A. Nath

发表

The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations.

C. O’Hern, Adam J. Trexler, E. Rhoades, 2012, Biophysical journal.

Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors

W. Atkins, A. Nath, M. Zientek, 2010, Drug Metabolism and Disposition.

Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins.

S. Sligar, W. Atkins, A. Nath, 2007, Biochemistry.

Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance

M. Chiu, Michael J Watson, W. Atkins, 2018, Drug Metabolism and Disposition.

A quantitative index of substrate promiscuity.

W. Atkins, A. Nath, Abhinav Nath, 2008, Biochemistry.

Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.

A. Miranker, E. Rhoades, A. Nath, 2015, Biochemistry.

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

R. Klevit, M. Guttman, Amanda F. Clouser, 2019, bioRxiv.

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

R. Klevit, M. Guttman, Amanda F. Clouser, 2019, eLife.

Inferring Mechanistic Parameters from Amyloid Formation Kinetics by Approximate Bayesian Computation.

E. Nakatani-Webster, A. Nath, Abhinav Nath, 2017, Biophysical journal.

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

R. Klevit, Amanda F. Clouser, A. Nath, 2018, The Journal of Biological Chemistry.

In vitro to in vivo extrapolation of the complex drug‐drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation

N. Isoherranen, A. Nath, Jennifer E. Sager, 2017, Biochemical pharmacology.

Adenylylation and Catalytic Properties of Mycobacterium tuberculosis Glutamine Synthetase Expressed in Escherichia coli versus Mycobacteria*

D. Sherman, M. Hickey, W. Atkins, 2004, Journal of Biological Chemistry.

Release of a disordered domain enhances HspB1 chaperone activity toward tau

R. Klevit, Thanh Pham, A. Nath, 2020, Proceedings of the National Academy of Sciences.

CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins

A. Zelter, N. Isoherranen, A. Nath, 2018, Molecular Pharmacology.

A functional role for intrinsic disorder in the tau-tubulin complex

E. Rhoades, A. Melo, A. Nath, 2016, Proceedings of the National Academy of Sciences.

A Theoretical Validation of the Substrate Depletion Approach to Determining Kinetic Parameters

W. Atkins, A. Nath, 2006, Drug Metabolism and Disposition.

Towards a combinatorial approach for the prediction of immunoglobulin G half-life and clearance

Atkins, M. Chiu, Michael J Watson, 2018 .

Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR.

D. Braddock, E. Rhoades, A. Nath, 2010, Biochemistry.

Folded small molecule manipulation of islet amyloid polypeptide.

A. Miranker, Mark A. Brown, A. Nath, 2014, Chemistry & biology.

Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

W. Atkins, A. Nath, J. Lampe, 2008, Archives of biochemistry and biophysics.

Nile Red is a fluorescent allosteric substrate of cytochrome P450 3A4.

W. Atkins, A. Nath, J. Lampe, 2008, Biochemistry.

Ligand Binding to Cytochrome P450 3A4 in Phospholipid Bilayer Nanodiscs

S. Sligar, Y. Grinkova, W. Atkins, 2007, Journal of Biological Chemistry.

Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae

Maitreya J. Dunham, M. Dunham, D. Fowler, 2017, Drug Metabolism and Disposition.

The Rational Discovery of a Tau Aggregation Inhibitor.

A. Nath, D. Baggett, 2018, Biochemistry.

A Conformational Transition Observed in Single HIV-1 Gag Molecules during In Vitro Assembly of Virus-Like Particles

James B. Munro, W. Mothes, A. Rein, 2014, Journal of Virology.

A flash in the pan: Dissecting dynamic amyloid intermediates using fluorescence

E. Rhoades, A. Nath, 2013, FEBS letters.

Rapid formation of peptide/lipid co-aggregates by the amyloidogenic seminal peptide PAP248-286

L. Maibaum, A. Nath, S. He, 2020, bioRxiv.

Functional Promiscuity Correlates with Conformational Heterogeneity in A-class Glutathione S-Transferases*

W. Atkins, A. Roberts, A. Nath, 2007, Journal of Biological Chemistry.

Structure-Activity Relationships of Novel Tau Ligands: Passive Fibril Binders and Active Aggregation Inhibitors.

A. Nath, D. Baggett, Abhinav Nath, 2022, ACS chemical biology.

Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs.

Adam J. Trexler, A. Miranker, E. Rhoades, 2010, Methods in enzymology.

A membrane-bound antiparallel dimer of rat islet amyloid polypeptide.

A. Miranker, E. Rhoades, A. Nath, 2011, Angewandte Chemie.

MitoNEET's Reactivity of Lys55 toward Pyridoxal Phosphate Demonstrates its Activity as a Transaminase Enzyme.

W. Geldenhuys, M. Menze, A. Nath, 2022, ACS chemical biology.

Microsoft Word-43909582-file00

W. Atkins, A. Nath, B. Burke, 2010 .

Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2

Travis B. Smith, Catherine M. Lockhart, A. Rettie, 2017, British Journal of Ophthalmology.

Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum.

M. Chiu, W. Atkins, A. Nath, 2017, Biochemistry.

Protein-induced photophysical changes to the amyloid indicator dye thioflavin T

A. Miranker, Y. Xiong, A. Nath, 2010, Proceedings of the National Academy of Sciences.

Identification of a novel tedizolid resistance mutation in rpoB of MRSA after in vitro serial passage.

S. Salipante, A. Nath, B. Werth, 2020, The Journal of antimicrobial chemotherapy.

Identification of a novel tedizolid resistance mutation in rpoB of methicillin-resistant Staphylococcus aureus

S. Salipante, A. Nath, B. Werth, 2019, bioRxiv.

Using a FRET Library with Multiple Probe Pairs To Drive Monte Carlo Simulations of α-Synuclein.

Yi-Chih Lin, E James Petersson, John J Ferrie, 2018, Biophysical journal.

Single Molecule Studies of Unstructured Protein Function and Dynamics

C. O’Hern, A. Miranker, E. Rhoades, 2011 .

Catalytic versus inhibitory promiscuity in cytochrome P450s: implications for evolution of new function.

W. Atkins, N. Isoherranen, A. Nath, 2011, Biochemistry.

Expression and functional characterization of breast cancer-associated cytochrome P 450 4 Z 1 in Saccharomyces cerevisiae

M. Dunham, D. Fowler, A. Rettie, 2017 .

Molecular simulations of the fluctuating conformational dynamics of intrinsically disordered proteins.

C. O’Hern, E. Rhoades, W. Smith, 2012, Physical review. E, Statistical, nonlinear, and soft matter physics.

Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.

W. Atkins, A. Nath, M. Li, 2017, Biochemistry.

Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.

A. Miranker, E. Rhoades, A. Nath, 2015, Biochemistry.

A membrane-bound antiparallel dimer of rat islet amyloid polypeptide.

A. Miranker, E. Rhoades, A. Nath, 2011, Angewandte Chemie.

The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations.

C. O’Hern, Adam J. Trexler, E. Rhoades, 2012, Biophysical journal.

Inferring Mechanistic Parameters from Amyloid Formation Kinetics by Approximate Bayesian Computation.

E. Nakatani-Webster, A. Nath, 2017, Biophysical journal.

The Utility of Mixed Effects Models in the Evaluation of Complex Genomic Traits In Vitro

N. Isoherranen, K. Thummel, A. Nath, 2023, Drug Metabolism and Disposition.

Low molecular weight ligands bind to CYP3A4 via a branched induced fit mechanism: Implications for O2 binding.

W. Atkins, A. Nath, J. Hackett, 2023, Archives of biochemistry and biophysics.

Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy.

E. Rhoades, W. Atkins, A. Nath, 2008, Journal of the American Chemical Society.

Probing Interactions of Therapeutic Antibodies with Serum via Second Virial Coefficient Measurements

W. Atkins, A. Nath, Hayli A. Larsen, 2021, bioRxiv.