Hyttel, J. Arnt, 2009, Acta pharmacologica et toxicologica.

Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers

K. Bogeso, J. Larsen, J. Hyttel, 2004, Psychopharmacology.

Effects of S (+)-3-phenethyl-PP, a putative dopamine autoreceptors agonist with greater autoreceptor selectivity than 3-PPP enantiomers.

K. Bogeso, J. Larsen, J. Hyttel, 1984, European journal of pharmacology.

Effects of putative dopamine autoreceptor agonists in pharmacological models related to dopaminergic and neuroleptic activity.

J. Larsen, J. Hyttel, J. Arnt, 1982, European journal of pharmacology.

Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.

J. Hyttel, J. Arnt, John Hyttel, 1984, European journal of pharmacology.

3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.

K. Bogeso, T. Liljefors, J. Hyttel, 1985, Journal of medicinal chemistry.

The neuropharmacological profile of tefludazine, a potential antipsychotic drug with dopamine and serotonin receptor antagonistic effects

K. Bogeso, J. Larsen, J. Hyttel, 1986 .

Differential reversal by scopolamine of effects of neuroleptics in rats. Relevance for evaluation of therapeutic and extrapyramidal side-effect potential.

J. Hyttel, J. Arnt, A. V. Christensen, 1981, Neuropharmacology.

Neurochemical Profile of Lu 19‐005, a Potent Inhibitor of Uptake of Dopamine, Noradrenaline, and Serotonin

J. Larsen, J. Hyttel, John Hyttel, 1985, Journal of neurochemistry.

Inhibition of [3H]dopamine accumulation in rat striatal synaptosomes by psychotropic drugs.

J. Hyttel, 1978, Biochemical pharmacology.

Levels of HVA and DOPAC in mouse corpus striatum in the supersensitivity phase after neuroleptic treatment

J. Hyttel, 1977, Journal of neurochemistry.

Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats

J. Hyttel, J. Arnt, 2005, Journal of Neural Transmission.

A comparison of the effect of neuroleptic drugs on the binding of 3H-haloperidol and 3H-cis(Z)-flupenthixol and on adenylate cyclase activity in rat striatal tissue in vitro

J. Hyttel, 1978 .

Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.

K. G. Jensen, K. Bogeso, J. Hyttel, 1988, Journal of medicinal chemistry.

Biochemical and pharmacological differentiation of neuroleptic effect on dopamine D-1 and D-2 receptors.

J. Hyttel, A. V. Christensen, 1983, Journal of neural transmission. Supplementum.

Inactivation of dopamine D-1 or D-2 receptors differentially inhibits stereotypies induced by dopamine agonists in rats.

J. Hyttel, J. Arnt, E. Meier, 1988, European journal of pharmacology.

EEDQ, a tool for ex vivo measurement of occupancy of D-1 and D-2 dopamine receptors.

G. Nowak, J. Hyttel, J. Arnt, 1988, European journal of pharmacology.

Characterization of 3H-GABA receptor binding to rat brain synaptosomal membranes: Effect of non GABAergic compounds

J. Hyttel, 1979, Psychopharmacology.

Further evidence that 3H-cis(Z)flupenthixol binds to the adenylate cyclase-associated dopamine receptor (D-1) in rat corpus striatum

J. Hyttel, 2004, Psychopharmacology.

The St 587-induced flexor reflex in pithed rats: a model to evaluate central alpha 1-receptor blocking properties.

J. Hyttel, T. Skarsfeldt, 1986, European journal of pharmacology.

Neurochemical and in vivo pharmacological profile of sertindole, a limbic‐selective neuroleptic compound

C. Sánchez, J. Hyttel, J. Arnt, 1991 .

The acute effect of sertindole on brain 5-HT2, D2 and α1 receptors (ex vivo radioreceptor binding studies)

J. Nielsen, G. Nowak, J. Hyttel, 2005, Journal of Neural Transmission / General Section JNT.

Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram

J. Hyttel, J. Arnt, K. Overø, 2004, Psychopharmacology.

Interaction of the antiemetic metopimazine and anticancer agents with brain dopamine D2, 5-hydroxytryptamine3, histamine H1, muscarine cholinergic and α1 receptors

J. Hyttel, J. Herrstedt, J. Pedersen, 2004, Cancer Chemotherapy and Pharmacology.

Effect of prolonged treatment with neuroleptics on dopamine D-1 and D-2 receptor density in corpus striatum of mice.

J. Hyttel, 2009, Acta pharmacologica et toxicologica.

J. Hyttel, 1981, Life sciences.

Changes in catecholamine concentrations and synthesis rate in mouse brain during the ‘supersensitivity’ phase after treatment with neuroleptic drugs

J. Hyttel, I. M. Nielsen, 1976, Journal of neurochemistry.

LONG‐TERM EFFECTS OF TEFLUTIXOL ON THE SYNTHESIS AND ENDOGENOUS LEVELS OF MOUSE BRAIN CATECHOLAMINES

J. Hyttel, 1975, Journal of neurochemistry.

Dopamine-receptor binding and adenylate-cyclase activity in mouse striatal tissue in the supersensitivity phase after neuroleptic treatment

J. Hyttel, 1978, Psychopharmacology.

The dopamine D-1 antagonist SCH 23390 inhibits apomorphine but not pergolide induced rotation.

U. Ungerstedt, M. Herrera-Marschitz, J. Hyttel, 1984, Acta physiologica Scandinavica.

Serotonin-selective antidepressants.

J. Larsen, J. Hyttel, 2009, Acta pharmacologica et toxicologica.

Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.

K. Bogeso, J. Hyttel, J. Arnt, 1995, Journal of medicinal chemistry.

Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171

J. Hyttel, 1977, Psychopharmacology.

Parallel decrease in the density of dopamine D1 and D2 receptors in corpus striatum of rats from 3 to 25 months of age.

J. Hyttel, 1989, Pharmacology & toxicology.

J. Hyttel, 1987, Pharmacology & toxicology.

Prolonged treatment with the GABA agonist THIP increases dopamine receptor binding more than it changes dopaminergic behaviour in mice

J. Hyttel, A. V. Christensen, 1981 .

Effect of piflutixol on turnover of catecholamines in mouse brain and rat corpus striatum.

J. Hyttel, 2009, Acta pharmacologica et toxicologica.

Effect of neuroleptics on the disappearance rate of [14C] labelled catecholamines formed from [14C]tyrosine in mouse brain

J. Hyttel, 1974, The Journal of pharmacy and pharmacology.

SCH 23390 - the first selective dopamine D-1 antagonist.

J. Hyttel, 1983, European journal of pharmacology.

Effect of a dopamine D-1 agonist in rats treated chronically with zuclopenthixol.

B. Glenthøj, J. Hyttel, J. Arnt, 1990, Life sciences.

Target size of dopamine D-1 receptors in rat corpus striatum estimated by binding of the benzazepine 3H-SCH 23390.

J. Hyttel, O. Gredal, M. Nielsen, 1987, Pharmacology & toxicology.

Preferential Labelling of Adenylate Cyclase Coupled Dopamine Receptors with Thioxanthene Neuroleptics

J. Hyttel, 1982 .

Effects of a single administration of clozapine on mouse brain catecholamines.

J. Hyttel, 2009, Acta pharmacologica et toxicologica.

In vivo pharmacology of irindalone, a 5‐HT2 receptor antagonist with predominant peripheral effects

K. Bogeso, J. Hyttel, J. Arnt, 1989 .

Adaptational phenomena in neuroleptic treatment.

J. Hyttel, A. V. Christensen, I. M. Nielsen, 1978, Advances in biochemical psychopharmacology.

Functional evidence for selective dopamine D-1 receptor blockade by SCH 23390

J. Hyttel, 1984, Neuropharmacology.

Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)

J. Hyttel, 1994, International clinical psychopharmacology.

The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

K. Bogeso, J. Hyttel, J. Perregaard, 2005, Journal of Neural Transmission / General Section JNT.

Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity

J. Hyttel, John Hyttel, 1982, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Studies on lysosome stabilization by antirheumatic drugs.

J. Hyttel, A. Jørgensen, 1970, European journal of pharmacology.

Neuropharmacological properties of amitriptyline, nortriptyline and their metabolites.

J. Hyttel, A. V. Christensen, B. Fjalland, 2009, Acta pharmacologica et toxicologica.

Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.

T. Liljefors, J. Hyttel, J. Perregaard, 1996, Journal of medicinal chemistry.

Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.

K. Bogeso, J. Hyttel, J. Arnt, 1992, Journal of medicinal chemistry.

The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice

C. Sánchez, J. Hyttel, J. Arnt, 2005, Psychopharmacology.

Comparison of the Effects of Antidepressants and Their Metabolites on Reuptake of Biogenic Amines and on Receptor Binding

C. Sánchez, J. Hyttel, Connie Sánchez, 1999, Cellular and Molecular Neurobiology.

Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro

J. Hyttel, John Hyttel, 1978, Psychopharmacology.

Central 5-HTP decarboxylase inhibiting properties of Ro 4-4602 in relation to 5-HTP potentiation in mice.

J. Hyttel, B. Fjalland, 1972, European journal of pharmacology.

Peripheral and central muscarinic receptor affinity of psychotropic drugs

J. Hyttel, A. V. Christensen, B. Fjalland, 1977, Naunyn-Schmiedeberg's Archives of Pharmacology.

Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro.

C. Sánchez, J. Hyttel, J. Arnt, 1992, European journal of pharmacology.

Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.

J. Larsen, J. Hyttel, J. Arnt, 1984, Life sciences.

Receptor-binding profiles of neuroleptics.

J. Larsen, J. Hyttel, J. Arnt, 1985, Psychopharmacology. Supplementum.

Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI.

J. Hyttel, J. Arnt, John Hyttel, 1989, European journal of pharmacology.

Effects of neuroleptics on 3H-haloperidol and 3H-cis(Z)-flupenthixol binding and on adenylate cyclase activity in vitro.

J. Hyttel, John Hyttel, 1978, Life sciences.

Inhibition of SKF 38393- and pergolide-induced circling in rats with unilateral 6-OHDA lesion is correlated to dopamine D-1 and D-2 receptor affinitiesin vitro

J. Hyttel, J. Arnt, 2005, Journal of Neural Transmission.

Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats.

J. Hyttel, J. Arnt, J. Perregaard, 1987, European journal of pharmacology.

Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.

I. Creese, S. Leff, L. Adams, 1981, European journal of pharmacology.

Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors.

C. Sánchez, J. Hyttel, 1994, European journal of pharmacology.

Characterization of dopamine D-1 and D-2 receptors.

J. Hyttel, J. Arnt, 1986, Advances in experimental medicine and biology.

L-5-HTP facilitates the electrically stimulated flexor reflex in pithed rats: evidence for 5-HT2-receptor mediation.

J. Hyttel, J. Arnt, T. Skarsfeldt, 1990, European journal of pharmacology.

Neurochemical profile in vitro of irindalone: A5‐HT2‐receptor antagonist

K. Bogeso, J. Larsen, J. Hyttel, 1988 .

NEUROCHEMICAL PARAMETERS IN THE HYPERRESPONSIVE PHASE AFTER A SINGLE DOSE OF NEUROLEPTICS TO MICE

J. Hyttel, 1979, Journal of neurochemistry.

Pharmacological in vitro characterization of the arecoline bioisostere, Lu 25‐109‐T, a muscarinic compound with M1‐agonistic and M2/M3‐antagonistic properties

J. Hyttel, H. Pedersen, E. Meier, 1997 .

Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats

J. Hyttel, J. Arnt, 2004, Psychopharmacology.

Dopamine D-2 agonists with high and low efficacies: differentiation by behavioural techniques

J. Hyttel, J. Arnt, 2005, Journal of Neural Transmission / General Section JNT.

Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats.

K. Bogeso, J. Hyttel, J. Arnt, 1988, Pharmacology & toxicology.

Pharmacology in vivo of the phenylindan derivative, lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain

J. Hyttel, J. Arnt, A. V. Christensen, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Changes in rat dopamine- and serotonin function in vivo after prolonged administration of the specific 5-HT uptake inhibitor, citalopram

J. Hyttel, J. Arnt, Ruth H Olsen, 2004, Psychopharmacology.

Ontogeny of Dopamine D1 Receptors in Rat Striatum

J. Hyttel, W. Zeng, L. Murrin, 1988, Journal of neurochemistry.

5-HT-uptake inhibition potentiates antinociception induced by morphine, pethidine, methadone and ketobemidone in rats.

J. Larsen, J. Hyttel, 1985, Acta pharmacologica et toxicologica.

Flupentixol and dopamine receptor selectivity

J. Hyttel, 2004, Psychopharmacology.

Changes in dopamine synthesis rate in the supersensitivity phase after treatment with a single dose of neuroleptics

J. Hyttel, 1977, Psychopharmacology.

Selective inactivation of dopamine D1 and D2 receptors in 6-hydroxydopamine-lesioned rats: evidence that the effect of D1 and D2 agonists can be expressed in the absence of the heterologous DA receptor.

J. Hyttel, J. Arnt, 1989, Pharmacology & toxicology.

Effect of a selective 5-HT uptake inhibitor--Lu 10-171--on rat brain 5-HT turnover.

J. Hyttel, 2009, Acta pharmacologica et toxicologica.

Further studies of the mechanism behind scopolamine-induced reversal of antistereotypic and cataleptogenic effects of neuroleptics in rats.

J. Hyttel, J. Arnt, T. Bach-Lauritsen, 2009, Acta pharmacologica et toxicologica.

Serotonin uptake inhibitors

J. Hyttel, 2017, Reactions Weekly.

Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.

K. Bogeso, T. Liljefors, A. Carlsson, 1990, Journal of medicinal chemistry.

Down-regulation of dopamine D-2, 5-HT2 receptors and β-adrenoceptors in rat brain after prolonged treatment with a new potential antidepressant, Lu 19-005

G. Nowak, J. Hyttel, J. Arnt, 2005, Journal of Neural Transmission.

Differentiation of classical and novel antipsychotics using animal models

J. Hyttel, J. Arnt, T. Skarsfeldt, 1997 .

Neurochemical and behavioural profile of Lu 17‐133, (±)‐trans‐4‐[3‐(3,4‐dichlorophenyl)‐indan‐1‐yl]‐1‐piperazineethanol, an inhibitor of the uptake of dopamine and noradrenaline

K. Bogeso, J. Larsen, J. Hyttel, 1988 .

Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: effect on dopaminergic and serotonergic functions.

J. Hyttel, J. Arnt, K. Overø, 1984, Polish journal of pharmacology and pharmacy.

PHARMACOLOGICAL PROFILE OF THE ATYPICAL NEUROLEPTIC SERTINDOLE

B. Costall, G. Nowak, J. Hyttel, 1992, Clinical neuropharmacology.

Comparative pharmacology of selective serotonin re-uptake inhibitors (SSRIs)

J. Hyttel, 1993 .

Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.

K. Bogeso, J. Hyttel, J. Arnt, 1993, Journal of medicinal chemistry.

Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.

J. Hyttel, J. Perregaard, K. Andersen, 1992, Journal of medicinal chemistry.

Characterization of binding of3H-SCH 23390 to dopamine D-1 receptors. Correlation to other D-1 and D-2 measures and effect of selective lesions

J. Hyttel, J. Arnt, J. Hyttel, 2005, Journal of Neural Transmission.

Distinct target size of dopamine D-1 and D-2 receptors in rat striatum.

V. Klimek, J. Hyttel, M. Nielsen, 1984, Life sciences.

Endogenous levels and turnover of catecholamines in mouse brain after repeated administration of haloperidol

J. Hyttel, 1974, Psychopharmacologia.

DO DOPAMINE D-1 RECEPTORS CONTRIBUTE TO THE ANTIPSYCHOTIC EFFECTS AND SIDE EFFECTS OF NEUROLEPTIC DRUGS?

J. Hyttel, A. V. Christensen, 1984 .

The pharmacology of a new potent, long acting neuroleptic, piflutixol.

J. Hyttel, O. Svendsen, A. V. Christensen, 2009, Acta pharmacologica et toxicologica.